ZA887264B - Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use - Google Patents

Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use

Info

Publication number: ZA887264B
Authority: ZA; South Africa
Prior art keywords: renin; preparation; agents containing; dipeptides; inhibiting
Prior art date: 1987-09-30

Application number

ZA887264A

Other languages

English (en)

Inventor

Adalbert Wagner

Wagner Adalbert

Bernward Schoelkens

Schoelkens Bernward

Heinz-Werner Kleemann

Kleemann Heinz-Werner

Hansjoerg Urbach

Urbach Hansjoerg

Dieter Ruppert

Ruppert Dieter

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-30

Filing date

1988-09-28

Publication date

1989-06-28

1988-09-28 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-06-28 Publication of ZA887264B publication Critical patent/ZA887264B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA887264A 1987-09-30 1988-09-28 Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use ZA887264B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873732971 DE3732971A1 (de)	1987-09-30	1987-09-30	Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number	Publication Date
ZA887264B true ZA887264B (en)	1989-06-28

Family

ID=6337246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA887264A ZA887264B (en)	1987-09-30	1988-09-28	Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use

Country Status (13)

Country	Link
EP (1)	EP0310015A3 (xx)
JP (1)	JPH01121258A (xx)
KR (1)	KR890005146A (xx)
AU (1)	AU624579B2 (xx)
DE (1)	DE3732971A1 (xx)
DK (1)	DK543788A (xx)
FI (1)	FI884455A (xx)
HU (1)	HU203118B (xx)
IL (1)	IL87912A0 (xx)
NO (1)	NO884324L (xx)
NZ (1)	NZ226361A (xx)
PT (1)	PT88622B (xx)
ZA (1)	ZA887264B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL87614A0 (en) *	1987-09-16	1989-01-31	Abbott Lab	Peptidylheterocycles
DE3804793A1 (de) *	1988-02-16	1989-08-24	Hoechst Ag	Renin-hemmende aminosaeurederivate
DE3814325A1 (de) *	1988-04-28	1989-11-09	Merck Patent Gmbh	Aminosaeurederivate
DE3841520A1 (de) *	1988-12-09	1990-06-13	Hoechst Ag	Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3913290A1 (de) *	1989-04-22	1990-10-25	Hoechst Ag	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
TW225540B (xx) *	1990-06-28	1994-06-21	Shionogi & Co
US5554641A (en) *	1995-03-20	1996-09-10	Horwell; David C.	Nonpeptides as tachykinin antagonists
JP4696352B2 (ja) *	2000-11-30	2011-06-08	トヨタ自動車株式会社	車両用電源装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3538749A1 (de) *	1985-10-31	1987-05-07	Merck Patent Gmbh	Peptide
DE3601248A1 (de) *	1986-01-17	1987-07-23	Hoechst Ag	Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
ZA87563B (en) *	1986-02-03	1987-09-30	Squibb & Sons Inc	N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) *	1986-07-30	1988-02-04	Hoechst Ag	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
HU204285B (en) *	1986-10-31	1991-12-30	Pfizer	Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
NL8800100A (nl) *	1987-01-21	1988-08-16	Sandoz Ag	Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.

1987
- 1987-09-30 DE DE19873732971 patent/DE3732971A1/de not_active Withdrawn
1988
- 1988-09-27 IL IL87912A patent/IL87912A0/xx unknown
- 1988-09-28 FI FI884455A patent/FI884455A/fi not_active Application Discontinuation
- 1988-09-28 ZA ZA887264A patent/ZA887264B/xx unknown
- 1988-09-28 EP EP19880115958 patent/EP0310015A3/de not_active Withdrawn
- 1988-09-28 NZ NZ226361A patent/NZ226361A/en unknown
- 1988-09-29 AU AU22959/88A patent/AU624579B2/en not_active Ceased
- 1988-09-29 PT PT88622A patent/PT88622B/pt not_active IP Right Cessation
- 1988-09-29 DK DK543788A patent/DK543788A/da not_active Application Discontinuation
- 1988-09-29 JP JP63242625A patent/JPH01121258A/ja active Pending
- 1988-09-29 HU HU885066A patent/HU203118B/hu not_active IP Right Cessation
- 1988-09-29 NO NO88884324A patent/NO884324L/no unknown
- 1988-09-30 KR KR1019880012716A patent/KR890005146A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
FI884455A (fi)	1989-03-31
DK543788D0 (da)	1988-09-29
NZ226361A (en)	1991-12-23
PT88622A (pt)	1989-07-31
AU624579B2 (en)	1992-06-18
KR890005146A (ko)	1989-05-13
DE3732971A1 (de)	1989-04-20
NO884324D0 (no)	1988-09-29
DK543788A (da)	1989-03-31
PT88622B (pt)	1993-07-30
IL87912A0 (en)	1989-03-31
FI884455A0 (fi)	1988-09-28
JPH01121258A (ja)	1989-05-12
NO884324L (no)	1989-03-31
HU203118B (en)	1991-05-28
AU2295988A (en)	1989-06-29
EP0310015A3 (de)	1992-05-20
HUT48278A (en)	1989-05-29
EP0310015A2 (de)	1989-04-05

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