WO2025217632A1

WO2025217632A1 - Temperature-controlled container

Info

Publication number: WO2025217632A1
Application number: PCT/US2025/024538
Authority: WO
Inventors: Spencer Kyle SCARBER
Original assignee: Emergency Medicine Innovations LLC
Current assignee: Emergency Medicine Innovations LLC
Priority date: 2024-04-12
Filing date: 2025-04-14
Publication date: 2025-10-16
Anticipated expiration: 2026-10-12

Abstract

A temperature-controlled container (100) includes a main housing (102) having a top portion (116), a bottom portion (118), a sidewall (120), an interior surface (122), and an exterior surface (124). A storage cavity (126) is disposed in the main housing (102). A lid (132) coupled to the main housing (102) is configured to seal the storage cavity (126). A thermoelectric device (104) and a battery (106) in electrical communication with the thermoelectric device (104) are disposed in the main housing (102). A first heat absorption element (148) is coupled to the main housing (102) and adjacent to a first end of the thermoelectric device (104), and a second heat absorption element (150) is coupled to the main housing (102) and adjacent to a second end of the thermoelectric device (104). Each of the first and second heat absorption elements (148), (150) is in thermal communication with the thermoelectric device (104). A controller (110) is in communication with a sensor (112) through a transmitter (114) such as a near field communication chip.

Description

TEMPERATURE-CONTROLLED CONTAINER

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 63/633,387, filed on April 12, 2024, and U.S. Provisional Application No. 63/658,221, filed on June 10, 2024. The entire disclosures of the above applications are incorporated herein by reference.

FIELD

[0002] The present technology relates to containers, and, more particularly, to temperature-controlled containers, temperature regulation systems for temperature-controlled containers, and methods of using temperature-controlled containers.

INTRODUCTION

[0003] This section provides background information related to the present disclosure which is not necessarily prior art.

[0004] Temperature-sensitive materials such as certain pharmaceuticals, biological samples, and chemical compounds may require precise temperature control during storage and transportation to maintain their efficacy and stability. However, issues including temperature fluctuation, equipment malfunction, and insufficient monitoring of the temperature-sensitive material may occur when storing and transporting such materials and may lead to an ineffective and even deleterious outcome if used. For example, cooling systems used to store and transport temperature-sensitive materials often rely on bulk insulation and/or active refrigeration units, which can be problematic with respect to temperature fluctuation and equipment malfunction, and also cumbersome and energy-intensive during transport. Such cooling systems may also be inflexible with respect to varying temperature requirements or adaptability for changing environmental conditions.

[0005] Certain temperature-controlled containers may use a fixed phase change material (PCM) and/or mechanical cooling elements. However, these containers are not customizable or easy to adjust, often leading to inefficient thermal management, as the cooling capacity cannot be dynamically tailored to match the ambient conditions or the specific thermal characteristics of the temperature-sensitive materials. Integration of smart technology in temperature-controlled transport container systems may also be limited due to a lack of advanced communication tools capable of providing real-time monitoring and control, making remote management of the container difficult. These issues may lead to temperature deviations without timely detection and correction.

[0006] In emergency situations, such as those involving traumatic injuries and surgeries, biological materials including blood and plasma, for example, may be needed for treating and stabilizing a patient. Blood transfusions, for example, may be used to replace lost blood volume, restore oxygen-carrying capacity, and replenish clotting factors. Plasma may be used to provide vital proteins, electrolytes, and coagulation factors essential for maintaining circulatory function and preventing excessive bleeding. Effectiveness and safety of biological materials such as blood products may be compromised during storage and transport if a temperature control system or method fails.

[0007] Accordingly, there is a continuing need for a reliable, adaptable, energy-efficient, and user-friendly temperature-controlled container system. Desirably, the container system allows for modular customization of solid-state cooling elements, incorporates advanced materials for enhanced thermal management, and includes integrated smart technologies for realtime monitoring and control.

SUMMARY

[0008] In concordance with the instant disclosure, a reliable, adaptable, energy-efficient, and user-friendly temperature-controlled container system that allows for modular customization of cooling elements, incorporates advanced materials for enhanced thermal management, and includes integrated smart technologies for real-time monitoring and control, has surprisingly been discovered. The present technology includes articles of manufacture, systems, and processes that relate to a temperature-controlled container for storing and transporting a temperature-sensitive material.

