ZA200400449B - Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade. - Google Patents

Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.

Info

Publication number: ZA200400449B
Authority: ZA; South Africa
Prior art keywords: coagulation cascade; selective inhibition; polycyclic aryl; substituted polycyclic; heteroaryl
Prior art date: 1999-05-19

Application number

ZA200400449A

Inventor

Michael S South

Melvin L Rueppel

Ashton T Hamme Iii

Qingpeng Zeng

John J Parlow

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-19

Filing date

2004-01-21

Publication date

2004-11-24

2004-01-21 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2004-11-24 Publication of ZA200400449B publication Critical patent/ZA200400449B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200400449A 1999-05-19 2004-01-21 Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade. ZA200400449B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13481199P	1999-05-19	1999-05-19

Publications (1)

Publication Number	Publication Date
ZA200400449B true ZA200400449B (en)	2004-11-24

Family

ID=22465131

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA200109340A ZA200109340B (en)	1999-05-19	2001-11-13	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.
ZA200400449A ZA200400449B (en)	1999-05-19	2004-01-21	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ZA200109340A ZA200109340B (en)	1999-05-19	2001-11-13	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.

Country Status (21)

Country	Link
EP (1)	EP1178964A1 (en)
JP (1)	JP2002544260A (en)
KR (1)	KR20010113970A (en)
CN (1)	CN1378534A (en)
AR (1)	AR029635A1 (en)
AU (1)	AU771928B2 (en)
BR (1)	BR0011272A (en)
CA (1)	CA2373509A1 (en)
CZ (1)	CZ20014117A3 (en)
EA (1)	EA005367B1 (en)
HU (1)	HUP0201996A3 (en)
IL (1)	IL146244A0 (en)
MX (1)	MXPA01011805A (en)
MY (1)	MY138303A (en)
NO (1)	NO20015606L (en)
NZ (1)	NZ514875A (en)
PL (1)	PL352403A1 (en)
SK (1)	SK15862001A3 (en)
UY (1)	UY26154A1 (en)
WO (1)	WO2000069826A1 (en)
ZA (2)	ZA200109340B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6716838B1 (en)	1999-05-19	2004-04-06	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6750342B1 (en)	1999-05-19	2004-06-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en)	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6458952B1 (en)	1999-05-19	2002-10-01	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en)	1999-05-19	2003-11-25	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6664255B1 (en)	1999-05-19	2003-12-16	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en)	1999-05-19	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6852761B2 (en)	2000-03-13	2005-02-08	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
WO2001077079A2 (en)	2000-04-05	2001-10-18	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001249870A1 (en)	2000-04-05	2001-10-23	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
WO2001079195A2 (en) *	2000-04-14	2001-10-25	Corvas International, Inc.	Pyridine and pyrazine derivatives as thrombin inhibitors
AU2001253363A1 (en)	2000-04-17	2001-10-30	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001087842A1 (en) *	2000-05-18	2001-11-22	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7119094B1 (en)	2000-11-20	2006-10-10	Warner-Lambert Company	Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en)	2000-11-20	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
JP2004517074A (en)	2000-11-20	2004-06-10	ファルマシア・コーポレーション	Substituted polycyclic aryl and heteroaryl pyridines useful for selectively inhibiting the coagulation cascade
DK1357111T3 (en) *	2000-12-28	2009-11-02	Shionogi & Co	2-pyridone derivatives with affinity for cannabinoid type 2 receptor
BR0213099A (en)	2001-10-03	2004-10-19	Pharmacia Corp	Substituted 5-membered polycyclic compounds useful for selective inhibition of coagulation cascade
MXPA04003163A (en)	2001-10-03	2004-07-08	Pharmacia Corp	6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade.
WO2003048127A1 (en) *	2001-12-04	2003-06-12	Corvas International, Inc.	Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
TW200307667A (en)	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
US8846935B2 (en)	2010-05-07	2014-09-30	Glaxosmithkline Llc	Indazoles
TWI633089B (en) *	2013-03-28	2018-08-21	拜耳製藥股份有限公司	Substituted oxopyridine derivatives

