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ZA936225B - Process for preparing aryl piperazinyl-heterocyclic compounds - Google Patents

Process for preparing aryl piperazinyl-heterocyclic compounds

Info

Publication number
ZA936225B
ZA936225B ZA936225A ZA936225A ZA936225B ZA 936225 B ZA936225 B ZA 936225B ZA 936225 A ZA936225 A ZA 936225A ZA 936225 A ZA936225 A ZA 936225A ZA 936225 B ZA936225 B ZA 936225B
Authority
ZA
South Africa
Prior art keywords
heterocyclic compounds
chem
formula
preparing aryl
piperazine
Prior art date
Application number
ZA936225A
Inventor
Frank R Busch
Paul Bowles
Douglas J M Allen
Sabeto A Diroma
Dennis M Godek
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25468285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA936225(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of ZA936225B publication Critical patent/ZA936225B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Eye Examination Apparatus (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for preparing a compounds of the formula <CHEM> or a pharmaceutically acceptable acid addition salt thereof, which comprises reacting a piperazine of the formula <CHEM> with an alkyl halide containing compound of the formula <CHEM> in water with a reagent to neutralize the hydrohalic acid and heating the mixture under conditions which are suitable to effect the coupling of said piperazine with said alkyl halide containing compound.
ZA936225A 1992-08-26 1993-08-25 Process for preparing aryl piperazinyl-heterocyclic compounds ZA936225B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/936,179 US5206366A (en) 1992-08-26 1992-08-26 Process for preparing aryl piperazinyl-heterocyclic compounds

Publications (1)

Publication Number Publication Date
ZA936225B true ZA936225B (en) 1995-02-27

Family

ID=25468285

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA936225A ZA936225B (en) 1992-08-26 1993-08-25 Process for preparing aryl piperazinyl-heterocyclic compounds

Country Status (27)

Country Link
US (1) US5206366A (en)
EP (2) EP0584903B1 (en)
JP (1) JP2742370B2 (en)
KR (1) KR0123441B1 (en)
CN (1) CN1033089C (en)
AT (2) ATE273976T1 (en)
AU (1) AU642836B1 (en)
BR (1) BR9302065A (en)
CZ (1) CZ281893B6 (en)
DE (2) DE69333597T2 (en)
DK (2) DK1029861T3 (en)
EG (1) EG20214A (en)
ES (2) ES2225015T3 (en)
FI (1) FI111641B (en)
HU (1) HU223312B1 (en)
IL (1) IL105622A (en)
MX (1) MX9302813A (en)
MY (1) MY109731A (en)
NO (1) NO300685B1 (en)
NZ (1) NZ247539A (en)
PL (1) PL173840B1 (en)
PT (2) PT1029861E (en)
RU (1) RU2061695C1 (en)
SI (1) SI9300287A (en)
SK (1) SK280584B6 (en)
YU (1) YU48964B (en)
ZA (1) ZA936225B (en)