[0009] In certain embodiments, a temperature-controlled container may include a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface. A storage cavity may be disposed in the main housing. A lid may be coupled to the main housing and may be configured to seal the storage chamber. A thermoelectric device and a battery in electrical communication with the thermoelectric device may be disposed in the main housing. A first heat absorption element may be coupled to the main housing and adjacent to a first end of the thermoelectric device, and a second heat absorption element may be coupled to the main housing and adjacent to a second end of the thermoelectric device. Each of the first and second heat absorption elements may be in thermal communication with the thermoelectric device. A controller may be in communication with a sensor through a transmitter.

[0010] In certain embodiments, a system for monitoring and controlling the temperature of a temperature-sensitive material may include a temperature-controlled container. The container may include a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface. A storage cavity may be disposed in the main housing. A lid may be coupled to the main housing and may be configured to seal the storage chamber. A thermoelectric device and a battery in electrical communication with the thermoelectric device may be disposed in the main housing. A first heat absorption element may be coupled to the main housing and adjacent to a first end of the thermoelectric device, and a second heat absorption element may be coupled to the main housing and adjacent to a second end of the thermoelectric device. Each of the first and second heat absorption elements may be in thermal communication with the thermoelectric device. A controller may be in communication with a sensor through a transmitter. The system may also include a network and a user device in communication with the container through the network.

[0011] In certain embodiments, a method of using a temperature-controlled container for maintaining a desired temperature of a temperature sensitive material comprises a first step of providing a temperature-controlled container. The temperature-controlled container may include a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface. A storage cavity may be disposed in the main housing. A lid may be coupled to the main housing and may be configured to seal the storage chamber. A thermoelectric device and a battery in electrical communication with the thermoelectric device may be disposed in the main housing. A first heat absorption element may be coupled to the main housing and adjacent to a first end of the thermoelectric device, and a second heat absorption element may be coupled to the main housing and adjacent to a second end of the thermoelectric device. Each of the first and second heat absorption elements may be in thermal communication with the thermoelectric device. A controller may be in communication with a sensor through a transmitter. A second step may include inserting the temperature-sensitive material into the storage cavity of the temperature-controlled container, and a third step may include determining the desired temperature of the temperature-sensitive material. Additional steps may include arranging the temperature-controlled container such that the desired temperature may be reached and maintained over a predetermined period of time and securing the temperature-sensitive material within the storage cavity of the temperature-controlled container.

[0012] Further areas of applicability will become apparent from the description provided herein. The description and specific examples in this summary are intended for purposes of illustration only and are not intended to limit the scope of the present disclosure.

DRAWINGS

[0013] The drawings described herein are for illustrative purposes only of selected embodiments and not all possible implementations and are not intended to limit the scope of the present disclosure.

[0014] FIG. 1 is a schematic block diagram of a temperature-controlled container, according to one embodiment;

[0015] FIG. 2 is an exploded perspective view of a temperature-controlled container, according to one embodiment;

[0016] FIG. 3 is a top perspective view of a temperature-controlled container having removable phase change material (PCM) cartridges, according to one embodiment;

[0017] FIG. 4 is an exploded view of a PCM cartridge, according to one embodiment;

[0018] FIG. 5 is a schematic block diagram of a temperature-controlled container, according to one embodiment;

[0019] FIG. 6 is a top perspective view of a temperature-controlled container, according to one embodiment;

[0020] FIG. 7 is a cutaway top perspective view of a temperature-controlled container, according to one embodiment;

[0021] FIG. 8 is a cutaway top perspective view of an outer housing of a temperature- controlled container, according to one embodiment; [0022] FIG. 9 is a cutaway top perspective view of a battery housing of a temperature- controlled container, according to one embodiment;

[0023] FIG. 10 is a cutaway top perspective view of a top portion of a temperature- controlled container, according to one embodiment;

[0024] FIG. 11 is a top perspective view of a climate control assembly of a temperature- controlled container, according to one embodiment;

[0025] FIG. 12 is a schematic diagram of a system including a temperature-controlled container, according to one embodiment; and

[0026] FIG. 13 is a flow diagram illustrating a method of using a temperature-controlled container, according to one embodiment.

