YU19099A - Supstituisani tricikli - Google Patents
Supstituisani tricikliInfo
- Publication number
- YU19099A YU19099A YU19099A YU19099A YU19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A YU 19099 A YU19099 A YU 19099A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- nitrogen
- sulfur
- hydrogen
- carbon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ovaj pronalazak se odnosi na nova supstituisana triciklicna jedinjenja koja su pogodna za inhibiranje sPLA2 posredno oslobodjenog iz masnih kiselina u uslovima kao sto je septicni sok, i koja se mogu predstaviti opstom formulom I: A je fenil ili piridin, gde je azot u polozaju 5-, 6-, 7- ili 8; jedan od B ili D je azot i drugi je ugljenik; Z-cikloheksenil ili fenil, piridil, pri cemu azot je u polozaju 1-, 2- ili 3-, ili 6-clani heterociklicni prsten sa jednim heteroatomom izabranim iz grupe koju cine sumpor ili kiseonik u polozaju 1-, 2-, ili 3- i azot u polozaju 1-, 2-, 3-, ili 4-; ---- je dvostruka ili jednostruka veza; R20 se bira iz grupa (a), (b) i (c) gde je: (a) -(C5-C20) alkil, -(C5-C20) alkenil, -(C5-C20) alkinil, karbociklicni radikali, ili heterociklicni radikali, ili (b) clan od (a) supstituisan sa jednim ili vise nezavisno izabranih ne-interreagujucih substituenata; ili (c) je grupa -(L)-R80; gde, (L)-je dvovalentna vezujuca grupa od 1 ili 12 atoma izabranih od ugljenika, vodonika, kiseonika, azota, ili sumpora; gde je kombinacija atoma u -(L) izabrana iz grupe koja se sastoji od (i) ugljenika i vodonika jedino, (ii) samo jednog sumpora, (iii) samo jednog kiseonika, (iv) jedino od jednog ili dva azota i vodonika, (v) samo od ugljenika, vodonika, i jednog sumpora, i (vi) samo od ugljenika, vodonika i kiseonika; i gde je R80 je grupa izabrana iz (a) ili (b); R21 je ne-interreagujucih substituenata gde je f od 1-3; R1 je -NHNH2, -NH2, ili -CONH2; R2 se bira iz grupa koje sadrze -OH, i -O(CH2)tR5 gde R5 je H, -CH, -NH2, -CONH2, -CONR9R10 - NHSO2R15, -CONHSO2R15 gde R15 cini -(C1-C6) alkil ili -CF3; fenil ili fenil supstituisan sa -CO2H ili -CO2(C1-C4) alkil; i-(La)-kisela grupa, gde je -(La)- je kiseli veznik koji ima duzinu kiselog veznog dela od 1 do 7 i t je 1-5. R3 se bira od ne-interagujucih substituenata, karbociklicnih radikala, i heterociklicnih radikala substituisanih sa ne-interagujucim substituentima; ili farmaceutski prihvatljivih racemata, solvata, tautomera, optickih izomera, prolekovitih derivata ili njihovih soli; pod uslovom da jedan od A ili Z je heterociklicni prsten i kada D je azot, hetero atom u Z se bira iz grupe koju cine sumpor ili kiseonik u polozaju 1-, 2-, ili 3-, i azot u polozaju 1-, 2-, 3-, ili 4-.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6216598A | 1998-04-17 | 1998-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU19099A true YU19099A (sh) | 2001-09-28 |
Family
ID=22040624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU19099A YU19099A (sh) | 1998-04-17 | 1999-04-16 | Supstituisani tricikli |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP0950661B1 (sh) |
| JP (1) | JP4435325B2 (sh) |
| KR (1) | KR19990083234A (sh) |
| CN (1) | CN1235968A (sh) |
| AR (1) | AR018185A1 (sh) |
| AT (2) | ATE259818T1 (sh) |
| AU (1) | AU757454B2 (sh) |
| BR (1) | BR9901275A (sh) |
| CA (1) | CA2269256A1 (sh) |
| CO (1) | CO5080728A1 (sh) |
| CZ (1) | CZ137199A3 (sh) |
| DE (2) | DE69914951T2 (sh) |
| EA (1) | EA003129B1 (sh) |
| ES (2) | ES2213668T3 (sh) |
| HU (1) | HUP9901219A1 (sh) |
| ID (1) | ID23219A (sh) |
| IL (1) | IL129484A0 (sh) |
| NO (1) | NO991823L (sh) |
| NZ (1) | NZ335252A (sh) |
| PE (1) | PE20000472A1 (sh) |
| PL (1) | PL332564A1 (sh) |
| SG (1) | SG106035A1 (sh) |
| SV (1) | SV1999000052A (sh) |
| TR (1) | TR199900842A2 (sh) |
| TW (1) | TW555760B (sh) |
| YU (1) | YU19099A (sh) |
| ZA (1) | ZA992773B (sh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610728B2 (en) * | 1997-08-28 | 2003-08-26 | Eli Lilly And Company | Method for treatment of non-rheumatoid arthritis |
| AU2001244635A1 (en) * | 2000-03-30 | 2001-10-15 | Yamanouchi Pharmaceutical Co..Ltd. | Hydrazide derivatives |
