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YU50002A - Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju - Google Patents

Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju

Info

Publication number
YU50002A
YU50002A YU50002A YUP50002A YU50002A YU 50002 A YU50002 A YU 50002A YU 50002 A YU50002 A YU 50002A YU P50002 A YUP50002 A YU P50002A YU 50002 A YU50002 A YU 50002A
Authority
YU
Yugoslavia
Prior art keywords
compounds
production
methods
medicaments containing
substituted piperidines
Prior art date
Application number
YU50002A
Other languages
English (en)
Inventor
Klaus Rudolf
Wolfgang Eberlein
Alexander Dreyer
Stephan Georg Muller
Henri Doods
Eckhart Bauer
Rudolf Hurnaus
Original Assignee
Boehringer Ingelheim Pharma Gmbh. & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh. & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh. & Co.Kg.
Publication of YU50002A publication Critical patent/YU50002A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovaj se pronalazak odnosi na supstituisane piperidine, opšte formule (I), u kojoj su A1, A2, R, R1 i R2 definisani kao u zahtevu (1), na njihove tautomere, njihove dijastereomere, njihove enantiomere, njihove smeše i njihove soli, naročito njihove fiziološki podnošljive soli sa neorganskim ili organskim kiselinama ili bazama, koji ispoljavaju dragocena farmakološka svojstva, naročito CGRP-antagonistička svojstva, na lekove koji sadrže ova jedinjenja, na njihovu primenu i postupke za njihovo pripremanje.[The invention relates to substituted piperdines of general formula (I) in which A1, A2, R, R1 and R2 are defined as in Claim No. 1, to their tautomers, diastereomers, enantiomers, mixtures, and to their salts, in particular, their physiologically compatible salts with inorganic or organic acids or bases, which comprise valuable pharmacological properties, in particular, CGRP-antagonistic properties. The invention also relates to medicaments containing these compounds, to their use and to methods for the production thereof.
YU50002A 1999-12-30 2000-12-22 Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju YU50002A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19963868A DE19963868A1 (de) 1999-12-30 1999-12-30 Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
YU50002A true YU50002A (sh) 2005-11-28

Family

ID=7935059

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50002A YU50002A (sh) 1999-12-30 2000-12-22 Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju

Country Status (29)

