YU94003A - Novo heterociklično jedinjenje i njegova medicinska upotreba - Google Patents
Novo heterociklično jedinjenje i njegova medicinska upotrebaInfo
- Publication number
- YU94003A YU94003A YU94003A YUP94003A YU94003A YU 94003 A YU94003 A YU 94003A YU 94003 A YU94003 A YU 94003A YU P94003 A YUP94003 A YU P94003A YU 94003 A YU94003 A YU 94003A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- agent
- alkyl
- remedy
- same meaning
- heterocyclic compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novo heterociklicno jedinjenje iz ovog pronalaska je novo heterociklicno jedinjenje koje ima formulu (I) gde je R1 H ili C1-6alkil, R2 je H, -CO-C(R4)=C(R4)-R5, gde je R4 H ili C1-4alkil, a R5 je C4-8alkil, C2-8alkenil i slicno, Y je sledeca grupa, gde X predstavlja O ili S, R7 je isti kao R4, R8 je R10-C(R9)=C(R9)-, gde je R9 isti kao R4, a R10 je C3-6alkil i slicno, i slicno, R14 je isti kao R4, a R15 je aril i slicno, Y-(CH2)n-O- je vezana u polozaju 6 ili 7 tetrahidroizohinolinskog skeleta, a n je ceo broj od 1 do 4, ili njegova farmaceutski prihvatljiva so. Jedinjenje (I) iz ovog pronalaska je koristan hipoglikemicki agens, hipolipidemicki agens, poboljsavac u pogledu rezistentnosti prema insulinu, terapeutski agens za dijabetes, terapeutski agens za komplikacije od dijabetesa, poboljsavac tolerancije glukoze, agens protiv arterioskleroze, agens protiv gojaznosti, antiinflamatorni agens, agens za profilaksu ili tretman bolesti posredovanih sa PPAR i agens za profilaksu ili tretman sindroma X.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001161489 | 2001-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU94003A true YU94003A (sh) | 2006-08-17 |
Family
ID=19004756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU94003A YU94003A (sh) | 2001-05-29 | 2002-05-27 | Novo heterociklično jedinjenje i njegova medicinska upotreba |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7557123B2 (sh) |
| EP (1) | EP1403253A4 (sh) |
| JP (1) | JP4279136B2 (sh) |
| KR (2) | KR20040030647A (sh) |
| CN (1) | CN1242994C (sh) |
| AR (1) | AR036036A1 (sh) |
| AU (1) | AU2002308889B2 (sh) |
| BR (1) | BR0209711A (sh) |
| CA (1) | CA2448634A1 (sh) |
| CO (1) | CO5540342A2 (sh) |
| CZ (1) | CZ20033450A3 (sh) |
| HK (1) | HK1069385A1 (sh) |
| HU (1) | HUP0401862A3 (sh) |
| IL (1) | IL159085A0 (sh) |
| MX (1) | MXPA03010811A (sh) |
| NO (1) | NO326688B1 (sh) |
| NZ (1) | NZ530358A (sh) |
| PL (1) | PL367639A1 (sh) |
| RU (1) | RU2299197C2 (sh) |
| TW (1) | TWI297008B (sh) |
| WO (1) | WO2002096880A1 (sh) |
| YU (1) | YU94003A (sh) |
| ZA (1) | ZA200309757B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL159084A0 (en) | 2001-05-29 | 2004-05-12 | Kyoto Pharma Ind | Tetrahydroisoquinoline carboxylic acid derivatives and pharmaceutical compositions containing the same |
| US7816385B2 (en) * | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
| JPWO2004106542A1 (ja) * | 2003-05-29 | 2006-07-20 | 三共株式会社 | インスリン抵抗性改善剤及びそのスクリーニング方法 |
| TWI359810B (en) | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| US7790745B2 (en) * | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| WO2007058504A1 (en) * | 2005-11-21 | 2007-05-24 | Lg Life Sciences, Ltd. | Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same |
| WO2012033195A1 (ja) * | 2010-09-10 | 2012-03-15 | 京都薬品工業株式会社 | 複素環化合物 |
| CN102807526B (zh) * | 2011-06-21 | 2015-12-02 | 寿光富康制药有限公司 | 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用 |
