[go: up one dir, main page]

McLean et al., 1989 - Google Patents

Synthesis and pharmacological evaluation of conjugates of prednisolone and non-steroidal anti-inflammatory agents

McLean et al., 1989

Document ID
10958486488055414143
Author
McLean H
Lee H
Publication year
Publication venue
Steroids

External Links

Snippet

Esters of prednisolone with ibuprofen and indomethacin were prepared by coupling the 21- hydroxy moiety of the glucocorticoid to the carboxylic group of the non-steroidal anti- inflammatory agents. The local and systemic anti-inflammatory activities of the conjugates …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/899Menstrual disorder
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Similar Documents

Publication Publication Date Title
AT395157B (en) METHOD FOR PRODUCING NEW SUBSTITUTED ANDROSTA-1,4-DIEN-3,17-DIONES
DE3871965T2 (en) STEROID 5 ALPHA REDUCTASE INHIBITORS.
Kwon et al. New steroidal antiinflammatory antedrugs: steroidal [16. alpha., 17. alpha.-d]-3'-carbethoxyisoxazolines
US5674861A (en) Fluorinated steroids
Shashoua et al. . gamma.-Aminobutyric acid esters. I. Synthesis, brain uptake, and pharmacological studies of aliphatic and steroid esters of. gamma.-aminobutyric acid
CZ252995A3 (en) Novel prednisolone derivatives, process of their preparation and pharmaceutical compositions containing thereof
NO311646B1 (en) androstene
EP1772462A2 (en) Steroid sulfamates, method for the production and use thereof
Bodor et al. Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems
Andersson et al. In vitro biotransformation of glucocorticoids in liver and skin homogenate fraction from man, rat and hairless mouse
AU646066B2 (en) Corticoid-17-alkylcarbonates substituted in the 17-position process for their preparation and pharmaceuticals containing them
HU183717B (en) Process for preparing 4-pregnene derivatives
US4820700A (en) Novel androstane-17β-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588530A (en) Anti-inflammatory prednisolone steroids
EP0165902B1 (en) Epoxy steroids
EP0200692B1 (en) Androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
McLean et al. Synthesis and pharmacological evaluation of conjugates of prednisolone and non-steroidal anti-inflammatory agents
FI57114B (en) FOERFARANDE FOER FRAMSTAELLNING AV NYA VID CANCERTERAPI ANVAENDBARA TERAPEUTISKT VAERDEFULLA ENOLESTRAR AV STEROIDER
Kim et al. Synthesis of new antiinflammatory steroidal 20-carboxamides:(20R)-and (20S)-21-(N-substituted amino)-11. beta., 17, 20-trihydroxy-3, 21-dioxo-1, 4-pregnadiene
Hagen et al. Testosterone biosynthesis in the canine in vivo following infusion of 17α-hydroxy [4-14C] progesterone and [7α-3H] dehydroepiandrosterone via the spermatic artery
Heiman et al. New steroidal anti-inflammatory antedrugs: methyl 3, 20-dioxo-9α-fluoro-11β, 17α, 21-trihydroxy-1, 4-pregnadiene-16α-carboxylate and methyl 21-acetyloxy-3, 20-dioxo-11β, 17α-dihydroxy-9α-fluoro-1, 4-pregnadiene-16α-carboxylate
Lee et al. A novel approach to the discovery of non-systemic anti-inflammatory steroids; antedrug
Bird et al. Topical anti-inflammatory activity of esters of steroid 21-oic acids
PH26685A (en) Novel steroid derivatives pharmaceutical compositions containing them and method of use thereof
RU2081879C1 (en) 16α,17a-ACETAL-SUBSTITUTED ANDROSTANE-17b-CARBOXYLIC ACID ESTERS OR THEIR STEREOISOMERS