ZA766303B - Disubstituted phenol ethers of 3-amino-2-hydroxypropane processes for their preparation and their use as medicament - Google Patents

Disubstituted phenol ethers of 3-amino-2-hydroxypropane processes for their preparation and their use as medicament

Info

Publication number: ZA766303B
Authority: ZA; South Africa
Prior art keywords: hydroxypropane; medicament; amino; processes; preparation
Prior art date: 1975-10-23

Application number

ZA766303A

Other languages

English (en)

Inventor

F Hoffmeister

A Heise

S Kazda

R Hiltmann

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-10-23

Filing date

1976-10-22

Publication date

1977-09-28

1976-10-22 Application filed by Bayer Ag filed Critical Bayer Ag

1977-09-28 Publication of ZA766303B publication Critical patent/ZA766303B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA766303A 1975-10-23 1976-10-22 Disubstituted phenol ethers of 3-amino-2-hydroxypropane processes for their preparation and their use as medicament ZA766303B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19752547524 DE2547524A1 (de)	1975-10-23	1975-10-23	Disubstituierte phenolaether des 3-amino-2-hydroxypropans, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number	Publication Date
ZA766303B true ZA766303B (en)	1977-09-28

Family

ID=5959934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA766303A ZA766303B (en)	1975-10-23	1976-10-22	Disubstituted phenol ethers of 3-amino-2-hydroxypropane processes for their preparation and their use as medicament

Country Status (29)

Country	Link
US (1)	US4110472A (xx)
JP (1)	JPS5935387B2 (xx)
AT (2)	AT344682B (xx)
AU (1)	AU502167B2 (xx)
BE (1)	BE847541A (xx)
BG (2)	BG27732A3 (xx)
CA (1)	CA1085417A (xx)
CH (2)	CH623562A5 (xx)
CS (2)	CS191344B2 (xx)
DD (1)	DD128555A5 (xx)
DE (1)	DE2547524A1 (xx)
DK (1)	DK480376A (xx)
ES (1)	ES452616A1 (xx)
FI (1)	FI67075C (xx)
FR (1)	FR2328458A1 (xx)
GB (1)	GB1497500A (xx)
GR (1)	GR61598B (xx)
HU (1)	HU174097B (xx)
IE (1)	IE43745B1 (xx)
IL (1)	IL50732A (xx)
LU (1)	LU76057A1 (xx)
NL (1)	NL7611683A (xx)
NO (1)	NO143844C (xx)
PL (2)	PL110002B1 (xx)
PT (1)	PT65737B (xx)
RO (1)	RO76883A (xx)
SE (1)	SE432926B (xx)
SU (2)	SU639443A3 (xx)
ZA (1)	ZA766303B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1223395B (it) *	1987-12-01	1990-09-19	Simes	Composti ad attivita' cardiovascolare
US5541204A (en) *	1994-12-02	1996-07-30	Bristol-Myers Squibb Company	Aryloxypropanolamine β 3 adrenergic agonists
WO2008131368A2 (en)	2007-04-20	2008-10-30	Acucela Inc.	Styrenyl derivative compounds for treating ophthalmic diseases and disorders
FR3030514A1 (fr) *	2014-12-18	2016-06-24	Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad)	Dimeres polyaromatiques
EP3144289A1 (en) *	2015-09-16	2017-03-22	Evonik Technochemie GmbH	[(2-ethoxy-5-trans-1-propen-1-yl)-phenoxyl]-terminated compounds
EP3522877B1 (en)	2016-10-05	2023-12-06	University of Pittsburgh - Of the Commonwealth System of Higher Education	Small molecule ampk activators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3758583A (en) *	1971-01-21	1973-09-11	Syntex Corp	2-(2-hydroxy-3-aminopropyl-1-yloxy)-1,6-dilfuoro-and-1,6-methano-{8 10{9 annulenes and the salts thereof

