[go: up one dir, main page]

YU17591A - Triazolni fungicidni agensi - Google Patents

Triazolni fungicidni agensi

Info

Publication number
YU17591A
YU17591A YU17591A YU17591A YU17591A YU 17591 A YU17591 A YU 17591A YU 17591 A YU17591 A YU 17591A YU 17591 A YU17591 A YU 17591A YU 17591 A YU17591 A YU 17591A
Authority
YU
Yugoslavia
Prior art keywords
triazolni
fungicidni
agency
alkyl
ocf3
Prior art date
Application number
YU17591A
Other languages
English (en)
Other versions
YU48105B (sh
Inventor
R.S. James
R. Kenneth
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU17591(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU17591A publication Critical patent/YU17591A/sh
Publication of YU48105B publication Critical patent/YU48105B/sh
Priority to BA970298A priority Critical patent/BA97298A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

TRIAZOLNI FUNGICIDNI AGENSI, pronalazak omogućava fungicidna jedinjenja formule: i farmaceutski prihvatljive odnosne soli, gde R je fenil substituisan sa 1 do 3 substituenta, svaki nezavisno izabran od halo, -CF3 i -OCF3; R1 je C1-C4 alkil; R2 je H ili C1-C4 alkil; X je CH ili N; i Y je F ili Cl.
YU17591A 1990-02-02 1991-02-01 Derivati triazola i postupak za njihovo dobijanje YU48105B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BA970298A BA97298A (bs) 1990-02-02 1998-03-30 Triazolni fungicidni agensi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002375A GB9002375D0 (en) 1990-02-02 1990-02-02 Triazole antifungal agents

Publications (2)

Publication Number Publication Date
YU17591A true YU17591A (sh) 1994-01-20
YU48105B YU48105B (sh) 1997-03-07

Family

ID=10670334

Family Applications (1)

Application Number Title Priority Date Filing Date
YU17591A YU48105B (sh) 1990-02-02 1991-02-01 Derivati triazola i postupak za njihovo dobijanje

Country Status (42)

