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YU19302A - 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena - Google Patents

4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena

Info

Publication number
YU19302A
YU19302A YU19302A YUP19302A YU19302A YU 19302 A YU19302 A YU 19302A YU 19302 A YU19302 A YU 19302A YU P19302 A YUP19302 A YU P19302A YU 19302 A YU19302 A YU 19302A
Authority
YU
Yugoslavia
Prior art keywords
compounds
heteroanalogues
producing
methods
benzylaminoquinoline
Prior art date
Application number
YU19302A
Other languages
English (en)
Inventor
Armin Hofmeister
Eugen Falk
Heinz-Werner Kleeman
Hans-Willi Jansen
Martin Bickel
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999145385 external-priority patent/DE19945385A1/de
Priority claimed from DE2000128193 external-priority patent/DE10028193A1/de
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU19302A publication Critical patent/YU19302A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Pronalazak se odnosi na supstituisani 4-benzilaminohinolin i njegove heteroanaloge, kao i na njihove farmaceutski pogodne soli i fiziološki funkcionalne derivate. Opisuju se jedinjenja Formule I, u kojoj ostaci imaju navedena značenja, kao i njihove fiziološki podesne soli, fiziološki funkcionalni derivati i postupci za njihovu proizvodnju. Jedinjenja su pogodna, na primer, kao medikamenti za profilaksu odnosno za lečenje kamena u žuči.[The invention relates to substituted 4-benzylaminoquinolines of formula (I), wherein the radicals have the meanings given, and to their heteroanalogues, their pharmaceutically compatible salts and their physiologically functional derivatives. The invention also relates to methods for producing said compounds. These compounds are suitable for use e.g. as medicaments for preventing or treating gall stones.
YU19302A 1999-09-22 2000-09-06 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena YU19302A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999145385 DE19945385A1 (de) 1999-09-22 1999-09-22 Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE2000128193 DE10028193A1 (de) 2000-06-09 2000-06-09 Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente

Publications (1)

Publication Number Publication Date
YU19302A true YU19302A (sh) 2004-11-25

Family

ID=26005994

Family Applications (1)

Application Number Title Priority Date Filing Date
YU19302A YU19302A (sh) 1999-09-22 2000-09-06 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena

Country Status (26)

Country Link
US (1) US6339077B1 (sh)
EP (1) EP1218401B1 (sh)
JP (1) JP4833471B2 (sh)
KR (1) KR20030010575A (sh)
CN (1) CN1158299C (sh)
AT (1) ATE269352T1 (sh)
AU (1) AU779412B2 (sh)
BR (1) BR0014233A (sh)
CA (1) CA2385445A1 (sh)
CZ (1) CZ2002992A3 (sh)
DE (1) DE50006842D1 (sh)
DK (1) DK1218401T3 (sh)
EE (1) EE200200143A (sh)
ES (1) ES2218222T3 (sh)
HK (1) HK1049169B (sh)
HR (1) HRP20020238A2 (sh)
HU (1) HUP0203045A3 (sh)
IL (1) IL148739A0 (sh)
NO (1) NO20021337L (sh)
NZ (1) NZ517899A (sh)
PL (1) PL353992A1 (sh)
PT (1) PT1218401E (sh)
RU (1) RU2247125C2 (sh)
SK (1) SK3862002A3 (sh)
WO (1) WO2001021642A1 (sh)
YU (1) YU19302A (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
SG174211A1 (en) * 2009-03-24 2011-10-28 Abbott Lab Process for preparing antiviral compound
WO2011123693A1 (en) * 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
BR112014003285B1 (pt) 2011-08-12 2020-01-14 Firmenich Incorporated modificador de sabor doce
CA2963901A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
WO2020041673A1 (en) 2018-08-23 2020-02-27 President And Fellows Of Harvard College Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
TW289021B (sh) * 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
DE4432708A1 (de) 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
AU7552198A (en) * 1997-06-11 1998-12-30 Sankyo Company Limited Benzylamine derivatives

Also Published As

Publication number Publication date
KR20030010575A (ko) 2003-02-05
JP4833471B2 (ja) 2011-12-07
EE200200143A (et) 2003-04-15
EP1218401A1 (de) 2002-07-03
DK1218401T3 (da) 2004-10-04
NZ517899A (en) 2004-03-26
BR0014233A (pt) 2002-05-21
RU2247125C2 (ru) 2005-02-27
HUP0203045A2 (hu) 2003-01-28
CN1374968A (zh) 2002-10-16
DE50006842D1 (de) 2004-07-22
CA2385445A1 (en) 2001-03-29
HK1049169B (zh) 2005-04-22
CN1158299C (zh) 2004-07-21
EP1218401B1 (de) 2004-06-16
NO20021337D0 (no) 2002-03-18
PL353992A1 (en) 2003-12-15
US6339077B1 (en) 2002-01-15
NO20021337L (no) 2002-05-15
IL148739A0 (en) 2002-09-12
CZ2002992A3 (cs) 2002-06-12
HK1049169A1 (en) 2003-05-02
JP2003510255A (ja) 2003-03-18
SK3862002A3 (en) 2003-01-09
AU7515600A (en) 2001-04-24
AU779412B2 (en) 2005-01-20
HUP0203045A3 (en) 2004-06-28
HRP20020238A2 (en) 2004-04-30
ATE269352T1 (de) 2004-07-15
ES2218222T3 (es) 2004-11-16
PT1218401E (pt) 2004-10-29
WO2001021642A1 (de) 2001-03-29

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