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ZA924522B - Compounds with renin-inhibiting properties,a process for the preparation thereof and the use thereof - Google Patents

Compounds with renin-inhibiting properties,a process for the preparation thereof and the use thereof

Info

Publication number
ZA924522B
ZA924522B ZA924522A ZA924522A ZA924522B ZA 924522 B ZA924522 B ZA 924522B ZA 924522 A ZA924522 A ZA 924522A ZA 924522 A ZA924522 A ZA 924522A ZA 924522 B ZA924522 B ZA 924522B
Authority
ZA
South Africa
Prior art keywords
renin
compounds
preparation
inhibiting properties
inhibiting
Prior art date
Application number
ZA924522A
Inventor
Holger Heitsch
Heitsch Holger
Hansjoerg Urbach
Urbach Hansjoerg
Wolfgang Linz
Linz Wolfgang
Rainer Henning
Henning Rainer
Dieter Ruppert
Ruppert Dieter
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA924522B publication Critical patent/ZA924522B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA924522A 1991-06-21 1992-06-19 Compounds with renin-inhibiting properties,a process for the preparation thereof and the use thereof ZA924522B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4120510 1991-06-21

Publications (1)

Publication Number Publication Date
ZA924522B true ZA924522B (en) 1993-02-24

Family

ID=6434452

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA924522A ZA924522B (en) 1991-06-21 1992-06-19 Compounds with renin-inhibiting properties,a process for the preparation thereof and the use thereof

Country Status (14)

Country Link
EP (1) EP0519433A1 (en)
JP (1) JPH05186461A (en)
KR (1) KR930000506A (en)
CN (1) CN1068112A (en)
BR (1) BR9202325A (en)
CA (1) CA2071744A1 (en)
CZ (1) CZ190692A3 (en)
FI (1) FI922875A (en)
HU (1) HUT61744A (en)
IE (1) IE921995A1 (en)
MX (1) MX9203070A (en)
NO (1) NO922426L (en)
PL (1) PL294870A1 (en)
ZA (1) ZA924522B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
JPH07504654A (en) 1992-03-11 1995-05-25 ナルヘックス　リミテッド Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
ATE253050T1 (en) 1992-03-11 2003-11-15 Narhex Ltd AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6369063B1 (en) 1997-04-14 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
EP0977772A1 (en) 1997-04-14 2000-02-09 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2285705A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
ECSP003707A (en) * 1999-10-13 2002-05-23 Novartis Ag DIAZEPANES
US6399599B1 (en) 1999-10-13 2002-06-04 Novartis Ag Substituted 2-oxo-1,4-diazacycloalkanes
WO2002060894A2 (en) 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Sulfonamide lactam inhibitors of factor xa
WO2005070870A2 (en) * 2004-01-23 2005-08-04 Speedel Experimenta Ag Amino alcohol derivatives and their use as renin inhibitors
CN1910135A (en) 2004-01-23 2007-02-07 斯皮德尔实验股份公司 Amino alcohol derivatives and their activity as renin inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
GB8707412D0 (en) * 1987-03-27 1987-04-29 Fujisawa Pharmaceutical Co Peptide compounds
IL87614A0 (en) * 1987-09-16 1989-01-31 Abbott Lab Peptidylheterocycles
DE3856166T2 (en) * 1987-09-29 1998-08-06 Banyu Pharma Co Ltd N-acylamino acid derivatives and their use
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
DE3839559A1 (en) * 1988-11-24 1990-05-31 Hoechst Ag RENIN-INHIBITING AMINODIOL DERIVATIVES
DE3841732A1 (en) * 1988-12-10 1990-06-13 Hoechst Ag DIPEPTIDE DERIVATIVES WITH ENZYME-INHIBITOR EFFECT
DE3913272A1 (en) * 1989-04-22 1990-10-25 Hoechst Ag DIPEPTIDE DERIVATIVES WITH ENZYME-INHIBITOR EFFECT

Also Published As

Publication number Publication date
HU9202062D0 (en) 1992-10-28
PL294870A1 (en) 1993-02-08
HUT61744A (en) 1993-03-01
CN1068112A (en) 1993-01-20
KR930000506A (en) 1993-01-15
JPH05186461A (en) 1993-07-27
FI922875A0 (en) 1992-06-18
FI922875A (en) 1992-12-22
EP0519433A1 (en) 1992-12-23
NO922426L (en) 1992-12-22
CZ190692A3 (en) 1993-01-13
CA2071744A1 (en) 1992-12-22
NO922426D0 (en) 1992-06-19
BR9202325A (en) 1993-01-19
MX9203070A (en) 1992-12-01
IE921995A1 (en) 1992-12-30

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