ZA200204126B - Azaindoles. - Google Patents
Azaindoles.Info
- Publication number
- ZA200204126B ZA200204126B ZA200204126A ZA200204126A ZA200204126B ZA 200204126 B ZA200204126 B ZA 200204126B ZA 200204126 A ZA200204126 A ZA 200204126A ZA 200204126 A ZA200204126 A ZA 200204126A ZA 200204126 B ZA200204126 B ZA 200204126B
- Authority
- ZA
- South Africa
- Prior art keywords
- ny3y4
- compounds
- halo
- heteroaryl
- cyano
- Prior art date
Links
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910014033 C-OH Inorganic materials 0.000 abstract 1
- 229910014570 C—OH Inorganic materials 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R1 is aryl or heteroaryl; R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms; R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y; and X1 represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenyl, C-alkynyl or C-NO2; and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of fomula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930698.7A GB9930698D0 (en) | 1999-12-24 | 1999-12-24 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200204126B true ZA200204126B (en) | 2003-08-25 |
Family
ID=10867079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200204126A ZA200204126B (en) | 1999-12-24 | 2002-05-23 | Azaindoles. |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP4871474B2 (en) |
| AT (2) | ATE480537T1 (en) |
| DE (1) | DE60044946D1 (en) |
| DK (2) | DK1263759T3 (en) |
| ES (2) | ES2348861T3 (en) |
| GB (1) | GB9930698D0 (en) |
| ME (1) | MEP49908A (en) |
| PL (1) | PL218884B1 (en) |
| PT (2) | PT1990343E (en) |
| RS (2) | RS20100123A (en) |
| UA (1) | UA76410C2 (en) |
| ZA (1) | ZA200204126B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| KR20080083680A (en) * | 2005-12-23 | 2008-09-18 | 스미스클라인 비참 코포레이션 | Azaindole Inhibitors of Aurora Kinases |
| CL2007002617A1 (en) * | 2006-09-11 | 2008-05-16 | Sanofi Aventis | COMPOUNDS DERIVED FROM PIRROLO [2,3-B] PIRAZIN-6-ILO; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT INFLAMMATION OF THE ARTICULATIONS, Rheumatoid Arthritis, TUMORS, LYMPHOMA OF THE CELLS OF THE MANTO. |
| JP5274805B2 (en) * | 2006-09-20 | 2013-08-28 | 三菱化学株式会社 | Method for producing fluorinated aromatic compound |
| WO2010063634A1 (en) * | 2008-12-05 | 2010-06-10 | F. Hoffmann-La Roche Ag | Pyrrolopyrazinyl urea kinase inhibitors |
| EP2470531A1 (en) * | 2009-08-26 | 2012-07-04 | Nycomed GmbH | Methylpyrrolopyridinecarboxamides |
| EP2970264A1 (en) * | 2013-03-14 | 2016-01-20 | AbbVie Inc. | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE264318T1 (en) * | 1996-11-19 | 2004-04-15 | Amgen Inc | ARYL AND HETEROARYL SUBSTITUTED CONDENSED PYRROLES AS ANTI-INFLAMMATORY AGENTS |
| AU7132998A (en) * | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| HUP0100348A3 (en) * | 1997-10-20 | 2002-12-28 | Hoffmann La Roche | Bicycles containing a six menbered ring with one or two nitrogen atoms, process for their preparation, use of them, pharmaceutical compositions containing the same and intermediates |
-
1999
- 1999-12-24 GB GBGB9930698.7A patent/GB9930698D0/en not_active Ceased
-
2000
- 2000-12-27 JP JP2001549392A patent/JP4871474B2/en not_active Expired - Fee Related
- 2000-12-27 ES ES00985695T patent/ES2348861T3/en not_active Expired - Lifetime
- 2000-12-27 RS RSP-2010/0123A patent/RS20100123A/en unknown
- 2000-12-27 DK DK00985695.6T patent/DK1263759T3/en active
- 2000-12-27 DK DK08162392.8T patent/DK1990343T3/en active
- 2000-12-27 PL PL386205A patent/PL218884B1/en unknown
- 2000-12-27 ES ES08162392T patent/ES2382759T3/en not_active Expired - Lifetime
- 2000-12-27 PT PT08162392T patent/PT1990343E/en unknown
- 2000-12-27 AT AT00985695T patent/ATE480537T1/en active
- 2000-12-27 DE DE60044946T patent/DE60044946D1/en not_active Expired - Lifetime
- 2000-12-27 PT PT00985695T patent/PT1263759E/en unknown
- 2000-12-27 RS YUP-462/02A patent/RS51303B/en unknown
- 2000-12-27 AT AT08162392T patent/ATE552258T1/en active
- 2000-12-27 ME MEP-499/08A patent/MEP49908A/en unknown
- 2000-12-27 UA UA2002076056A patent/UA76410C2/en unknown
-
2002
- 2002-05-23 ZA ZA200204126A patent/ZA200204126B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1990343T3 (en) | 2012-07-23 |
| ES2382759T3 (en) | 2012-06-13 |
| UA76410C2 (en) | 2006-08-15 |
| PT1990343E (en) | 2012-05-22 |
| RS51303B (en) | 2010-12-31 |
| DE60044946D1 (en) | 2010-10-21 |
| JP4871474B2 (en) | 2012-02-08 |
| RS20100123A (en) | 2010-12-31 |
| PL218884B1 (en) | 2015-02-27 |
| MEP49908A (en) | 2011-02-10 |
| YU46202A (en) | 2005-06-10 |
| JP2003519144A (en) | 2003-06-17 |
| GB9930698D0 (en) | 2000-02-16 |
| ATE552258T1 (en) | 2012-04-15 |
| DK1263759T3 (en) | 2011-01-10 |
| ATE480537T1 (en) | 2010-09-15 |
| ES2348861T3 (en) | 2010-12-16 |
| PT1263759E (en) | 2010-11-02 |
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