Country Link
US (2) US5567817A (sh)
EP (1) EP0440372B1 (sh)
JP (2) JP2625584B2 (sh)
KR (1) KR930011039B1 (sh)
CN (2) CN1026788C (sh)
AP (2) AP9000237A0 (sh)
AT (1) ATE90090T1 (sh)
AU (1) AU625188B2 (sh)
BA (1) BA97298A (sh)
BG (1) BG60032B2 (sh)
BR (1) BR9100435A (sh)
CA (2) CA2035314C (sh)
CZ (1) CZ279339B6 (sh)
DE (2) DE10299035I2 (sh)
DK (1) DK0440372T3 (sh)
EG (1) EG19750A (sh)
ES (1) ES2055523T4 (sh)
FI (3) FI107608B (sh)
GB (1) GB9002375D0 (sh)
HK (1) HK219396A (sh)
HU (2) HU205351B (sh)
IE (1) IE64774B1 (sh)
IL (2) IL97045A (sh)
IN (1) IN176148B (sh)
IS (1) IS1629B (sh)
LU (1) LU90960I2 (sh)
LV (1) LV10615B (sh)
MA (1) MA22054A1 (sh)
MX (1) MX24363A (sh)
MY (1) MY105494A (sh)
NL (1) NL300100I2 (sh)
NO (2) NO176796C (sh)
NZ (1) NZ247205A (sh)
OA (1) OA09480A (sh)
PE (1) PE31691A1 (sh)
PL (3) PL169307B1 (sh)
PT (1) PT96617B (sh)
RO (1) RO109648B1 (sh)
RU (2) RU2036194C1 (sh)
SK (1) SK278215B6 (sh)
YU (1) YU48105B (sh)
ZA (1) ZA91761B (sh)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
GB2281297A (en) * 1993-08-27 1995-03-01 Merck & Co Inc Quinazoline compounds
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE19500379A1 (de) * 1995-01-09 1996-07-11 Basf Ag Fluorierte Pyrimidine als Herbizide
GB9516121D0 (en) 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
US7193083B2 (en) * 1996-07-26 2007-03-20 Pfizer, Inc. Preparation of triazoles by organometallic addition to ketones and intermediates therefor
GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
CN1081189C (zh) * 1998-07-17 2002-03-20 国家医药管理局四川抗菌素工业研究所 唑醇类新衍生物及其制备方法和医药用途
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6391903B1 (en) * 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
AU2002249935A1 (en) * 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
CN100379733C (zh) * 2002-10-08 2008-04-09 南京康泽医药科技有限公司 三唑类抗真菌药物及其制备方法
US20040098839A1 (en) * 2002-11-27 2004-05-27 Pfizer Inc. Crystallization method and apparatus using an impinging plate assembly
CA2590687C (en) 2004-12-14 2013-09-10 Dr. Reddy's Laboratories Ltd. Process for preparing voriconazole
US7812045B2 (en) 2005-03-30 2010-10-12 Daewoong Pharmaceutical Co., Ltd. Antifungal triazole derivatives
EP2024344A2 (en) * 2006-02-01 2009-02-18 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
AR061889A1 (es) * 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
CA2669887A1 (en) * 2006-11-21 2008-05-29 Viamet Pharmaceuticals, Inc. Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2009137611A2 (en) * 2008-05-06 2009-11-12 Board Of Regents, The University Of Texas System Treatment of pulmonary fungal infection with voriconazole via inhalation
JP2009286756A (ja) 2008-05-30 2009-12-10 Fujifilm Finechemicals Co Ltd トリアゾール誘導体またはその塩
EP2303265B1 (en) * 2008-06-06 2014-12-10 Glenmark Pharmaceuticals Limited Stable topical formulation comprising voriconazole
WO2010095145A1 (en) * 2009-02-17 2010-08-26 Glenmark Generics Limited Process for the preparation of voriconazole
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
ES2573982T3 (es) 2009-08-19 2016-06-13 Ratiopharm Gmbh Proceso para la producción de coevaporados y complejos que comprenden voriconazol y ciclodextrina
KR20120104975A (ko) 2009-10-01 2012-09-24 앱탈리스 파마테크, 인코포레이티드 경구 투여용 코르티코스테로이드 조성물
WO2011064558A2 (en) 2009-11-30 2011-06-03 Cipla Limited Pharmaceutical composition
CN102753543A (zh) 2009-12-30 2012-10-24 麦迪凯姆股份公司 药用用途的1-(1h-1,2,4-三唑-1-基)-2-丁醇衍生物，以及使用具有基本上未定义晶形的1-(1h-1,2,4-三唑-1-基)-2-丁醇衍生物制备所述1-(1h-1,2,4-三唑-1-基) -2-丁醇衍生物
