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YU44102A - Ciklična kvaternerna amonijum jedinjenja - Google Patents

Ciklična kvaternerna amonijum jedinjenja

Info

Publication number
YU44102A
YU44102A YU44102A YUP44102A YU44102A YU 44102 A YU44102 A YU 44102A YU 44102 A YU44102 A YU 44102A YU P44102 A YUP44102 A YU P44102A YU 44102 A YU44102 A YU 44102A
Authority
YU
Yugoslavia
Prior art keywords
quaternary ammonium
ammonium compounds
cyclic quaternary
formula
compounds
Prior art date
Application number
YU44102A
Other languages
English (en)
Inventor
Lewis Siu Leung Choi
Gregory N. Beatch
Clie P. Page
Original Assignee
Ucb Farchim S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Farchim S.A. filed Critical Ucb Farchim S.A.
Publication of YU44102A publication Critical patent/YU44102A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

U jednom aspektu, predmetni pronalazak se bavi upotrebom odredjenih cikličnih kvaternernih amonijum jedinjenja kao aktivnih sastojaka u proizvodnji lekova za lečenje i/ili prevenciju kašlja kod toplokrvnih životinja, uključujući i čoveka, kao što su jedinjenja sa formulom (I) gde je n ceo broj od 0 do 4; R1 i E su nezavisno odabrani izmedju -CH2-R16 i grupe predstavljene formulom (II).[In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula (I) wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by formula (II).
YU44102A 1999-12-15 2000-12-15 Ciklična kvaternerna amonijum jedinjenja YU44102A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2292351 1999-12-15

Publications (1)

Publication Number Publication Date
YU44102A true YU44102A (sh) 2005-09-19

Family

ID=4164887

Family Applications (1)

Application Number Title Priority Date Filing Date
YU44102A YU44102A (sh) 1999-12-15 2000-12-15 Ciklična kvaternerna amonijum jedinjenja

Country Status (19)

Country Link
US (1) US20030166629A1 (sh)
EP (1) EP1278731A1 (sh)
JP (1) JP2003516966A (sh)
KR (1) KR20020074170A (sh)
CN (1) CN1425005A (sh)
AU (1) AU2334501A (sh)
BG (1) BG106816A (sh)
BR (1) BR0016431A (sh)
CZ (1) CZ20022095A3 (sh)
EE (1) EE200200314A (sh)
HU (1) HUP0301686A2 (sh)
IL (1) IL150179A0 (sh)
IS (1) IS6417A (sh)
MX (1) MXPA02006051A (sh)
NO (1) NO20022870L (sh)
PL (1) PL356032A1 (sh)
WO (1) WO2001044192A1 (sh)
YU (1) YU44102A (sh)
ZA (1) ZA200205566B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2101819B1 (en) 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis
US20110086818A1 (en) * 2008-03-11 2011-04-14 Presidents And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritus
CN102725401A (zh) 2009-07-10 2012-10-10 哈佛大学校长及研究员协会 作为抗炎药的永久带电荷的钠和钙通道阻断剂
US10130632B2 (en) 2012-11-27 2018-11-20 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
US10604809B2 (en) 2014-02-04 2020-03-31 Beth Israel Deaconess Medical Center, Inc. Methods and kits for the diagnosis and treatment of pancreatic cancer
EP3331609A4 (en) 2015-08-03 2019-03-27 President and Fellows of Harvard College LOADED ION CHANNEL BLOCKS AND METHOD OF USE
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP3938345A4 (en) 2019-03-11 2023-01-18 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
SG11202109713PA (en) 2019-03-11 2021-10-28 Nocion Therapeutics Inc Ester substituted ion channel blockers and methods for use
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2020185881A1 (en) 2019-03-11 2020-09-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4054586A4 (en) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3155586A1 (en) 2019-11-06 2021-05-14 Bridget M. Cole Charged ion channel blockers and methods for use
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN115279731B (zh) 2020-03-11 2024-09-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI58632C (fi) * 1978-02-07 1981-03-10 Orion Yhtymae Oy Foerfarande foer framstaellning av anilider med antitussiv verkan

Also Published As

Publication number Publication date
CN1425005A (zh) 2003-06-18
ZA200205566B (en) 2003-11-17
BG106816A (en) 2003-04-30
KR20020074170A (ko) 2002-09-28
EE200200314A (et) 2003-08-15
WO2001044192A1 (en) 2001-06-21
PL356032A1 (en) 2004-06-14
NO20022870D0 (no) 2002-06-14
AU2334501A (en) 2001-06-25
JP2003516966A (ja) 2003-05-20
IS6417A (is) 2002-06-12
HUP0301686A2 (hu) 2003-08-28
US20030166629A1 (en) 2003-09-04
NO20022870L (no) 2002-08-14
IL150179A0 (en) 2002-12-01
CZ20022095A3 (cs) 2003-02-12
MXPA02006051A (es) 2004-08-23
EP1278731A1 (en) 2003-01-29
BR0016431A (pt) 2002-10-01

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