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ZA200304679B - Thiazole derivatives for treating PPAR related disorders. - Google Patents

Thiazole derivatives for treating PPAR related disorders. Download PDF

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Publication number
ZA200304679B
ZA200304679B ZA200304679A ZA200304679A ZA200304679B ZA 200304679 B ZA200304679 B ZA 200304679B ZA 200304679 A ZA200304679 A ZA 200304679A ZA 200304679 A ZA200304679 A ZA 200304679A ZA 200304679 B ZA200304679 B ZA 200304679B
Authority
ZA
South Africa
Prior art keywords
methyl
thiazol
phenoxy
propionic acid
phenyl
Prior art date
Application number
ZA200304679A
Other languages
English (en)
Inventor
Rodolfo Cadilla
Ramain Luc Marie Gosmini
Lambert Millard Hurst Iii
Michael Lawrence Sierra
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA200304679B publication Critical patent/ZA200304679B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200304679A 2000-12-20 2003-06-17 Thiazole derivatives for treating PPAR related disorders. ZA200304679B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0031107.6A GB0031107D0 (en) 2000-12-20 2000-12-20 Chemical compounds

Publications (1)

Publication Number Publication Date
ZA200304679B true ZA200304679B (en) 2004-10-04

Family

ID=9905492

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200304679A ZA200304679B (en) 2000-12-20 2003-06-17 Thiazole derivatives for treating PPAR related disorders.

Country Status (28)

Country Link
EP (1) EP1343773B1 (hu)
JP (1) JP4209681B2 (hu)
KR (1) KR100815022B1 (hu)
CN (1) CN1252057C (hu)
AR (1) AR035522A1 (hu)
AT (1) ATE344253T1 (hu)
AU (1) AU2002246713B2 (hu)
BR (1) BR0116370A (hu)
CA (1) CA2432188A1 (hu)
CY (1) CY1105915T1 (hu)
CZ (1) CZ20031737A3 (hu)
DE (1) DE60124302T2 (hu)
DK (1) DK1343773T3 (hu)
ES (1) ES2274914T3 (hu)
GB (1) GB0031107D0 (hu)
HK (1) HK1059925A1 (hu)
HU (1) HUP0400837A3 (hu)
IL (2) IL156436A0 (hu)
MX (1) MXPA03005699A (hu)
MY (1) MY136685A (hu)
NO (1) NO20032801L (hu)
NZ (1) NZ526543A (hu)
PL (1) PL365797A1 (hu)
PT (1) PT1343773E (hu)
SI (1) SI1343773T1 (hu)
TW (1) TWI292759B (hu)
WO (1) WO2002062774A1 (hu)
ZA (1) ZA200304679B (hu)

