[go: up one dir, main page]

ZA984640B - 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives their preparations and use - Google Patents

9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives their preparations and use

Info

Publication number
ZA984640B
ZA984640B ZA984640A ZA984640A ZA984640B ZA 984640 B ZA984640 B ZA 984640B ZA 984640 A ZA984640 A ZA 984640A ZA 984640 A ZA984640 A ZA 984640A ZA 984640 B ZA984640 B ZA 984640B
Authority
ZA
South Africa
Prior art keywords
monocyclic
membered heteroaryl
heteroaryl group
alkynyl
cycloalkyl
Prior art date
Application number
ZA984640A
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Simon Feldbaek Nielsen
Elsebet Ostergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of ZA984640B publication Critical patent/ZA984640B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA984640A 1997-05-30 1998-05-29 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives their preparations and use ZA984640B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK62897 1997-05-30

Publications (1)

Publication Number Publication Date
ZA984640B true ZA984640B (en) 1998-12-11

Family

ID=8095743

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA984640A ZA984640B (en) 1997-05-30 1998-05-29 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives their preparations and use

Country Status (12)

Country Link
US (1) US6392045B1 (xx)
EP (1) EP0984966B1 (xx)
JP (1) JP2002502383A (xx)
CN (1) CN1205210C (xx)
AT (1) ATE231861T1 (xx)
AU (1) AU736798B2 (xx)
CA (1) CA2289570C (xx)
DE (1) DE69811070T2 (xx)
DK (1) DK0984966T3 (xx)
NZ (1) NZ500645A (xx)
WO (1) WO1998054182A1 (xx)
ZA (1) ZA984640B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2278700A (en) * 1999-01-28 2000-08-18 Neurosearch A/S Novel azabicyclo derivatives and their use
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
HUP0200332A3 (en) * 1999-01-29 2002-09-30 Abbott Lab Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands pharmaceutical compositions comprising thereof and their use
WO2000066586A1 (en) * 1999-05-04 2000-11-09 Neurosearch A/S Heteroaryl diazabicycloalkanes, their preparation and use
JP2003516988A (ja) 1999-12-14 2003-05-20 ニューロサーチ、アクティーゼルスカブ 新規ヘテロアリール−ジアザビシクロアルカン類
MY137020A (en) * 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
CA2409644A1 (en) 2000-05-25 2001-11-29 Targacept, Inc. Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands
WO2001091925A1 (en) * 2000-05-31 2001-12-06 Board Of Control Of Michigan Technological University Compositions and methods for wood preservation
AU2001265831B9 (en) * 2000-07-04 2006-08-31 Neurosearch A/S Aryl and heteroaryl diazabicycloalkanes, their preparation and use
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
MXPA03003264A (es) * 2000-10-13 2003-06-06 Neurosearch As Tratamiento de trastornos afectivos mediante la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergica.
DE60203007T2 (de) * 2001-06-01 2005-07-07 Neurosearch A/S Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren
US7238715B2 (en) 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
CN1735414A (zh) † 2002-12-06 2006-02-15 北岸长岛犹太人研究学院 用α7受体结合类胆碱激动剂抑制炎症
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
ATE495178T1 (de) 2005-02-16 2011-01-15 Neurosearch As Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
BRPI0617772A2 (pt) * 2005-12-06 2011-08-09 Neurosearch As composto, composição farmacêutica, e, uso de um composto
EP1984366B1 (en) * 2006-02-10 2010-12-15 NeuroSearch A/S 3, 9-diazabicyclo ý3.3. 1¨nonane derivatives and their use as monoamine?neurotransmitter re-uptake inhibitors
AU2007213669A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2641685A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists
EP1987032A1 (en) 2006-02-14 2008-11-05 NeuroSearch A/S 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists
TW200845977A (en) 2007-03-30 2008-12-01 Targacept Inc Sub-type selective azabicycloalkane derivatives
KR20110075044A (ko) 2007-04-02 2011-07-05 파킨슨즈 인스티튜트 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물
US8697722B2 (en) 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
WO2009058120A1 (en) * 2007-11-02 2009-05-07 Sri International Nicotinic acetylcholine receptor modulators
EP2288609A2 (en) * 2008-06-10 2011-03-02 NeuroSearch A/S Indolyl-pyridazinyl-diazabicyclononane derivatives in labelled and unlabelled form and their use in diagnostic methods
EP2331522B1 (en) 2008-08-01 2013-09-18 Purdue Pharma LP Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof
JP5840143B2 (ja) 2010-01-11 2016-01-06 アストライア セラピューティクス， エルエルシーＡｓｔｒａｅａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ ニコチン性アセチルコリン受容体モジュレーター
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
AU2018205529B2 (en) 2017-01-06 2023-08-10 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
DE1174793B (de) * 1962-11-13 1964-07-30 Boehringer & Soehne Gmbh Verfahren zur Herstellung von 3ª‡-Phenyl-granatanen und ihren Hydrohalogeniden
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
EP0093488A3 (en) 1982-03-18 1984-05-23 Beecham Group Plc Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
CA2109585C (en) * 1991-05-29 2000-02-15 David S. Garvey Isoxazole and isothiazole compounds that enhance cognitive function
JPH11512443A (ja) * 1995-09-22 1999-10-26 ノボ ノルディスク アクティーゼルスカブ 新規な置換アザ環式またはアザ二環式化合物
ID22349A (id) * 1996-11-26 1999-09-30 Zeneca Ltd Turunan dari 8-azabisiklo [3.2.1] oktana-, 8-azabisiklo [3.2.1] okt-6-ena-, 9-azabisiklo-[3.3.1] nonana-, 9-aza-3-oksabisiklo [3.3.1] nonana- dan 9-aza-3-tiobisiklo [3.3.1] nonana, pembuatannya dan penggunaannya sebagai insektisida

