ZA977301B - IL-8 receptor antagonists. - Google Patents

IL-8 receptor antagonists.

Info

Publication number: ZA977301B
Authority: ZA; South Africa
Prior art keywords: receptor antagonists; antagonists; receptor
Prior art date: 1996-08-15

Application number

ZA9707301A

Other languages

English (en)

Inventor

Deborah Lynn Bryan

John Gerald Gleason

Katherine L Widdowson

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-15

Filing date

1997-08-14

Publication date

1998-02-16

1997-08-14 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1998-02-16 Publication of ZA977301B publication Critical patent/ZA977301B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA9707301A 1996-08-15 1997-08-14 IL-8 receptor antagonists. ZA977301B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2341496P	1996-08-15	1996-08-15

Publications (1)

Publication Number	Publication Date
ZA977301B true ZA977301B (en)	1998-02-16

Family

ID=21814968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9707301A ZA977301B (en)	1996-08-15	1997-08-14	IL-8 receptor antagonists.

Country Status (18)

Country	Link
US (1)	US6204294B1 (zh)
EP (1)	EP0929302A4 (zh)
JP (1)	JP2000516619A (zh)
KR (1)	KR20000030003A (zh)
CN (1)	CN1152675C (zh)
AR (1)	AR008290A1 (zh)
AU (1)	AU723816B2 (zh)
BR (1)	BR9711140A (zh)
CA (1)	CA2263388A1 (zh)
CO (1)	CO5031286A1 (zh)
CZ (1)	CZ46799A3 (zh)
IL (1)	IL128501A0 (zh)
NO (2)	NO312458B1 (zh)
PL (1)	PL331539A1 (zh)
TR (1)	TR199900318T2 (zh)
TW (1)	TW461878B (zh)
WO (1)	WO1998006397A1 (zh)
ZA (1)	ZA977301B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69716424T2 (de)	1996-05-24	2003-02-20	Neurosearch A/S, Ballerup	Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker
JP2000513360A (ja)	1996-06-27	2000-10-10	スミスクライン・ビーチャム・コーポレイション	Ｉｌ―８レセプターアンタゴニスト
US6335352B1 (en) *	1996-08-15	2002-01-01	Smithkline Beecham Corporation	IL-8 receptor antagonists
CA2245224A1 (en) *	1998-08-14	2000-02-14	Jiang-Hong Giong	Chemokine receptor antagonists and chemotherapeutics
ATE258444T1 (de)	1998-03-13	2004-02-15	Univ British Columbia	Therapeutische chemokine rezeptor antagonisten
CA2305787A1 (en) *	2000-05-09	2001-11-09	The University Of British Columbia	Cxcr4 antagonist treatment of hematopoietic cells
AR029361A1 (es) *	1999-05-28	2003-06-25	Smithkline Beecham Corp	Compuestos de guanidina ciclicas antagonistas de los receptores de la il- 8, composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento
CO5170514A1 (es) *	1999-05-28	2002-06-27	Smithkline Beecham Corp	Antagonistas de los receptores de la il-8 nistas del receptor de la il-8
ECSP003525A (es) *	1999-06-16	2002-01-25	Smithkline Beecham Corp	Antagonistas del receptor de il- 8 iv
UY26627A1 (es) *	2000-03-24	2001-09-28	Smithkline Beecham Corp	Antagonistas de receptores de il-8
US7368425B2 (en) *	2006-03-24	2008-05-06	Chemokine Therapeutics Corp.	Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
US20050059584A1 (en) *	2002-08-16	2005-03-17	Ahmed Merzouk	Novel chemokine mimetics synthesis and their use
CA2335109A1 (en) *	2000-04-12	2001-10-12	Chemokine Therapeutics Corporation	Cxcr4 agonist treatment of hematopoietic cells
US7378098B2 (en) *	2000-04-12	2008-05-27	The University Of British Columbia	CXC chemokine receptor 4 agonist peptides
AU2001248753B2 (en)	2000-04-14	2004-12-23	Kureha Corporation	Nitrogenous compounds and antiviral drugs containing the same
US6515001B2 (en)	2001-03-05	2003-02-04	Chemokine Therapeutic Corporation	IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases
US20040157818A1 (en) *	2001-05-24	2004-08-12	Mikiro Yanaka	Cxcr4-antagonistic drugs composed of nitrogen-containing compound
US7176227B2 (en)	2002-09-11	2007-02-13	Kureha Corporation	Amine compounds and use thereof
TW200418812A (en) *	2002-10-29	2004-10-01	Smithkline Beecham Corp	IL-8 receptor antagonists
KR101149124B1 (ko)	2004-03-10	2012-05-25	가부시끼가이샤 구레하	아민계 염기성 화합물과 그의 용도
US7326729B2 (en)	2004-05-12	2008-02-05	Schering Corporation	CXCR1 and CXCR2 chemokine antagonists
EP1634573A1 (en) *	2004-08-16	2006-03-15	The Procter and Gamble Company	2-(Amino or substituted Amino)-5,6-substituted Phenol compounds, dyeing compositions containing them, and use thereof
WO2006023435A1 (en)	2004-08-16	2006-03-02	The Procter & Gamble Company	2-(amino or substituted amino)-5, 6-substituted phenol compounds, dyeing compositions containing them, and use thereof
US20070249625A1 (en) *	2004-10-20	2007-10-25	Jakob Busch-Petersen	Il-8 Receptor Antagonists
AU2007240365B2 (en) *	2006-04-21	2011-12-15	Glaxosmithkline Llc	IL-8 receptor antagonists
EP2010180A4 (en) *	2006-04-21	2010-10-13	Glaxosmithkline Llc	IL-8 RECEPTOR ANTAGONISTS
PE20080943A1 (es) *	2006-06-23	2008-09-27	Smithkline Beecham Corp	Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US537186A (en) *		1895-04-09		Jacob ebert
US4269837A (en) *	1980-02-19	1981-05-26	Pfizer Inc.	Hypoglycemic guanylamidines, compositions and use
NZ229828A (en) *	1988-08-09	1992-03-26	Squibb & Sons Inc	Aryl cyanoguanidine derivatives and pharmaceutical compositions
JP2742084B2 (ja) *	1989-03-13	1998-04-22	キヤノン株式会社	グアニジン二量化物およびグアニジン二量化物を含有する静電荷像現像用トナー
US5214208A (en) *	1989-03-13	1993-05-25	Canon Kabushiki Kaisha	Toner containing a dimer of diarylguanidine type compound for developing electrostatic image
US5792444A (en) *	1989-05-09	1998-08-11	The General Hospital Corporation	Labeled chemotactic peptides to image focal sites of infection or inflammation
US5371086A (en)	1991-03-15	1994-12-06	The Green Cross Corporation	Aminopyridine compounds
AU4530693A (en) *	1992-08-13	1994-03-15	Upjohn Company, The	Cyanoguanidines as potassium channel blockers
DK41193D0 (da) *	1993-04-07	1993-04-07	Neurosearch As	Ionkanalaabnere
US5401758A (en)	1993-10-07	1995-03-28	Bristol-Myers Squibb Company	Pyridinyl cyanoguanidine compounds

