ZA200802587B - Anti-hypercholesterolemic compounds - Google Patents

Anti-hypercholesterolemic compounds

Info

Publication number: ZA200802587B
Authority: ZA; South Africa
Prior art keywords: hypercholesterolemic compounds; hypercholesterolemic; compounds
Prior art date: 2005-10-05

Application number

ZA200802587A

Other languages

English (en)

Inventor

Robert J Devita

Gregori J Morriello

Lin Peter

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-05

Filing date

2008-03-20

Publication date

2009-06-24

2008-03-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2009-06-24 Publication of ZA200802587B publication Critical patent/ZA200802587B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200802587A 2005-10-05 2008-03-20 Anti-hypercholesterolemic compounds ZA200802587B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US72378105P	2005-10-05	2005-10-05

Publications (1)

Publication Number	Publication Date
ZA200802587B true ZA200802587B (en)	2009-06-24

Family

ID=37845278

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200802587A ZA200802587B (en)	2005-10-05	2008-03-20	Anti-hypercholesterolemic compounds

Country Status (25)

Country	Link
US (2)	US20090137546A1 (xx)
EP (1)	EP1934175B1 (xx)
JP (1)	JP4879991B2 (xx)
KR (1)	KR20080050610A (xx)
CN (1)	CN101277930A (xx)
AR (1)	AR058068A1 (xx)
AT (1)	ATE488495T1 (xx)
AU (1)	AU2006302584B2 (xx)
BR (1)	BRPI0616834A2 (xx)
CA (1)	CA2624481C (xx)
CR (1)	CR9903A (xx)
DE (1)	DE602006018341D1 (xx)
DO (1)	DOP2006000211A (xx)
EA (1)	EA200801008A1 (xx)
ES (1)	ES2354460T3 (xx)
GT (1)	GT200600444A (xx)
IL (1)	IL190434A0 (xx)
MA (1)	MA30006B1 (xx)
NO (1)	NO20082075L (xx)
PE (1)	PE20070493A1 (xx)
SV (1)	SV2009002863A (xx)
TN (1)	TNSN08153A1 (xx)
TW (1)	TW200806623A (xx)
WO (1)	WO2007044318A2 (xx)
ZA (1)	ZA200802587B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7176193B2 (en) *	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) *	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
GB0329778D0 (en) *	2003-12-23	2004-01-28	Astrazeneca Ab	Chemical compounds
CN100471835C (zh) *	2003-12-23	2009-03-25	默克公司	抗高胆固醇血症化合物
BRPI0418004A (pt) *	2003-12-23	2007-04-17	Astrazeneca Ab	composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis
UY29607A1 (es) *	2005-06-20	2007-01-31	Astrazeneca Ab	Compuestos quimicos
SA06270191B1 (ar) *	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR057380A1 (es) *	2005-06-22	2007-11-28	Astrazeneca Ab	Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos
AR054482A1 (es) *	2005-06-22	2007-06-27	Astrazeneca Ab	Derivados de azetidinona para el tratamiento de hiperlipidemias
AR057383A1 (es) *	2005-06-22	2007-12-05	Astrazeneca Ab	Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR057072A1 (es) *	2005-06-22	2007-11-14	Astrazeneca Ab	Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
TW200806623A (en) *	2005-10-05	2008-02-01	Merck & Co Inc	Anti-hypercholesterolemic compounds
DE102005055726A1 (de) *	2005-11-23	2007-08-30	Sanofi-Aventis Deutschland Gmbh	Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AR060623A1 (es) *	2006-04-27	2008-07-02	Astrazeneca Ab	Compuestos derivados de 2-azetidinona y un metodo de preparacion
WO2008085300A1 (en) *	2006-12-20	2008-07-17	Merck & Co., Inc.	Anti-hypercholesterolemic compounds
DE102009023046B4 (de)	2008-05-30	2016-10-13	Hyundai Motor Company	Automatisch schaltbares Getriebe eines Kraftfahrzeuges
WO2010056788A1 (en) *	2008-11-17	2010-05-20	Merck Sharp & Dohme Corp.	Anti-hypercholesterolemic compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993002048A1 (en) *	1991-07-23	1993-02-04	Schering Corporation	Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
CA2191455A1 (en) *	1994-06-20	1995-12-28	Wayne Vaccaro	Substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) *	1994-11-18	1997-04-29	Schering Corporation	Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
CZ20031732A3 (cs) *	2000-12-21	2003-09-17	Aventis Pharma Deutschland Gmbh	1,2-Difenylazetidinony a farmaceutické prostředky s jejich obsahem k léčení poruch metabolismu lipidů
TWI291957B (en) *	2001-02-23	2008-01-01	Kotobuki Pharmaceutical Co Ltd	Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US7176194B2 (en) *	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176193B2 (en) *	2002-06-19	2007-02-13	Sanofi-Aventis Deutschland Gmbh	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ES2311806T3 (es) *	2003-03-07	2009-02-16	Schering Corporation	Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
JP2005015434A (ja) *	2003-06-27	2005-01-20	Kotobuki Seiyaku Kk	血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
CN100471835C (zh) *	2003-12-23	2009-03-25	默克公司	抗高胆固醇血症化合物
WO2006086562A2 (en) *	2005-02-09	2006-08-17	Microbia, Inc.	Phenylazetidinone derivatives
AU2006259646A1 (en) *	2005-06-15	2006-12-28	Merck Sharp & Dohme Corp.	Anti-hypercholesterolemic compounds
TW200806623A (en) *	2005-10-05	2008-02-01	Merck & Co Inc	Anti-hypercholesterolemic compounds
DE102005055726A1 (de) *	2005-11-23	2007-08-30	Sanofi-Aventis Deutschland Gmbh	Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
KR20090091120A (ko) *	2006-11-02	2009-08-26	사노피-아벤티스 도이칠란트 게엠베하	향상된 약리학적 특성을 갖는 피페라진-1-설폰산으로 치환된 신규한 디페닐아제티디논

