ZA762320B - Piperazinyl pyrazines as anorectic agents - Google Patents

Piperazinyl pyrazines as anorectic agents

Info

Publication number: ZA762320B
Authority: ZA; South Africa
Prior art keywords: anorectic agents; pyrazines; piperazinyl; piperazinyl pyrazines; anorectic
Prior art date: 1975-04-21

Application number

ZA762320A

Other languages

English (en)

Inventor

W Saari

W Lumma

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-20

Publication date

1977-11-30

1976-04-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1977-11-30 Publication of ZA762320B publication Critical patent/ZA762320B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Child & Adolescent Psychology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA762320A 1975-04-21 1976-04-20 Piperazinyl pyrazines as anorectic agents ZA762320B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21

Publications (1)

Publication Number	Publication Date
ZA762320B true ZA762320B (en)	1977-11-30

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA762320A ZA762320B (en)	1975-04-21	1976-04-20	Piperazinyl pyrazines as anorectic agents

Country Status (36)

Country	Link
JP (1)	JPS51136688A (pt)
AR (1)	AR210349A1 (pt)
AT (1)	AT353795B (pt)
AU (1)	AU496854B2 (pt)
BE (1)	BE840904A (pt)
BG (1)	BG34185A3 (pt)
CA (1)	CA1059128A (pt)
CH (1)	CH619462A5 (pt)
CS (1)	CS195726B2 (pt)
CY (1)	CY1090A (pt)
DD (1)	DD124599A5 (pt)
DE (1)	DE2617205C3 (pt)
DK (1)	DK143899C (pt)
EG (1)	EG12387A (pt)
ES (4)	ES447150A1 (pt)
FI (1)	FI62666C (pt)
FR (1)	FR2308367A1 (pt)
GB (1)	GB1492528A (pt)
GR (1)	GR59900B (pt)
HK (1)	HK60380A (pt)
HU (1)	HU172684B (pt)
IE (1)	IE42979B1 (pt)
IL (1)	IL49391A (pt)
KE (1)	KE3088A (pt)
LU (1)	LU74795A1 (pt)
MY (1)	MY8100225A (pt)
NL (1)	NL167692C (pt)
NO (1)	NO146599C (pt)
PH (1)	PH12274A (pt)
PL (1)	PL99664B1 (pt)
PT (1)	PT65027B (pt)
RO (1)	RO73278A (pt)
SE (1)	SE421695B (pt)
SU (1)	SU638260A3 (pt)
YU (1)	YU100676A (pt)
ZA (1)	ZA762320B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
JP4570773B2 (ja)	1997-10-27	2010-10-27	ニューロサーチ、アクティーゼルスカブ	ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン
ATE245153T1 (de) *	1999-04-26	2003-08-15	Neurosearch As	Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
US6995161B2 (en) *	2000-02-16	2006-02-07	Neurogen Corporation	Substituted arylpyrazines
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds
BR0312789A (pt) *	2002-07-19	2005-05-03	Biovitrum Ab	Novos derivados de piperazinil - pirazinona para o tratamento de distúrbios relacionados ao receptor 5-ht2a

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
1977
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
LU74795A1 (pt)	1977-02-07
SU638260A3 (ru)	1978-12-15
DD124599A5 (pt)	1977-03-02
IL49391A (en)	1979-09-30
AU496854B2 (en)	1978-11-02
FI62666B (fi)	1982-10-29
DK164476A (da)	1976-10-22
CS195726B2 (en)	1980-02-29
DK143899C (da)	1982-04-13
NO761207L (pt)	1976-10-22
ES459405A1 (es)	1978-08-16
AR210349A1 (es)	1977-07-29
SE7604093L (sv)	1976-10-22
AU1296676A (en)	1977-10-20
FR2308367A1 (fr)	1976-11-19
EG12387A (en)	1978-12-31
MY8100225A (en)	1981-12-31
GB1492528A (en)	1977-11-23
ATA288376A (de)	1979-05-15
DE2617205A1 (de)	1976-10-28
BE840904A (fr)	1976-08-16
NL167692C (nl)	1982-01-18
IL49391A0 (en)	1976-06-30
FI62666C (fi)	1983-02-10
DE2617205B2 (de)	1980-05-08
BG34185A3 (bg)	1983-07-15
FI760978A7 (pt)	1976-10-22
YU100676A (en)	1982-08-31
NO146599C (no)	1982-11-03
JPS5522475B2 (pt)	1980-06-17
NL7603800A (nl)	1976-10-25
KE3088A (en)	1980-11-07
JPS51136688A (en)	1976-11-26
AT353795B (de)	1979-12-10
HU172684B (hu)	1978-11-28
DE2617205C3 (de)	1981-01-29
CH619462A5 (en)	1980-09-30
PH12274A (en)	1978-12-12
PT65027B (en)	1978-04-03
NL167692B (nl)	1981-08-17
SE421695B (sv)	1982-01-25
RO73278A (ro)	1982-09-09
ES459407A1 (es)	1978-08-16
PL99664B1 (pl)	1978-07-31
FR2308367B1 (pt)	1979-09-21
PT65027A (en)	1976-05-01
CY1090A (en)	1980-12-27
IE42979L (en)	1976-10-21
IE42979B1 (en)	1980-11-19
GR59900B (en)	1978-03-16
NO146599B (no)	1982-07-26
CA1059128A (en)	1979-07-24
DK143899B (da)	1981-10-26
HK60380A (en)	1980-11-07
ES459406A1 (es)	1978-08-16
ES447150A1 (es)	1977-09-16

Publication	Publication Date	Title
ZA762966B (en)	1977-05-25	Chemitherapeutic agents
HK20383A (en)	1983-06-24	Chair
GB1542520A (en)	1979-03-21	Disinfecting agents
GB1556251A (en)	1979-11-21	Chair
JPS522656A (en)	1977-01-10	Chair
MY8100290A (en)	1981-12-31	Gielling agents
ZA762320B (en)	1977-11-30	Piperazinyl pyrazines as anorectic agents
JPS51128983A (en)	1976-11-10	344dihydrospiroo2hh133 benzoxazines
GB1544669A (en)	1979-04-25	Chair
AU1508976A (en)	1978-01-05	Chair
JPS5263186A (en)	1977-05-25	Clouddproofing agents
JPS5197388A (en)	1976-08-26	Sohogata mos denkaikokatoranjisutanoseizohoho
JPS5212070A (en)	1977-01-29	Chair
GB1539288A (en)	1979-01-31	Heat-sensitising agents
ZA764928B (en)	1977-07-27	Chair
JPS5192186A (en)	1976-08-12	mos shusekikairono seizohoho
AU1195076A (en)	1977-09-15	Taeniacidal agents
AU2073576A (en)	1978-06-29	Diamino diphenyl-methanes
JPS5245450A (en)	1977-04-09	Chair
GB1549062A (en)	1979-08-01	Brushes
JPS527099A (en)	1977-01-19	Stool
JPS528354A (en)	1977-01-22	Stool
JPS521197A (en)	1977-01-06	Various use table
JPS5181569A (en)	1976-07-16	mos denkaikokagatatoranjisutano seizohoho
JPS5180784A (en)	1976-07-14	mos gatahandotaisochinoseizohoho