1997
- 1997-08-12 AR ARP970103665A patent/AR008290A1/es not_active Application Discontinuation
- 1997-08-14 ZA ZA9707301A patent/ZA977301B/xx unknown
- 1997-08-15 BR BR9711140A patent/BR9711140A/pt not_active Application Discontinuation
- 1997-08-15 EP EP19970938425 patent/EP0929302A4/en not_active Withdrawn
- 1997-08-15 CZ CZ99467A patent/CZ46799A3/cs unknown
- 1997-08-15 CA CA002263388A patent/CA2263388A1/en not_active Abandoned
- 1997-08-15 JP JP10510106A patent/JP2000516619A/ja not_active Ceased
- 1997-08-15 US US09/230,977 patent/US6204294B1/en not_active Expired - Fee Related
- 1997-08-15 PL PL97331539A patent/PL331539A1/xx unknown
- 1997-08-15 TR TR1999/00318T patent/TR199900318T2/xx unknown
- 1997-08-15 CN CNB971986037A patent/CN1152675C/zh not_active Expired - Fee Related
- 1997-08-15 WO PCT/US1997/014581 patent/WO1998006397A1/en not_active Application Discontinuation
- 1997-08-15 AU AU40750/97A patent/AU723816B2/en not_active Ceased
- 1997-08-15 KR KR1019997001283A patent/KR20000030003A/ko not_active Application Discontinuation
- 1997-08-15 CO CO97047171A patent/CO5031286A1/es unknown
- 1997-08-15 IL IL12850197A patent/IL128501A0/xx unknown
- 1997-10-03 TW TW086111871A patent/TW461878B/zh not_active IP Right Cessation
1999
- 1999-02-12 NO NO19990668A patent/NO312458B1/no not_active IP Right Cessation
2001
- 2001-12-12 NO NO20016067A patent/NO314301B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2263388A1 (en)	1998-02-19
CN1152675C (zh)	2004-06-09
IL128501A0 (en)	2000-01-31
AU4075097A (en)	1998-03-06
TW461878B (en)	2001-11-01
NO20016067L (no)	1999-04-12
EP0929302A4 (en)	2002-10-31
KR20000030003A (ko)	2000-05-25
CO5031286A1 (es)	2001-04-27
US6204294B1 (en)	2001-03-20
JP2000516619A (ja)	2000-12-12
EP0929302A1 (en)	1999-07-21
PL331539A1 (en)	1999-07-19
CN1232398A (zh)	1999-10-20
NO990668L (no)	1999-04-12
AU723816B2 (en)	2000-09-07
TR199900318T2 (xx)	1999-05-21
NO990668D0 (no)	1999-02-12
AR008290A1 (es)	1999-12-29
CZ46799A3 (cs)	1999-12-15
BR9711140A (pt)	1999-08-17
NO312458B1 (no)	2002-05-13
NO20016067D0 (no)	2001-12-12
NO314301B1 (no)	2003-03-03
WO1998006397A1 (en)	1998-02-19

