ZA200006173B - Crystalline Efavirenz. - Google Patents

Crystalline Efavirenz.

Info

Publication number: ZA200006173B
Authority: ZA; South Africa
Prior art keywords: crystalline efavirenz; efavirenz; crystalline
Prior art date: 1998-06-11

Application number

ZA200006173A

Inventor

Lilian A Radesca

Shelley R Rabel

James R Moore

Michael B Maurin

Original Assignee

Du Pont Pharm Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-11

Filing date

2000-10-31

Publication date

2001-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22214647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200006173(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-10-31 Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co

2001-10-31 Publication of ZA200006173B publication Critical patent/ZA200006173B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA200006173A 1998-06-11 2000-10-31 Crystalline Efavirenz. ZA200006173B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8898198P	1998-06-11	1998-06-11

Publications (1)

Publication Number	Publication Date
ZA200006173B true ZA200006173B (en)	2001-10-31

Family

ID=22214647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200006173A ZA200006173B (en)	1998-06-11	2000-10-31	Crystalline Efavirenz.

Country Status (21)

Country	Link
EP (1)	EP1086087A1 (en)
JP (1)	JP2002517487A (en)
CN (1)	CN1307568A (en)
AR (3)	AR018670A1 (en)
AU (1)	AU758114C (en)
BR (1)	BR9911523A (en)
CA (1)	CA2333550A1 (en)
EE (1)	EE05547B1 (en)
HR (1)	HRP990182A2 (en)
HU (1)	HUP0103819A3 (en)
IL (1)	IL139793A (en)
MY (1)	MY126450A (en)
NO (1)	NO20006255L (en)
NZ (1)	NZ507713A (en)
PL (1)	PL198504B1 (en)
SG (3)	SG134977A1 (en)
SK (1)	SK18182000A3 (en)
TW (1)	TWI235152B (en)
UA (1)	UA74324C2 (en)
WO (1)	WO1999064405A1 (en)
ZA (1)	ZA200006173B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5965729A (en)	1997-02-05	1999-10-12	Merck & Co., Inc.	Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US20060235008A1 (en)	2004-08-19	2006-10-19	Hetero Drugs Limited	Novel polymorphs of efavirenz
PE20060587A1 (en) *	2004-09-02	2006-07-09	Bristol Myers Squibb Co	SYNTHESIS OF (S) -6-CHLORO-4-CYCLOPROPYLETINYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONA
WO2008108630A1 (en) *	2007-03-02	2008-09-12	Ultimorphix Technologies B.V.	Polymorphic forms of efavirenz
WO2009011567A1 (en) *	2007-07-16	2009-01-22	Ultimorphix Technologies B.V.	Crystalline forms of efavirenz
PL2303267T3 (en)	2008-02-04	2013-11-29	Pfizer Ltd	Polymorphic form of a [1, 2, 4] triazolo [4, 3-a]pyridine derivative for treating inflammatory diseases
EP2367804B1 (en)	2008-12-22	2013-11-06	Hetero Research Foundation	Process for preparing efavirenz polymorph
DE102009041443A1 (en)	2009-09-16	2011-03-31	Archimica Gmbh	Salts of 6-chloro-4- (cyclopropylethynyl) -1,4-dihydro-4- (trifluoromethyl) -2H-3,1-benzoxazin-2-one and their synthesis, purification and use as precursors of efavirenz
EP2471783A1 (en)	2010-12-23	2012-07-04	Esteve Química, S.A.	Novel polymorphic form of efavirenz
CN103508973B (en) *	2012-06-25	2016-04-27	上海迪赛诺药业有限公司	Prepare the method for efavirenz I type crystallization
CN102924398B (en) *	2012-11-22	2015-11-18	安徽贝克生物制药有限公司	For removing the method for the corresponding isomer of efavirenz
MX2015009546A (en) *	2013-01-23	2015-11-25	Alienor Farma	Increased dosage of efavirenz for the treatment of cancer.
CN105037175B (en) *	2014-07-18	2017-02-22	盐城迪赛诺制药有限公司	Method of improving optical purity of efavirenz intermediate
CN105001101B (en) *	2015-05-28	2017-11-28	乐平市瑞盛制药有限公司	A kind of synthetic method of the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine 2
CN108947855B (en) *	2018-08-10	2021-10-22	江苏沙星化工有限公司	Synthesis method of efavirenz key intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL106507A (en) *	1992-08-07	1997-11-20	Merck & Co Inc	Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
AU1694295A (en) *	1994-01-28	1995-08-15	Merck & Co., Inc.	Benzoxazinones as inhibitors of hiv reverse transcriptase
US5633405A (en) *	1995-05-25	1997-05-27	Merck & Co., Inc.	Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
WO1998004535A1 (en) *	1996-07-26	1998-02-05	Du Pont Pharmaceuticals Company	A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
JP4212650B2 (en) *	1996-10-02	2009-01-21	ブリストル‐マイヤーズスクイブファーマカンパニー	4,4-Disubstituted-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors, and intermediates and methods for making them
EE03827B1 (en) *	1997-02-05	2002-08-15	Merck & Co., Inc.	A method for crystallizing a transcriptase rotary inhibitor using an anti-solvent