DETAILED DESCRIPTION

[0027] The following description of technology is merely exemplary in nature of the subject matter, manufacture and use of one or more inventions, and is not intended to limit the scope, application, or uses of any specific invention claimed in this application or in such other applications as may be filed claiming priority to this application, or patents issuing therefrom. Regarding methods disclosed, the order of the steps presented is exemplary in nature, and thus, the order of the steps can be different in various embodiments, including where certain steps can be simultaneously performed, unless expressly stated otherwise. “A” and “an” as used herein indicate “at least one” of the item is present; a plurality of such items may be present, when possible. Except where otherwise expressly indicated, all numerical quantities in this description are to be understood as modified by the word “about” and all geometric and spatial descriptors are to be understood as modified by the word “substantially” in describing the broadest scope of the technology. “About” when applied to numerical values indicates that the calculation or the measurement allows some slight imprecision in the value (with some approach to exactness in the value; approximately or reasonably close to the value; nearly). If, for some reason, the imprecision provided by “about” and/or “substantially” is not otherwise understood in the art with this ordinary meaning, then “about” and/or “substantially” as used herein indicates at least variations that may arise from ordinary methods of measuring or using such parameters.

[0028] All documents, including patents, patent applications, and scientific literature cited in this detailed description are incorporated herein by reference, unless otherwise expressly indicated. Where any conflict or ambiguity may exist between a document incorporated by reference and this detailed description, the present detailed description controls.

[0029] Although the open-ended term “comprising,” as a synonym of non-restrictive terms such as including, containing, or having, is used herein to describe and claim embodiments of the present technology, embodiments may alternatively be described using more limiting terms such as “consisting of’ or “consisting essentially of.” Thus, for any given embodiment reciting materials, components, or process steps, the present technology also specifically includes embodiments consisting of, or consisting essentially of, such materials, components, or process steps excluding additional materials, components or processes (for consisting of) and excluding additional materials, components or processes affecting the significant properties of the embodiment (for consisting essentially of), even though such additional materials, components or processes are not explicitly recited in this application. For example, recitation of a composition or process reciting elements A, B and C specifically envisions embodiments consisting of, and consisting essentially of, A, B and C, excluding an element D that may be recited in the art, even though element D is not explicitly described as being excluded herein.

[0030] Disclosures of ranges are, unless specified otherwise, inclusive of endpoints and include all distinct values and further divided ranges within the entire range. Thus, for example, a range of “from A to B” or “from about A to about B” is inclusive of A and of B. Disclosure of values and ranges of values for specific parameters (such as amounts, weight percentages, etc.) are not exclusive of other values and ranges of values useful herein. It is envisioned that two or more specific exemplified values for a given parameter may define endpoints for a range of values that may be claimed for the parameter. For example, if Parameter X is exemplified herein to have value A and also exemplified to have value Z, it is envisioned that Parameter X may have a range of values from about A to about Z. Similarly, it is envisioned that disclosure of two or more ranges of values for a parameter (whether such ranges are nested, overlapping or distinct) subsume all possible combination of ranges for the value that might be claimed using endpoints of the disclosed ranges. For example, if Parameter X is exemplified herein to have values in the range of 1-10, or 2-9, or 3-8, it is also envisioned that Parameter X may have other ranges of values including 1-9, 1-8, 1-3, 1-2, 2-10, 2-8, 2-3, 3-10, 3-9, and so on.

[0031] When an element or layer is referred to as being “on,” “engaged to,” “connected to,” or “coupled to” another element or layer, it may be directly on, engaged, connected or coupled to the other element or layer, or intervening elements or layers may be present. In contrast, when an element is referred to as being “directly on,” “directly engaged to,” “directly connected to” or “directly coupled to” another element or layer, there may be no intervening elements or layers present. Other words used to describe the relationship between elements should be interpreted in a like fashion (e.g., “between” versus “directly between,” “adjacent” versus “directly adjacent,” etc.). As used herein, the term “and/or” includes any and all combinations of one or more of the associated listed items.

