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ZA948669B - New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions - Google Patents

New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions

Info

Publication number
ZA948669B
ZA948669B ZA948669A ZA948669A ZA948669B ZA 948669 B ZA948669 B ZA 948669B ZA 948669 A ZA948669 A ZA 948669A ZA 948669 A ZA948669 A ZA 948669A ZA 948669 B ZA948669 B ZA 948669B
Authority
ZA
South Africa
Prior art keywords
preparation
pharmaceutical compositions
carboxamide derivatives
pyrazine carboxamide
new pyrazine
Prior art date
Application number
ZA948669A
Inventor
Otto Roos
Georg Speck
Walter Loesel
Dietrich Arndts
Wolf-Dietrich Bechtel
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA948669B publication Critical patent/ZA948669B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The novel compounds of formula (I), which is explained in the description, can be conventionally produced and used as medical substances.
ZA948669A 1993-11-04 1994-11-03 New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions ZA948669B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4337609A DE4337609A1 (en) 1993-11-04 1993-11-04 Novel pyrazinecarboxamide derivatives, their preparation and their use in medicines

Publications (1)

Publication Number Publication Date
ZA948669B true ZA948669B (en) 1995-07-04

Family

ID=6501757

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948669A ZA948669B (en) 1993-11-04 1994-11-03 New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions

Country Status (17)

Country Link
EP (1) EP0726899B1 (en)
JP (1) JPH09505035A (en)
KR (1) KR960705815A (en)
CN (1) CN1134151A (en)
AT (1) ATE188965T1 (en)
AU (1) AU690588B2 (en)
CA (1) CA2175837A1 (en)
CO (1) CO4290432A1 (en)
DE (2) DE4337609A1 (en)
DK (1) DK0726899T3 (en)
ES (1) ES2140565T3 (en)
GR (1) GR3033034T3 (en)
NZ (1) NZ274848A (en)
PL (1) PL314187A1 (en)
PT (1) PT726899E (en)
WO (1) WO1995012592A1 (en)
ZA (1) ZA948669B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548812A1 (en) * 1995-12-27 1997-07-03 Hoechst Ag Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
DE19738604A1 (en) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Use of Na<+>/H<+> exchange inhibitors
EP1182194A4 (en) 1999-06-03 2004-02-11 Takeda Chemical Industries Ltd Pernasal preparations
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
BR0309398A (en) 2002-04-19 2005-02-01 Cellular Genomics Inc A compound or a salt, hydrate, solvate, crystalline form thereof, diastereomer, pharmaceutically acceptable prodrug, or mixtures thereof, pharmaceutical composition, and methods for treating a condition involved with kinase in a mammal, for treating cancer, and for identifying a kinase.
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
MXPA05013905A (en) 2003-07-02 2006-02-24 Hoffmann La Roche Arylamine-substituted quinazolinone compounds.
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
ATE546452T1 (en) 2003-09-23 2012-03-15 Vertex Pharma PYRAZOLOPYRROL DERIVATIVES AS PROTEIN KINASE INHIBITORS
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
SG171991A1 (en) 2008-12-08 2011-07-28 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
CA2745871C (en) 2008-12-08 2018-02-20 Gilead Connecticut, Inc. Imidazopyrazine syk inhibitors
PT2545052E (en) 2010-03-11 2015-02-18 Gilead Connecticut Inc Imidazopyridines syk inhibitors
SG188402A1 (en) 2010-09-13 2013-04-30 Otsuka Pharma Co Ltd Heterocyclic compounds for treating or preventing disorders caused by reduced neurotransmission of serotonin, norephnephrine or dopamine.
MD4659B1 (en) 2013-07-30 2019-11-30 Gilead Connecticut Inc Polymorph of SYK inhibitors
CN105431137A (en) 2013-07-30 2016-03-23 吉利德康涅狄格公司 Formulation of SYK inhibitors
CN103467392B (en) * 2013-10-09 2016-08-17 重庆工商大学 A kind of polyhalo pyrazinecarboxamide derivatives and its esters, preparation method and purposes
EA201690608A1 (en) 2013-12-04 2016-12-30 Джилид Сайэнс, Инк. METHODS OF TREATMENT OF CANCER DISEASES
TWI735853B (en) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 Syk inhibitors
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
MX2017000610A (en) 2014-07-14 2017-04-27 Gilead Sciences Inc Combinations for treating cancers.
EP3672974A1 (en) 2017-08-25 2020-07-01 Gilead Sciences, Inc. Polymorphs of syk inhibitors
CA3130848A1 (en) 2019-02-22 2020-08-27 Kronos Bio, Inc. Solid forms of condensed pyrazines as syk inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (en) * 1962-10-30
TW213903B (en) * 1991-08-16 1993-10-01 Boehringer Ingelheim Kg

Also Published As

Publication number Publication date
CO4290432A1 (en) 1996-04-17
DE59409094D1 (en) 2000-02-24
EP0726899A1 (en) 1996-08-21
KR960705815A (en) 1996-11-08
PT726899E (en) 2000-04-28
EP0726899B1 (en) 2000-01-19
JPH09505035A (en) 1997-05-20
DE4337609A1 (en) 1995-05-11
CN1134151A (en) 1996-10-23
PL314187A1 (en) 1996-09-02
AU690588B2 (en) 1998-04-30
ATE188965T1 (en) 2000-02-15
AU7993694A (en) 1995-05-23
DK0726899T3 (en) 2000-06-26
WO1995012592A1 (en) 1995-05-11
ES2140565T3 (en) 2000-03-01
CA2175837A1 (en) 1995-05-11
GR3033034T3 (en) 2000-08-31
NZ274848A (en) 1998-03-25

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