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Hämäläinen et al., 1995 - Google Patents

Quantitative Polymerase Chain Reaction of Lysyl Oxidase mRNA in Malignantly Transformed Human Cell Lines Demonstrates That Their Low Lysyl Oxidase Activity Is …

Hämäläinen et al., 1995

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Document ID
11176656258461569746
Author
Hämäläinen E
Kemppainen R
Kuivaniemi H
Tromp G
Vaheri A
Pihlajaniemi T
Kivirikko K
Publication year
Publication venue
Journal of Biological Chemistry

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Lysyl oxidase (EC 1.4. 3.13), an extracellular copper amino oxidase, initiates the cross- linking of collagens and elastin by catalyzing oxidative deamination of the ɛ-amino group in certain lysine and hydroxylysine residues. We developed here a polymerase chain reaction …
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Hybridisation probes
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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