ZA951059B - 4-amino-1-piperidylbenzoylguanidine - Google Patents

4-amino-1-piperidylbenzoylguanidine

Info

Publication number: ZA951059B
Authority: ZA; South Africa
Prior art keywords: alk; hal; opt; alkylene; amino
Prior art date: 1994-02-10

Application number

ZA951059A

Other languages

English (en)

Inventor

Rolf Gericke

Dieter Dorsch

Klaus-Otto Minck

Manfred Baumgarth

Norbert Beier

Ingeborg Lues

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-10

Filing date

1995-02-09

Publication date

1995-10-13

1995-02-09 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-10-13 Publication of ZA951059B publication Critical patent/ZA951059B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA951059A 1994-02-10 1995-02-09 4-amino-1-piperidylbenzoylguanidine ZA951059B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4404183A DE4404183A1 (de)	1994-02-10	1994-02-10	4-Amino-1-piperidylbenzoylguanidine

Publications (1)

Publication Number	Publication Date
ZA951059B true ZA951059B (en)	1995-10-13

Family

ID=6509922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA951059A ZA951059B (en)	1994-02-10	1995-02-09	4-amino-1-piperidylbenzoylguanidine

Country Status (22)

Country	Link
US (1)	US5461066A (xx)
EP (1)	EP0667341B1 (xx)
JP (1)	JPH07267926A (xx)
KR (1)	KR950321212A (xx)
CN (1)	CN1082948C (xx)
AT (1)	ATE204864T1 (xx)
AU (1)	AU693496B2 (xx)
CA (1)	CA2142070A1 (xx)
CZ (1)	CZ286681B6 (xx)
DE (2)	DE4404183A1 (xx)
DK (1)	DK0667341T3 (xx)
ES (1)	ES2161789T3 (xx)
GR (1)	GR3036839T3 (xx)
HU (1)	HU215601B (xx)
NO (1)	NO303685B1 (xx)
PL (1)	PL179255B1 (xx)
PT (1)	PT667341E (xx)
RU (1)	RU2140412C1 (xx)
SK (1)	SK281721B6 (xx)
TW (1)	TW291476B (xx)
UA (1)	UA43834C2 (xx)
ZA (1)	ZA951059B (xx)

Families Citing this family (48)

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DE4328352A1 (de) *	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421495A1 (de) *	1994-06-20	1995-12-21	Merck Patent Gmbh	Heterocyclyloxy-benzoylguanidine
DE4430212A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Ortho-substituierte Benzoesäure-Derivate
DE4430861A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Heterocyclyl-benzoylguanidine
DE19601303A1 (de) *	1996-01-16	1997-07-17	Boehringer Ingelheim Kg	Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
DE19608162A1 (de) *	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161A1 (de) *	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7620611B1 (en) *	1999-07-20	2009-11-17	Trilithic, Inc.	Neural networks for ingress monitoring
AU780006B2 (en) *	2000-03-06	2005-02-24	Acadia Pharmaceuticals, Inc.	Azacyclic compounds for use in the treatment of serotonin related diseases
DE60236206D1 (de) *	2001-12-28	2010-06-10	Acadia Pharm Inc	Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
US7538222B2 (en) *	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) *	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
EP1562937A2 (en) *	2002-06-24	2005-08-17	Acadia Pharmaceuticals Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
MY139563A (en) *	2002-09-04	2009-10-30	Bristol Myers Squibb Co	Heterocyclic aromatic compounds useful as growth hormone secretagogues
DE60307308T2 (de) *	2002-10-04	2006-12-28	Ucb S.A.	4-aminopiperidin-derivate, verfahren zur herstellung und ihre verwendung als arzneimittel
BRPI0406591B8 (pt)	2003-01-16	2021-05-25	Acadia Pharm Inc	composto e composição farmacêutica
US20050261278A1 (en) *	2004-05-21	2005-11-24	Weiner David M	Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) *	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
US7902367B2 (en) *	2004-08-11	2011-03-08	Kyorin Pharmaceutical Co., Ltd.	Cyclic amino benzoic acid derivative
EP1794126B1 (en) *	2004-09-27	2013-03-20	Acadia Pharmaceuticals Inc.	Crystalline form of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide hemi-tartrate
US7790899B2 (en) *	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
DE102004054054A1 (de) *	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1852108A1 (en)	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
CA2810522A1 (en)	2006-05-04	2007-11-15	Boehringer Ingelheim International Gmbh	Polymorphs
US20090053329A1 (en)	2007-03-19	2009-02-26	Acadia Pharmaceuticals, Inc.	Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
WO2009039460A2 (en) *	2007-09-21	2009-03-26	Acadia Pharmaceuticals, Inc.	Co-administration of pimavanserin with other agents
PE20091730A1 (es)	2008-04-03	2009-12-10	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt)	2008-08-06	2020-12-15	Boehringer Ingelheim International Gmbh	Inibidor de dpp-4 e seu uso
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CA2745037C (en)	2008-12-23	2020-06-23	Boehringer Ingelheim International Gmbh	Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine
AU2010323068B2 (en)	2009-11-27	2015-09-03	Boehringer Ingelheim International Gmbh	Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
MX366325B (es)	2010-05-05	2019-07-05	Boehringer Ingelheim Int	Terapia de combinacion.
KR20230051307A (ko)	2010-06-24	2023-04-17	베링거 인겔하임 인터내셔날 게엠베하	당뇨병 요법
US9034883B2 (en)	2010-11-15	2015-05-19	Boehringer Ingelheim International Gmbh	Vasoprotective and cardioprotective antidiabetic therapy
US8962636B2 (en)	2011-07-15	2015-02-24	Boehringer Ingelheim International Gmbh	Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
EP3685839A1 (en)	2012-05-14	2020-07-29	Boehringer Ingelheim International GmbH	Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2015128453A1 (en)	2014-02-28	2015-09-03	Boehringer Ingelheim International Gmbh	Medical use of a dpp-4 inhibitor
WO2017015272A1 (en)	2015-07-20	2017-01-26	Acadia Pharmaceuticals Inc.	Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
WO2017211979A1 (en)	2016-06-10	2017-12-14	Boehringer Ingelheim International Gmbh	Combinations of linagliptin and metformin
EP3558311A1 (en)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en)	2017-04-28	2021-10-05	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
US20210077479A1 (en)	2017-08-30	2021-03-18	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4117904A1 (de) *	1991-05-31	1992-12-03	Basf Ag	Substituierte n-phenylpiperidine
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE59305042D1 (de) *	1992-09-22	1997-02-20	Hoechst Ag	Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
ES2129485T3 (es) *	1992-12-02	1999-06-16	Hoechst Ag	Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.