1999
- 1999-06-08 HR HR60/088,981A patent/HRP990182A2/en not_active Application Discontinuation
- 1999-06-10 BR BR9911523-9A patent/BR9911523A/en not_active Application Discontinuation
- 1999-06-10 JP JP2000553414A patent/JP2002517487A/en active Pending
- 1999-06-10 SK SK1818-2000A patent/SK18182000A3/en unknown
- 1999-06-10 SG SG200207226-2A patent/SG134977A1/en unknown
- 1999-06-10 WO PCT/US1999/013199 patent/WO1999064405A1/en active Search and Examination
- 1999-06-10 MY MYPI99002384A patent/MY126450A/en unknown
- 1999-06-10 EE EEP200000743A patent/EE05547B1/en unknown
- 1999-06-10 EP EP99927468A patent/EP1086087A1/en not_active Withdrawn
- 1999-06-10 SG SG200207221A patent/SG111981A1/en unknown
- 1999-06-10 UA UA2000127048A patent/UA74324C2/en unknown
- 1999-06-10 NZ NZ507713A patent/NZ507713A/en not_active IP Right Cessation
- 1999-06-10 PL PL345221A patent/PL198504B1/en unknown
- 1999-06-10 CA CA002333550A patent/CA2333550A1/en not_active Abandoned
- 1999-06-10 SG SG200207220A patent/SG111980A1/en unknown
- 1999-06-10 HU HU0103819A patent/HUP0103819A3/en unknown
- 1999-06-10 IL IL139793A patent/IL139793A/en not_active IP Right Cessation
- 1999-06-10 CN CN99807219A patent/CN1307568A/en active Pending
- 1999-06-10 AU AU44364/99A patent/AU758114C/en not_active Expired
- 1999-06-11 AR ARP990102809A patent/AR018670A1/en not_active Application Discontinuation
- 1999-07-03 TW TW088109817A patent/TWI235152B/en not_active IP Right Cessation
2000
- 2000-10-31 ZA ZA200006173A patent/ZA200006173B/en unknown
- 2000-12-08 NO NO20006255A patent/NO20006255L/en not_active Application Discontinuation
2010
- 2010-07-08 AR ARP100102491A patent/AR077469A2/en not_active Application Discontinuation
- 2010-07-08 AR ARP100102490A patent/AR077407A2/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL345221A1 (en)	2001-12-03
IL139793A0 (en)	2002-02-10
CN1307568A (en)	2001-08-08
AR018670A1 (en)	2001-11-28
EP1086087A1 (en)	2001-03-28
NO20006255D0 (en)	2000-12-08
BR9911523A (en)	2001-09-18
TWI235152B (en)	2005-07-01
NO20006255L (en)	2001-02-12
HUP0103819A3 (en)	2003-05-28
IL139793A (en)	2006-10-31
JP2002517487A (en)	2002-06-18
NZ507713A (en)	2003-08-29
HUP0103819A2 (en)	2002-02-28
HRP990182A2 (en)	2000-02-29
UA74324C2 (en)	2005-12-15
AU758114C (en)	2003-10-30
AU4436499A (en)	1999-12-30
AU758114B2 (en)	2003-03-13
WO1999064405A1 (en)	1999-12-16
AR077407A2 (en)	2011-08-24
EE200000743A (en)	2002-10-15
SG134977A1 (en)	2007-09-28
SG111980A1 (en)	2005-06-29
AR077469A2 (en)	2011-08-31
SG111981A1 (en)	2005-06-29
SK18182000A3 (en)	2001-08-06
CA2333550A1 (en)	1999-12-16
EE05547B1 (en)	2012-06-15
MY126450A (en)	2006-10-31
PL198504B1 (en)	2008-06-30

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