Publication	Publication Date	Title
ZA975671B (en)	1997-12-29	IL-8 receptor antagonists.
IL127666A0 (en)	1999-10-28	IL-8 receptor antagonists
EP0932405A4 (en)	2001-10-17	IL-8 RECEPTOR ANTAGONISTS
ZA977301B (en)	1998-02-16	IL-8 receptor antagonists.
ZA988100B (en)	1999-03-05	IL-8 receptor antagonists
IL131004A0 (en)	2001-01-28	Il-8 receptor antagonists
EP0809492A4 (en)	2007-01-24	IL-8 RECEPTOR ANTAGONISTS
EP1000017A4 (en)	2000-10-18	ANTAGONISTS OF THE IL-8 RECEPTOR
EP0907362A4 (en)	1999-12-01	IL-8 RECEPTOR ANTAGONISTS
EP1019035A4 (en)	2001-10-17	IL-8 RECEPTOR ANTAGONISTS
EP0920417A4 (en)	1999-12-29	IL-8 RECEPTOR ANTAGONISTS
IL131005A0 (en)	2001-01-28	Il-8 receptor antagonists
HK1028730A1 (en)	2001-03-02	Il-8 receptor antagonists
EP0923373A4 (en)	2001-10-17	IL-8 RECEPTOR ANTAGOISTS
EP0971908A4 (en)	2000-05-17	IL-8 RECEPTOR ANTAGONISTS
EP0939634A4 (en)	2001-02-21	IL-8 RECEPTOR ANTAGONISTS
EP0957907A4 (en)	2001-08-16	IL-8 RECEPTOR ANTAGONISTS
EP0934066A4 (en)	2001-10-17	IL-8 RECEPTOR ANTAGONISTS
EP1039903A4 (en)	2001-12-05	INTERLEUKIN-8 RECEPTOR ANTAGONISTS
EP1047424A4 (en)	2002-05-22	IL-8 RECEPTOR ANTAGONISTS
EP0920253A4 (en)	2001-10-17	IL-8 RECEPTOR ANTAGONISTS
EP0948330A4 (en)	1999-12-01	COOLING ANTENNA WITH CURVED SEGMENTS
ZA975743B (en)	1997-12-29	IL-8 receptor antagonists.
IL140983A0 (en)	2002-02-10	Il-8 receptor antagonists
HUP9904303A3 (en)	2000-08-28	Il-8 receptor antagonists