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US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
MX9709451A (en) * 1995-06-06 1998-02-28 Hoechst Marion Roussel Inc Benzisoxazole and indazole derivatives as antipsychotic agents.
EA001180B1 (en) * 1996-05-07 2000-10-30 Пфайзер Инк. Mesylate trihydrate 5-(2-(4-(1,2-benzisothiazol-3yl)-1-pipeazinyl)-6-chloro-1,3-dihydro-2h-indol-2-one, pharmaceutical composition and method for treating psychotic disorders
TW491847B (en) * 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
US5945421A (en) * 1997-08-11 1999-08-31 Warner-Lambert Company Dopamine D4 receptor antagonists
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Pharmaceutical compositions containing piperazinyl-heterocyclic compounds for treating psychiatric disorders
NZ506217A (en) * 1998-03-06 2002-05-31 Astra Ab Compound for treatment of tuberculosis and other mycobacterial diseases
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (en) * 2002-02-20 2003-10-31 Pfizer Prod Inc ZIPRASIDONE COMPOSITION AND SYNTHETIC CONTROLS
EA200500342A1 (en) * 2002-09-17 2005-08-25 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си HETEROCYCLIC SUBSTITUTED PIPERASINES FOR THE TREATMENT OF SCHIZOPHRENIA
CN100340557C (en) * 2002-10-24 2007-10-03 辉瑞产品公司 Acyl derivatives of 5-(2-(4-(1,2 benzisothiazole-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one having neuroleptic activity
WO2004041793A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
AU2003300814A1 (en) 2002-12-04 2004-06-23 Dr. Reddy's Laboratories Inc. Polymorphic forms of ziprasidone and its hydrochloride
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
CN1255105C (en) * 2002-12-17 2006-05-10 上海医药工业研究院 Water soluble dressing materials of ziracitone and its salts and their preparation
US20050143396A1 (en) * 2003-04-11 2005-06-30 Hertero Drugs Limited Novel crystalline forms of ziprasidone hydrochloride
US7678799B2 (en) * 2003-06-03 2010-03-16 Teva Pharmaceutical Industries Ltd. Crystalline ziprasidone HCl and processes for preparation thereof
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
US7667037B2 (en) 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
US20050197347A1 (en) * 2003-12-18 2005-09-08 Judith Aronhime Polymorphic form B2 of ziprasidone base
ES2334800T3 (en) * 2004-02-27 2010-03-16 Ranbaxy Laboratories Limited PROCESS FOR PREPARATION OF ZIPRASIDONA.
ITMI20040944A1 (en) * 2004-05-11 2004-08-11 Dinamite Dipharma S P A In For ZIPRASIDONE HYDROCHLORIDE POLYMORPH AND PROCEDURE FOR ITS PREPARATION
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) * 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7728136B2 (en) 2004-06-18 2010-06-01 Lupin Limited Method for the preparation of aryl piperazinyl-heterocyclic compounds
US9044503B2 (en) * 2004-08-27 2015-06-02 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally
ES2250001B1 (en) * 2004-09-29 2007-06-01 Medichem, S.A. PROCESS FOR THE PURIFICATION OF ZIPRASIDONA.
ES2250000B1 (en) * 2004-09-29 2007-06-01 Medichem, S.A. PROCEDURE FOR PREPARATION OF ZIPRASIDONE.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
CA2593497A1 (en) * 2005-02-11 2006-08-17 Judith Aronhime Amorphous ziprasidone mesylate
EP1858892A1 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Anhydrous ziprasidone mesylate and a process for its preparation
WO2006098834A2 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
CN101189237A (en) * 2005-04-01 2008-05-28 沃尼尔·朗伯有限责任公司 Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia
HU230479B1 (en) * 2006-05-02 2016-07-28 Richter Gedeon Nyrt. Process for the preparation of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one (ziprasidon)
HUP0600868A3 (en) * 2006-11-24 2009-03-30 Richter Gedeon Nyrt 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
US8410268B2 (en) * 2008-03-11 2013-04-02 Alkem Laboratories Limited Process for the preparation of ziprasidone
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PL391810A1 (en) 2010-07-14 2012-01-16 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna New ziprasidone salts and processes for the preparation thereof
WO2012020424A1 (en) 2010-08-12 2012-02-16 Arch Pharmalabs Limited A short process for the preparation of ziprasidone and intermediates thereof
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US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds

Also Published As

Publication number Publication date
DK0584903T3 (en) 2001-12-03
IL105622A0 (en) 1993-09-22
DE69330853D1 (en) 2001-11-08
CN1083061A (en) 1994-03-02
PT584903E (en) 2002-02-28
PL173840B1 (en) 1998-05-29
EP0584903A1 (en) 1994-03-02
DE69333597D1 (en) 2004-09-23
ES2161703T3 (en) 2001-12-16
MX9302813A (en) 1994-02-28
JP2742370B2 (en) 1998-04-22
EP1029861A1 (en) 2000-08-23
ES2225015T3 (en) 2005-03-16
BR9302065A (en) 1994-07-26
PT1029861E (en) 2004-11-30
IL105622A (en) 1998-06-15
ATE206422T1 (en) 2001-10-15
CZ87793A3 (en) 1994-04-13
YU48964B (en) 2003-01-31
HU223312B1 (en) 2004-05-28
US5206366A (en) 1993-04-27
FI932012A (en) 1994-02-27
EP0584903B1 (en) 2001-10-04
SK280584B6 (en) 2000-04-10
HUT65750A (en) 1994-07-28
MY109731A (en) 1997-05-31
YU56593A (en) 1996-07-24
NZ247539A (en) 1995-09-26
FI932012A0 (en) 1993-05-04
SI9300287A (en) 1994-03-31
AU642836B1 (en) 1993-10-28
SK48593A3 (en) 1994-04-06
CN1033089C (en) 1996-10-23
NO931656D0 (en) 1993-05-06
KR940003952A (en) 1994-03-14
DE69333597T2 (en) 2005-09-15
ATE273976T1 (en) 2004-09-15
EP1029861B1 (en) 2004-08-18
NO931656L (en) 1994-02-28
HU9301291D0 (en) 1993-07-28
EG20214A (en) 1997-11-30
KR0123441B1 (en) 1997-11-24
DK1029861T3 (en) 2004-11-15
CZ281893B6 (en) 1997-03-12
JPH06184143A (en) 1994-07-05
NO300685B1 (en) 1997-07-07
DE69330853T2 (en) 2002-05-02
FI111641B (en) 2003-08-29
PL299002A1 (en) 1994-03-21
RU2061695C1 (en) 1996-06-10

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