ZA917766B - Hybrid growth factors. - Google Patents

Hybrid growth factors.

Info

Publication number: ZA917766B
Authority: ZA; South Africa
Prior art keywords: growth factors; hybrid growth; hybrid; factors; growth
Prior art date: 1990-09-28

Application number

ZA917766A

Inventor

Jonathan I Rosen

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-27

Publication date

1993-03-29

1991-09-27 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1993-03-29 Publication of ZA917766B publication Critical patent/ZA917766B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA917766A 1990-09-28 1991-09-27 Hybrid growth factors. ZA917766B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58995890A	1990-09-28	1990-09-28

Publications (1)

Publication Number	Publication Date
ZA917766B true ZA917766B (en)	1993-03-29

Family

ID=24360286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA917766A ZA917766B (en)	1990-09-28	1991-09-27	Hybrid growth factors.

Country Status (8)

Country	Link
EP (1)	EP0503050A4 (en)
JP (1)	JPH05502463A (en)
AU (2)	AU8735991A (en)
CA (1)	CA2069746A1 (en)
IE (1)	IE913426A1 (en)
PT (1)	PT99107A (en)
WO (1)	WO1992006116A1 (en)
ZA (1)	ZA917766B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5718893A (en) *	1984-04-15	1998-02-17	Foster; Preston F.	Use of G-CSF to reduce acute rejection
CA2089553C (en) *	1990-08-29	2000-06-27	Paul Schendel	Multidomain hematopoiesis stimulators
US6153183A (en)	1992-11-24	2000-11-28	G. D. Searle & Company	Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
DE69333243T2 (en) *	1992-11-24	2004-08-19	G.D. Searle & Co., Chicago	MUTTED INTERLEUKIN-3 (IL-3) POLYPEPTIDES
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US5501962A (en) *	1993-06-21	1996-03-26	G. D. Searle & Co.	Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
WO1995028427A1 (en) *	1994-04-15	1995-10-26	Imclone Systems Incorporated	Chimeric interleukin-3/mutein interleukin-6 lymphokine
US5536495A (en) *	1994-04-15	1996-07-16	Foster; Preston F.	Use of G-CSF to reduce acute rejection
ITFI940106A1 (en) *	1994-05-27	1995-11-27	Menarini Ricerche Sud Spa	HYBRID MOLECULE OF GM-CSF-L-EPO OR EPO-L-GM-CSF FORMULA FOR ERYTHROPOIETIC STIMULATION
IT1271688B (en) *	1994-08-04	1997-06-04	Menarini Ricerche Sud Spa	HYBRID MOLECULES FOR ANTI-CANCER TREATMENT THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
ES2276401T3 (en) *	1995-04-26	2007-06-16	Kyowa Hakko Kogyo Co., Ltd.	FUSION PROTEINS G-CSF TPO.
US6066318A (en) *	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
IL129028A0 (en) *	1996-09-20	2000-02-17	Ortho Mcneil Pharm Inc	Method for in vitro determination of erythropoietin bioactivity
NZ334546A (en) *	1996-10-25	2000-12-22	G	Erythropoietin receptor agonist and use in the treatment of hematopoietic disorders
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
RO120919B1 (en) *	1996-10-25	2006-09-29	G.D. Searle & Co.	Hematopoietic protein, nucleic acid molecule encoding the same, pharmaceutical composition and use of said protein
US6187564B1 (en) *	1997-07-10	2001-02-13	Beth Israel Deaconess Medical Center	DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6165476A (en) *	1997-07-10	2000-12-26	Beth Israel Deaconess Medical Center	Fusion proteins with an immunoglobulin hinge region linker
ATE255634T1 (en) *	1997-09-01	2003-12-15	Aventis Pharma Gmbh	RECOMBINANT HUMAN ERYTHROPOIETIN WITH ADVANTAGEOUS GLYCOSYLATION PATTERN
WO1999041382A2 (en) *	1998-02-17	1999-08-19	Hyseq, Inc.	A novel interleukin-3 and uses thereof
BR9917606A (en) *	1998-11-06	2002-12-31	Bio Sidus S A	Procedure for the purification of recombinant human erythropoietin from cell culture supernatants and recombinant human erythropoietin obtained with such procedure
PT1311285E (en) *	2000-05-15	2005-06-30	Hoffmann La Roche	Liquid pharmaceutical composition containing a derivative of erythropoietin
US7220407B2 (en)	2003-10-27	2007-05-22	Amgen Inc.	G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
ATE544463T1 (en)	2004-11-05	2012-02-15	Univ Northwestern	USE OF SCF AND G-SCF IN THE TREATMENT OF BRAIN SCHEMIA AND NEUROLOGICAL DISORDERS
PE20130557A1 (en)	2010-03-04	2013-05-19	Pfenex Inc	METHOD TO PRODUCE SOLUBLE RECOMBINANT INTERFERON PROTEINS WITHOUT DENATURALIZATION
AU2011235210B2 (en)	2010-04-01	2015-07-16	Pfenex Inc.	Methods for G-CSF production in a Pseudomonas host cell
US9574045B2 (en)	2012-07-31	2017-02-21	Asahi Kasei E-Materials Corporation	Epoxy resin composition, epoxy resin, and cured product
LT6161B (en)	2013-09-27	2015-06-25	Uab Profarma	Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1203672B (en) *	1982-05-12	1989-02-15	Harvard College	HYBRID PROTEIN INCLUDING PROTEIN FRAGMENTS LINKED TO PEPTIDAL BONDS AND RELATED GENE OF MELTING COMPOSITION CONTAINING SUCH PROTEIN
US4935352A (en) *	1985-10-21	1990-06-19	Takeda Chemical Industries, Ltd.	Expression vector for animal cell line and use thereof
US4935233A (en) *	1985-12-02	1990-06-19	G. D. Searle And Company	Covalently linked polypeptide cell modulators
KR970008217B1 (en) *	1986-08-01	1997-05-22	알프레드 퍼넷트	Recombinant vaccine
JPH04500508A (en) *	1988-07-20	1992-01-30	イミュネックス・コーポレーション	Non-glycosylated human interleukin-3 composition
US5166322A (en) *	1989-04-21	1992-11-24	Genetics Institute	Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1991001004A1 (en) *	1989-07-06	1991-01-24	Seragen, Inc.	Hybrid molecules
DE69007975T2 (en) *	1989-08-22	1994-07-21	Immunex Corp	FUSION PROTEIN CONSISTING OF GM-CSF AND IL-3.
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
IL96477A0 (en) *	1989-12-01	1991-08-16	Amgen Inc	Megakaryocyte production
CA2089553C (en) *	1990-08-29	2000-06-27	Paul Schendel	Multidomain hematopoiesis stimulators

