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YU207990A - JODOTHYRONINE POLYMERS - Google Patents

JODOTHYRONINE POLYMERS

Info

Publication number
YU207990A
YU207990A YU207990A YU207990A YU207990A YU 207990 A YU207990 A YU 207990A YU 207990 A YU207990 A YU 207990A YU 207990 A YU207990 A YU 207990A YU 207990 A YU207990 A YU 207990A
Authority
YU
Yugoslavia
Prior art keywords
iodine
polymers
independently
repeating units
jodothyronine
Prior art date
Application number
YU207990A
Other languages
Serbo-Croatian (sh)
Inventor
K.R. Latham
V.E. Latham
Original Assignee
Boots Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pharmaceuticals Inc. filed Critical Boots Pharmaceuticals Inc.
Publication of YU207990A publication Critical patent/YU207990A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Polimeri jodotironina koji imaju više jedinica koje se ponavljaju, formule I u kojoj je A jod, a B, C i D su nezavisno H ili jod, dobijaju se polimerizacijom N-karboksianhidrida, formule III kojoj su A,B,C i D kao što su definisani prethodno. Polimeri u kojima su A i C jod, a B i D su nezavisno H ili jod i u kojima su suštinski sve jedinice koje se ponavljaju L-stereoizomeri, su korisni u tretiranj nedostataka tiroidnog hormona. kojoj su A,B,C i D kao što su definisani prethodno. Polimeri u kojima su A i C jod, a B i D su nezavisno H ili jod i u kojima su suštinski sve jedinice koje se ponavljaju L-stereoizomeri, su korisni u tretiranj nedostataka tiroidnog hormona.Polymers of iodothyronine having multiple repeating units of formula I wherein A is iodine and B, C and D are independently H or iodine are obtained by polymerizing N-carboxyanhydride, of formula III wherein A, B, C and D are as are defined previously. Polymers in which A and C are iodine, and B and D are independently H or iodine, and in which substantially all repeating units are L-stereoisomers, are useful in treating thyroid hormone deficiencies. which A, B, C and D are as previously defined. Polymers in which A and C are iodine, and B and D are independently H or iodine, and in which substantially all repeating units are L-stereoisomers, are useful in treating thyroid hormone deficiencies.

YU207990A 1989-11-03 1990-11-02 JODOTHYRONINE POLYMERS YU207990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43099089A 1989-11-03 1989-11-03

Publications (1)

Publication Number Publication Date
YU207990A true YU207990A (en) 1993-05-28

Family

ID=23709961

Family Applications (1)

Application Number Title Priority Date Filing Date
YU207990A YU207990A (en) 1989-11-03 1990-11-02 JODOTHYRONINE POLYMERS

Country Status (9)

Country Link
AU (1) AU6639790A (en)
CA (1) CA2072613C (en)
IE (1) IE903851A1 (en)
IL (1) IL96226A0 (en)
PL (1) PL287594A1 (en)
PT (1) PT95773A (en)
WO (1) WO1991006569A1 (en)
YU (1) YU207990A (en)
ZA (1) ZA908802B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
WO2006128058A2 (en) 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
WO2011044567A1 (en) 2009-10-11 2011-04-14 Rutgers, The State University Of New Jersey Biocompatible polymers for medial devices
AU2013214799B2 (en) 2012-02-03 2016-05-12 Rutgers, The State Of University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
CN107108863B (en) 2014-12-23 2021-03-19 新泽西鲁特格斯州立大学 Biocompatible iodinated diphenol monomers and polymers
WO2018094265A2 (en) 2016-11-21 2018-05-24 Viking Therapeutics, Inc. Method of treating glycogen storage disease
JP7168660B2 (en) 2017-06-05 2022-11-09 バイキング・セラピューティクス・インコーポレイテッド Compositions for the treatment of fibrosis
US11787828B2 (en) 2018-03-22 2023-10-17 Viking Therapeutics, Inc. Crystalline forms and methods of producing crystalline forms of a compound
JP2022510691A (en) 2018-12-05 2022-01-27 バイキング・セラピューティクス・インコーポレイテッド Compositions for the treatment of fibrosis and inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2416941A1 (en) * 1974-04-08 1975-10-09 Helmut Pratzel Peptide synthesis - using arginine N-carboxyanhydride hydrobromide and polyethyleneimine as support
FR2625507B1 (en) * 1988-01-06 1990-06-22 Delalande Sa PROCESS FOR THE PREPARATION OF A COPOLYMER OF TWO ACIDS (ALPHA) -AMINES AND COPOLYMER THUS OBTAINED

Also Published As

Publication number Publication date
CA2072613C (en) 2002-02-05
WO1991006569A1 (en) 1991-05-16
IL96226A0 (en) 1991-08-16
IE903851A1 (en) 1991-05-08
AU6639790A (en) 1991-05-31
CA2072613A1 (en) 1991-05-04
ZA908802B (en) 1991-06-26
PL287594A1 (en) 1992-01-27
PT95773A (en) 1991-09-13

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