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YU12003A - Novi derivati aminocikloheksana - Google Patents

Novi derivati aminocikloheksana

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Publication number
YU12003A
YU12003A YU12003A YUP12003A YU12003A YU 12003 A YU12003 A YU 12003A YU 12003 A YU12003 A YU 12003A YU P12003 A YUP12003 A YU P12003A YU 12003 A YU12003 A YU 12003A
Authority
YU
Yugoslavia
Prior art keywords
novel
prophylaxis
compounds
treatment
pharmaceutically acceptable
Prior art date
Application number
YU12003A
Other languages
English (en)
Inventor
Jean Ackermann
Johannes Aebi
Denise Blum
Alexander Chucholowski
Henrietta Dehmlow
Hans-Peter Maerki
Olivier Morand
Rene Trussardi
Elisabeth Von Der Mark
Sabine Wallbaum
Thomas Weller
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU12003A publication Critical patent/YU12003A/sh

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/52—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Ovaj pronalazak se odnosi na jedinjenja formule (I) u kojoj su U, V, W, A1, A2, A3, A4, A5, A6, m i n definisani kao što je dato u opisu i zahtevima i na njihove farmaceutski prihvatljive soli i/ili farmaceutski prihvatljive estre. Ova jedinjenja su primenljiva za terapiju i/ili profilaksu bolesti koje su u vezi sa 2,3-oksidoskvalen-lanosterol ciklazom kao što su hiperholesterolemija, hiperlipemija, arterioskleroza, vaskularne bolesti, mikoze, žučni kamenci, tumori i/ili profilaksu smanjene tolerancije glukoze i dijabetesa.[The present invention relates to compounds of formula (I) wherein U, V, W, A1, A2, A3, A4, A5, A6, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
YU12003A 2000-08-16 2001-08-08 Novi derivati aminocikloheksana YU12003A (sh)

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AU9374401A (en) * 2000-08-16 2002-02-25 Hoffmann La Roche Novel aminocyclohexane derivatives
CN100408556C (zh) * 2002-10-07 2008-08-06 加利福尼亚大学董事会 通过阻断花生四烯酰乙醇酰胺的水解调节焦虑
TW200524849A (en) 2003-07-02 2005-08-01 Hoffmann La Roche Hydroxyalkylamide derivatives
JPWO2005097738A1 (ja) * 2004-04-06 2008-02-28 大日本住友製薬株式会社 新規スルホンアミド誘導体
EP1768658A1 (en) * 2004-07-09 2007-04-04 F.Hoffmann-La Roche Ag Hydroxyalkylamides
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
RU2449988C1 (ru) * 2011-04-29 2012-05-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) 2,2,2-трифтор-1-трифторметилэтиловый эфир циклогексилкарбаминовой кислоты в качестве эффективного средства для селективного необратимого ингибирования карбоксилэстеразы
CN102584618A (zh) * 2012-01-18 2012-07-18 浙江工业大学 一种4-取代酰氨基环己酮的制备方法
CN113600163B (zh) * 2021-09-13 2022-06-14 厦门大学 一种光催化剂及其应用、n-烷基哌嗪及其衍生物的制备方法
CN115780487B (zh) * 2023-01-05 2023-05-05 河北东丽新材料有限公司 一种萃取剂及利用其处理4,4`-联苯醚二酐生产固废的方法

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BR0113408A (pt) 2003-06-17
US20020045777A1 (en) 2002-04-18
NO20030657D0 (no) 2003-02-10
UY26891A1 (es) 2002-02-28
NO20030657L (no) 2003-02-13
HUP0303105A3 (en) 2005-05-30
MXPA03001269A (es) 2003-06-09
ATE403646T1 (de) 2008-08-15
PA8525101A1 (es) 2002-07-30
NZ523879A (en) 2004-09-24
AU9374401A (en) 2002-02-25
US6858651B2 (en) 2005-02-22
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EP1311475A1 (en) 2003-05-21
CA2418744A1 (en) 2002-02-21
AR030712A1 (es) 2003-09-03
US20050176766A1 (en) 2005-08-11
HUP0303105A2 (hu) 2004-03-01
MA26941A1 (fr) 2004-12-20
CZ2003451A3 (cs) 2003-10-15
RU2225393C1 (ru) 2004-03-10
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DE60135230D1 (de) 2008-09-18
CN1468214A (zh) 2004-01-14
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