| CA2413582A1 (en) * | 2000-07-14 | 2002-01-24 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
| AU2002239264A1 (en) * | 2000-12-18 | 2002-07-01 | Eli Lilly And Company | Tetracyclic derivatives as spla2 inhibitors |
| ATE353876T1 (de) * | 2001-03-28 | 2007-03-15 | Lilly Co Eli | Substituierte carbazole als inhibitoren von spla2 |
| ATE312817T1 (de) * | 2001-08-09 | 2005-12-15 | Lilly Co Eli | Cyclohept'bö indolderivate als spla2-inhibitoren |
| JP2005527464A (ja) | 2001-08-09 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体 |
| US6992100B2 (en) | 2001-12-06 | 2006-01-31 | Eli Lilly And Company | sPLA2 inhibitors |
| EP1807427A2 (en) | 2004-11-01 | 2007-07-18 | Wyeth | Substituted indolizines and derivatives as cns agents |
| BRPI0907122B8 (pt) | 2008-01-11 | 2021-05-25 | Albany Molecular Res Inc | compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| SG193902A1 (en) * | 2011-04-14 | 2013-11-29 | Actelion Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
| EA026431B1 (ru) | 2012-03-16 | 2017-04-28 | Вайтаи Фармасьютиклз, Инк. | Модуляторы x рецепторов печени |
| JP6114814B2 (ja) | 2012-03-16 | 2017-04-12 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 肝臓ｘレセプターモジュレーター |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| BR9508298A (pt) * | 1994-07-21 | 1998-11-03 | Shionogi & Co | Inibidores de indolizina de spla2 |
| ES2159347T3 (es) * | 1995-12-13 | 2001-10-01 | Lilly Co Eli | Naftil-acetamidas como inhibidores de spla2. |
| BR9713261A (pt) * | 1996-10-30 | 2000-03-28 | Lilly Co Eli | Tricìclicos substituìdos |
| EP1007056A1 (en) * | 1997-09-26 | 2000-06-14 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
| EP1043991A4 (en) * | 1997-11-14 | 2005-02-02 | Lilly Co Eli | TREATMENT OF ALZHEIMER DISEASE |
-
1999
- 1999-04-15 IL IL12948499A patent/IL129484A0/xx unknown
- 1999-04-15 ID IDP990342D patent/ID23219A/id unknown
- 1999-04-16 CN CN99108097A patent/CN1235968A/zh active Pending
- 1999-04-16 ES ES01203116T patent/ES2213668T3/es not_active Expired - Lifetime
- 1999-04-16 AU AU23818/99A patent/AU757454B2/en not_active Ceased
- 1999-04-16 JP JP10965699A patent/JP4435325B2/ja not_active Expired - Fee Related
- 1999-04-16 DE DE69914951T patent/DE69914951T2/de not_active Expired - Fee Related
- 1999-04-16 ES ES99302969T patent/ES2210979T3/es not_active Expired - Lifetime
- 1999-04-16 SG SG9901844A patent/SG106035A1/en unknown
- 1999-04-16 EP EP99302969A patent/EP0950661B1/en not_active Expired - Lifetime
- 1999-04-16 EA EA199900304A patent/EA003129B1/ru not_active IP Right Cessation
- 1999-04-16 KR KR1019990013439A patent/KR19990083234A/ko not_active Application Discontinuation
- 1999-04-16 SV SV1999000052A patent/SV1999000052A/es not_active Application Discontinuation
- 1999-04-16 CA CA002269256A patent/CA2269256A1/en not_active Abandoned
- 1999-04-16 TW TW088106131A patent/TW555760B/zh not_active IP Right Cessation
- 1999-04-16 EP EP01203116A patent/EP1156050B1/en not_active Expired - Lifetime
- 1999-04-16 NZ NZ335252A patent/NZ335252A/xx unknown
- 1999-04-16 AT AT01203116T patent/ATE259818T1/de not_active IP Right Cessation
- 1999-04-16 PL PL99332564A patent/PL332564A1/xx not_active Application Discontinuation
- 1999-04-16 NO NO991823A patent/NO991823L/no not_active Application Discontinuation
- 1999-04-16 CZ CZ991371A patent/CZ137199A3/cs unknown
- 1999-04-16 AT AT99302969T patent/ATE254128T1/de not_active IP Right Cessation
- 1999-04-16 PE PE1999000321A patent/PE20000472A1/es not_active Application Discontinuation
- 1999-04-16 AR ARP990101769A patent/AR018185A1/es not_active Application Discontinuation
- 1999-04-16 HU HU9901219A patent/HUP9901219A1/hu unknown
- 1999-04-16 CO CO99022891A patent/CO5080728A1/es unknown
- 1999-04-16 DE DE69912670T patent/DE69912670T2/de not_active Expired - Fee Related
- 1999-04-16 ZA ZA9902773A patent/ZA992773B/xx unknown
- 1999-04-16 BR BR9901275-8A patent/BR9901275A/pt not_active IP Right Cessation
- 1999-04-16 TR TR1999/00842A patent/TR199900842A2/xx unknown
- 1999-04-16 YU YU19099A patent/YU19099A/sh unknown
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