2006
- 2006-09-26 TW TW095135631A patent/TW200806623A/zh unknown
- 2006-09-27 AR ARP060104231A patent/AR058068A1/es unknown
- 2006-09-29 EA EA200801008A patent/EA200801008A1/ru unknown
- 2006-09-29 US US11/992,990 patent/US20090137546A1/en not_active Abandoned
- 2006-09-29 WO PCT/US2006/038551 patent/WO2007044318A2/en active Application Filing
- 2006-09-29 CN CNA2006800369359A patent/CN101277930A/zh active Pending
- 2006-09-29 KR KR1020087008305A patent/KR20080050610A/ko not_active Withdrawn
- 2006-09-29 JP JP2008534613A patent/JP4879991B2/ja not_active Expired - Fee Related
- 2006-09-29 EP EP06816084A patent/EP1934175B1/en active Active
- 2006-09-29 BR BRPI0616834A patent/BRPI0616834A2/pt not_active IP Right Cessation
- 2006-09-29 CA CA2624481A patent/CA2624481C/en not_active Expired - Fee Related
- 2006-09-29 DE DE602006018341T patent/DE602006018341D1/de active Active
- 2006-09-29 ES ES06816084T patent/ES2354460T3/es active Active
- 2006-09-29 AT AT06816084T patent/ATE488495T1/de not_active IP Right Cessation
- 2006-09-29 AU AU2006302584A patent/AU2006302584B2/en not_active Ceased
- 2006-10-03 GT GT200600444A patent/GT200600444A/es unknown
- 2006-10-03 PE PE2006001201A patent/PE20070493A1/es not_active Application Discontinuation
- 2006-10-04 US US11/542,966 patent/US7704988B2/en not_active Expired - Fee Related
- 2006-10-05 DO DO2006000211A patent/DOP2006000211A/es unknown
2008
- 2008-03-20 ZA ZA200802587A patent/ZA200802587B/xx unknown
- 2008-03-25 IL IL190434A patent/IL190434A0/en unknown
- 2008-04-04 SV SV2008002863A patent/SV2009002863A/es not_active Application Discontinuation
- 2008-04-04 TN TNP2008000153A patent/TNSN08153A1/en unknown
- 2008-04-18 CR CR9903A patent/CR9903A/es not_active Application Discontinuation
- 2008-05-02 NO NO20082075A patent/NO20082075L/no not_active Application Discontinuation
- 2008-05-02 MA MA30894A patent/MA30006B1/fr unknown