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GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US20040072838A1 (en) 2000-12-20 2004-04-15 Pierette Banker Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
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AU2003214932A1 (en) 2002-02-25 2003-09-09 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
ATE369855T1 (de) * 2002-02-25 2007-09-15 Lilly Co Eli Modulatoren von peroxisome proliferator- aktivierten rezeptoren
US20030207924A1 (en) * 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
US7244763B2 (en) 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
US6987118B2 (en) * 2003-05-21 2006-01-17 Pfizer Inc. Tetrahydroisoquinoline derivatives as PPAR-alpha activators
AU2004247355A1 (en) * 2003-06-06 2004-12-23 F. Hoffmann-La Roche Ag Aniline derivatives
AU2004255580B2 (en) 2003-07-02 2009-10-08 F. Hoffmann-La Roche Ag Indolyl derivatives substituted with a thiazole ring and their use as PPAR modulators
ES2378435T3 (es) 2003-09-19 2012-04-12 Janssen Pharmaceutica N.V. �?cidos 4-((fenoxialquil)tio)-fenoxiacéticos y análogos
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
WO2005086661A2 (en) * 2004-02-27 2005-09-22 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
US8053598B2 (en) 2004-05-05 2011-11-08 High Point Pharmaceuticals, Llc Compounds, their preparation and use
ATE486055T1 (de) 2004-05-05 2010-11-15 High Point Pharmaceuticals Llc Neue verbindungen, ihre herstellung und verwendung
MY145712A (en) * 2004-09-15 2012-03-30 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
MY147518A (en) 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
EP1856072A4 (en) * 2005-02-25 2009-10-21 Seoul Nat Univ Ind Foundation THIAZONE DERIVATIVES AS PPAR DELTA LIGANDS AND METHOD FOR THEIR PREPARATION
JP5191744B2 (ja) * 2005-02-25 2013-05-08 ソウル ナショナル ユニバーシティー インダストリー ファンデーション ペルオキシソーム増殖子活性化受容体デルタリガンドのチアゾール誘導体及びその製造方法
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
KR101333101B1 (ko) 2005-06-30 2013-11-26 하이 포인트 파마슈티칼스, 엘엘씨 Ｐｐａｒ-델타 활성제로서의 페녹시 아세트산
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
NZ568488A (en) 2005-12-22 2011-07-29 High Point Pharmaceuticals Llc Phenoxy acetic acids as PPAR delta activators
CN101007790B (zh) * 2006-01-27 2011-03-30 北京摩力克科技有限公司 草氨酸衍生物、其制备方法和医药用途
US7943612B2 (en) 2006-03-09 2011-05-17 High Point Pharmaceuticals, Llc Compounds that modulate PPAR activity, their preparation and use
UY30288A1 (es) * 2006-04-18 2007-08-31 Janssen Pharmaceutica Nv Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol
WO2008030618A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
WO2008030520A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Heterocyclic gpr40 modulators
US8519145B2 (en) 2006-12-02 2013-08-27 Seoul National University Industry Foundation Aryl compounds as PPAR ligands and their use
US8236831B2 (en) 2007-01-08 2012-08-07 Seoul National University Industry Foundation Thiazole compound (as PPARδ) ligand and pharmaceutical, cosmetic and health food comprised thereof
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
AU2008241490B2 (en) 2007-04-16 2011-07-21 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid GPR40 modulators
US8030354B2 (en) 2007-10-10 2011-10-04 Amgen Inc. Substituted biphenyl GPR40 modulators
MX2010009654A (es) 2008-03-06 2010-09-28 Amgen Inc Derivados de acido carboxilico de conformacion restringida utiles para tratar trastornos metabolicos.
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Also Published As

Publication number Publication date
GB0031107D0 (en) 2001-01-31
AU2002246713B2 (en) 2004-09-09
MXPA03005699A (es) 2003-10-06
WO2002062774A1 (en) 2002-08-15
IL156436A0 (en) 2004-01-04
JP2004518702A (ja) 2004-06-24
EP1343773A1 (en) 2003-09-17
HUP0400837A3 (en) 2007-11-28
KR20030072571A (ko) 2003-09-15
ES2274914T3 (es) 2007-06-01
PL365797A1 (en) 2005-01-10
ATE344253T1 (de) 2006-11-15
NO20032801L (no) 2003-08-04
SI1343773T1 (sl) 2007-04-30
TWI292759B (en) 2008-01-21
HK1059925A1 (en) 2004-07-23
EP1343773B1 (en) 2006-11-02
CY1105915T1 (el) 2011-04-06
CZ20031737A3 (cs) 2003-10-15
HUP0400837A2 (hu) 2004-08-30
MY136685A (en) 2008-11-28
DE60124302T2 (de) 2007-05-03
NO20032801D0 (no) 2003-06-19
AR035522A1 (es) 2004-06-02
CN1252057C (zh) 2006-04-19
KR100815022B1 (ko) 2008-03-18
DE60124302D1 (de) 2006-12-14
IL156436A (en) 2008-06-05
NZ526543A (en) 2004-11-26
CA2432188A1 (en) 2002-08-15
DK1343773T3 (da) 2007-02-05
PT1343773E (pt) 2007-02-28
JP4209681B2 (ja) 2009-01-14
CN1527822A (zh) 2004-09-08
BR0116370A (pt) 2003-12-09

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