ZA965505B - Novel compounds. - Google Patents

Novel compounds.

Info

Publication number: ZA965505B
Authority: ZA; South Africa
Prior art keywords: novel compounds; novel; compounds
Prior art date: 1995-06-30

Application number

ZA9605505A

Other languages

English (en)

Inventor

Lan Mong Nguyen

Eric Niesor

Craig Leigh Bentzen

Hieu Trung Phan

Vinh Van Diep

Simon Floret

Raymond Azoulay

Alexandre Bulla

Yves Guyon-Gellin

Robert John Ife

Original Assignee

Symphar Sa

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-30

Filing date

1996-06-28

Publication date

1998-03-30

1996-06-28 Application filed by Symphar Sa, Smithkline Beecham Plc filed Critical Symphar Sa

1998-03-30 Publication of ZA965505B publication Critical patent/ZA965505B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA9605505A 1995-06-30 1996-06-28 Novel compounds. ZA965505B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH01920/95A CH690264A5 (fr)	1995-06-30	1995-06-30	Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.

Publications (1)

Publication Number	Publication Date
ZA965505B true ZA965505B (en)	1998-03-30

Family

ID=4221681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9605505A ZA965505B (en)	1995-06-30	1996-06-28	Novel compounds.

Country Status (27)

Country	Link
US (2)	US6060464A (xx)
EP (1)	EP0835116A1 (xx)
JP (1)	JPH11508576A (xx)
KR (1)	KR19990028542A (xx)
CN (1)	CN1113654C (xx)
AP (1)	AP778A (xx)
AR (1)	AR004498A1 (xx)
AU (1)	AU705206B2 (xx)
BG (1)	BG102215A (xx)
BR (1)	BR9609653A (xx)
CA (1)	CA2225391A1 (xx)
CH (1)	CH690264A5 (xx)
CZ (1)	CZ422097A3 (xx)
EA (1)	EA199800106A1 (xx)
HU (1)	HUP9901684A3 (xx)
IL (1)	IL122717A0 (xx)
MA (1)	MA24340A1 (xx)
MX (1)	MX9800189A (xx)
NO (1)	NO976128L (xx)
NZ (1)	NZ312696A (xx)
OA (1)	OA10554A (xx)
PL (1)	PL187024B1 (xx)
SK (1)	SK178397A3 (xx)
TR (1)	TR199701700T1 (xx)
TW (1)	TW413681B (xx)
WO (1)	WO1997002037A1 (xx)
ZA (1)	ZA965505B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548084B2 (en)	1995-07-20	2003-04-15	Smithkline Beecham Plc	Controlled release compositions
GB9626536D0 (en) *	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626615D0 (en) *	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626616D0 (en) *	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
DE19748659A1 (de) *	1997-11-04	1999-05-06	Hoechst Ag	Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen
US6017918A (en) *	1998-08-06	2000-01-25	Warner-Lambert Company	Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
US6284795B1 (en)	1998-09-04	2001-09-04	Warner-Lambert Company	Sulfonamide compounds and methods of treating atherosclerosis and restenosis
WO2001030339A1 (en)	1999-10-27	2001-05-03	Teva Pharmaceutical Industries, Ltd.	Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder
EP1263740B1 (en)	2000-02-16	2006-07-19	SmithKline Beecham plc	Pyrimidine-4-one derivative as ldl-pla2 inhibitor
US20030114421A1 (en) *	2000-09-27	2003-06-19	Phan Hieu Trung	Alpha-substituted beta-aminoethyl phosphonate derivatives
JP2004513891A (ja)	2000-09-27	2004-05-13	アイレックス　オンコロジー　リサーチ　エス．エイ．	α−置換β−アミノエチルホスホネート
GB0024808D0 (en)	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0025849D0 (en) *	2000-10-23	2000-12-06	Smithkline Beecham Plc	Novel compounds
EP1482953A4 (en) *	2002-02-11	2006-12-13	Ilex Products Inc	ALPHA-SUBSTITUTED HETEROARYL ALKYL PHOSPHONATE DERIVATIVES
US20060128667A1 (en) *	2002-05-11	2006-06-15	Montes Imber F	Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
WO2004019889A2 (en) *	2002-08-30	2004-03-11	Biostratum, Inc.	Inhibitors of post-amadori advanced glycation end products
KR101861883B1 (ko)	2010-12-06	2018-05-28	글락소 그룹 리미티드	Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
UY34216A (es)	2011-07-27	2013-02-28	Glaxo Group Ltd	Nuevos compuestos que inhiben la actividad de la Lp-PLA2
CA2842965A1 (en)	2011-07-27	2013-01-31	Glaxo Group Limited	2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors
EP2751094B1 (en)	2011-09-01	2018-06-20	Glaxo Group Limited	Novel crystal form
KR20150108897A (ko)	2013-01-25	2015-09-30	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	2,3-디히드로이미다졸[1,2-c]피리미딘-5(1h)-온계의 지단백질-연관 포스포리파제 a2 (lp-pla2) 억제제
KR20150111356A (ko)	2013-01-25	2015-10-05	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	화합물
AU2014210260B2 (en)	2013-01-25	2016-08-04	Glaxosmithkline Intellectual Property Development Limited	Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN112778331B (zh)	2019-11-09	2022-07-05	上海赛默罗生物科技有限公司	三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH683996A5 (fr) *	1992-03-05	1994-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de) *	1994-09-19	1996-03-28	Hoechst Ag	Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen

