ZA200903499B - Indoles which act as via receptor antagonists - Google Patents

Indoles which act as via receptor antagonists

Info

Publication number: ZA200903499B
Authority: ZA; South Africa
Prior art keywords: indoles; act; receptor antagonists; via receptor; antagonists
Prior art date: 2006-12-08

Application number

ZA200903499A

Other languages

English (en)

Inventor

Caterina Bissantz

Christophe Grundschober

Raffaello Masciadri

Hasane Ratni

Mark Rogers-Evans

Patrick Schnider

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-08

Filing date

2009-05-20

Publication date

2010-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38983746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200903499(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-05-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-03-31 Publication of ZA200903499B publication Critical patent/ZA200903499B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA200903499A 2006-12-08 2009-05-20 Indoles which act as via receptor antagonists ZA200903499B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06125663		2006-12-08

Publications (1)

Publication Number	Publication Date
ZA200903499B true ZA200903499B (en)	2010-03-31

Family

ID=38983746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200903499A ZA200903499B (en)	2006-12-08	2009-05-20	Indoles which act as via receptor antagonists

Country Status (21)

Country	Link
US (4)	US20080139618A1 (es)
EP (1)	EP2089381B1 (es)
JP (1)	JP2010511660A (es)
KR (1)	KR101050558B1 (es)
CN (1)	CN101541786A (es)
AR (1)	AR064137A1 (es)
AT (1)	ATE472544T1 (es)
AU (1)	AU2007328994B2 (es)
BR (1)	BRPI0720441A2 (es)
CA (1)	CA2671324A1 (es)
CL (1)	CL2007003503A1 (es)
DE (1)	DE602007007512D1 (es)
ES (1)	ES2345132T3 (es)
IL (1)	IL198683A0 (es)
MX (1)	MX2009005541A (es)
NO (1)	NO20091832L (es)
PE (1)	PE20081380A1 (es)
RU (1)	RU2009120443A (es)
TW (1)	TW200829570A (es)
WO (1)	WO2008068184A1 (es)
ZA (1)	ZA200903499B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE602007007512D1 (de) *	2006-12-08	2010-08-12	Hoffmann La Roche	Als via-rezeptor-antagonisten verwendbare indole
JP2010511659A (ja) *	2006-12-08	2010-04-15	エフ．ホフマン−ラロシュアーゲー	インドール
PE20081401A1 (es) *	2006-12-28	2008-10-24	Hoffmann La Roche	Derivados de indol como antagonistas de receptores vasopresina
EP2199967A1 (en) *	2008-12-08	2010-06-23	Electronics and Telecommunications Research Institute	Apparatus for providing digital contents using dmb channel and method thereof
CA2901577A1 (en) *	2013-02-18	2014-08-21	The Scripps Research Institute	Modulators of vasopressin receptors with therapeutic potential
GB201521059D0 (en)	2015-11-30	2016-01-13	Isis Innovation	Inhibitors of metallo-beta-lactamases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5924990B2 (ja) *	1979-11-21	1984-06-13	協和醗酵工業株式会社	新規なピペリジン誘導体
TW199153B (es) *	1990-08-07	1993-02-01	Dtsuka Seiyaku Kk
JPH09500134A (ja)	1993-07-16	1997-01-07	メルクエンドカンパニーインコーポレーテッド	ベンゾオキサジノンおよびベンゾピリミジノンピペリジニル早産防止オキシトシン受容体拮抗剤
CO5150201A1 (es)	1998-09-07	2002-04-29	Hoffmann La Roche	Derivados de piperidina
DK1283838T3 (da)	2000-05-12	2004-03-22	Solvay Pharm Bv	Piperazin- og piperidinforbindelser
PL377215A1 (pl)	2002-10-17	2006-01-23	Amgen Inc.	Pochodne benzimidazolu oraz ich zastosowanie w charakterze ligandów receptora waniloidowego
DE602006004997D1 (de)	2005-07-14	2009-03-12	Hoffmann La Roche	Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
JP4839374B2 (ja) *	2005-07-21	2011-12-21	エフ．ホフマン−ラロシュアーゲー	Ｖ１ａ受容体アンタゴニストとしてのインドール−３−イル−カルボニル−ピペリジン−ベンゾイミダゾール誘導体
JP4908513B2 (ja)	2005-09-28	2012-04-04	エフ．ホフマン−ラロシュアーゲー	バソプレッシン受容体アンタゴニストとしてのインドール−３−イル−カルボニル−アザスピロ誘導体
DE602007007512D1 (de) *	2006-12-08	2010-08-12	Hoffmann La Roche	Als via-rezeptor-antagonisten verwendbare indole

