[go: up one dir, main page]

YU49442B - PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE - Google Patents

PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

Info

Publication number
YU49442B
YU49442B YU15195A YU15195A YU49442B YU 49442 B YU49442 B YU 49442B YU 15195 A YU15195 A YU 15195A YU 15195 A YU15195 A YU 15195A YU 49442 B YU49442 B YU 49442B
Authority
YU
Yugoslavia
Prior art keywords
formula
ribofuranosylselenazole
added
anhydro
methanol
Prior art date
Application number
YU15195A
Other languages
Serbo-Croatian (sh)
Other versions
YU15195A (en
Inventor
dr. Vjera Pejanović
Jadranka Vojmirović
Original Assignee
Galenika A.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenika A.D. filed Critical Galenika A.D.
Priority to YU15195A priority Critical patent/YU49442B/en
Priority to US08/603,106 priority patent/US5907036A/en
Priority to AU52980/96A priority patent/AU5298096A/en
Priority to PCT/US1996/002512 priority patent/WO1996026212A1/en
Priority to EP96909514A priority patent/EP0804447A1/en
Priority to SK1202-97A priority patent/SK120297A3/en
Publication of YU15195A publication Critical patent/YU15195A/en
Publication of YU49442B publication Critical patent/YU49442B/en

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Postupak za dobijanje 2-β-D-ribofuranozilselenazol-4-karboksiamida, formule I, naznačen time, što reaguje 2,3-anhidro-3,4,6-tri-O-benzoil-D-alononitril formule II sa natrijum-metoksidom u metanolu na temperaturi od 35-45 В°C u atmosferi azota, dodaje metilen hlorid i dobija kristalni metil-2,5-anhidro-2-D-alonimidat formule III koji se dodaje u ekvimolarnom odnosu u smešu etanola ohladjenog na -20В°C i vodonik-selenida, na temperaturi od 0 do 5 В°C i dobija selenoamid formue IV koji se ne izoluje, nego in situ reaguje sa etil-α-bromopiruvatom i dobija etil 2-D-ribofuranozilselenazol-4-karboksilat formule V koji se, rastvoren u metanolu i ohladjen na 0 В°C, zasiti amonijakom i prevodi u 2-D-ribofuranozilselenazol-4-karboksiamida formule I. Prijava sadrži još 3 zavisna patentna zahteva.A process for the preparation of 2-β-D-ribofuranosylselenazole-4-carboxyamide of formula I by reacting with 2,3-anhydro-3,4,6-tri-O-benzoyl-D-alononitrile formula II with sodium methoxide in methanol at a temperature of 35-45 V ° C under a nitrogen atmosphere, methylene chloride is added and crystalline methyl-2,5-anhydro-2-D-alonimidate of formula III is added which is added in equimolar ratio to a mixture of ethanol cooled to -20V ° C and hydrogen selenide, at a temperature of from 0 to 5 V ° C, gives a selenoamide of formula IV which is not isolated but in situ reacted with ethyl α-bromopyruvate to give ethyl 2-D-ribofuranosylselenazole-4-carboxylate of formula V which , dissolved in methanol and cooled to 0 ° C, is saturated with ammonia and converted to 2-D-ribofuranosylselenazole-4-carboxamide of formula I. The application contains 3 more dependent claims.

YU15195A 1995-02-17 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE YU49442B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
YU15195A YU49442B (en) 1995-03-07 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE
US08/603,106 US5907036A (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-C-nucleosides
AU52980/96A AU5298096A (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-c-nucleosides
PCT/US1996/002512 WO1996026212A1 (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-c-nucleosides
EP96909514A EP0804447A1 (en) 1995-03-07 1996-02-20 Procedures for obtaining ribo-c-nucleosides
SK1202-97A SK120297A3 (en) 1995-03-07 1996-02-20 Procedures for obtaining ribo-c-nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU15195A YU49442B (en) 1995-03-07 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

Publications (2)

Publication Number Publication Date
YU15195A YU15195A (en) 1998-07-10
YU49442B true YU49442B (en) 2006-03-03

Family

ID=25548578

Family Applications (1)

Application Number Title Priority Date Filing Date
YU15195A YU49442B (en) 1995-02-17 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

Country Status (3)

Country Link
EP (1) EP0804447A1 (en)
SK (1) SK120297A3 (en)
YU (1) YU49442B (en)

Also Published As

Publication number Publication date
YU15195A (en) 1998-07-10
SK120297A3 (en) 1998-01-14
EP0804447A1 (en) 1997-11-05

Similar Documents

Publication Publication Date Title
US4239683A (en) Pyrrolo benzodiazepine compounds
KR860003255A (en) Preparation of Purine Derivatives
DK0763024T3 (en) Process and intermediates for the preparation of piperazine derivatives
YU49442B (en) PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE
KR830005110A (en) Method for preparing fluorene derivative
UA26400C2 (en) METHOD OF OBTAINING DERIVATIVE ERGOLICH
Tamura et al. Syntheses and nucleophilic reactions of N-alkyldiphenylsulfilimines
HUP9903806A2 (en) A process for the biotransformation of colchicionid compounds into the corresponding 3-glycosyl derivatives
Georg et al. A one-step transformation of aromatic aldehydes to nitriles, using S, S-Dimethylsulfurdiimide as iminating agent. Isolation of dithiatetrazocines as reaction intermediates.
ES8609195A1 (en) Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives.
KR860002575A (en) Preparation method of sapramycin A derivative
US4284562A (en) Process for preparing pyrrole-2-acetic acids
KR890012988A (en) Preparation of 3,3-Diarylacrylic Acid Amide
Nagraba et al. Electron impact mass spectra of some enols and their alkyl ethers
Tanaka et al. N-Acyl-1-chloro-2, 2, 2-trifluoroethylamine as a 2, 2, 2-Trifluoroethylamine-Building Block.
KR860003204A (en) Method for preparing diphenylmethylimine derivative
KR880001659A (en) Tetracyclic indole derivatives
SE8300432D0 (en) REACTIVE CINNIC ACID DERIVATIVES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE AMIDES
Kitagawa et al. Preparation and plant growth-regulatory activity of N'-substituted N-furfuryloxamides
JPS57146790A (en) Novel synthesis of organopolysilane
KR840006227A (en) Synthesis of 5-thio-1,2,3-thiadiazole
DK0546875T3 (en) New Process for Preparation of 20-Oxo-17-Alpha, 21-Dihydroxy Derivatives of Pregnancy and Intermediates Therefor
JPS55143960A (en) Novel acetal compound and its preparation
Crombie et al. Synthesis of homaline and epi-homaline
KR920012087A (en) Method for preparing benzoxazine derivatives