KR100971371B1 (ko) 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011110198A1 (en) 2010-03-10 2011-09-15 Synthron B.V. A process for making voriconazole
EP2409699B1 (en) * 2010-07-23 2014-04-30 Combino Pharm, S.L. Stable compositions of voriconazole
CN101914091B (zh) * 2010-07-25 2015-05-27 浙江华海药业股份有限公司 一种制备伏立康唑中间体的方法
PL2678333T3 (pl) 2011-02-21 2015-08-31 Ranbaxy Laboratories Ltd Ulepszony sposób otrzymywania worykonazolu i jego produktów pośrednich
EP2720723B1 (en) 2011-06-15 2018-04-11 Synthon BV Stabilized voriconazole composition
EP2561863A1 (en) 2011-08-22 2013-02-27 Farmaprojects, S.A.U. Pharmaceutical compositions comprising voriconazole
IN2014MN02236A (sh) 2012-05-11 2015-07-24 Cipla Ltd
SG11201502237RA (en) * 2012-10-15 2015-05-28 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogues thereof
CN105102443B (zh) * 2013-02-04 2017-07-28 先正达参股股份有限公司 新颖的杀微生物剂
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
JP6262972B2 (ja) * 2013-09-17 2018-01-17 公益財団法人微生物化学研究会 化合物、及びその製造方法、並びにボリコナゾールの製造方法
BR112017021109A2 (pt) 2015-04-02 2018-07-03 Bayer Cropscience Ag derivados de triazol como fungicidas
CN104987325B (zh) * 2015-06-30 2017-03-29 扬子江药业集团南京海陵药业有限公司 一种伏立康唑的制备方法
CN106117186B (zh) * 2016-06-12 2018-08-24 重庆莱美隆宇药业有限公司 一种伏立康唑及其中间体的制备方法
CN107556294A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型抗真菌感染药物及其制备方法和用途
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
MX2019006164A (es) * 2016-11-28 2019-11-28 Cellix Bio Private Ltd Composiciones y metodos para el tratamiento de infecciones fungicas.
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
WO2018149359A1 (zh) * 2017-02-17 2018-08-23 武汉朗来科技发展有限公司 三氮唑抗菌衍生物、其药物组合物和用途
CN109705102A (zh) 2019-02-19 2019-05-03 浙江华海立诚药业有限公司 伏立康唑及其中间体的制备方法
CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN114907319B (zh) * 2021-02-06 2024-06-14 华创合成制药股份有限公司 一种氘代三唑类化合物及其制备方法和用途
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法
CN118307408A (zh) * 2024-04-10 2024-07-09 上海恩氟佳科技有限公司 2-氟丙酰乙酸乙酯的制备方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980781A (en) * 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) * 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
DE2431407C2 (de) * 1974-06-29 1982-12-02 Bayer Ag, 5090 Leverkusen 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4927839A (en) * 1979-03-07 1990-05-22 Imperial Chemical Industries Plc Method of preventing fungal attack on wood, hides, leather or paint films using a triazole
US4654332A (en) * 1979-03-07 1987-03-31 Imperial Chemical Industries Plc Heterocyclic compounds
US4551469A (en) * 1979-03-07 1985-11-05 Imperial Chemical Industries Plc Antifungal triazole ethanol derivatives
US4259505A (en) * 1980-03-04 1981-03-31 Ciba-Geigy Corporation Process for the preparation of 1H-azole derivatives
US5395942A (en) * 1980-06-02 1995-03-07 Zeneca Limited Heterocyclic compounds
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
DE3177275D1 (de) * 1980-08-18 1992-04-16 Ici Plc Verwendung von triazolylaethanol-derivate und deren zusammensetzungen als nichtlandwirtschaftliche fungizide.
EP0158741A3 (en) * 1980-11-19 1986-02-12 Imperial Chemical Industries Plc Intermediates for fungicidal triazole and imidazole compounds
EP0061835B1 (en) * 1981-03-18 1989-02-01 Imperial Chemical Industries Plc Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them
US5466821A (en) * 1981-03-18 1995-11-14 Zeneca Limited Heterocyclic compounds
US5204363A (en) * 1981-03-18 1993-04-20 Imperial Chemical Industries Plc Heterocyclic compounds
