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Prommer, 2005 - Google Patents

Aprepitant (EMEND) the role of substance P in nausea and vomiting

Prommer, 2005

Document ID
10072006715285536632
Author
Prommer E
Publication year
Publication venue
Journal of pain & palliative care pharmacotherapy

External Links

Snippet

Aprepitant (EMEND) is the first commercially available drug from a new class o agents, the Substance P/neurokinin NK-1 receptor antagonists. Aprepitant is indicated for preven tion of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated wit …
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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