ZA9710643B - 5-cyclo indole compounds - Google Patents
5-cyclo indole compoundsInfo
- Publication number
- ZA9710643B ZA9710643B ZA9710643A ZA9710643A ZA9710643B ZA 9710643 B ZA9710643 B ZA 9710643B ZA 9710643 A ZA9710643 A ZA 9710643A ZA 9710643 A ZA9710643 A ZA 9710643A ZA 9710643 B ZA9710643 B ZA 9710643B
- Authority
- ZA
- South Africa
- Prior art keywords
- loweralkyl
- optionally substituted
- membered
- independently selected
- ht1d
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hybrid Cells (AREA)
- Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75580596A | 1996-11-26 | 1996-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9710643B true ZA9710643B (en) | 1998-09-02 |
Family
ID=25040731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9710643A ZA9710643B (en) | 1996-11-26 | 1997-11-26 | 5-cyclo indole compounds |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0944595B1 (de) |
| JP (1) | JP2001504501A (de) |
| CN (1) | CN1289479C (de) |
| AT (1) | ATE251136T1 (de) |
| AU (1) | AU738668B2 (de) |
| CA (1) | CA2273328C (de) |
| DE (1) | DE69725337T2 (de) |
| ES (1) | ES2208955T3 (de) |
| TW (1) | TW432059B (de) |
| WO (1) | WO1998023587A1 (de) |
| ZA (1) | ZA9710643B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| US6329390B1 (en) * | 1998-07-17 | 2001-12-11 | Nps Allelix Corp. | 5-Bicycloindole compounds |
| US6562809B1 (en) * | 1998-09-18 | 2003-05-13 | Nps Allelix Corp. | 3-bicycloindole compounds |
| AU779073B2 (en) * | 1998-12-23 | 2005-01-06 | Nps Allelix Corp. | Indole and indolizidine derivatives for the treatment of migraine |
| HUP0400684A2 (hu) | 2000-12-22 | 2004-07-28 | Wyeth | 5-Hidroxitriptamin-6-ligandumként használható heterociklilindazol- és -azaindazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények |
| EP1803720A1 (de) * | 2000-12-22 | 2007-07-04 | Wyeth a Corporation of the State of Delaware | Hetorocyclindazole und -Azaindazole Verbindungen als 5-Hydroxytryptamine-6 Liganden |
| BRPI0407493A (pt) | 2003-02-14 | 2006-02-14 | Wyeth Corp | derivados heterociclil-3-sulfinilazaindol ou -azaindazol como ligantes de 5-hidroxitriptamina-6 |
| US8030257B2 (en) | 2005-05-13 | 2011-10-04 | Exxonmobil Research And Engineering Company | Catalytic antioxidants |
| CN102936240A (zh) * | 2012-10-30 | 2013-02-20 | 浙江省医学科学院 | 一种(r)-5-取代-3-(n-苄氧羰基吡咯烷-2-基羰基)-1h-吲哚的合成方法 |
| CN107698558B (zh) * | 2017-10-24 | 2019-04-02 | 温州大学 | 一种氮杂环硫化物的制备方法及其净化提纯方法 |
| US20200157088A1 (en) * | 2017-12-01 | 2020-05-21 | Taiwanj Pharmaceuticals Co., Ltd. | Benzene fused heterocyclic compound and use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225726B1 (de) * | 1985-11-08 | 1991-04-17 | Glaxo Group Limited | Indolderivate |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5300645A (en) * | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
| JP2802169B2 (ja) * | 1993-04-22 | 1998-09-24 | ファイザー・インコーポレーテッド | 片頭痛に用いる５−ｈｔ▲下１▼様アゴニストとしてのインドール誘導体 |
-
1997
- 1997-11-24 WO PCT/CA1997/000900 patent/WO1998023587A1/en active IP Right Grant
- 1997-11-24 CA CA002273328A patent/CA2273328C/en not_active Expired - Fee Related
- 1997-11-24 EP EP97945687A patent/EP0944595B1/de not_active Expired - Lifetime
- 1997-11-24 AU AU51122/98A patent/AU738668B2/en not_active Ceased
- 1997-11-24 DE DE69725337T patent/DE69725337T2/de not_active Expired - Fee Related
- 1997-11-24 ES ES97945687T patent/ES2208955T3/es not_active Expired - Lifetime
- 1997-11-24 AT AT97945687T patent/ATE251136T1/de not_active IP Right Cessation
- 1997-11-24 JP JP52408398A patent/JP2001504501A/ja active Pending
- 1997-11-24 CN CNB971815127A patent/CN1289479C/zh not_active Expired - Fee Related
- 1997-11-26 ZA ZA9710643A patent/ZA9710643B/xx unknown
- 1997-12-18 TW TW086119400A patent/TW432059B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1026689A1 (en) | 2000-12-22 |
| CN1289479C (zh) | 2006-12-13 |
| EP0944595A1 (de) | 1999-09-29 |
| CA2273328A1 (en) | 1998-06-04 |
| AU738668B2 (en) | 2001-09-20 |
| JP2001504501A (ja) | 2001-04-03 |
| ES2208955T3 (es) | 2004-06-16 |
| CN1245491A (zh) | 2000-02-23 |
| DE69725337T2 (de) | 2004-07-15 |
| WO1998023587A1 (en) | 1998-06-04 |
| CA2273328C (en) | 2009-04-28 |
| EP0944595B1 (de) | 2003-10-01 |
| ATE251136T1 (de) | 2003-10-15 |
| AU5112298A (en) | 1998-06-22 |
| TW432059B (en) | 2001-05-01 |
| DE69725337D1 (de) | 2003-11-06 |
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