| WO2020013116A1 (ja) * | 2018-07-10 | 2020-01-16 | 京都薬品工業株式会社 | Ｐｔｐ－１ｂ阻害剤およびその用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| AR240698A1 (es) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| ATE186724T1 (de) | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| EP1019378B1 (en) * | 1996-07-01 | 2004-09-29 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| CA2259487A1 (en) | 1996-07-01 | 1998-01-08 | Margaret Mary Faul | Hypoglycemic and hypolipidemic compounds |
| GB9817118D0 (en) | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| HUP0203431A3 (en) * | 1999-12-03 | 2003-11-28 | Kyoto Pharma Ind | Novel heterocyclic compounds and salts thereof and pharmaceutical compositions containing and use of the same |
| US20020037897A1 (en) | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| IL159084A0 (en) | 2001-05-29 | 2004-05-12 | Kyoto Pharma Ind | Tetrahydroisoquinoline carboxylic acid derivatives and pharmaceutical compositions containing the same |
-
2002
- 2002-05-27 US US10/478,862 patent/US7557123B2/en not_active Expired - Fee Related
- 2002-05-27 HU HU0401862A patent/HUP0401862A3/hu unknown
- 2002-05-27 NZ NZ530358A patent/NZ530358A/en unknown
- 2002-05-27 CA CA002448634A patent/CA2448634A1/en not_active Abandoned
- 2002-05-27 EP EP02774070A patent/EP1403253A4/en not_active Withdrawn
- 2002-05-27 WO PCT/JP2002/005097 patent/WO2002096880A1/ja active Application Filing
- 2002-05-27 AU AU2002308889A patent/AU2002308889B2/en not_active Ceased
- 2002-05-27 CZ CZ20033450A patent/CZ20033450A3/cs unknown
- 2002-05-27 RU RU2003137574/04A patent/RU2299197C2/ru not_active IP Right Cessation
- 2002-05-27 PL PL02367639A patent/PL367639A1/xx unknown
- 2002-05-27 ZA ZA200309757A patent/ZA200309757B/en unknown
- 2002-05-27 BR BR0209711-7A patent/BR0209711A/pt not_active IP Right Cessation
- 2002-05-27 CN CNB028109643A patent/CN1242994C/zh not_active Expired - Fee Related
- 2002-05-27 YU YU94003A patent/YU94003A/sh unknown
- 2002-05-27 JP JP2003500060A patent/JP4279136B2/ja not_active Expired - Fee Related
- 2002-05-27 KR KR10-2003-7015611A patent/KR20040030647A/ko not_active IP Right Cessation
- 2002-05-27 MX MXPA03010811A patent/MXPA03010811A/es active IP Right Grant
- 2002-05-27 KR KR1020087023698A patent/KR100898358B1/ko not_active IP Right Cessation
- 2002-05-27 IL IL15908502A patent/IL159085A0/xx unknown
- 2002-05-28 TW TW091111315A patent/TWI297008B/zh active
- 2002-05-29 AR ARP020102002A patent/AR036036A1/es unknown
-
2003
- 2003-11-28 NO NO20035331A patent/NO326688B1/no not_active IP Right Cessation
- 2003-12-29 CO CO03112806A patent/CO5540342A2/es not_active Application Discontinuation
-
2005
- 2005-03-02 HK HK05101815A patent/HK1069385A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0209711A (pt) | 2004-11-03 |
| IL159085A0 (en) | 2004-05-12 |
| CN1242994C (zh) | 2006-02-22 |
| US7557123B2 (en) | 2009-07-07 |
| RU2299197C2 (ru) | 2007-05-20 |
| EP1403253A1 (en) | 2004-03-31 |
| US20040220215A1 (en) | 2004-11-04 |
| MXPA03010811A (es) | 2004-02-27 |
| CZ20033450A3 (cs) | 2004-05-12 |
| AR036036A1 (es) | 2004-08-04 |
| JP4279136B2 (ja) | 2009-06-17 |
| HUP0401862A2 (hu) | 2004-12-28 |
| CO5540342A2 (es) | 2005-07-29 |
| KR20040030647A (ko) | 2004-04-09 |
| TWI297008B (en) | 2008-05-21 |
| EP1403253A4 (en) | 2005-03-30 |
| CN1527819A (zh) | 2004-09-08 |
| KR100898358B1 (ko) | 2009-05-20 |
| NZ530358A (en) | 2005-04-29 |
| AU2002308889B2 (en) | 2007-09-06 |
| WO2002096880A1 (fr) | 2002-12-05 |
| PL367639A1 (en) | 2005-03-07 |
| ZA200309757B (en) | 2004-12-22 |
| RU2003137574A (ru) | 2005-05-20 |
| KR20080093076A (ko) | 2008-10-17 |
| NO20035331D0 (no) | 2003-11-28 |
| HUP0401862A3 (en) | 2009-03-30 |
| HK1069385A1 (en) | 2005-05-20 |
| JPWO2002096880A1 (ja) | 2004-09-09 |
| CA2448634A1 (en) | 2002-12-05 |
| NO326688B1 (no) | 2009-01-26 |
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