1991
- 1991-09-26 CA CA002069746A patent/CA2069746A1/en not_active Abandoned
- 1991-09-26 JP JP3517013A patent/JPH05502463A/en active Pending
- 1991-09-26 AU AU87359/91A patent/AU8735991A/en not_active Abandoned
- 1991-09-26 WO PCT/US1991/007053 patent/WO1992006116A1/en not_active Application Discontinuation
- 1991-09-26 EP EP19910918221 patent/EP0503050A4/en not_active Withdrawn
- 1991-09-27 ZA ZA917766A patent/ZA917766B/en unknown
- 1991-09-27 IE IE342691A patent/IE913426A1/en not_active Application Discontinuation
- 1991-09-27 PT PT99107A patent/PT99107A/en not_active Application Discontinuation
1995
- 1995-02-06 AU AU11576/95A patent/AU1157695A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0503050A1 (en)	1992-09-16
WO1992006116A1 (en)	1992-04-16
AU1157695A (en)	1995-04-13
IE913426A1 (en)	1992-04-08
CA2069746A1 (en)	1992-03-29
PT99107A (en)	1992-08-31
AU8735991A (en)	1992-04-28
JPH05502463A (en)	1993-04-28
EP0503050A4 (en)	1994-07-06

Publication	Publication Date	Title
ZA917766B (en)	1993-03-29	Hybrid growth factors.
DE69107059D1 (en)	1995-03-09	Sigma-delta-modulator.
AR244753A1 (en)	1993-11-30	Azo-colouring.
GR3022463T3 (en)	1997-04-30	1-H-3-aryl-pyrrolidin-2,4-dion-derivatives
GB2251034B (en)	1995-05-17	Shrouded aerofoils
EP0565582A4 (en)	1995-01-11	Novel csaids.
DE69111595D1 (en)	1995-08-31	Squarylium- und crokonyliumfarbstoffe.
DE69112211D1 (en)	1995-09-21	Luftreinigungsvorrichtung.
DE69104185D1 (en)	1994-10-27	Luftreservoir.
ZA928647B (en)	1993-06-21	Novel hybrid transforming growth factors.
EP0649734A3 (en)	1996-02-07	Packaging.
DE69106281D1 (en)	1995-02-09	Phenanthrenderivat.
AU9030991A (en)	1992-05-26	Improved capacitor-sensor
DE69102074D1 (en)	1994-06-23	Thermographische elemente.
DE69102644D1 (en)	1994-07-28	Demodulationsreferenzsignalquelle.
DE69114491D1 (en)	1995-12-14	Olefincopolymere.
DE69110012D1 (en)	1995-06-29	Linienerkennungsverfahren.
AR245079A1 (en)	1993-12-30	Procedure for preparing peroxomonosulphuric acid.
DE59102290D1 (en)	1994-08-25	Thermo-fixierstation mit bandtransport.
ZA931481B (en)	1993-09-23	Implants.
EP0575731A3 (en)	1994-10-26	Charger.
DE59100097D1 (en)	1993-06-03	Plungerzylinder.
IL96902A0 (en)	1992-03-29	T cell growth factor
ZA919371B (en)	1993-05-27	Containers.
GB2217943B (en)	1992-12-23	Epitaxial deposition.