2007
- 2007-11-29 DE DE602007007512T patent/DE602007007512D1/de active Active
- 2007-11-29 CA CA002671324A patent/CA2671324A1/en not_active Abandoned
- 2007-11-29 WO PCT/EP2007/062984 patent/WO2008068184A1/en active Application Filing
- 2007-11-29 RU RU2009120443/04A patent/RU2009120443A/ru not_active Application Discontinuation
- 2007-11-29 EP EP07847501A patent/EP2089381B1/en not_active Not-in-force
- 2007-11-29 US US11/947,195 patent/US20080139618A1/en not_active Abandoned
- 2007-11-29 ES ES07847501T patent/ES2345132T3/es active Active
- 2007-11-29 KR KR1020097011629A patent/KR101050558B1/ko not_active IP Right Cessation
- 2007-11-29 AU AU2007328994A patent/AU2007328994B2/en not_active Ceased
- 2007-11-29 US US11/998,371 patent/US7799923B2/en not_active Expired - Fee Related
- 2007-11-29 CN CNA2007800421348A patent/CN101541786A/zh active Pending
- 2007-11-29 BR BRPI0720441-8A patent/BRPI0720441A2/pt not_active IP Right Cessation
- 2007-11-29 US US11/947,146 patent/US8071622B2/en not_active Expired - Fee Related
- 2007-11-29 JP JP2009539706A patent/JP2010511660A/ja active Pending
- 2007-11-29 MX MX2009005541A patent/MX2009005541A/es active IP Right Grant
- 2007-11-29 US US11/947,266 patent/US20080139617A1/en not_active Abandoned
- 2007-11-29 AT AT07847501T patent/ATE472544T1/de active
- 2007-12-05 AR ARP070105428A patent/AR064137A1/es unknown
- 2007-12-05 CL CL200703503A patent/CL2007003503A1/es unknown
- 2007-12-06 TW TW096146544A patent/TW200829570A/zh unknown
- 2007-12-07 PE PE2007001745A patent/PE20081380A1/es not_active Application Discontinuation
2009
- 2009-05-11 NO NO20091832A patent/NO20091832L/no not_active Application Discontinuation
- 2009-05-11 IL IL198683A patent/IL198683A0/en unknown
- 2009-05-20 ZA ZA200903499A patent/ZA200903499B/xx unknown

Also Published As

Publication number	Publication date
US20080269290A1 (en)	2008-10-30
NO20091832L (no)	2009-07-07
ES2345132T3 (es)	2010-09-15
BRPI0720441A2 (pt)	2014-01-07
AU2007328994A1 (en)	2008-06-12
CN101541786A (zh)	2009-09-23
US8071622B2 (en)	2011-12-06
AU2007328994B2 (en)	2012-03-08
RU2009120443A (ru)	2011-01-20
EP2089381B1 (en)	2010-06-30
AR064137A1 (es)	2009-03-18
KR20090078368A (ko)	2009-07-17
ATE472544T1 (de)	2010-07-15
KR101050558B1 (ko)	2011-07-19
US20080139548A1 (en)	2008-06-12
EP2089381A1 (en)	2009-08-19
IL198683A0 (en)	2010-02-17
PE20081380A1 (es)	2008-09-18
US7799923B2 (en)	2010-09-21
US20080139617A1 (en)	2008-06-12
WO2008068184A1 (en)	2008-06-12
US20080139618A1 (en)	2008-06-12
CA2671324A1 (en)	2008-06-12
JP2010511660A (ja)	2010-04-15
TW200829570A (en)	2008-07-16
CL2007003503A1 (es)	2008-07-04
DE602007007512D1 (de)	2010-08-12
MX2009005541A (es)	2009-06-05

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