ZA854762B - Indole-2-alkanoic acids - Google Patents

Indole-2-alkanoic acids

Info

Publication number: ZA854762B
Authority: ZA; South Africa
Prior art keywords: indole; alkanoic acids; alkanoic; acids
Prior art date: 1984-06-25

Application number

ZA854762A

Other languages

English (en)

Inventor

Yvan Guindon

Christiane Yoakim

Rejean Fortin

John W Gillard

Thomas R Jones

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-25

Filing date

1985-06-25

Publication date

1986-02-26

1985-06-25 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

1986-02-26 Publication of ZA854762B publication Critical patent/ZA854762B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

ZA854762A 1984-06-25 1985-06-25 Indole-2-alkanoic acids ZA854762B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US62417384A	1984-06-25	1984-06-25

Publications (1)

Publication Number	Publication Date
ZA854762B true ZA854762B (en)	1986-02-26

Family

ID=24500964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA854762A ZA854762B (en)	1984-06-25	1985-06-25	Indole-2-alkanoic acids

Country Status (12)

Country	Link
EP (1)	EP0166591B1 (fr)
JP (1)	JPS6163653A (fr)
KR (1)	KR860000258A (fr)
AU (1)	AU4377685A (fr)
CA (1)	CA1241660A (fr)
DE (1)	DE3574372D1 (fr)
DK (1)	DK284485A (fr)
ES (1)	ES8609245A1 (fr)
GR (1)	GR851494B (fr)
IL (1)	IL75586A (fr)
PT (1)	PT80698B (fr)
ZA (1)	ZA854762B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2543952B1 (fr) *	1982-09-03	1986-02-21	Bristol Myers Co	Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
GB8607294D0 (en) *	1985-04-17	1986-04-30	Ici America Inc	Heterocyclic amide derivatives
US5179112A (en) *	1985-04-17	1993-01-12	Ici Americas Inc.	Heterocyclic amide derivatives and pharmaceutical use
NO864131L (no) *	1985-10-17	1987-04-21	Ici America Inc	Fremgangsmaate for fremstilling av terapeutisk aktive indol-og indazol-ketosulfon-derivater.
GB8623429D0 (en) *	1985-10-17	1986-11-05	Ici America Inc	Carboximide derivatives
GB8707051D0 (en) *	1986-04-15	1987-04-29	Ici America Inc	Heterocyclic carboxamides
GB8609175D0 (en) *	1986-04-15	1986-05-21	Ici America Inc	Heterocyclic carboxamides
US5081138A (en) *	1986-12-17	1992-01-14	Merck Frosst Canada, Inc.	3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
IL84796A (en) *	1986-12-17	1992-03-29	Merck Frosst Canada Inc	Substituted n-benzyl-indoles and pharmaceutical compositions containing them
EP0300675A3 (fr) *	1987-07-21	1990-04-11	Merck Frosst Canada Inc.	Méthode pour l'amélioration des traitements par la cyclosporine
DE3807922A1 (de) *	1988-03-10	1989-09-21	Boehringer Mannheim Gmbh	Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IT1227362B (it) *	1988-11-18	1991-04-08	Istituto Biochimico Italiano	Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici
US5093351A (en) *	1989-01-05	1992-03-03	Du Pont Merck Pharmaceutical Company	Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors
US5204344A (en) *	1989-08-22	1993-04-20	Merck Frosst Canada, Inc.	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5272145A (en) *	1989-08-22	1993-12-21	Merck Frosst Canada, Inc.	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
NZ234883A (en) *	1989-08-22	1995-01-27	Merck Frosst Canada Inc	Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
GB9108811D0 (en) *	1991-04-24	1991-06-12	Erba Carlo Spa	N-imidazolyl derivatives of substituted indole
CA2079374C (fr) *	1991-09-30	2003-08-05	Merck Frosst Canada Incorporated	Indol (azaarylmethoxy bicyclique) comme inhibiteur de leucotriene biosynthetique
US5290798A (en) *	1991-09-30	1994-03-01	Merck Frosst Canada, Inc.	(hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) *	1991-09-30	1993-03-02	Merck Frosst Canada, Inc.	(Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) *	1991-09-30	1994-05-03	Merck Frosst Canada, Inc.	(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) *	1991-09-30	1995-02-14	Merck Frosst Canada, Inc.	(Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
CA2129429A1 (fr) *	1992-02-13	1993-08-14	Richard Frenette	(azaaromaticalkoxy) indoles utilises comme inhibiteurs de la biosynthese de la leucotriene
US5374635A (en) *	1993-03-29	1994-12-20	Merck Frosst Canada, Inc.	Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
EP0802183B1 (fr) *	1996-04-19	2001-10-10	American Home Products Corporation	Composés oestrogènes
US6069153A (en) *	1998-05-12	2000-05-30	American Home Products Corporation	Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en)	1998-05-15	2002-11-12	Wyeth	2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
GB9902461D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
US6159959A (en) *	1999-05-06	2000-12-12	American Home Products Corporation	Combined estrogen and antiestrogen therapy
ATE340796T1 (de) *	2001-05-23	2006-10-15	Merck Frosst Canada Inc	Dihydropyrrolo(1,2-aöindol- und tetrahydropyrido)1,2-aöindolderivate als prostaglandin rezeptor antagonisten
WO2004039807A1 (fr)	2002-10-30	2004-05-13	Merck Frosst Canada & Co.	Pyridopyrrolizine et derives de pyridoindolizine
CA2593155A1 (fr)	2005-01-19	2006-07-27	Biolipox Ab	Indoles utiles dans le traitement de l'inflammation
WO2007121578A1 (fr) *	2006-04-24	2007-11-01	Merck Frosst Canada Ltd.	Dérivés d'indolamide comme antagonistes du récepteur ep4
CN113329996B (zh) *	2018-06-25	2023-03-10	博远医药(苏州)有限公司	用于治疗刺猬途径相关病症的化合物和方法
CN109535060B (zh) *	2018-12-20	2022-03-25	苏州麦迪耐斯医药科技有限公司	一种刺猬通路抑制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH455777A (de) *	1965-05-13	1968-05-15	Geigy Ag J R	Verfahren zur Herstellung von neuen Indolderivaten
CH454858A (de) *	1965-05-13	1968-04-30	Geigy Ag J R	Verfahren zur Herstellung von neuen Indolderivaten