Also Published As

Publication number Publication date
DE69811070D1 (de) 2003-03-06
NZ500645A (en) 2001-06-29
ATE231861T1 (de) 2003-02-15
US6392045B1 (en) 2002-05-21
JP2002502383A (ja) 2002-01-22
DK0984966T3 (da) 2003-05-05
CA2289570C (en) 2007-04-03
CN1205210C (zh) 2005-06-08
WO1998054182A1 (en) 1998-12-03
EP0984966B1 (en) 2003-01-29
AU7426098A (en) 1998-12-30
CN1257500A (zh) 2000-06-21
CA2289570A1 (en) 1998-12-03
DE69811070T2 (de) 2003-10-02
AU736798B2 (en) 2001-08-02
EP0984966A1 (en) 2000-03-15

Similar Documents

Publication Publication Date Title
ZA984640B (en) 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives their preparations and use
CA2289574A1 (en) 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
AR002011A1 (es) Compuestos derivados de piperidina, sus sales y n-oxidos, procedimiento de preparacion y composiciones farmaceuticas.
TW367327B (en) Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use
NO942316L (no) Isatinderivater, fremgangsmåter for deres fremstilling og farmasöytisk preparat omfattende slike derivater
HUP0300641A2 (hu) Triazaspiro[5.5]undekán-származékok és hatóanyagként ezeket tartalmazó gyógyszerkészítmények
IL123583A0 (en) 8-Azabicyclo [3,2,1] oct-2-ene derivatives their preparation and use
ATE254618T1 (de) Spiro chinuclidin-derivate, ihre herstellung und verwendung
MX9709951A (es) Derivados de benzamida y su uso como antagonistas de vasopresina.
BR9611300A (pt) Derivados de tropano em fusão suas preparações e uso
SE0101579D0 (sv) New compounds
AU2267495A (en) Benzamide derivatives as vasopressin antagonists
ES468173A1 (es) Un procedimiento para la preparacion de derivados de morfina
HK1032234A1 (en) Azaring-ether derivatives and their use as nicotinic ach receptor modulators.
MY120033A (en) 1,2,3,4- tetrahydro- benzofuro[3,2-c] pyridine derivatives
ZA984638B (en) Azacyclooctane and heptane derivatives their preparation and use
DE3264708D1 (en) 4-aryloxy-1,2,3,4-tetrahydroisoquinolines, and intermediates, a process for preparing the same, a pharmaceutical composition containing the same and their use as medicaments
BG105331A (en) BENZOTHIENO[3,4-c]PYRIDINES AS ALPHA2 ANTAGONISTS
EP1116486A4 (en) MEDICAL COMPOSITION CONTAINING NITROETHENAMINE DERIVATIVES OR SALTS AS ACTIVE INGREDIENTS
AU2003260569A1 (en) Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics
ES8200668A1 (es) Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina
CO4920233A1 (es) Acidos aminobutiricos gamma substituidos como agentes farmaceuticos