1975
- 1975-10-23 DE DE19752547524 patent/DE2547524A1/de not_active Withdrawn
1976
- 1976-10-08 NO NO763442A patent/NO143844C/no unknown
- 1976-10-13 US US05/732,118 patent/US4110472A/en not_active Expired - Lifetime
- 1976-10-18 CH CH1318976A patent/CH623562A5/de not_active IP Right Cessation
- 1976-10-18 SU SU762413401A patent/SU639443A3/ru active
- 1976-10-19 BG BG034473A patent/BG27732A3/xx unknown
- 1976-10-19 BG BG035324A patent/BG31796A3/xx unknown
- 1976-10-19 AU AU18797/76A patent/AU502167B2/en not_active Expired
- 1976-10-20 IL IL50732A patent/IL50732A/xx unknown
- 1976-10-20 PT PT65737A patent/PT65737B/pt unknown
- 1976-10-21 GB GB43725/76A patent/GB1497500A/en not_active Expired
- 1976-10-21 NL NL7611683A patent/NL7611683A/xx not_active Application Discontinuation
- 1976-10-21 HU HU76BA3468A patent/HU174097B/hu unknown
- 1976-10-21 SE SE7611686A patent/SE432926B/xx unknown
- 1976-10-21 FI FI763010A patent/FI67075C/fi not_active IP Right Cessation
- 1976-10-21 JP JP51125582A patent/JPS5935387B2/ja not_active Expired
- 1976-10-21 DD DD7600195393A patent/DD128555A5/xx unknown
- 1976-10-21 AT AT784476A patent/AT344682B/de not_active IP Right Cessation
- 1976-10-21 AT AT606377A patent/AT345792B/de not_active IP Right Cessation
- 1976-10-22 FR FR7631948A patent/FR2328458A1/fr active Granted
- 1976-10-22 CA CA263,964A patent/CA1085417A/en not_active Expired
- 1976-10-22 IE IE2332/76A patent/IE43745B1/en unknown
- 1976-10-22 DK DK480376A patent/DK480376A/da not_active Application Discontinuation
- 1976-10-22 PL PL1976213281A patent/PL110002B1/pl unknown
- 1976-10-22 CS CS777809A patent/CS191344B2/cs unknown
- 1976-10-22 CS CS766837A patent/CS191322B2/cs unknown
- 1976-10-22 LU LU76057A patent/LU76057A1/xx unknown
- 1976-10-22 GR GR51997A patent/GR61598B/el unknown
- 1976-10-22 PL PL1976193206A patent/PL110007B1/pl unknown
- 1976-10-22 BE BE171708A patent/BE847541A/xx not_active IP Right Cessation
- 1976-10-22 ZA ZA766303A patent/ZA766303B/xx unknown
- 1976-10-22 RO RO7696832A patent/RO76883A/ro unknown
- 1976-10-22 ES ES452616A patent/ES452616A1/es not_active Expired
1977
- 1977-07-15 SU SU772502200A patent/SU664559A3/ru active
1980
- 1980-09-08 CH CH672680A patent/CH630058A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1085417A (en)	1980-09-09
IL50732A0 (en)	1976-12-31
BE847541A (fr)	1977-04-22
DD128555A5 (de)	1977-11-23
LU76057A1 (xx)	1977-05-31
IE43745B1 (en)	1981-05-20
NO143844C (no)	1981-04-22
CS191344B2 (en)	1979-06-29
US4110472A (en)	1978-08-29
SE432926B (sv)	1984-04-30
AT345792B (de)	1978-10-10
BG27732A3 (en)	1979-12-12
FR2328458A1 (fr)	1977-05-20
IE43745L (en)	1977-04-23
SU664559A3 (ru)	1979-05-25
FI67075B (fi)	1984-09-28
AU502167B2 (en)	1979-07-12
JPS5935387B2 (ja)	1984-08-28
DK480376A (da)	1977-04-24
PL110002B1 (en)	1980-06-30
ES452616A1 (es)	1978-01-16
CH630058A5 (de)	1982-05-28
CH623562A5 (xx)	1981-06-15
SU639443A3 (ru)	1978-12-25
FI763010A (xx)	1977-04-24
JPS5251352A (en)	1977-04-25
GB1497500A (en)	1978-01-12
PT65737B (en)	1978-04-20
HU174097B (hu)	1979-11-28
RO76883A (ro)	1981-08-30
PL110007B1 (en)	1980-06-30
NO763442L (xx)	1977-04-26
CS191322B2 (en)	1979-06-29
PL193206A1 (pl)	1979-03-12
PT65737A (en)	1976-11-01
BG31796A3 (en)	1982-03-15
ATA784476A (de)	1977-12-15
IL50732A (en)	1979-12-30
NL7611683A (nl)	1977-04-26
AT344682B (de)	1978-08-10
FR2328458B1 (xx)	1979-03-02
SE7611686L (sv)	1977-04-24
AU1879776A (en)	1978-04-27
DE2547524A1 (de)	1977-04-28
NO143844B (no)	1981-01-12
GR61598B (en)	1978-12-02
FI67075C (fi)	1985-01-10
ATA606377A (de)	1978-02-15