1994
- 1994-02-10 DE DE4404183A patent/DE4404183A1/de not_active Withdrawn
1995
- 1995-02-06 AU AU11571/95A patent/AU693496B2/en not_active Ceased
- 1995-02-07 DE DE59509543T patent/DE59509543D1/de not_active Expired - Fee Related
- 1995-02-07 SK SK157-95A patent/SK281721B6/sk unknown
- 1995-02-07 CN CN95101910A patent/CN1082948C/zh not_active Expired - Fee Related
- 1995-02-07 TW TW084100981A patent/TW291476B/zh active
- 1995-02-07 DK DK95101575T patent/DK0667341T3/da active
- 1995-02-07 ES ES95101575T patent/ES2161789T3/es not_active Expired - Lifetime
- 1995-02-07 EP EP95101575A patent/EP0667341B1/de not_active Expired - Lifetime
- 1995-02-07 PT PT95101575T patent/PT667341E/pt unknown
- 1995-02-07 AT AT95101575T patent/ATE204864T1/de not_active IP Right Cessation
- 1995-02-08 UA UA95028120A patent/UA43834C2/uk unknown
- 1995-02-08 CZ CZ1995327A patent/CZ286681B6/cs not_active IP Right Cessation
- 1995-02-08 CA CA002142070A patent/CA2142070A1/en not_active Abandoned
- 1995-02-09 KR KR1019950002288A patent/KR950321212A/ko active IP Right Grant
- 1995-02-09 ZA ZA951059A patent/ZA951059B/xx unknown
- 1995-02-09 RU RU95101843A patent/RU2140412C1/ru active
- 1995-02-09 PL PL95307190A patent/PL179255B1/pl unknown
- 1995-02-09 NO NO950485A patent/NO303685B1/no not_active IP Right Cessation
- 1995-02-09 US US08/385,790 patent/US5461066A/en not_active Expired - Fee Related
- 1995-02-09 HU HU9500396A patent/HU215601B/hu not_active IP Right Cessation
- 1995-02-10 JP JP7022475A patent/JPH07267926A/ja active Pending
2001
- 2001-10-09 GR GR20010401701T patent/GR3036839T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0667341A1 (de)	1995-08-16
HUT72306A (en)	1996-04-29
RU2140412C1 (ru)	1999-10-27
DE4404183A1 (de)	1995-08-17
CZ286681B6 (en)	2000-06-14
HU9500396D0 (en)	1995-03-28
HU215601B (hu)	1999-01-28
ATE204864T1 (de)	2001-09-15
NO950485L (no)	1995-08-11
EP0667341B1 (de)	2001-08-29
SK281721B6 (sk)	2001-07-10
PL179255B1 (pl)	2000-08-31
JPH07267926A (ja)	1995-10-17
DK0667341T3 (da)	2001-10-22
AU693496B2 (en)	1998-07-02
CN1112550A (zh)	1995-11-29
PT667341E (pt)	2001-12-28
KR950321212A (ko)	1995-12-20
RU95101843A (ru)	1997-03-10
NO950485D0 (no)	1995-02-09
CA2142070A1 (en)	1995-08-11
UA43834C2 (uk)	2002-01-15
CZ32795A3 (en)	1995-10-18
ES2161789T3 (es)	2001-12-16
CN1082948C (zh)	2002-04-17
AU1157195A (en)	1995-08-17
GR3036839T3 (en)	2002-01-31
SK15795A3 (en)	1995-09-13
DE59509543D1 (de)	2001-10-04
TW291476B (xx)	1996-11-21
US5461066A (en)	1995-10-24
PL307190A1 (en)	1995-08-21
NO303685B1 (no)	1998-08-17

Publication	Publication Date	Title
TW291476B (xx)	1996-11-21
DE59610164D1 (de)	2003-04-03	Arylalkyl-diazinone als Phosphodiesterase IV-Hemmer
AR026351A1 (es)	2003-02-05	Derivados de pirrol como inhibidores de la fosfodiesterasa vii
PT93687A (pt)	1990-11-20	Processo para a preparacao de antagonistas de serotonina de tetra-hidrobenz,d}indole
DE69232681D1 (de)	2002-08-22	4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung
PT90912A (pt)	1989-12-29	Processo para a preparacao de derivados de tiofenol
DE3876402D1 (de)	1993-01-14	N-(2-alkyl-3-mercapto-1,5-dioxoalkyl)glycinamid-derivate und deren verwendung als kollagenase-inhibitoren.
ATE226202T1 (de)	2002-11-15	Zyklische harnstoffe mit antiarrhythmischer und antifibrillatorischer wirkung
ATE64734T1 (de)	1991-07-15	Pyran-derivate.
ES2008633A6 (es)	1989-07-16	Un procedimiento para la obtencion de derivados de tiofeno.