YU42658B - Process for preparing new pleuromutiline derivatives - Google Patents

Process for preparing new pleuromutiline derivatives

Info

Publication number: YU42658B
Authority: YU; Yugoslavia
Prior art keywords: preparing new; pleuromutiline; derivatives; pleuromutiline derivatives; preparing
Prior art date: 1979-01-12

Application number

YU62/80A

Other languages

English (en)

Other versions

YU6280A (en

Inventor

H Berner

F Turnowsky

G Laber

J Hildebrandt

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-12

Filing date

1980-01-10

Publication date

1988-10-31

1980-01-10 Application filed by Sandoz Ag filed Critical Sandoz Ag

1983-02-28 Publication of YU6280A publication Critical patent/YU6280A/xx

1988-10-31 Publication of YU42658B publication Critical patent/YU42658B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

YU62/80A 1979-01-12 1980-01-10 Process for preparing new pleuromutiline derivatives YU42658B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH30979		1979-01-12
CH727479		1979-08-08

Publications (2)

Publication Number	Publication Date
YU6280A YU6280A (en)	1983-02-28
YU42658B true YU42658B (en)	1988-10-31

Family

ID=25684188

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU62/80A YU42658B (en)	1979-01-12	1980-01-10	Process for preparing new pleuromutiline derivatives

Country Status (17)

Country	Link
US (1)	US4428953A (xx)
EP (1)	EP0013768B1 (xx)
AU (1)	AU533691B2 (xx)
CA (1)	CA1125778A (xx)
CY (1)	CY1353A (xx)
DE (1)	DE2966635D1 (xx)
DK (1)	DK155669C (xx)
ES (1)	ES8101536A1 (xx)
FI (1)	FI65994C (xx)
HK (1)	HK40587A (xx)
IE (1)	IE49356B1 (xx)
IL (1)	IL59108A (xx)
MY (1)	MY8700726A (xx)
NZ (1)	NZ192576A (xx)
PH (1)	PH17391A (xx)
PT (1)	PT70682A (xx)
YU (1)	YU42658B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT400674B (de) *	1991-07-24	1996-02-26	Biochemie Gmbh	Pharmazeutische pleuromutilin-zubereitung
AT397654B (de) *	1992-05-04	1994-06-27	Biochemie Gmbh	Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
NZ325837A (en) *	1996-01-03	1999-11-29	Smithkline Beecham P	Carbamoyloxy derivatives of mutiline and their use as antibacterials
UY25225A1 (es) *	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9912657D0 (en) *	1999-06-01	1999-07-28	Smithkline Beecham Plc	Novel compounds
GB9918037D0 (en) *	1999-07-30	1999-09-29	Biochemie Gmbh	Organic compounds
PE20020676A1 (es)	2000-09-13	2002-08-27	Biochemie Gmbh	Compuestos de mutilina como antibacterianos
GB0207495D0 (en) *	2002-03-28	2002-05-08	Biochemie Gmbh	Organic compounds
GB0308114D0 (en) *	2003-04-08	2003-05-14	Glaxo Group Ltd	Novel compounds
DE602004024417D1 (de) *	2003-09-03	2010-01-14	Glaxo Group Ltd	Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) *	2005-03-02	2005-04-06	Glaxo Group Ltd	Novel polymorph
US20080171766A1 (en) *	2005-03-10	2008-07-17	Smithkline Beecham Corporation	Novel Method
EP1808431A1 (en) *	2006-01-16	2007-07-18	Nabriva Therapeutics Forschungs GmbH	Mutilin derivatives and their use as pharmaceutical
EP2149571A4 (en) *	2007-05-24	2010-09-01	Kyorin Seiyaku Kk	MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
CN110437157B (zh) *	2019-07-05	2022-05-17	西华大学	一种芳基嘧啶类截短侧耳素衍生物及其制备方法和用途
CN110818648B (zh) *	2019-12-05	2021-03-16	华南农业大学	一种具有三氮唑侧链的截短侧耳素衍生物及其制备方法和应用
CN111253322A (zh) *	2020-03-12	2020-06-09	中国农业科学院兰州畜牧与兽药研究所	含有n-烷基化嘧啶侧链的截短侧耳素类衍生物及其应用
CN111689914B (zh) *	2020-06-18	2021-09-24	华南农业大学	一种具有1,2,4-三唑席夫碱的截短侧耳素衍生物及制备与应用
CN114716384B (zh) *	2022-03-10	2023-09-26	中国农业科学院兰州畜牧与兽药研究所	一种含有3,4-二氢嘧啶或嘧啶侧链的截短侧耳素类衍生物及其制备与应用
CN114736194A (zh) *	2022-03-29	2022-07-12	中牧实业股份有限公司	一种具有抗病原微生物活性的含吡啶季铵盐侧链的截短侧耳素衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT301753B (de) *	1969-07-25	1972-09-25	Biochemie Gmbh	Verfahren zur Herstellung neuer Pleuromutilin-Derivate

