ZA958647B - Aroyl-piperidine derivatives - Google Patents

Aroyl-piperidine derivatives

Info

Publication number: ZA958647B
Authority: ZA; South Africa
Prior art keywords: aroyl; piperidine derivatives; substd; opt; halo
Prior art date: 1994-10-14

Application number

ZA958647A

Other languages

English (en)

Inventor

Silvio Ofner

Siem Jacob Veenstra

Walter Schilling

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-14

Filing date

1995-10-13

Publication date

1996-04-15

1995-10-13 Application filed by Ciba Geigy filed Critical Ciba Geigy

1996-04-15 Publication of ZA958647B publication Critical patent/ZA958647B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Insulating Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Suspension Of Electric Lines Or Cables (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

ZA958647A 1994-10-14 1995-10-13 Aroyl-piperidine derivatives ZA958647B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH309194		1994-10-14

Publications (1)

Publication Number	Publication Date
ZA958647B true ZA958647B (en)	1996-04-15

Family

ID=4248427

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA958647A ZA958647B (en)	1994-10-14	1995-10-13	Aroyl-piperidine derivatives

Country Status (23)

Country	Link
US (1)	US5965562A (xx)
EP (1)	EP0707006B1 (xx)
JP (1)	JP3022951B2 (xx)
KR (1)	KR100413985B1 (xx)
CN (1)	CN1066445C (xx)
AT (1)	ATE178602T1 (xx)
AU (1)	AU705851B2 (xx)
CA (1)	CA2160444C (xx)
DE (1)	DE59505575D1 (xx)
DK (1)	DK0707006T3 (xx)
ES (1)	ES2132580T3 (xx)
FI (1)	FI114795B (xx)
GR (1)	GR3030515T3 (xx)
HU (1)	HUT74103A (xx)
IL (1)	IL115572A (xx)
MX (1)	MX9504349A (xx)
MY (1)	MY114679A (xx)
NO (1)	NO308034B1 (xx)
NZ (1)	NZ280212A (xx)
RU (1)	RU2158731C2 (xx)
SA (1)	SA96160637B1 (xx)
TW (1)	TW397825B (xx)
ZA (1)	ZA958647B (xx)

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TW397825B (en) *	1994-10-14	2000-07-11	Novartis Ag	Aroyl-piperidine derivatives
RU2156250C2 (ru) *	1995-04-24	2000-09-20	Новартис Аг	Производные хромона, способ их получения и фармацевтическая композиция
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JP2001294582A (ja) *	2000-04-12	2001-10-23	Fuji Chemical Industries Ltd	光学活性アミノブチロラクトンの製造法
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GB0220953D0 (en)	2002-09-10	2002-10-23	Novartis Ag	Organic compounds
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CN1777584A (zh)	2003-04-18	2006-05-24	伊莱利利公司	作为5－ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物
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ES2382814T3 (es)	2005-05-17	2012-06-13	Merck Sharp & Dohme Ltd.	Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2008204380B2 (en)	2007-01-10	2013-08-15	Msd Italia S.R.L.	Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5501227B2 (ja)	2007-06-27	2014-05-21	メルク・シャープ・アンド・ドーム・コーポレーション	ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
MX2011011907A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
MX2011011901A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
KR20120023072A (ko)	2009-05-12	2012-03-12	브리스톨-마이어스 스큅 컴퍼니	（Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
MY174452A (en)	2009-10-14	2020-04-19	Schering Corp	Substituted piperidines that increase p53 activity and the uses thereof
WO2012018754A2 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
AU2011292261B2 (en)	2010-08-17	2015-05-14	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
WO2012036997A1 (en)	2010-09-16	2012-03-22	Schering Corporation	Fused pyrazole derivatives as novel erk inhibitors
DK2632472T3 (en)	2010-10-29	2018-03-19	Sirna Therapeutics Inc	RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
IN2013MN02170A (xx)	2011-04-21	2015-06-12	Piramal Entpr Ltd
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
AU2013323508B2 (en)	2012-09-28	2017-11-02	Merck Sharp & Dohme Corp.	Novel compounds that are ERK inhibitors
AU2013352568B2 (en)	2012-11-28	2019-09-19	Merck Sharp & Dohme Llc	Compositions and methods for treating cancer
US8846657B2 (en)	2012-12-20	2014-09-30	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as HDM2 inhibitors
US9540377B2 (en)	2013-01-30	2017-01-10	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785A4 (en)	2016-10-12	2020-03-25	Merck Sharp & Dohme Corp.	KDM5 INHIBITORS
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2019094311A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US12173026B2 (en)	2018-08-07	2024-12-24	Merck Sharp & Dohme Llc	PRMT5 inhibitors
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MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
US5145967A (en) *	1989-04-20	1992-09-08	Anaquest, Inc.	Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
IE903957A1 (en) *	1989-11-06	1991-05-08	Sanofi Sa	Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
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TW397825B (en) *	1994-10-14	2000-07-11	Novartis Ag	Aroyl-piperidine derivatives

