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YU46684B - Posupak za dobijanje hinolinskog derivata - Google Patents

Posupak za dobijanje hinolinskog derivata

Info

Publication number
YU46684B
YU46684B YU198989A YU198989A YU46684B YU 46684 B YU46684 B YU 46684B YU 198989 A YU198989 A YU 198989A YU 198989 A YU198989 A YU 198989A YU 46684 B YU46684 B YU 46684B
Authority
YU
Yugoslavia
Prior art keywords
group
amino
carbon atoms
pharmaceutically acceptable
lower alkyl
Prior art date
Application number
YU198989A
Other languages
English (en)
Other versions
YU198989A (en
Inventor
J. Matsumoto
A. Minamida
M. Fujita
T. Hirose
J. Nakano
S. Nakamura
Original Assignee
Dainippon Pharmaceutical Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co. Ltd. filed Critical Dainippon Pharmaceutical Co. Ltd.
Publication of YU198989A publication Critical patent/YU198989A/xx
Publication of YU46684B publication Critical patent/YU46684B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSUPAK ZA DOBIVANJE HINOLINSKOG DERIVATA, opšte formule u kojoj Z je amino grupa ili halogenski atom i R1, R2 i R3 su isti ili različiti i svaki predstavlja atom vodonika ili nižu alkil grupu koja ima 1-5 atoma ugljenika; ili njegovog farmaceutski prihvatljivog estra ili farmaceutski prihvatljive soli ovog derivata ili estra, nazn ačen time, što se uklanja zaštitna grupa jedinjenja formule u kojoj Z' je amino grupa, halogenski atom ili zaštićena amino grupa, R'1 je atom vodonika, niža alkil grupa koja ima 1-5 atoma ugljenika ili amino-zaštitna grupa uz predpostavku da ima bar jedna amino zaštitna grupa u Z'i R'1, Y je atom vodonika ili niža alkil grupa koja ima 1'5 atoma ugljenika, i R2 i R3 su kao što je definisano napred, u aprotičnom rastvaraču takvom kao etanol i voda na 0 do 150 C u prisustvu kiseline takve kao HC1 ili baze takve kao NaOH i NaCO3, ili u inertnom rastvaraču takvom kao etanol, sirćetna kiselina i voda na 10-60 C sa strujom vodonika u prisustvu katalizatora takvog kao što je paladijum i Raney nikl, i ako se želi dobiveno jedinjenje se hidrolizuje i po izboru prevodi u svoju farmaceutski prihvatljivu so.
YU198989A 1987-10-16 1989-10-13 Posupak za dobijanje hinolinskog derivata YU46684B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26244187 1987-10-16
JP10884088 1988-04-30

Publications (2)

Publication Number Publication Date
YU198989A YU198989A (en) 1990-04-30
YU46684B true YU46684B (sh) 1994-04-05

Family

ID=26448650

Family Applications (3)

Application Number Title Priority Date Filing Date
YU192288A YU46647B (sh) 1987-10-16 1988-10-14 Postupak za dobijanje hinolinskih derivata
YU198989A YU46684B (sh) 1987-10-16 1989-10-13 Posupak za dobijanje hinolinskog derivata
YU199089A YU46703B (sh) 1987-10-16 1989-10-13 Postupak za dobijanje hinolinskih derivata

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU192288A YU46647B (sh) 1987-10-16 1988-10-14 Postupak za dobijanje hinolinskih derivata

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU199089A YU46703B (sh) 1987-10-16 1989-10-13 Postupak za dobijanje hinolinskih derivata

Country Status (16)

Country Link
US (1) US5013841A (sh)
EP (1) EP0312085B1 (sh)
KR (1) KR930006774B1 (sh)
CN (1) CN1021967C (sh)
DE (1) DE3880953T2 (sh)
DK (1) DK573788A (sh)
ES (1) ES2054762T3 (sh)
FI (1) FI884752A (sh)
HU (1) HU204521B (sh)
IL (1) IL88003A (sh)
NO (1) NO171016C (sh)
NZ (1) NZ226574A (sh)
PH (1) PH25530A (sh)
PT (1) PT88769A (sh)
RU (2) RU1780534C (sh)
YU (3) YU46647B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
ES2147721T3 (es) 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
TW252107B (sh) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
FR2916446B1 (fr) * 2007-05-24 2009-08-21 Biocodex Sa Nouveau procede de synthese de fluoroquinolones
WO2019148293A1 (en) 2018-02-02 2019-08-08 Interface Biologics, Inc. Glass formulations comprising steroid dimers and uses thereof
WO2021220061A2 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK573788D0 (da) 1988-10-14
PT88769A (pt) 1989-07-31
YU192288A (en) 1990-04-30
AU619214B2 (en) 1992-01-23
YU198989A (en) 1990-04-30
NO171016C (no) 1993-01-13
IL88003A0 (en) 1989-06-30
CN1021967C (zh) 1993-09-01
YU46647B (sh) 1994-01-20
DK573788A (da) 1989-04-17
YU199089A (en) 1990-04-30
HU204521B (en) 1992-01-28
DE3880953T2 (de) 1993-10-14
DE3880953D1 (de) 1993-06-17
IL88003A (en) 1992-11-15
ES2054762T3 (es) 1994-08-16
YU46703B (sh) 1994-04-05
NZ226574A (en) 1991-07-26
RU1830067C (ru) 1993-07-23
CN1033996A (zh) 1989-07-19
US5013841A (en) 1991-05-07
AU2375488A (en) 1989-04-20
EP0312085A2 (en) 1989-04-19
FI884752A (fi) 1989-04-17
HUT49342A (en) 1989-09-28
FI884752A0 (fi) 1988-10-14
NO884599D0 (no) 1988-10-14
NO171016B (no) 1992-10-05
PH25530A (en) 1991-07-24
KR890006620A (ko) 1989-06-14
KR930006774B1 (ko) 1993-07-23
EP0312085B1 (en) 1993-05-12
EP0312085A3 (en) 1990-05-30
RU1780534C (ru) 1992-12-07
NO884599L (no) 1989-04-17

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