1979
- 1979-12-31 DE DE7979105421T patent/DE2966635D1/de not_active Expired
- 1979-12-31 CY CY135379A patent/CY1353A/xx unknown
- 1979-12-31 EP EP79105421A patent/EP0013768B1/en not_active Expired
1980
- 1980-01-03 DK DK004280A patent/DK155669C/da not_active IP Right Cessation
- 1980-01-03 FI FI800024A patent/FI65994C/fi not_active IP Right Cessation
- 1980-01-10 ES ES487584A patent/ES8101536A1/es not_active Expired
- 1980-01-10 CA CA343,450A patent/CA1125778A/en not_active Expired
- 1980-01-10 NZ NZ192576A patent/NZ192576A/en unknown
- 1980-01-10 IE IE46/80A patent/IE49356B1/en unknown
- 1980-01-10 IL IL59108A patent/IL59108A/xx unknown
- 1980-01-10 AU AU54535/80A patent/AU533691B2/en not_active Ceased
- 1980-01-10 PT PT70682A patent/PT70682A/pt unknown
- 1980-01-10 YU YU62/80A patent/YU42658B/xx unknown
- 1980-01-11 PH PH23500A patent/PH17391A/en unknown
1982
- 1982-03-08 US US06/356,043 patent/US4428953A/en not_active Expired - Fee Related
1987
- 1987-05-21 HK HK405/87A patent/HK40587A/xx unknown
- 1987-12-30 MY MY726/87A patent/MY8700726A/xx unknown

Also Published As

Publication number	Publication date
IL59108A (en)	1983-07-31
IL59108A0 (en)	1980-05-30
AU5453580A (en)	1980-07-17
PH17391A (en)	1984-08-08
CY1353A (en)	1987-04-24
US4428953A (en)	1984-01-31
IE800046L (en)	1980-07-12
EP0013768B1 (en)	1984-02-01
ES487584A0 (es)	1981-02-16
IE49356B1 (en)	1985-09-18
FI65994B (fi)	1984-04-30
DK4280A (da)	1980-07-13
AU533691B2 (en)	1983-12-08
FI800024A (fi)	1980-07-13
ES8101536A1 (es)	1981-02-16
HK40587A (en)	1987-05-29
DK155669C (da)	1989-09-25
NZ192576A (en)	1984-05-31
DK155669B (da)	1989-05-01
DE2966635D1 (en)	1984-03-08
MY8700726A (en)	1987-12-31
CA1125778A (en)	1982-06-15
YU6280A (en)	1983-02-28
FI65994C (fi)	1984-08-10
PT70682A (en)	1980-02-01
EP0013768A1 (en)	1980-08-06

Publication	Publication Date	Title
YU42064B (en)	1988-04-30	Process for obtaining new glycevol derivatives
YU42658B (en)	1988-10-31	Process for preparing new pleuromutiline derivatives
YU317180A (en)	1983-02-28	Process for preparing new nitrothiophenes
PT71328A (en)	1980-06-01	Process for preparing new hydroxyamino-eburnane derivatives
DE3061037D1 (en)	1982-12-09	Process for preparing dimethylaminosilanes
PT70407A (en)	1979-12-01	Process for preparing new aryltrifluoroethanol derivatives
PT71812A (en)	1980-10-01	Process for preparing pyridazopyridazine derivatives
DE3060089D1 (en)	1982-01-28	Process for preparing 1-amino-2-phenoxy-4-hydroxy-anthraquinone
ZA804922B (en)	1981-08-26	New process for preparing 1-halogen-e-homo
YU321880A (en)	1983-12-31	Process for preparing new pyrrolo-benzotriazepines
HU178523B (en)	1982-05-28	Process for preparing new pyrazolo-quinazoline derivatives
PT71807B (en)	1981-07-02	Process for preparing 15-sulfonamidoprostaglandin derivatives
GB2058068B (en)	1983-05-11	Process for preparing 5-chloro-2-nitrophenol
YU42675B (en)	1988-10-31	Process for obtaining new nitroalkanol derivatives
HU182184B (en)	1983-12-28	Process for preparing nitroso-carbamide derivatives
DE3060850D1 (en)	1982-11-04	Process for preparing naphthalenesulphochloride
YU100280A (en)	1983-10-31	Process for obtaining new aminoisoquinazoline derivatives
PT71056A (en)	1980-05-01	Process for preparing substituted 2-aminopirazines
YU42530B (en)	1988-10-31	Process for preparing new 3-amino-2-oxo -oxazalidine derivatives
GB2055827B (en)	1983-06-02	Process for preparing chlorothiolformates
YU239680A (en)	1983-06-30	Process for obtaiing new decahydroquinolinone derivatives
HU178004B (en)	1982-02-28	Process for preparing new encephaline derivatives
RO84707B (ro)	1984-09-30	Procedeu pentru prepararea unor derivati de indolizina
DE3063194D1 (en)	1983-06-16	Process for preparing cyclopentenolones
HRP930487B1 (en)	1996-04-30	Process for preparing new 3-amino-2-oxo-oxazalidine derivatives