[0032] Although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms may be only used to distinguish one element, component, region, layer or section from another region, layer or section. Terms such as “first,” “second,” and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the example embodiments.

[0033] Spatially relative terms, such as “inner,” “outer,” “beneath,” “below,” “lower,” “above,” “upper,” and the like, may be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. Spatially relative terms may be intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as “below” or “beneath” other elements or features would then be oriented “above” the other elements or features. Thus, the example term “below” can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

[0034] The present technology improves the accuracy, efficiency, reliability, portability, and monitoring of a temperature-controlled container used to store and transport temperaturesensitive materials such as biological and pharmaceutical materials. The temperature-controlled container allows for precise temperature regulation that may be tailored to meet the needs of specific materials requiring precise temperature control during storage and transport, thereby

- 1 - enhancing the safety and efficacy of the materials. The present technology, by integrating removable and customizable modular phase change elements and smart monitoring capabilities, enhances the adaptability and reliability of the temperature-controlled container. As such, the temperature-controlled container is optimized for complex applications such as medical and emergency applications involving sensitive biological and pharmaceutical materials.

[0035] With reference to FIGS. 1-4, the present disclosure relates to a temperature- controlled container 100. The temperature-controlled container 100 may be configured to maintain a desired temperature of a temperature sensitive material (not shown) during storage and/or transport. The temperature-controlled container 100 may include a main housing 102, a thermoelectric device 104, a battery 106, a heat absorption element 108, a controller 110, a sensor 112, and a transmitter 114.

[0036] The main housing 102 may include a top portion 116, a bottom portion 118, and at least one sidewall 120 extending from the bottom portion 118 to the top portion 116. One or more of the top portion 116, the bottom portion 118, and the sidewall or outer housing 120 may be integrally formed with one another, permanently or semi-permanently coupled to one another, and/or removably coupled to one another. The main housing 102 may have an interior surface 122 and an exterior surface 124. The interior surface 122 may define a storage cavity 126 configured to receive the temperature sensitive material. In certain embodiments, one or more bumpers 128 may be disposed on one or more comers 130 formed in the main housing 102 of the temperature-controlled container 100. The bumpers 128 may be configured to enhance the structural integrity of the temperature-controlled container 100 and/or provide thermal insulation.

[0037] A lid 132 may be removably or rotatingly coupled to the main housing 102 and configured to seal the storage cavity 126 when secured to the main housing 102. The lid 132 may be coupled to the main housing 102 using any suitable connecting mechanism 134 such as a clasp, a latch, a snap fit, a threaded fit, a friction fit, a hinge, and any combination thereof, as examples. The lid 132 may be configured to form an airtight seal with the main housing 102 or one or more components housed in the main housing 102. A locking mechanism 136 may be integrally formed with or coupled to one or both of the lid 132 and the main housing 102. In certain embodiments, the lid 132 may be integral formed with or coupled to the top portion 116 of the main housing 102. [0038] The temperature-controlled container 100 may be any shape, size, and configuration suitable for housing and transporting the temperature sensitive material, as determined by one of skill in the art. As examples, the temperature-controlled container 100 may be substantially cuboid or cylindrical in shape. The main housing 102 and the lid 132 may be fabricated using any suitable material or combination of materials adapted to maintain a desired internal temperature within the storage cavity 126. As examples, materials such as plastic, stainless steel, and one or more thermally insulative foams such as polystyrene, phenolic, and polyisocyanurate may be used. In certain embodiments, the temperature-controlled container 100 may be a vacuum insulated container.

