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ZA200903633B - Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same - Google Patents

Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same

Info

Publication number
ZA200903633B
ZA200903633B ZA2009/03633A ZA200903633A ZA200903633B ZA 200903633 B ZA200903633 B ZA 200903633B ZA 2009/03633 A ZA2009/03633 A ZA 2009/03633A ZA 200903633 A ZA200903633 A ZA 200903633A ZA 200903633 B ZA200903633 B ZA 200903633B
Authority
ZA
South Africa
Prior art keywords
hla
peptide
restricted
same
pharmaceutical composition
Prior art date
Application number
ZA2009/03633A
Other languages
English (en)
Inventor
Haruo Sugiyama
Original Assignee
Int Inst Cancer Immunology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Inst Cancer Immunology Inc filed Critical Int Inst Cancer Immunology Inc
Publication of ZA200903633B publication Critical patent/ZA200903633B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
ZA2009/03633A 2006-12-28 2009-05-26 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same ZA200903633B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006355356 2006-12-28
PCT/JP2007/074146 WO2008081701A1 (ja) 2006-12-28 2007-12-14 Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物

Publications (1)

Publication Number Publication Date
ZA200903633B true ZA200903633B (en) 2010-02-24

Family

ID=39588385

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2009/03633A ZA200903633B (en) 2006-12-28 2009-05-26 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same

Country Status (27)