Publication	Publication Date	Title
IL50814A0 (en)	1977-01-31	New phenol ethers their preparation and pharmaceutical compositions containing them
PH12959A (en)	1979-10-19	Preparation of pharmaceutical unit dosage form
JPS51115910A (en)	1976-10-13	Gradually releaseetype medical composition and its preparation
EG12218A (en)	1985-03-31	Process for preparing of novel diphenyl ethers and their use as insecticides
GR61175B (en)	1978-10-03	Preparation process of (1-phenyl-2-triazolyl-ethyl)-ether-derivatives and use thereof as fungicides
JPS51146449A (en)	1976-12-16	Preparation of novel cromanci compound and pharmaceutical composition
IL50657A0 (en)	1976-12-31	11-deoxy acetylenic arylprostaglandins and their preparation
GR61763B (en)	1979-01-09	Preparation process of 2-substituted-5-alkyl resorcinols
ZA766303B (en)	1977-09-28	Disubstituted phenol ethers of 3-amino-2-hydroxypropane processes for their preparation and their use as medicament
PH13199A (en)	1980-01-28	Methods and pharmaceutical preparation for the treatment of hypercholesterolaenia
GB1552333A (en)	1979-09-12	Lanthanide phosphor and processes for its preparation
IL50514A (en)	1979-07-25	Clavulanic acid ethers their preparation and pharmaceutical compositions containing them
PT64945B (en)	1977-08-25	Preparation of therapeutic compounds
JPS5277081A (en)	1977-06-29	Pfnicillins process for preparing same and medical composition containing same
GB1539733A (en)	1979-01-31	Preparation of 3-phenoxybenzaldehydes
JPS527419A (en)	1977-01-20	Heterocolloidal deblicin containing medical composition and its preparation
JPS51144720A (en)	1976-12-13	Stable medical composition and its preparation of ergotalkaloids
EG12318A (en)	1978-12-31	Method for preparation of substituted(2-methylamino)thiazolin and uses as parasiticide
JPS5218810A (en)	1977-02-12	Complex medical composition of estrogennprostaglangin
JPS5217454A (en)	1977-02-09	Preparation and use of novel 22hydroxynaphthalinee 11aldehyde
AU1076476A (en)	1977-08-11	Preparation of 3-hydroxymethyl diphenyl ether
JPS533509A (en)	1978-01-13	Preparation of tumor vaccine
JPS5223028A (en)	1977-02-21	Preparation of alpha* alpha* alpha alpha alphaapentachlorooooxylol
PH13439A (en)	1980-04-23	Method of preparing solid pharmaceutical unit dosage form
JPS5276416A (en)	1977-06-27	Preparation of medical material with antiaggulutinating activity