1995
- 1995-10-02 TW TW084110255A patent/TW397825B/zh not_active IP Right Cessation
- 1995-10-05 EP EP95810628A patent/EP0707006B1/de not_active Expired - Lifetime
- 1995-10-05 AT AT95810628T patent/ATE178602T1/de active
- 1995-10-05 DE DE59505575T patent/DE59505575D1/de not_active Expired - Lifetime
- 1995-10-05 ES ES95810628T patent/ES2132580T3/es not_active Expired - Lifetime
- 1995-10-05 DK DK95810628T patent/DK0707006T3/da active
- 1995-10-10 AU AU33174/95A patent/AU705851B2/en not_active Ceased
- 1995-10-10 MY MYPI95003026A patent/MY114679A/en unknown
- 1995-10-11 FI FI954829A patent/FI114795B/fi not_active IP Right Cessation
- 1995-10-11 IL IL11557295A patent/IL115572A/en not_active IP Right Cessation
- 1995-10-12 NZ NZ280212A patent/NZ280212A/en not_active IP Right Cessation
- 1995-10-12 CA CA002160444A patent/CA2160444C/en not_active Expired - Fee Related
- 1995-10-13 MX MX9504349A patent/MX9504349A/es unknown
- 1995-10-13 KR KR1019950035296A patent/KR100413985B1/ko not_active IP Right Cessation
- 1995-10-13 RU RU95117719/04A patent/RU2158731C2/ru not_active IP Right Cessation
- 1995-10-13 HU HU9502973A patent/HUT74103A/hu not_active Application Discontinuation
- 1995-10-13 NO NO954067A patent/NO308034B1/no not_active IP Right Cessation
- 1995-10-13 ZA ZA958647A patent/ZA958647B/xx unknown
- 1995-10-13 JP JP7265610A patent/JP3022951B2/ja not_active Expired - Fee Related
- 1995-10-13 CN CN95116776A patent/CN1066445C/zh not_active Expired - Fee Related
1996
- 1996-03-02 SA SA96160637A patent/SA96160637B1/ar unknown
1997
- 1997-10-30 US US08/961,546 patent/US5965562A/en not_active Expired - Fee Related
1999
- 1999-06-15 GR GR990401590T patent/GR3030515T3/el unknown

Also Published As

Publication number	Publication date
EP0707006B1 (de)	1999-04-07
IL115572A0 (en)	1996-01-19
TW397825B (en)	2000-07-11
FI114795B (fi)	2004-12-31
HU9502973D0 (en)	1995-12-28
JPH08176145A (ja)	1996-07-09
CA2160444A1 (en)	1996-04-15
GR3030515T3 (en)	1999-10-29
SA96160637B1 (ar)	2005-06-14
NO308034B1 (no)	2000-07-10
ES2132580T3 (es)	1999-08-16
CN1066445C (zh)	2001-05-30
FI954829A (fi)	1996-04-15
AU3317495A (en)	1996-04-26
DK0707006T3 (da)	1999-10-18
KR100413985B1 (ko)	2004-03-26
HUT74103A (en)	1996-11-28
KR960014121A (ko)	1996-05-22
IL115572A (en)	2001-05-20
RU2158731C2 (ru)	2000-11-10
AU705851B2 (en)	1999-06-03
JP3022951B2 (ja)	2000-03-21
CN1133839A (zh)	1996-10-23
DE59505575D1 (de)	1999-05-12
US5965562A (en)	1999-10-12
MX9504349A (es)	1997-03-29
FI954829A0 (fi)	1995-10-11
ATE178602T1 (de)	1999-04-15
NO954067L (no)	1996-04-15
NO954067D0 (no)	1995-10-13
CA2160444C (en)	2006-11-28
NZ280212A (en)	2001-10-26
EP0707006A1 (de)	1996-04-17
MY114679A (en)	2002-12-31

Publication	Publication Date	Title
GR3030515T3 (en)	1999-10-29	Aroyl-piperidine derivatives
DE3879264D1 (de)	1993-04-22	N-substituierte azole.
ATE207905T1 (de)	2001-11-15	Tricyclische pyrazol-derivate
DE3683175D1 (de)	1992-02-13	Azolylmethyloxirane - ihre herstellung und verwendung als pflanzenschutzmittel.
NO20033765L (no)	2000-02-09	4-Fenylpiperidinforbindelser
DE69701923D1 (de)	2000-06-15	3-(Piperid-4-yl)-1,2-benzisoxazol- und 3-(Piperazin-4-yl)-1,2-benzisoxazol-Derivate als Antipsychotika
NO994115L (no)	1999-08-25	Nye 1,4-diazacykloheptanderivater og deres anvendelse i haaroksydasjonsfargestoffer
MY132009A (en)	2007-09-28	Pharmaceutical compounds.
CA2152902A1 (fr)	1994-07-21	Ligands selectifs des recepteurs 5-ht1d-5ht1b derives d'indole-piperazine utiles comme medicaments
FI834730A0 (fi)	1983-12-22	1-karboxialkanoylperhydro-indol-2-karboxylsyror och deras derivat
MX9701949A (es)	1997-06-28	Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.
DE59507220D1 (de)	1999-12-16	Verwendung von 1,2-überbrückten 1,4-Dihydropyridinen als selektive Kaliumkanalmodulatoren
NO304314B1 (no)	1998-11-30	Cykloheksanderivater og anvendelse av forbindelsene for fremstilling av legemidler
DE3867563D1 (en)	1992-02-20	2-amino-5-hydroxy-4-pyrimidone.
ES2059928T3 (es)	1994-11-16	Ciclopropanotiocarboxiamidas.
ECSP951529A (es)	1997-05-16	Compuestos farmaceuticos
DE60239284D1 (de)	2011-04-07	Azotierte tetrahydropyridyl-alkyl-heterozyklen mit tnf-wirkung