Country Link
US (1) US6949541B2 (sh)
EP (1) EP1252153A1 (sh)
JP (1) JP2003519222A (sh)
KR (1) KR100736063B1 (sh)
CN (1) CN1203069C (sh)
AR (1) AR027113A1 (sh)
AU (1) AU783275B2 (sh)
BG (1) BG106848A (sh)
BR (1) BR0017063A (sh)
CA (1) CA2395541C (sh)
CZ (1) CZ20022628A3 (sh)
DE (1) DE19963868A1 (sh)
EA (1) EA005600B1 (sh)
EE (1) EE200200369A (sh)
HK (1) HK1054026A1 (sh)
HR (1) HRP20020560A2 (sh)
HU (1) HUP0300002A3 (sh)
IL (2) IL150377A0 (sh)
MX (1) MXPA02006509A (sh)
NO (1) NO323700B1 (sh)
NZ (1) NZ519939A (sh)
PL (1) PL356400A1 (sh)
SK (1) SK9412002A3 (sh)
TW (1) TWI255267B (sh)
UA (1) UA75346C2 (sh)
UY (1) UY26513A1 (sh)
WO (1) WO2001049676A1 (sh)
YU (1) YU50002A (sh)
ZA (1) ZA200205181B (sh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211770A1 (de) * 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7842808B2 (en) * 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
KR20120004541A (ko) 2002-06-05 2012-01-12 브리스톨-마이어스 스큅 컴퍼니 칼시토닌 유전자 관련 펩티드 수용체 길항제
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
AU2004229518B2 (en) * 2003-04-15 2010-02-18 Merck Sharp & Dohme Corp. CGRP receptor antagonists
AU2004252150B2 (en) * 2003-06-26 2008-11-20 Merck Sharp & Dohme Corp. Benzodiazepine CGRP receptor antagonists
EP1641423B1 (en) * 2003-06-26 2010-03-17 Merck Sharp & Dohme Corp. Benzodiazepine cgrp receptor antagonists
BR0318637A (pt) 2003-12-05 2007-02-13 Bristol Myers Squibb Co antagonistas de receptores de peptìdios relacionados com o gene de calcitonina
US7569578B2 (en) * 2003-12-05 2009-08-04 Bristol-Meyers Squibb Company Heterocyclic anti-migraine agents
JP4769082B2 (ja) * 2003-12-17 2011-09-07 武田薬品工業株式会社 ウレア誘導体、その製造法及び用途
EP1765805B1 (en) * 2004-01-29 2013-11-20 Merck Sharp & Dohme Corp. Cgrp receptor antagonists
DE102004006893A1 (de) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin
US20050192230A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim International Gambh Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
ATE463245T1 (de) * 2004-09-09 2010-04-15 Merck Sharp & Dohme Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
US7750010B2 (en) * 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
EP1770091A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2006103701A1 (en) * 2005-04-01 2006-10-05 Pankaj Kehr Reusable metal blade handle
US7834007B2 (en) * 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
WO2023055827A1 (en) * 2021-09-30 2023-04-06 Crinetics Pharmaceuticals, Inc. Parathyroid hormone (pth) receptor antagonists and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5011390A (sh) * 1973-05-30 1975-02-05
WO1996035713A1 (en) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
NZ334543A (en) * 1996-09-10 2000-06-23 Thomae Gmbh Dr K Modified amino acids for production of antibodies and labelled compounds suitable for RIA and ELISA assays
DE19636623A1 (de) * 1996-09-10 1998-03-12 Thomae Gmbh Dr K Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JP2002525371A (ja) * 1998-09-30 2002-08-13 メルク シャープ エンド ドーム リミテッド Ｃｇｒｐリガンドとしてのベンゾイミダゾリニルピペリジン
DE10250080A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
HRP20020560A2 (en) 2005-04-30
CN1414960A (zh) 2003-04-30
SK9412002A3 (en) 2002-11-06
UA75346C2 (en) 2006-04-17
CA2395541A1 (en) 2001-07-12
HUP0300002A3 (en) 2006-01-30
AU3537901A (en) 2001-07-16
BR0017063A (pt) 2002-10-22
TWI255267B (en) 2006-05-21
JP2003519222A (ja) 2003-06-17
PL356400A1 (en) 2004-06-28
ZA200205181B (en) 2003-09-30
NO323700B1 (no) 2007-06-25
US20030212057A1 (en) 2003-11-13
CZ20022628A3 (cs) 2002-10-16
UY26513A1 (es) 2001-07-31
HK1054026A1 (en) 2003-11-14
EA200200651A1 (ru) 2002-12-26
NZ519939A (en) 2006-08-31
US6949541B2 (en) 2005-09-27
EE200200369A (et) 2003-10-15
EP1252153A1 (de) 2002-10-30
AU783275B2 (en) 2005-10-06
BG106848A (bg) 2002-12-29
CN1203069C (zh) 2005-05-25
NO20023161D0 (no) 2002-06-28
MXPA02006509A (es) 2002-11-29
WO2001049676A1 (de) 2001-07-12
IL150377A (en) 2007-06-17
CA2395541C (en) 2008-09-23
AR027113A1 (es) 2003-03-12
KR100736063B1 (ko) 2007-07-06
IL150377A0 (en) 2002-12-01
DE19963868A1 (de) 2001-07-12
EA005600B1 (ru) 2005-04-28
KR20020073493A (ko) 2002-09-26
HUP0300002A2 (en) 2003-05-28
NO20023161L (no) 2002-06-28

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