[0039] The thermoelectric device 104 may be disposed in or coupled to the main housing 102 and adapted to maintain a specific temperature within the storage cavity 126 of the temperature-controlled container 100 using the Peltier effect. In certain embodiments, the thermoelectric device 104 may be a thermoelectric cooler configured to use electricity to move heat from the storage cavity 126 of the temperature-controlled container 100 to an area outside of the storage cavity 126 and/or to an area outside of the temperature-controlled container 100. It should be appreciated that the thermoelectric device 104 may also be a thermoelectric heater. The thermoelectric device 104 may have a first end 138 adjacent the storage cavity 126 of the temperature-controlled container 100 and a second end 140 adjacent the exterior surface 124 of the temperature-controlled container 100 and/or the environment outside of the temperature- controlled container 100. An electric current may pass through a junction of two different materials causing the first end 138 to cool down and the second end 140 to heat up. The thermoelectric device 104 may include one or more elements and materials such as ceramic substrates, conductive metals, and semiconductor materials such as bismuth telluride (E Tes), lead telluride (PbTe), and silicon germanium (SiGe), as examples, and any other suitable elements and/or materials, as determined by a skilled artisan. In certain embodiments, the thermoelectric device 104 may be disposed in the sidewall 120 of the temperature-controlled container 100. It should be appreciated that the thermoelectric device 104 may be disposed in and/or coupled to any portion of the temperature-controlled container 100 such as the sidewall 120, top portion 116, bottom portion 118, and the storage cavity 126, as examples. It should also be appreciated that the temperature-controlled container 100 may include more than one thermoelectric device 104 disposed therein. [0040] The battery 106 may be in electrical communication with the thermoelectric device 104. Any suitable battery 106 having a desirable voltage, current, and capacity may be utilized to power the thermoelectric device 104, such as a lithium-ion battery 106, as one example. The battery 106 may be configured for wired charging and/or wireless charging and may be in wired communication or wireless communication with one or more of the thermoelectric device 104, the controller 110, and the sensor 112, as determined by a skilled artisan.

[0041] In certain embodiments, the battery 106 may be disposed in or coupled to the main housing 102 of the temperature-controlled container 100. The battery 106 may be removably disposed in the main housing 102 of the temperature-controlled container 100. The battery 106 may be accessible by removing a cover plate 142 that is removably coupled to the main housing 102. Alternatively, the battery 106 may be coupled to the main housing 102 using a snap fit, sliding fit, or friction fit, as examples. In certain embodiments, the battery 106 may be permanently or semi-permanently housed in the main housing 102 such that the battery 106 may not be readily accessible to a user.

[0042] The heat absorption element 108 may be adapted to absorb thermal energy at a first end 144 of the heat absorption element 108 and dissipate the thermal energy at a second end 146 of the heat absorption element 108. In certain embodiments, the heat absorption element 108 may be a heat sink. Any suitable material or combination of materials capable of absorbing and conducting heat, such as aluminum or copper, as examples, may be used. The heat absorption element 108 may utilize any suitable heat transfer mechanism such as convection and conduction, as determined by one of skill in the art. The heat absorption element 108 may be a passive heat sink, an active heat sink, or a phase change material (PCM), as examples. It should be appreciated that a skilled artisan may include any additional mechanisms for enhancing thermal energy transfer, such as heat pipes and vapor chambers, as desired.

[0043] In certain embodiments, a first heat absorption element 148 may be disposed at the first end 138 of the thermoelectric device 104 and a second heat absorption element 150 may be disposed at the second end 140 of the thermoelectric device 104. The first heat absorption element 148 may be housed in the storage cavity 126 of the temperature-controlled container 100. The second heat absorption element 150 may be disposed in a recess 152 formed in the sidewall 120 of the temperature-controlled container 100 or coupled to the exterior surface 124 of the temperature-controlled container 100. At least one of the first and second heat absorption elements 148, 150 may be directly or indirectly coupled to the thermoelectric device 104.

[0044] In certain embodiments, the heat absorption element 108 may be a PCM cartridge 154, as shown in FIG. 4. The PCM cartridge 154 may include a front cover 156, a back cover 158, and a heat sink portion 160 disposed in between the front cover 156 and the back cover 158. The front cover 156 and the back cover 158 may be fabricated using any suitable thermally conductive material. The heat sink portion 160 may include a plurality of fins 162, such as pin fins or rectangular fins, as examples, and may have PCM 164 disposed therebetween. The plurality of fins 162 may be utilized to increase a surface area of the heat sink portion 160 and may be fabricated using any desirable thermally conductive material. Any suitable configuration of the plurality of fins 162 adapted for optimal heat transfer may be employed. The PCM 164 may be organic PCM, inorganic PCM, eutectic materials, and or a combination thereof, as determined by one of skill in the art. In certain embodiments, graphene may be included in or with the PCM 164. It should be appreciated that a skilled artisan may select the PCM 164 based on the specific thermal properties required by the temperature-sensitive materials being stored in the temperature-controlled container 100. In certain embodiments, the PCM cartridge 154 may be a removable PCM cartridge 154.