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
US4510148A (en) * 1982-06-12 1985-04-09 Pfizer Inc. 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
ES523184A0 (es) * 1982-06-17 1985-04-01 Pfizer Un procedimiento para la preparacion de un compuesto dotado de propiedades fungicidas
DE3228870A1 (de) * 1982-08-03 1984-02-09 Bayer Ag, 5090 Leverkusen Diazolyl-alkanole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
US4505919A (en) * 1982-10-09 1985-03-19 Pfizer Inc. Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols
DE3242252A1 (de) * 1982-11-15 1984-05-17 Bayer Ag, 5090 Leverkusen Heterocyclisch substituierte hydroxyalkyl-azolyl-derivate
DE3242236A1 (de) * 1982-11-15 1984-05-17 Bayer Ag, 5090 Leverkusen "antimykotische mittel"
DE3245504A1 (de) * 1982-12-09 1984-06-14 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
GB8301699D0 (en) * 1983-01-21 1983-02-23 Pfizer Ltd Antifungal agents
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
JPS59142480U (ja) * 1983-03-15 1984-09-22 サンデン株式会社 スクロ−ル型流体装置
GR81556B (sh) * 1983-05-09 1984-12-11 Stauffer Chemical Co
DE3325313A1 (de) * 1983-07-13 1985-01-31 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
US4483863A (en) * 1984-01-20 1984-11-20 Pfizer Inc. Triazole antifungal agents
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
GB8424799D0 (en) * 1984-10-02 1984-11-07 Ici Plc Biocide composition
GB8506619D0 (en) * 1985-03-14 1985-04-17 Pfizer Ltd Triazole antifungal agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
DE3784787T2 (de) * 1986-06-23 1994-01-20 Du Pont Merck Pharma Fungizide Karbinole.
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
US4980367A (en) * 1987-12-17 1990-12-25 E. I. Du Pont De Nemours And Company Antifungal carbinols
US4965281A (en) * 1986-06-23 1990-10-23 E. I. Du Pont De Nemours And Cmopany Antifungal carbinols
US5084465A (en) * 1986-06-23 1992-01-28 Du Pont Merck Pharmaceutical Company Antifungal carbinols
US4876259A (en) * 1987-01-05 1989-10-24 E. I. Du Pont De Nemours And Company 3,3-disubstituted indolines
EP0279263B1 (en) * 1987-02-10 1993-08-04 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
DE3813841A1 (de) * 1987-06-03 1988-12-15 Bayer Ag Heterocyclische hydroxyethylazole
GB8716651D0 (en) * 1987-07-15 1987-08-19 Ici Plc 2-propanol derivatives
GB8729083D0 (en) * 1987-12-12 1988-01-27 Pfizer Ltd Triazole antifungal agents
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
DE3806089A1 (de) * 1988-02-26 1989-09-07 Basf Ag Azolylmethyloxirane und diese enthaltende fungizide
DK105189A (da) * 1988-03-04 1989-09-05 Sankyo Co Triazolderivater og fremgangsmaade til fremstilling deraf samt fungicide midler indeholdende derivaterne
DE3809069A1 (de) * 1988-03-18 1989-09-28 Basf Ag Azolylmethylallylalkohole und diese enthaltende fungizide
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5278175A (en) * 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
US5132319A (en) * 1991-03-28 1992-07-21 Merck Frosst Canada, Inc. 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
US5205354A (en) * 1992-01-28 1993-04-27 Lesage Philip G Vehicle radiator and method of making
EP0613890A1 (en) * 1993-02-28 1994-09-07 Nihon Nohyaku Co., Ltd. Novel triazole compound, process for preparing the same and antifungal agent containing the same
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
CA2145458A1 (en) * 1994-03-28 1995-09-29 Hiroki Kodama Triazole compound and production process and use thereof
CN1137099C (zh) * 1995-01-30 2004-02-04 曾尼卡有限公司 4,6-二氯嘧啶的制法

