YU47723B - Postupak za dobivanje derivata 2-imino-3-heterocikloalkilbenzotiazolina - Google Patents
Postupak za dobivanje derivata 2-imino-3-heterocikloalkilbenzotiazolinaInfo
- Publication number
- YU47723B YU47723B YU133990A YU133990A YU47723B YU 47723 B YU47723 B YU 47723B YU 133990 A YU133990 A YU 133990A YU 133990 A YU133990 A YU 133990A YU 47723 B YU47723 B YU 47723B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- preparation
- heterocyclocylbenzotiazoline
- imino
- derivatives
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
POSTUPAK ZA DOBIVANJE DERIVATA 2-IMINO-3-HETEROCIKLOALKILBENZOTIAZOLINA (b) fenil-radikal koji je supstituisan sa najmanje jednim supstituentom odabranim izmedju atoma halogena, alkil-radikala i alkoksi-radikala, (c) fenillalkil-radikal, (d) piridil-radikal ili (e) pirimidinil-radikal, .1,2,3,6-tetrahidro-1-piridinil-radikal koji je supstituisan u položaju 4 radikalom fenil ili fenil-radikalom koji je supstituisan sa najmanje jednim supstituentom odabranim izmedju atoma halogena, alkil- i alkoksi-radikala, . piperidino-radikal koji je supstituisan u položaju 4 radikalom fenil ili radikalom fenil koji je supstituisan sa najmanje jednim supstituen-tom odabranim izmedju atoma halogena, alkil-radikala i alkoksi-radikala, - R2 označava polifluoralkoksi-radikal, - n je jednako 2 ili 3, pri čemu se podrazumeva da alkil-radikali i alkoksi-radikali i delovi alkila i alkoksi-grupa sadrže 1-4 atoma ugljenika u račvastom ili neračvastom nizu, kao i njihovih soli sa mineralnom ili organskom kiselinom, naznačen time, što se A - za dobivanje jedinjenja formule (I), hidrolizuje derivat formule u kojoj R1, R2 i n imaju ista značenja kao i formuli (I), izoluje dobiveni produkt i u datom slučaju transformiše u adicionu so sa mineralnom ili organskom kiselinom, B - za dobivanje jedinjenja formule (I), reaguje brom i alkalnometal-ni tiocijanat sa derivatom formule u kojoj R1, R2 i n imaju ista značenja kao u formuli (I), izoluje dobiveni produkt i u datom slučaju transformiše u adicionu so sa mineralnom ili organskom kiselinom. Prijava sadrži još 1 zavisan zahtev.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8909483A FR2649704B1 (fr) | 1989-07-13 | 1989-07-13 | Derives d'imino-2 ethyl-3 benzothiazoline, leurs procedes de preparation et les medicaments les contenant |
| FR9005889A FR2661910B1 (fr) | 1990-05-11 | 1990-05-11 | Derives d'imino-2 heterocyclylalkyl-3 benzothiazoline, leur preparation et les medicaments les contenant. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU133990A YU133990A (sh) | 1992-07-20 |
| YU47723B true YU47723B (sh) | 1996-01-08 |
Family
ID=26227474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU133990A YU47723B (sh) | 1989-07-13 | 1990-07-11 | Postupak za dobivanje derivata 2-imino-3-heterocikloalkilbenzotiazolina |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0409692B1 (sh) |
| JP (1) | JPH0386871A (sh) |
| AT (1) | ATE102612T1 (sh) |
| AU (1) | AU624972B2 (sh) |
| CA (1) | CA2021031A1 (sh) |
| CZ (1) | CZ281164B6 (sh) |
| DE (1) | DE69007196T2 (sh) |
| DK (1) | DK0409692T3 (sh) |
| ES (1) | ES2062445T3 (sh) |
| FI (1) | FI93109C (sh) |
| HU (1) | HU210827B (sh) |
| IE (1) | IE63318B1 (sh) |
| IL (1) | IL95053A (sh) |
| NO (1) | NO175590C (sh) |
| NZ (1) | NZ234487A (sh) |
| PL (2) | PL164326B1 (sh) |
| PT (1) | PT94701B (sh) |
| RU (1) | RU1836368C (sh) |
| SK (1) | SK278908B6 (sh) |
| YU (1) | YU47723B (sh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674853B1 (fr) * | 1991-04-03 | 1995-01-20 | Synthelabo | Derives de piperidinylguanidine, leur preparation et leur application en therapeutique. |
| FR2678619B1 (fr) * | 1991-07-04 | 1993-09-17 | Rhone Poulenc Rorer Sa | Derives de 1,2,4-thiadiazolo[3,4-b]benzothiazole, leur preparation et les medicaments les contenant. |
| WO1993021170A1 (fr) * | 1992-04-15 | 1993-10-28 | Rhone-Poulenc Rorer S.A. | Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant |
| FR2696457B1 (fr) * | 1992-10-02 | 1994-11-25 | Rhone Poulenc Rorer Sa | Dérivés de 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxyde, leur préparation et les médicaments les contenant. |
| US5889010A (en) * | 1995-05-18 | 1999-03-30 | Pfizer Inc. | Benzimidazole derivatives having dopaminergic activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2631163B2 (de) * | 1976-07-10 | 1978-06-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 2-Iminobenzothiazolen |
| FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
| FR2649701B2 (fr) * | 1988-12-15 | 1991-11-22 | Rhone Poulenc Sante | Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant |
| EP0375510B1 (fr) * | 1988-12-15 | 1992-11-11 | Rhone-Poulenc Sante | Dérivés d'imino-2 polyfluoroalcoxy-6 benzothiazole, leurs procédés de préparation et les médicaments les contenant |
-
1990
- 1990-07-09 EP EP90401976A patent/EP0409692B1/fr not_active Expired - Lifetime
- 1990-07-09 DK DK90401976.7T patent/DK0409692T3/da active
- 1990-07-09 ES ES90401976T patent/ES2062445T3/es not_active Expired - Lifetime
- 1990-07-09 DE DE69007196T patent/DE69007196T2/de not_active Expired - Fee Related
- 1990-07-09 AT AT90401976T patent/ATE102612T1/de not_active IP Right Cessation
- 1990-07-10 AU AU58847/90A patent/AU624972B2/en not_active Ceased
- 1990-07-11 SK SK3425-90A patent/SK278908B6/sk unknown
- 1990-07-11 CZ CS903425A patent/CZ281164B6/cs unknown
- 1990-07-11 YU YU133990A patent/YU47723B/sh unknown
- 1990-07-12 PL PL90300986A patent/PL164326B1/pl unknown
- 1990-07-12 NO NO903113A patent/NO175590C/no unknown
- 1990-07-12 JP JP2182893A patent/JPH0386871A/ja active Pending
- 1990-07-12 IL IL9505390A patent/IL95053A/en not_active IP Right Cessation
- 1990-07-12 NZ NZ234487A patent/NZ234487A/en unknown
- 1990-07-12 CA CA002021031A patent/CA2021031A1/fr not_active Abandoned
- 1990-07-12 FI FI903531A patent/FI93109C/fi not_active IP Right Cessation
- 1990-07-12 HU HU904189A patent/HU210827B/hu not_active IP Right Cessation
- 1990-07-12 IE IE255190A patent/IE63318B1/en not_active IP Right Cessation
- 1990-07-12 PL PL90286036A patent/PL164152B1/pl unknown
- 1990-07-13 PT PT94701A patent/PT94701B/pt not_active IP Right Cessation
-
1992
- 1992-01-08 RU SU925010496A patent/RU1836368C/ru active
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