ZA928297B - Quinoline derivatives, process for their preparation, and their therapeutic applications. - Google Patents
Quinoline derivatives, process for their preparation, and their therapeutic applications.Info
- Publication number
- ZA928297B ZA928297B ZA928297A ZA928297A ZA928297B ZA 928297 B ZA928297 B ZA 928297B ZA 928297 A ZA928297 A ZA 928297A ZA 928297 A ZA928297 A ZA 928297A ZA 928297 B ZA928297 B ZA 928297B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- alkoxy
- aryl
- independently
- preparation
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- -1 1H-tetrazol-5-yl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Quinoline Compounds (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Communication Cables (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9113240A FR2683819B1 (fr) | 1991-10-28 | 1991-10-28 | Derives de quinoleine, leur procede de preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA928297B true ZA928297B (en) | 1993-05-07 |
Family
ID=9418349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA928297A ZA928297B (en) | 1991-10-28 | 1992-10-27 | Quinoline derivatives, process for their preparation, and their therapeutic applications. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0540400B1 (fi) |
| JP (1) | JPH05239053A (fi) |
| KR (1) | KR930007935A (fi) |
| CN (1) | CN1073171A (fi) |
| AT (1) | ATE126798T1 (fi) |
| AU (1) | AU651740B2 (fi) |
| CA (1) | CA2081537A1 (fi) |
| CZ (1) | CZ324292A3 (fi) |
| DE (1) | DE69204252T2 (fi) |
| FI (1) | FI924869L (fi) |
| FR (1) | FR2683819B1 (fi) |
| HU (1) | HUT62883A (fi) |
| IL (1) | IL103568A0 (fi) |
| MX (1) | MX9206169A (fi) |
| NO (1) | NO924138L (fi) |
| NZ (1) | NZ244892A (fi) |
| PL (1) | PL296369A1 (fi) |
| ZA (1) | ZA928297B (fi) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| IT1255461B (it) * | 1992-07-28 | 1995-11-02 | Luso Farmaco Inst | Eteri di imidazoli ad attivita' a ii antagonista |
| FR2699174B1 (fr) * | 1992-12-14 | 1995-01-20 | Synthelabo | Dérivés de 3-(quinoléin-6-yl-méthyl)-4H-imidazol-4-one, leur préparation et leur application en thérapeutique. |
| FR2710914B1 (fr) * | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| FR2716196B1 (fr) * | 1994-02-16 | 1996-04-05 | Synthelabo | Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique. |
| JPH09202774A (ja) | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | ２−アリールキノリン類およびその製造方法 |
| DE19706161A1 (de) * | 1997-02-17 | 1998-08-20 | Oswald Hartmut Prof Dr Med | Verwendung von Cyaninen, Isocyaninen und Pseudoisocyaninen als Diuretika |
| KR100744826B1 (ko) * | 2006-04-05 | 2007-08-01 | 한국화학연구원 | 이미다졸기가 치환된 퀴놀리논 유도체 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN103804349A (zh) * | 2012-11-01 | 2014-05-21 | 杨子娇 | 一类治疗青光眼的化合物及其用途 |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
| CN108558750B (zh) * | 2018-07-11 | 2021-01-05 | 武汉工程大学 | 无溶剂法合成3-硝基喹啉衍生物的工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| MX9200299A (es) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
| DE4117750A1 (de) * | 1991-05-30 | 1992-12-24 | Bayer Ag | Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| ES2101824T3 (es) * | 1991-08-15 | 1997-07-16 | Ciba Geigy Ag | N-acil-n-heterociclil-onaftalenil-alquil-aminoacidos como antagonistas de angiotensina ii. |
-
1991
- 1991-10-28 FR FR9113240A patent/FR2683819B1/fr not_active Expired - Fee Related
-
1992
- 1992-10-22 EP EP92402879A patent/EP0540400B1/fr not_active Revoked
- 1992-10-22 DE DE69204252T patent/DE69204252T2/de not_active Revoked
- 1992-10-22 AT AT92402879T patent/ATE126798T1/de active
- 1992-10-27 FI FI924869A patent/FI924869L/fi not_active Application Discontinuation
- 1992-10-27 PL PL29636992A patent/PL296369A1/xx unknown
- 1992-10-27 KR KR1019920019802A patent/KR930007935A/ko not_active Withdrawn
- 1992-10-27 CA CA002081537A patent/CA2081537A1/en not_active Abandoned
- 1992-10-27 NO NO92924138A patent/NO924138L/no unknown
- 1992-10-27 NZ NZ244892A patent/NZ244892A/xx unknown
- 1992-10-27 MX MX9206169A patent/MX9206169A/es unknown
- 1992-10-27 ZA ZA928297A patent/ZA928297B/xx unknown
- 1992-10-27 IL IL103568A patent/IL103568A0/xx unknown
- 1992-10-27 CN CN92113784A patent/CN1073171A/zh active Pending
- 1992-10-27 CZ CS923242A patent/CZ324292A3/cs unknown
- 1992-10-27 AU AU27348/92A patent/AU651740B2/en not_active Ceased
- 1992-10-27 HU HU9203374A patent/HUT62883A/hu unknown
- 1992-10-27 JP JP4288458A patent/JPH05239053A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI924869L (fi) | 1993-04-29 |
| ATE126798T1 (de) | 1995-09-15 |
| CN1073171A (zh) | 1993-06-16 |
| EP0540400B1 (fr) | 1995-08-23 |
| NO924138L (no) | 1993-04-29 |
| HUT62883A (en) | 1993-06-28 |
| CZ324292A3 (en) | 1993-09-15 |
| MX9206169A (es) | 1993-07-01 |
| FR2683819B1 (fr) | 1994-02-11 |
| FR2683819A1 (fr) | 1993-05-21 |
| AU651740B2 (en) | 1994-07-28 |
| CA2081537A1 (en) | 1993-04-29 |
| DE69204252T2 (de) | 1996-04-18 |
| EP0540400A1 (fr) | 1993-05-05 |
| PL296369A1 (en) | 1993-05-31 |
| AU2734892A (en) | 1993-04-29 |
| IL103568A0 (en) | 1993-03-15 |
| NZ244892A (en) | 1994-06-27 |
| JPH05239053A (ja) | 1993-09-17 |
| DE69204252D1 (de) | 1995-09-28 |
| HU9203374D0 (en) | 1993-01-28 |
| KR930007935A (ko) | 1993-05-20 |
| NO924138D0 (no) | 1992-10-27 |
| FI924869A0 (fi) | 1992-10-27 |
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