Also Published As

Publication number	Publication date
CA2624481C (en)	2012-04-03
TNSN08153A1 (en)	2009-10-30
AR058068A1 (es)	2008-01-23
AU2006302584B2 (en)	2011-10-13
US20070078098A1 (en)	2007-04-05
WO2007044318A3 (en)	2007-07-12
MA30006B1 (fr)	2008-12-01
BRPI0616834A2 (pt)	2016-08-23
CR9903A (es)	2008-07-29
DOP2006000211A (es)	2007-05-31
CN101277930A (zh)	2008-10-01
WO2007044318A2 (en)	2007-04-19
DE602006018341D1 (de)	2010-12-30
SV2009002863A (es)	2009-02-19
EP1934175A2 (en)	2008-06-25
KR20080050610A (ko)	2008-06-09
TW200806623A (en)	2008-02-01
JP2009511475A (ja)	2009-03-19
US20090137546A1 (en)	2009-05-28
IL190434A0 (en)	2008-11-03
ATE488495T1 (de)	2010-12-15
JP4879991B2 (ja)	2012-02-22
ES2354460T3 (es)	2011-03-15
US7704988B2 (en)	2010-04-27
EP1934175B1 (en)	2010-11-17
GT200600444A (es)	2007-05-04
EA200801008A1 (ru)	2009-02-27
PE20070493A1 (es)	2007-06-13
AU2006302584A1 (en)	2007-04-19
NO20082075L (no)	2008-07-04
CA2624481A1 (en)	2007-04-19

Publication	Publication Date	Title
IL190434A0 (en)	2008-11-03	Anti-hypercholesterolemic compounds
GB0508472D0 (en)	2005-06-01	Compounds
IL190803A0 (en)	2008-12-29	Compounds
GB0503962D0 (en)	2005-04-06	Compounds
GB0507602D0 (en)	2005-05-18	Compounds
GB0502418D0 (en)	2005-03-16	Compounds
GB0502316D0 (en)	2005-03-16	Compounds
AP2007004220A0 (en)	2007-10-31	Motilide compounds
EP2124549A4 (en)	2010-01-20	ANTIHYPERCHOLESTERINAMIC COMPOUNDS
EP1907385A4 (en)	2009-05-06	LINKS
GB0502299D0 (en)	2005-03-16	Compounds
GB0502310D0 (en)	2005-03-16	Compounds
GB0503961D0 (en)	2005-04-06	Compounds
GB0505084D0 (en)	2005-04-20	Compounds
GB0505086D0 (en)	2005-04-20	Compounds
GB0604216D0 (en)	2006-04-12	Compounds
EP1867650A4 (en)	2010-09-22	HYDROXYMETHYLBORVERBINDUNGEN
GB0501985D0 (en)	2005-03-09	Compounds
GB0501984D0 (en)	2005-03-09	Compounds
GB0505085D0 (en)	2005-04-20	Compounds
GB0503145D0 (en)	2005-03-23	Compounds
GB0515903D0 (en)	2005-09-07	Compounds
GB0519492D0 (en)	2005-11-02	Compounds
GB0500889D0 (en)	2005-02-23	Compounds
GB0500890D0 (en)	2005-02-23	Compounds