ZA201503540B - Process for preparing polycyclic carbamoyl pyridone derivatives - Google Patents
Process for preparing polycyclic carbamoyl pyridone derivativesInfo
- Publication number
- ZA201503540B ZA201503540B ZA2015/03540A ZA201503540A ZA201503540B ZA 201503540 B ZA201503540 B ZA 201503540B ZA 2015/03540 A ZA2015/03540 A ZA 2015/03540A ZA 201503540 A ZA201503540 A ZA 201503540A ZA 201503540 B ZA201503540 B ZA 201503540B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridone derivatives
- preparing polycyclic
- carbamoyl pyridone
- polycyclic carbamoyl
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1686MU2014 | 2014-05-20 | ||
| IN4MU2015 | 2015-01-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201503540B true ZA201503540B (en) | 2016-10-26 |
Family
ID=53269685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2015/03540A ZA201503540B (en) | 2014-05-20 | 2015-05-20 | Process for preparing polycyclic carbamoyl pyridone derivatives |
Country Status (2)
| Country | Link |
|---|---|
| WO (1) | WO2015177537A1 (en) |
| ZA (1) | ZA201503540B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2770050T3 (en) | 2014-01-21 | 2020-06-30 | Laurus Labs Ltd | New procedure for the preparation of dolutegravir and its pharmaceutically acceptable salts |
| CZ201599A3 (en) * | 2015-02-13 | 2016-08-24 | Zentiva, K.S. | Solid forms of dolutegravir salts and process for preparing thereof |
| JP2019501163A (en) * | 2015-12-21 | 2019-01-17 | ルピン・リミテッド | Method for producing HIV integrase inhibitor |
| CN106565747A (en) * | 2016-11-10 | 2017-04-19 | 顾世海 | Novel method for preparing dolutegravir |
| WO2018109786A1 (en) * | 2016-12-16 | 2018-06-21 | Cipla Limited | Novel polymoprphs and salts of polycyclic carbamoyl pyridone derivatives |
| MX388699B (en) * | 2017-02-16 | 2025-03-20 | Viiv Healthcare Uk No 3 Ltd | Crystalline forms of sodium cabotegravir |
| EP3363802B1 (en) | 2017-02-16 | 2019-11-20 | Sandoz AG | Crystalline form of cabotegravir sodium |
| AU2018344739B2 (en) | 2017-10-06 | 2023-04-13 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| WO2019159199A1 (en) * | 2018-02-16 | 2019-08-22 | Cipla Limited | Continues flow process for the preparation of active pharmaceutical ingredients - polycyclic carbamoyl pyridone derivatives and intermediates thereof |
| EP3820875B1 (en) * | 2018-07-12 | 2024-01-17 | Laurus Labs Limited | A process for purification of protected polycyclic carbamoylpyridone derivatives |
| JP7685522B2 (en) | 2020-11-17 | 2025-05-29 | 塩野義製薬株式会社 | Novel acridinium salt and method for producing same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0610030B8 (en) * | 2005-04-28 | 2022-01-11 | Glaxosmithkline Llc | Compound, pharmaceutical composition, and use of a compound |
| JP5572168B2 (en) * | 2008-12-11 | 2014-08-13 | ビーブ・ヘルスケア・カンパニー | Process for producing carbamoylpyridone HIV integrase inhibitor and intermediate |
| TWI582097B (en) * | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | Process for preparing carbamoylpyridone derivatives and intermediates |
| PE20151499A1 (en) * | 2012-12-21 | 2015-10-29 | Gilead Sciences Inc | POLYCYCLICAL CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE |
| WO2015019310A1 (en) * | 2013-08-07 | 2015-02-12 | Mylan Laboratories Ltd | Process for the preparation of dolute-gravir and intermediates thereof |
-
2015
- 2015-05-20 ZA ZA2015/03540A patent/ZA201503540B/en unknown
- 2015-05-20 WO PCT/GB2015/051473 patent/WO2015177537A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015177537A1 (en) | 2015-11-26 |
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