[go: up one dir, main page]

YU58601A - Derivati fenilalaninola - Google Patents

Derivati fenilalaninola

Info

Publication number
YU58601A
YU58601A YU58601A YUP58601A YU58601A YU 58601 A YU58601 A YU 58601A YU 58601 A YU58601 A YU 58601A YU P58601 A YUP58601 A YU P58601A YU 58601 A YU58601 A YU 58601A
Authority
YU
Yugoslavia
Prior art keywords
binding
phenylalaninol derivatives
phenylalaninol
derivatives
inflammation
Prior art date
Application number
YU58601A
Other languages
English (en)
Inventor
Achytharao Sidduri
Jefferson Wright Tilley
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU58601A publication Critical patent/YU58601A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Jedinjenja formule (1) i njihove farmaceutski prihvatljive soli i estri, u kojima su X i Y kako je opisano u prijavi, su efikasni inhibitori vezivanja VCAM-1 za VLA-4 in vivo i korisna su kod tretmana zapaljenja vezanih za hronična zapaljenska oboljenja, kod kojih takvo vezivanje deluje u smislu izazivanja zapaljenja.
YU58601A 1999-02-18 2000-02-12 Derivati fenilalaninola YU58601A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12049899P 1999-02-18 1999-02-18

Publications (1)

Publication Number Publication Date
YU58601A true YU58601A (sh) 2004-05-12

Family

ID=22390691

Family Applications (1)

Application Number Title Priority Date Filing Date
YU58601A YU58601A (sh) 1999-02-18 2000-02-12 Derivati fenilalaninola

Country Status (29)

Country Link
US (1) US6420600B1 (sh)
EP (1) EP1154987B1 (sh)
JP (1) JP2002537283A (sh)
KR (1) KR100636458B1 (sh)
CN (1) CN1213020C (sh)
AT (1) ATE264835T1 (sh)
AU (1) AU771938B2 (sh)
BR (1) BR0008368A (sh)
CA (1) CA2362833C (sh)
CZ (1) CZ20012984A3 (sh)
DE (1) DE60010049T2 (sh)
DK (1) DK1154987T3 (sh)
ES (1) ES2218116T3 (sh)
HK (1) HK1043589A1 (sh)
HR (1) HRP20010594B1 (sh)
HU (1) HUP0200343A3 (sh)
ID (1) ID30057A (sh)
IL (2) IL144641A0 (sh)
MA (1) MA26772A1 (sh)
MX (1) MXPA01008178A (sh)
NO (1) NO20013946L (sh)
PL (1) PL349463A1 (sh)
PT (1) PT1154987E (sh)
RU (1) RU2238265C2 (sh)
SI (1) SI1154987T1 (sh)
TR (1) TR200102395T2 (sh)
WO (1) WO2000048988A1 (sh)
YU (1) YU58601A (sh)
ZA (1) ZA200106075B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
CN1377268A (zh) * 1999-08-13 2002-10-30 比奥根公司 细胞粘合抑制剂
US6388084B1 (en) 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
US6380387B1 (en) 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
AU2004240940A1 (en) 2003-05-20 2004-12-02 Genentech, Inc. Thiocarbamate inhibitors of alpha-4 integrins
WO2006081986A1 (en) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Bambuterol and integrin inhibitor combination
WO2006094640A2 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Roflumilast and integrin inhibitor combination and method of treatment
IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE584914A (sh) 1958-11-24
US3527793A (en) 1967-08-18 1970-09-08 Bristol Myers Co Phenylglycine derivatives
IT1190378B (it) 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US5039805A (en) 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5463116A (en) 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
US5840732A (en) 1994-06-20 1998-11-24 Takeda Chemical Industries Ltd. Imidazopyridine or imidazopyrimidine compounds, their production and use
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US5804595A (en) 1995-12-05 1998-09-08 Regents Of The University Of Minnesota Kappa opioid receptor agonists
ES2172780T3 (es) * 1996-03-29 2002-10-01 Searle & Co Derivados de acido fenilpropanoico sustituidos en para como antagonistas de integrina.
PT889877E (pt) 1996-03-29 2002-02-28 Searle & Co Derivados fenileno meta substituidos e sua utilizacao como antagonitas ou inibidores integrina alfa v beta3
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
PL193283B1 (pl) * 1997-08-22 2007-01-31 Hoffmann La Roche Nowe pochodne N-aroilofenyloalaniny, ich zastosowanie i środek leczniczy
TR200000481T2 (tr) * 1997-08-22 2000-06-21 F.Hoffmann-La Roche Ag N-Alkonoilfenilalenin türevleri.
ES2226413T3 (es) 1998-02-26 2005-03-16 Celltech Therapeutics Limited Derivados de fenilalanina como inhibidores de alfa-4 integrinas.
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds

Also Published As

Publication number Publication date
MA26772A1 (fr) 2004-12-20
TR200102395T2 (tr) 2001-12-21
AU771938B2 (en) 2004-04-08
KR100636458B1 (ko) 2006-10-18
NO20013946D0 (no) 2001-08-14
EP1154987B1 (en) 2004-04-21
CN1340043A (zh) 2002-03-13
DE60010049D1 (de) 2004-05-27
EP1154987A1 (en) 2001-11-21
US6420600B1 (en) 2002-07-16
KR20010102260A (ko) 2001-11-15
ES2218116T3 (es) 2004-11-16
HK1043589A1 (en) 2002-09-20
MXPA01008178A (es) 2002-03-13
ID30057A (id) 2001-11-01
ATE264835T1 (de) 2004-05-15
RU2238265C2 (ru) 2004-10-20
AU2548600A (en) 2000-09-04
CN1213020C (zh) 2005-08-03
ZA200106075B (en) 2002-10-24
IL144641A (en) 2006-09-05
WO2000048988A1 (en) 2000-08-24
CZ20012984A3 (cs) 2002-02-13
HUP0200343A3 (en) 2005-04-28
DK1154987T3 (da) 2004-08-09
PT1154987E (pt) 2004-08-31
CA2362833C (en) 2009-04-07
JP2002537283A (ja) 2002-11-05
NO20013946L (no) 2001-08-14
HUP0200343A2 (en) 2002-06-29
CA2362833A1 (en) 2000-08-24
HRP20010594B1 (en) 2006-02-28
SI1154987T1 (en) 2004-08-31
HRP20010594A2 (en) 2002-08-31
BR0008368A (pt) 2001-11-06
DE60010049T2 (de) 2005-03-31
PL349463A1 (en) 2002-07-29
IL144641A0 (en) 2002-05-23

Similar Documents

Publication Publication Date Title
YU58701A (sh) Derivati tioamida
UA84175C2 (ru) Гетероциклические ингибиторы мэк и их применение
EA201001455A1 (ru) Пиридины и пиразины в качестве ингибиторов pi3k (фосфатидилинозиткиназы-3)
ATE267801T1 (de) N-alkanoylphenylalaninderivate
EA200200058A1 (ru) Пиримидин-2,4,6-трионовые ингибиторы металлопротеиназ
DK1156798T3 (da) Felbamat-afledte forbindelser
AR067495A1 (es) Composiciones farmaceuticas y procedimientode tratamientos de trastornos de ojo seco
RS52823B (en) NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
MY140841A (en) Indozolone derivatives as 11b-hsd1 inhibitors
EE200100355A (et) Rakkude adhesiooni inhibeerivad põletikuvastased ja immunosupressiivsed ühendid
YU40502A (sh) 4-piridinil-n-acil-l-fenilalanini
YU58601A (sh) Derivati fenilalaninola
RU2005132004A (ru) Стабилизированные композиции для местного применения, содержащие кетопрофен
EA200701835A1 (ru) Амидные производные в качестве лигандов ионных каналов, их фармацевтические композиции и способы их применения
SE0402763D0 (sv) Nitro indazole derivatives