1995
- 1995-06-30 CH CH01920/95A patent/CH690264A5/fr not_active IP Right Cessation
1996
- 1996-06-26 CN CN96196395A patent/CN1113654C/zh not_active Expired - Fee Related
- 1996-06-26 AP APAP/P/1997/001160A patent/AP778A/en active
- 1996-06-26 EA EA199800106A patent/EA199800106A1/ru unknown
- 1996-06-26 KR KR1019970709860A patent/KR19990028542A/ko not_active Application Discontinuation
- 1996-06-26 JP JP9504801A patent/JPH11508576A/ja not_active Withdrawn
- 1996-06-26 AU AU64185/96A patent/AU705206B2/en not_active Ceased
- 1996-06-26 SK SK1783-97A patent/SK178397A3/sk unknown
- 1996-06-26 TR TR97/01700T patent/TR199701700T1/xx unknown
- 1996-06-26 WO PCT/EP1996/002842 patent/WO1997002037A1/en not_active Application Discontinuation
- 1996-06-26 CA CA002225391A patent/CA2225391A1/en not_active Abandoned
- 1996-06-26 BR BR9609653-5A patent/BR9609653A/pt not_active Application Discontinuation
- 1996-06-26 IL IL12271796A patent/IL122717A0/xx unknown
- 1996-06-26 EP EP96923971A patent/EP0835116A1/en not_active Withdrawn
- 1996-06-26 CZ CZ974220A patent/CZ422097A3/cs unknown
- 1996-06-26 MX MX9800189A patent/MX9800189A/es unknown
- 1996-06-26 US US08/973,669 patent/US6060464A/en not_active Expired - Fee Related
- 1996-06-26 HU HU9901684A patent/HUP9901684A3/hu unknown
- 1996-06-26 NZ NZ312696A patent/NZ312696A/en unknown
- 1996-06-26 PL PL96324341A patent/PL187024B1/pl unknown
- 1996-06-28 MA MA24297A patent/MA24340A1/fr unknown
- 1996-06-28 AR ARP960103399A patent/AR004498A1/es unknown
- 1996-06-28 ZA ZA9605505A patent/ZA965505B/xx unknown
- 1996-07-01 TW TW085107922A patent/TW413681B/zh not_active IP Right Cessation
1997
- 1997-12-29 NO NO976128A patent/NO976128L/no not_active Application Discontinuation
- 1997-12-30 OA OA70171A patent/OA10554A/en unknown
1998
- 1998-01-28 BG BG102215A patent/BG102215A/xx unknown
2000
- 2000-04-03 US US09/541,217 patent/US6660724B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA199800106A1 (ru)	1998-08-27
AP9701160A0 (en)	1998-01-31
AR004498A1 (es)	1998-12-16
MX9800189A (es)	1998-04-30
IL122717A0 (en)	1998-08-16
OA10554A (en)	2002-05-29
BG102215A (en)	1998-09-30
EP0835116A1 (en)	1998-04-15
CZ422097A3 (cs)	1998-10-14
AU6418596A (en)	1997-02-05
US6060464A (en)	2000-05-09
JPH11508576A (ja)	1999-07-27
NZ312696A (en)	1999-10-28
US6660724B1 (en)	2003-12-09
PL324341A1 (en)	1998-05-25
CN1193913A (zh)	1998-09-23
AP778A (en)	1999-10-29
CA2225391A1 (en)	1997-01-23
WO1997002037A1 (en)	1997-01-23
CH690264A5 (fr)	2000-06-30
BR9609653A (pt)	1999-12-21
TR199701700T1 (xx)	1998-03-21
CN1113654C (zh)	2003-07-09
NO976128D0 (no)	1997-12-29
PL187024B1 (pl)	2004-04-30
TW413681B (en)	2000-12-01
NO976128L (no)	1998-02-10
MA24340A1 (fr)	1998-07-01
KR19990028542A (ko)	1999-04-15
AU705206B2 (en)	1999-05-20
HUP9901684A2 (hu)	1999-09-28
HUP9901684A3 (en)	2000-04-28
SK178397A3 (en)	1998-06-03

Publication	Publication Date	Title
ZA9610858B (en)	1998-06-23	Heteroclyclic compounds.
ZA967315B (en)	1998-03-02	Biphenylamides.
ZA9711092B (en)	1999-07-22	Novel compounds.
AP9701021A0 (en)	1997-07-31	Novel compounds
EP0802908A4 (en)	2001-04-11	NEW COMPOUNDS
IL122296A0 (en)	1998-04-05	Quinolizinone type compounds
MX213417B (es)	2003-03-27	Fenilpiridazinonas.
ZA965505B (en)	1998-03-30	Novel compounds.
GB9507203D0 (en)	1995-05-31	Novel compounds
ZA964468B (en)	1997-02-06	Triazolylmethyl-cyclopentanols.
ZA961955B (en)	1997-09-11	Indazolecarboxamides.
DE69610844D1 (en)	2000-12-07	Hydroformylierungsverfahren.
ZA966399B (en)	1997-02-19	Endothelin-receptor-antagonists.
ZA964560B (en)	1997-12-03	Anit-viral compounds.
ZA966750B (en)	1997-02-18	Halogenobenzimidazoles.
ZA966933B (en)	1997-02-19	Endothelin-receptor-antagonists.
ZA967314B (en)	1998-03-02	Carbamoylcarboxamides.
GB9503717D0 (en)	1995-04-12	Novel compounds
ZA969560B (en)	1998-05-14	Substituted 1-methyl-3-phenylpyrazoles.
ZA965504B (en)	1997-12-29	Novel compounds.
ZA967181B (en)	1998-02-23	Substituted Benzylaminopiperidine Compounds.
GR2001727Y (en)	1995-12-18	Card-envelope.
ZA97809B (en)	1998-03-02	Skinktuit en houer daarmee toegerus.
ZA969780B (en)	1998-05-21	Cyclopeptolides.
GR950200126U (en)	1997-01-31	Pencil-case.