Also Published As

Publication number Publication date
US5567817A (en) 1996-10-22
AP9000237A0 (en) 1991-01-31
CA2035314A1 (en) 1991-08-03
LU90960I2 (fr) 2003-04-02
OA09480A (fr) 1992-11-15
FI971238A0 (fi) 1997-03-25
ES2055523T3 (es) 1994-08-16
CA2285891C (en) 2004-01-06
ZA91761B (en) 1992-09-30
AP223A (en) 1992-08-27
RO109648B1 (ro) 1995-04-28
IS3671A7 (is) 1991-08-03
FI107608B (fi) 2001-09-14
JPH04211078A (ja) 1992-08-03
FI910508A (fi) 1991-08-03
HU211582A9 (en) 1995-12-28
MY105494A (en) 1994-10-31
HK219396A (en) 1997-01-03
US5773443A (en) 1998-06-30
KR910021398A (ko) 1991-12-20
CA2285891A1 (en) 1991-08-03
EP0440372B1 (en) 1993-06-02
PE31691A1 (es) 1991-11-29
DE10299035I2 (de) 2003-06-26
BG60032B2 (bg) 1993-07-30
NL300100I1 (nl) 2002-11-01
ES2055523T4 (es) 2011-04-11
ATE90090T1 (de) 1993-06-15
CN1100421A (zh) 1995-03-22
DK0440372T3 (da) 1993-06-28
JP2625584B2 (ja) 1997-07-02
JP2848811B2 (ja) 1999-01-20
PL169332B1 (pl) 1996-07-31
LV10615A (lv) 1995-04-20
IL110322A (en) 1996-10-31
NO176796B (no) 1995-02-20
HU205351B (en) 1992-04-28
FI971238A (fi) 1997-03-25
AU7022391A (en) 1991-09-05
BA97298A (bs) 2001-09-14
SK278215B6 (en) 1996-04-03
EG19750A (en) 1996-01-31
MX24363A (es) 1993-09-01
IL97045A0 (en) 1992-03-29
IL110322A0 (en) 1994-10-21
PT96617B (pt) 1998-07-31
AU625188B2 (en) 1992-07-02
NL300100I2 (nl) 2003-01-06
IN176148B (sh) 1996-02-10
CN1026788C (zh) 1994-11-30
BR9100435A (pt) 1991-10-22
CN1053787A (zh) 1991-08-14
KR930011039B1 (ko) 1993-11-20
GB9002375D0 (en) 1990-04-04
DE69100095T2 (de) 1993-09-09
FI20000084A (fi) 2000-01-17
IL97045A (en) 1995-11-27
NO910368L (no) 1991-08-05
PL288901A1 (en) 1992-01-27
PL169307B1 (pl) 1996-06-28
CS9100249A2 (en) 1991-09-15
DE69100095D1 (de) 1993-07-08
NO910368D0 (no) 1991-01-31
PL167294B1 (pl) 1995-08-31
FI910508A0 (fi) 1991-02-01
NO2002006I2 (no) 2004-10-11
HUT56361A (en) 1991-08-28
CA2035314C (en) 2000-01-18
RU2114838C1 (ru) 1998-07-10
IE64774B1 (en) 1995-09-06
RU2036194C1 (ru) 1995-05-27
DE10299035I1 (de) 2003-05-22
NZ247205A (en) 1993-09-27
PT96617A (pt) 1991-10-15
JPH09208583A (ja) 1997-08-12
LV10615B (en) 1995-12-20
IE910342A1 (en) 1991-08-14
MA22054A1 (fr) 1991-10-01
EP0440372A1 (en) 1991-08-07
CN1040504C (zh) 1998-11-04
YU48105B (sh) 1997-03-07
NO176796C (no) 1995-05-31
CZ279339B6 (cs) 1995-04-12
IS1629B (is) 1996-07-19

Similar Documents

Publication Publication Date Title
YU17591A (sh) Triazolni fungicidni agensi
FI862757A0 (fi) Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
ES8601220A1 (es) Procedimiento de preparacion de nuevas sales de derivados organofosforados
SE8404712D0 (sv) Azole derivatives, process for their production compositions containing them and their use
ES8203845A1 (es) Procedimiento para preparar derivados de piridoxina
IE831889L (en) Triazole antifungal agents
FI834730A0 (fi) 1-karboxialkanoylperhydro-indol-2-karboxylsyror och deras derivat
FI852223L (fi) Saosom fungicider anvaenda triazoler.
MY101140A (en) Benzoylurea compounds, and pesticidal and pharmaceutical compositions comprising same
YU142791A (sh) Heterociklična jedinjenja
FI854660A (fi) Triazol-antifungicider.
FI861036A (fi) Antifungala triazolfoereningar.
ES8604219A1 (es) Un procedimiento para la preparacion de benzoquinolicinas
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
ES8504176A1 (es) Un procedimiento para preparar derivados de esteres del acido propanoico
ATE17239T1 (de) Antifungi triazolverbindungen.
ES2003086A6 (es) Procedimiento de obtencion de tienoquinolicinsulfonamidas
DE3850222D1 (de) 1,4-Disubstituierte-piperidinyl-Verbindungen.
DE3369512D1 (en) Triazole antifungal agents
GB2017678A (en) Substituted Pyrazolidines
DK428087A (da) Dihydropyridin-5-phosphonsyre-cyclopropylenester
ES2019617B3 (es) Fungicidas.
MY134476A (en) Aromatic compounds, their production processes and their compositions for the control of insect pests
ES8606245A1 (es) Procedimiento para preparar fenoxianilinas y piridiloxianilinas sustituidas
ES8403467A1 (es) Procedimiento para la obtencion de derivados de oximino-cian-acetamida sustituidos por azol.