Country Link
US (4) US8653038B2 (xx)
EP (6) EP3026115B1 (xx)
JP (1) JP5484734B2 (xx)
KR (1) KR101525261B1 (xx)
CN (5) CN102335439B (xx)
AR (1) AR064555A1 (xx)
AU (1) AU2007340679B2 (xx)
BR (1) BRPI0720988A2 (xx)
CA (5) CA2886621A1 (xx)
CY (1) CY1116011T1 (xx)
DK (3) DK2479275T3 (xx)
ES (4) ES2556831T3 (xx)
IL (4) IL199052A0 (xx)
MX (1) MX2009007008A (xx)
MY (1) MY161664A (xx)
NO (1) NO20092774L (xx)
NZ (4) NZ577443A (xx)
PH (1) PH12014500902B1 (xx)
PL (1) PL2341142T3 (xx)
PT (1) PT2341142E (xx)
RU (1) RU2481398C2 (xx)
SG (1) SG177222A1 (xx)
SI (1) SI2341142T1 (xx)
TW (3) TWI417103B (xx)
UA (1) UA103154C2 (xx)
WO (1) WO2008081701A1 (xx)
ZA (1) ZA200903633B (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130062368A (ko) 2003-11-05 2013-06-12 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 Ｗｔ１ 유래의 ｈｌａ-ｄｒ 결합성 항원 펩티드
CA2900087C (en) 2005-10-17 2024-02-13 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
PL2010209T3 (pl) 2006-04-10 2017-04-28 Sloan Kettering Inst For Cancer Res Immunogeniczne peptydy WT-1 i sposoby ich użycia
BRPI0808084A2 (pt) 2007-02-27 2014-07-22 Int Inst Cancer Immunology Inc Método para ativação de células t auxiliadoras e composição para uso no método.
WO2012046730A1 (ja) * 2010-10-05 2012-04-12 国立大学法人大阪大学 ヘルパーｔ細胞の活性化方法
AU2012236068A1 (en) * 2011-04-01 2013-10-17 Eureka Therapeutics, Inc. T cell receptor-like antibodies specific for a WT1 peptide presented by HLA-A2
RU2633068C2 (ru) * 2011-09-14 2017-10-11 Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. Способ измерения антитела против wt1
HK1204261A1 (en) 2012-01-13 2015-11-13 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
WO2014042226A1 (ja) 2012-09-12 2014-03-20 株式会社癌免疫研究所 抗原特異的ヘルパーｔ細胞レセプター遺伝子
SG11201504558TA (en) 2012-12-11 2015-07-30 Einstein Coll Med Methods for high throughput receptor:ligand identification
NZ708990A (en) 2012-12-17 2020-03-27 Int Inst Cancer Immunology Inc Method for activating helper t cell
ES2832546T3 (es) 2013-01-15 2021-06-10 Memorial Sloan Kettering Cancer Center Péptidos WT-1 inmunogénicos y métodos de uso de los mismos
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
CN103961699B (zh) 2013-02-05 2018-11-06 日东电工株式会社 经皮给予用wt1肽癌症疫苗组合物
RU2014102945A (ru) 2013-02-05 2015-08-10 Нитто Денко Корпорейшн Вакцинная композиция
RU2687026C2 (ru) 2013-02-05 2019-05-06 Нитто Денко Корпорейшн Вакцинная композиция против злокачественной опухоли на основе пептида wt1 для мукозального введения
KR20140099828A (ko) 2013-02-05 2014-08-13 닛토덴코 가부시키가이샤 점막 투여용 백신 조성물
CA2840937A1 (en) 2013-02-05 2014-08-05 Nitto Denko Corporation Vaccine composition for transdermal administration
RU2687144C2 (ru) 2013-02-05 2019-05-07 Нитто Денко Корпорейшн Композиция противораковой вакцины, содержащей пептид wt1, для трансдермального введения
JP2014169280A (ja) 2013-02-05 2014-09-18 Nitto Denko Corp 経皮または粘膜投与用ワクチン組成物
US10195258B2 (en) 2013-02-05 2019-02-05 Nitto Denko Corporation Tape preparation of WT1 peptide cancer vaccine for transdermal administration
US10588952B2 (en) 2013-03-29 2020-03-17 Sumitomo Dainippon Pharma Co., Ltd. Conjugate vaccine using trimming function of ERAP1
JP5885885B2 (ja) 2013-03-29 2016-03-16 大日本住友製薬株式会社 Ｗｔ１抗原ペプチドコンジュゲートワクチン
KR102797324B1 (ko) 2014-12-11 2025-04-22 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 혈관 신생병의 면역 요법
AU2017266905B2 (en) 2016-05-18 2022-12-15 Albert Einstein College Of Medicine, Inc. Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
JP7071288B2 (ja) 2016-05-18 2022-05-18 キュー バイオファーマ， インコーポレイテッド Ｔ細胞調節多量体ポリペプチド及びその使用方法
KR102760578B1 (ko) 2016-12-22 2025-02-03 큐 바이오파마, 인크. T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE
EP4431109A3 (en) 2017-03-15 2024-11-27 Cue Biopharma, Inc. Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer
WO2019131722A1 (ja) * 2017-12-27 2019-07-04 大日本住友製薬株式会社 Ｗｔ１由来ペプチドのコンジュゲート体およびこれを含む組成物
WO2019139896A1 (en) 2018-01-09 2019-07-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2019189885A1 (ja) 2018-03-29 2019-10-03 ローム株式会社 半導体装置
CN115867303A (zh) * 2020-05-12 2023-03-28 住友制药株式会社 用于治疗癌症的药物组合物
JP2023526723A (ja) 2020-05-12 2023-06-23 キュー バイオファーマ， インコーポレイテッド 多量体ｔ細胞調節性ポリペプチド及びその使用方法
JP2023541366A (ja) 2020-09-09 2023-10-02 キュー バイオファーマ， インコーポレイテッド １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575374A (en) * 1983-02-16 1986-03-11 Anis Aziz Y Flexible anterior chamber lens
US5763209A (en) * 1988-09-26 1998-06-09 Arch Development Corporation Methods and materials relating to the functional domains of DNA binding proteins
US5584304A (en) * 1993-11-18 1996-12-17 Allergan, Inc. Method of inserting an IOL using a forceps inside a folding tube
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5984962A (en) * 1996-01-22 1999-11-16 Quantum Vision, Inc. Adjustable intraocular lens
US6207375B1 (en) * 1996-12-11 2001-03-27 Mayo Foundation For Medical Educational & Research TGF-β inducible early factor-1 (TIEF-1) and a method to detect breast cancer
US20030235557A1 (en) * 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7115272B1 (en) * 1998-09-30 2006-10-03 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7144581B2 (en) * 2000-10-09 2006-12-05 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7901693B2 (en) * 1998-09-30 2011-03-08 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7655249B2 (en) * 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030039635A1 (en) * 1998-09-30 2003-02-27 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030072767A1 (en) * 1998-09-30 2003-04-17 Alexander Gaiger Compositions and methods for WT1 specific immunotherapy
MY139226A (en) * 1998-09-30 2009-08-28 Corixa Corp Compositions and methods for wt1 specific immunotherapy
US7063854B1 (en) * 1998-09-30 2006-06-20 Corixa Corporation Composition and methods for WTI specific immunotherapy
PL354348A1 (en) * 1999-04-02 2004-01-12 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
WO2001025273A2 (en) * 1999-10-04 2001-04-12 Corixa Corporation Compositions and methods for wt1 specific immunotherapy
US20030082194A1 (en) * 2000-02-22 2003-05-01 Alexander Gaiger Compositions and methods for diagnosis and therapy of malignant mesothelioma
EP1261711A2 (en) * 2000-02-22 2002-12-04 Corixa Corporation Compositions and methods for diagnosis and therapy of malignant mesothelioma
DE60224508T2 (de) * 2001-03-22 2008-12-24 International Institute of Cancer Immunology, Inc., Suita-shi Wti-modifiziertes peptid
IL145015A0 (en) * 2001-08-21 2002-06-30 Nun Yehoshua Ben Accommodating lens
US7553494B2 (en) * 2001-08-24 2009-06-30 Corixa Corporation WT1 fusion proteins
ATE466084T1 (de) * 2002-06-12 2010-05-15 Int Inst Cancer Immunology Inc Hla-a24-restringiertes krebsantigenpeptid
CA2487489C (en) * 2002-06-14 2010-11-23 Merck & Co., Inc. Mitotic kinesin inhibitors
SE0201863D0 (en) * 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
KR101399678B1 (ko) 2003-01-15 2014-05-27 추가이 세이야쿠 가부시키가이샤 이량체화 펩티드
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
PT1731605E (pt) 2004-03-31 2010-04-14 Int Inst Cancer Immunology Inc Péptidos antigénicos de cancro derivados de wt1
JP2006045287A (ja) 2004-08-02 2006-02-16 Inax Corp 弾性接着剤及びタイル張り壁面
JP4719876B2 (ja) * 2005-04-04 2011-07-06 国立大学法人愛媛大学 Ｈｌａクラスｉｉ拘束性ｗｔ１抗原ペプチド
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring

Also Published As

Publication number Publication date
KR101525261B1 (ko) 2015-06-02
HK1221252A1 (en) 2017-05-26
CA2670658A1 (en) 2008-07-10
EP3026115B1 (en) 2017-05-17
NZ601175A (en) 2012-12-21
SG177222A1 (en) 2012-01-30
ES2526425T3 (es) 2015-01-12
TW201630620A (zh) 2016-09-01
RU2481398C2 (ru) 2013-05-10
WO2008081701A1 (ja) 2008-07-10
EP2341142A2 (en) 2011-07-06
EP2479275A1 (en) 2012-07-25
CN102335439A (zh) 2012-02-01
EP2479275B1 (en) 2015-10-28
EP2098595A4 (en) 2010-03-17
HK1173187A1 (en) 2013-05-10
IL215333A0 (en) 2011-11-30
CA2886621A1 (en) 2008-07-10
NZ592509A (en) 2012-11-30
CA2886619A1 (en) 2008-07-10
EP2479276A1 (en) 2012-07-25
EP2341142A3 (en) 2011-09-07
EP3026115A1 (en) 2016-06-01
UA103154C2 (uk) 2013-09-25
CA2886620A1 (en) 2008-07-10
IL215334A0 (en) 2011-11-30
AU2007340679A1 (en) 2008-07-10
TWI554280B (zh) 2016-10-21
SI2341142T1 (sl) 2015-03-31
CN102659924B (zh) 2015-11-25
CN102302788B (zh) 2016-06-15
EP2098595A1 (en) 2009-09-09
DK2479275T3 (en) 2015-12-14
IL199052A0 (en) 2010-03-28
NZ592510A (en) 2012-11-30
NZ577443A (en) 2011-12-22
PH12014500902A1 (en) 2016-01-11
EP2341142B8 (en) 2015-01-14
EP2479276B1 (en) 2015-12-09
US9272026B2 (en) 2016-03-01
TWI417103B (zh) 2013-12-01
PT2341142E (pt) 2015-02-13
DK2341142T3 (en) 2014-12-08
ES2556831T3 (es) 2016-01-20
EP2980219A1 (en) 2016-02-03
IL215332A0 (en) 2011-11-30
NO20092774L (no) 2009-07-27
TW200835513A (en) 2008-09-01
AR064555A1 (es) 2009-04-08
RU2009128979A (ru) 2011-02-10
CN101573448A (zh) 2009-11-04
US8653038B2 (en) 2014-02-18
PH12014500902B1 (en) 2018-08-10
KR20090102772A (ko) 2009-09-30
ES2554775T3 (es) 2015-12-23
CN101573448B (zh) 2012-07-11
JP5484734B2 (ja) 2014-05-07
TW201345544A (zh) 2013-11-16
CN102295682A (zh) 2011-12-28
HK1159686A1 (en) 2012-08-03
DK2479276T3 (en) 2015-12-21
MY161664A (en) 2017-04-28
EP2980219B1 (en) 2018-11-14
CN102659924A (zh) 2012-09-12
CA2886622A1 (en) 2008-07-10
AU2007340679B2 (en) 2013-09-12
EP2341142B1 (en) 2014-11-26
US20140134200A1 (en) 2014-05-15
CN102335439B (zh) 2015-04-22
PL2341142T3 (pl) 2015-04-30
US20110098233A1 (en) 2011-04-28
US20160199472A1 (en) 2016-07-14
CY1116011T1 (el) 2017-01-25
CN102302788A (zh) 2012-01-04
MX2009007008A (es) 2009-07-10
TWI599367B (zh) 2017-09-21
JPWO2008081701A1 (ja) 2010-04-30
ES2629578T3 (es) 2017-08-11
BRPI0720988A2 (pt) 2014-03-18
US20180064795A1 (en) 2018-03-08

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