1985
- 1985-06-17 CA CA000484174A patent/CA1241660A/fr not_active Expired
- 1985-06-18 AU AU43776/85A patent/AU4377685A/en not_active Abandoned
- 1985-06-19 GR GR851494A patent/GR851494B/el unknown
- 1985-06-20 IL IL75586A patent/IL75586A/xx unknown
- 1985-06-24 DK DK284485A patent/DK284485A/da not_active Application Discontinuation
- 1985-06-24 EP EP85304468A patent/EP0166591B1/fr not_active Expired
- 1985-06-24 KR KR1019850004471A patent/KR860000258A/ko not_active Application Discontinuation
- 1985-06-24 PT PT80698A patent/PT80698B/pt unknown
- 1985-06-24 DE DE8585304468T patent/DE3574372D1/de not_active Expired
- 1985-06-25 ES ES544524A patent/ES8609245A1/es not_active Expired
- 1985-06-25 ZA ZA854762A patent/ZA854762B/xx unknown
- 1985-06-25 JP JP60137091A patent/JPS6163653A/ja active Pending

Also Published As

Publication number	Publication date
JPS6163653A (ja)	1986-04-01
DK284485D0 (da)	1985-06-24
KR860000258A (ko)	1986-01-27
DE3574372D1 (en)	1989-12-28
AU4377685A (en)	1986-01-02
EP0166591B1 (fr)	1989-11-23
IL75586A (en)	1988-09-30
EP0166591A3 (en)	1986-06-25
GR851494B (fr)	1985-11-25
PT80698B (en)	1987-03-31
CA1241660A (fr)	1988-09-06
DK284485A (da)	1986-02-24
PT80698A (en)	1985-07-01
IL75586A0 (en)	1985-10-31
EP0166591A2 (fr)	1986-01-02
ES544524A0 (es)	1986-09-01
ES8609245A1 (es)	1986-09-01

Publication	Publication Date	Title
ZA854762B (en)	1986-02-26	Indole-2-alkanoic acids
CS232185A2 (en)	1987-08-13	Zarizeni pro raseni hadicovych obalu
CS464685A2 (en)	1987-07-16	Prostredek pro zachovani dusiku v pude
GB2176784B (en)	1989-07-12	3-acylamino-2-oxo-1-azetidinesulfonic acids
CS272984A1 (en)	1985-05-15	Zarizeni pro indikaci kovovych primesi v materialu
GR862164B (en)	1986-12-23	Cyclohexanealkanoic acids
CS1003084A1 (en)	1985-07-16	Zarizeni pro zasobovani pracovni drahy pravidelnym proudem balicku
IE850118L (en)	1985-07-19	Dithiaalkanedioic acids
IE842482L (en)	1985-03-29	Quinazolinone-1-alkanoic acids
IE841723L (en)	1985-01-07	Gamma-allenyl-gamma-aminobutyric acids
IE842481L (en)	1985-03-29	Quinazolinone-1-alkanoic acids
IE850609L (en)	1985-09-09	Methyleneaminophenylalkane-carboxylic acids
IE851538L (en)	1985-12-25	Indole - 2 - alkanoic acids
IE850795L (en)	1985-09-29	Substituted ó-amino acids
GB8428280D0 (en)	1984-12-19	Alkenoic acids
CS300084A1 (en)	1985-05-15	Michaci zarizeni pro homogenizaci suspenzi v hydrometalurgicke vyrobe
CS654184A1 (en)	1985-06-13	Zarizeni pro celni vrtani v mechanizovanych porubech
CS273084A1 (en)	1985-05-15	Zarizeni pro indikaci tvrdych primesi v proudu materialu
CS212185A1 (en)	1985-11-13	Rucni frezka pro vytvareni fixacni brazdy v spongioze kosti
CS339485A1 (en)	1988-03-15	Nakladaci zarizeni instalace pro suseni tenke disperzni latky v erupcni vrstve
CS400484A1 (en)	1985-05-15	Zarizeni pro pridrzovani kvetin v hrdle vazy
CS406284A1 (en)	1985-08-15	Zarizeni pro zamezeni podtlaku v nizkotlakem kotli
CS463884A1 (en)	1987-01-15	Zarizeni pro indukcni ohrev kovu v nadobach
CS178784A1 (en)	1985-08-15	Zarizeni pro presne vedeni pracovniho zarizeni v kruhovem pozemku
CS521184A1 (en)	1985-04-16	Zarizeni pro zpracovani signalu inkrementalnich cidel v mikropocitacovem systemu