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AU703744B2 (en) *	1995-06-27	1999-04-01	Merck & Co., Inc.	Pyridinone-thrombin inhibitors
CA2245811A1 (en) *	1996-02-22	1997-08-28	Merck & Co., Inc.	Pyridinone thrombin inhibitors
WO1998016525A1 (en) *	1996-10-11	1998-04-23	Cor Therapeutics, Inc.	SELECTIVE FACTOR Xa INHIBITORS
US5792779A (en) *	1997-02-19	1998-08-11	Merck & Co., Inc.	Pyridinone thrombin inhibitors
EP0969840A4 (en) *	1997-03-24	2001-02-28	Merck & Co Inc	Thrombin inhibitors
IL123986A (en) *	1997-04-24	2011-10-31	Organon Nv	Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them
ATE306261T1 (en) *	1997-06-26	2005-10-15	Lilly Co Eli	ANTITHROMBOTIC AGENTS
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2000
- 2000-05-15 KR KR1020017014751A patent/KR20010113970A/en not_active Application Discontinuation
- 2000-05-15 HU HU0201996A patent/HUP0201996A3/en unknown
- 2000-05-15 EA EA200101213A patent/EA005367B1/en not_active IP Right Cessation
- 2000-05-15 EP EP00930092A patent/EP1178964A1/en not_active Withdrawn
- 2000-05-15 NZ NZ514875A patent/NZ514875A/en unknown
- 2000-05-15 CZ CZ20014117A patent/CZ20014117A3/en unknown
- 2000-05-15 CN CN00810182A patent/CN1378534A/en active Pending
- 2000-05-15 AU AU47973/00A patent/AU771928B2/en not_active Ceased
- 2000-05-15 MX MXPA01011805A patent/MXPA01011805A/en active IP Right Grant
- 2000-05-15 WO PCT/US2000/008220 patent/WO2000069826A1/en not_active Application Discontinuation
- 2000-05-15 BR BR0011272-0A patent/BR0011272A/en not_active IP Right Cessation
- 2000-05-15 IL IL14624400A patent/IL146244A0/en unknown
- 2000-05-15 CA CA002373509A patent/CA2373509A1/en not_active Abandoned
- 2000-05-15 PL PL00352403A patent/PL352403A1/en not_active Application Discontinuation
- 2000-05-15 JP JP2000618243A patent/JP2002544260A/en active Pending
- 2000-05-15 SK SK1586-2001A patent/SK15862001A3/en unknown
- 2000-05-19 UY UY26154A patent/UY26154A1/en not_active Application Discontinuation
- 2000-05-19 AR ARP000102448A patent/AR029635A1/en unknown
- 2000-05-19 MY MYPI20002212A patent/MY138303A/en unknown
2001
- 2001-11-13 ZA ZA200109340A patent/ZA200109340B/en unknown
- 2001-11-16 NO NO20015606A patent/NO20015606L/en not_active Application Discontinuation
2004
- 2004-01-21 ZA ZA200400449A patent/ZA200400449B/en unknown

Also Published As

Publication number	Publication date
HUP0201996A2 (en)	2002-09-28
WO2000069826A1 (en)	2000-11-23
CA2373509A1 (en)	2000-11-23
JP2002544260A (en)	2002-12-24
NO20015606D0 (en)	2001-11-16
CZ20014117A3 (en)	2002-05-15
BR0011272A (en)	2002-05-07
SK15862001A3 (en)	2002-08-06
MY138303A (en)	2009-05-29
AU4797300A (en)	2000-12-05
EA200101213A1 (en)	2002-04-25
EA005367B1 (en)	2005-02-24
HUP0201996A3 (en)	2002-12-28
MXPA01011805A (en)	2003-09-04
ZA200109340B (en)	2004-05-26
NO20015606L (en)	2002-01-21
PL352403A1 (en)	2003-08-25
EP1178964A1 (en)	2002-02-13
AU771928B2 (en)	2004-04-08
AR029635A1 (en)	2003-07-10
KR20010113970A (en)	2001-12-28
NZ514875A (en)	2004-10-29
CN1378534A (en)	2002-11-06
UY26154A1 (en)	2000-12-29
IL146244A0 (en)	2002-07-25

Publication	Publication Date	Title
ZA200400449B (en)	2004-11-24	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade.
ZA200109341B (en)	2004-05-26	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade.
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NO20031626L (en)	2003-06-04	Pyridone derivatives for the treatment of atherosclerosis
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AU5056300A (en)	2000-12-28	Devices and compounds for treating arterial restenosis
ZA200400448B (en)	2004-09-29	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants.
AU2001243598A1 (en)	2001-09-24	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
AU2003260984A1 (en)	2004-04-30	S-(-)-amlodipine nicotinate and process for the preparation thereof
AU2001219236A1 (en)	2001-11-26	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
AU2002367752A8 (en)	2003-11-17	Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
AU5057600A (en)	2001-01-31	Component and method for the production thereof
AU2001295579A1 (en)	2002-04-02	Pants and method for the production thereof
AU2001217827A1 (en)	2001-11-26	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
AU2001222501A1 (en)	2001-11-26	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
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ZA200110474B (en)	2003-03-20	Method and device for the continuous of NaAlCl4 or NaFeCl4.
ZA991576B (en)	1999-08-27	Process for the preparation of substituted pyridines.
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