[go: up one dir, main page]

ZA885766B - 1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments - Google Patents

1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments

Info

Publication number
ZA885766B
ZA885766B ZA885766A ZA885766A ZA885766B ZA 885766 B ZA885766 B ZA 885766B ZA 885766 A ZA885766 A ZA 885766A ZA 885766 A ZA885766 A ZA 885766A ZA 885766 B ZA885766 B ZA 885766B
Authority
ZA
South Africa
Prior art keywords
indazoles
piperazinyl
medicaments
intermediates
phenyl
Prior art date
Application number
ZA885766A
Other languages
English (en)
Inventor
Joseph Thomas Strupezewski
Thomas Strupezewski Joseph
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA885766B publication Critical patent/ZA885766B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA885766A 1987-08-07 1988-08-05 1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments ZA885766B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8276087A 1987-08-07 1987-08-07

Publications (1)

Publication Number Publication Date
ZA885766B true ZA885766B (en) 1989-07-26

Family

ID=22173273

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA885766A ZA885766B (en) 1987-08-07 1988-08-05 1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments

Country Status (11)

Country Link
EP (1) EP0302423A3 (no)
JP (1) JPS6466171A (no)
KR (1) KR890003730A (no)
AU (2) AU607792B2 (no)
DK (1) DK440488A (no)
FI (1) FI883646A (no)
IL (1) IL87361A0 (no)
NO (1) NO171679C (no)
NZ (1) NZ225714A (no)
PT (1) PT88202A (no)
ZA (1) ZA885766B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
JP3462501B2 (ja) * 1992-11-23 2003-11-05 アベンティス・ファーマスーティカルズ・インコーポレイテツド 置換された３−（アミノアルキルアミノ）−１，２−ベンゾイソキサゾールおよび関連化合物
MX9709451A (es) * 1995-06-06 1998-02-28 Hoechst Marion Roussel Inc Derivados de benzisoxazol e indazol como agentes antipsicoticos.
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
JP2014166961A (ja) * 2011-06-20 2014-09-11 Dainippon Sumitomo Pharma Co Ltd 新規インダゾール誘導体

Also Published As

Publication number Publication date
AU6824290A (en) 1991-03-14
EP0302423A2 (en) 1989-02-08
AU607792B2 (en) 1991-03-14
PT88202A (pt) 1989-06-30
FI883646A0 (fi) 1988-08-04
FI883646A (fi) 1989-02-08
JPS6466171A (en) 1989-03-13
NO171679C (no) 1993-04-21
EP0302423A3 (en) 1991-01-09
NZ225714A (en) 1991-12-23
IL87361A0 (en) 1989-01-31
NO883465L (no) 1989-02-08
NO171679B (no) 1993-01-11
AU2043488A (en) 1989-02-09
NO883465D0 (no) 1988-08-04
KR890003730A (ko) 1989-04-17
DK440488A (da) 1989-02-08
DK440488D0 (da) 1988-08-05

Similar Documents

Publication Publication Date Title
ZA907174B (en) 3-(1-substituted-4-piperazinyl)-1h-indazoles,a process for their preparation and their use as medicaments
AU6824090A (en) Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
EP0283055A3 (en) 10-dihydro-10-deoxo-11-azaerythronolide a compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
AU7171787A (en) 1-hydroxy-2-pyridones, a process for their preparation, and medicaments which contain them, and intermediates formed in the preparation of the 1-hydroxy-2-pyridones
ZA903396B (en) N-heteroaryl-4-quinolinamines,a process for their preparation and their use as medicaments
IL87361A0 (en) 1-phenyl-3-(1-piperazinyl)-1h-indazoles,a process and intermediates for their preparation,and the use thereof as medicaments
AR243877A1 (es) Procedimiento para la preparacion de derivados de 8,13-epoxi-9alfa-hidroxi-1alfa lad-14-en-11-ona e intermediarios para uso en dicho procedimiento.
ZA875043B (en) 7-acyloxy-6-aminoacyloxypolyoxylabdanes,a process for their preparation,and their use as medicaments
EP0424848A3 (en) Aminopyridinylaminophenols and related compounds, a process and intermediates for their preparation and their use as medicaments
ZA879694B (en) Novel carbamoyloxylabdanes,intermediates and a process for the preparation thereof and their use as medicaments
ZA878659B (en) 12-halogenated forskolin derivatives,intermediates and a process for the preparation thereof and their use as medicaments
ZA885011B (en) Diyhdro-1,4-oxazino(2,3-c quinolines),a process and intermediates for the preparation thereof and their use as medicaments
ZA88409B (en) 3-methylenespiro/benzofuranpiperidines/,intermediates and a process for the preparation thereof,and their use as medicaments
ZA855584B (en) New combination product,a process for its preparation and its use as a medicament
ZA893374B (en) Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments
EP0435223A3 (en) Thienobenzoxepin- and naphthothiophene-derivatives, a process and intermediates for their preparation and their use as medicaments
IL94974A0 (en) 6-and 7-deoxyforskolin and derivatives thereof,intermediates and a process for their preparation and their use as medicaments
ZA888194B (en) New acyllabdane derivatives,a process for their preparation,and their use as medicaments
AU6823990A (en) Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
NZ220805A (en) Cytorhodin s derivatives,a process for their preparation and their use as medicaments
AU2272788A (en) 2,6-methanopyrrolo-3-benzazocines, a process and intermediates for their preparation and their use as medicaments
ZA887564B (en) New anthracycline derivatives,a process for the preparation thereof,and the use thereof as pharmaceuticals
ZA888936B (en) New labdane derivatives,a process for their preparation,and their use as medicaments
ZA888937B (en) New labdane derivatives,a process for their preparation,and their use as medicaments
ZA872745B (en) 1-hydroxy-2-pyridones,a process for their preparation,and medicaments which contain them,and intermediates formed in the preparation of the 1-hydroxy-2-pyridones