[0045] According to certain embodiments, a first removable PCM cartridge 166 may be removably disposed in the storage cavity 126 of the temperature-controlled container 100 adjacent the first end 138 of the thermoelectric device 104. The temperature-controlled container 100 may include a coupling mechanism 168 and/or a locking mechanism (not shown) configured to secure the first removable PCM cartridge 166 to the main housing 102 of the temperature- controlled container 100 and militate against movement of the first removable PCM cartridge 166 during use. In one example, the interior surface 122 of the temperature-controlled container 100 may include one or more flanges 170 extending outwardly from the interior surface 122 into the storage cavity 126 and configured to guide the first removable PCM cartridge 166 during installation and removal and secure the first removable PCM cartridge 166 in a desired position during use. The first removable PCM cartridge 166 may be configured to slide and/or lock in place within the storage cavity 126 of the temperature-controlled container 100 using the one or more flanges 170. The first removable PCM cartridge 166 may be further secured in the desired position by abutting the interior surface 122 of one or more of the top portion 116, the bottom portion 118, the sidewall 120, and the lid 132 of the temperature-controlled container 100 when the container is in a closed configuration. It should be appreciated that any suitable coupling mechanism and/or locking mechanism configured to removably couple and secure the first removable PCM cartridge 166 to the temperature-controlled container 100 may be employed, as determined by one of skill in the art. In certain embodiments, the first removable PCM cartridge 166 may be disposed in or otherwise coupled to the main housing 102 of the temperature- controlled container 100.

[0046] According to certain embodiments, the temperature-controlled container 100 may include a second removable PCM cartridge 172 disposed in or coupled to the main housing 102 adjacent the second end 140 of the thermoelectric device 104. The second removable PCM cartridge 172 may be disposed in the recess 152 formed in the exterior surface 124 of the sidewall 120 of the temperature-controlled container 100 or coupled to the exterior surface 124 of the temperature-controlled container 100, as determined by a skilled artisan. Any suitable coupling mechanism and/or locking mechanism may be employed to secure the second removable PCM cartridge 172 to the main housing 102 of the temperature-controlled container 100, such as a snap fit or a friction fit, as examples.

[0047] It should be appreciated that a plurality of PCM cartridges 154 may be utilized with the temperature-controlled container 100. According to certain embodiments, each PCM cartridge 154 may be adapted to maintain a desired temperature over a predetermined period of time. In one example, the plurality of PCM cartridges 154 may include one or more removable PCM cartridges 154 adapted to maintain a storage temperature of 4 degrees Celsius and one or more removable PCM cartridges 154 adapted to maintain a storage temperature of 12 degrees Celsius. It should be further appreciated that the temperature-controlled container 100 may include one or more fixed PCM cartridges 154.

[0048] The controller 110 may be configured to maintain a consistent temperature within the storage cavity 126 of the temperature-controlled container 100. In certain embodiments, the controller 110 may be a digital controller in communication with the sensor 112 using the transmitter 114. The controller 110 may be configured to receive wireless communication of temperature measurements taken by the sensor 112 and facilitate wireless or wired communication of the temperature measurements to an input/output interface 174 disposed in the main housing 102 of the temperature-controlled container 100. The input/output interface 174 may include one or more buttons 176, such as input buttons, and a display 178.

[0049] The buttons 176 may include a mode button, a select button, buttons corresponding to up and down (for time or temperature or the like), as examples. It should be appreciated that additional buttons, as well as different input configurations such as sliders and roller pots may be employed. The display 178 may include an OLED or LED display which may display data such as temperature, time, and battery status. The input/output interface 174 may be configured to receive and display information relating to the temperature inside one or more of the storage cavity 126, the heat absorption element 108, and the thermoelectric device 104.

[0050] The controller 110 may include a processor 180 and a memory 182 on which processor-executable instructions 184 may be tangibly stored. Each of the controller 110, the electronic display 174, and the sensor 112 may be powered, as needed, using the battery 106 or any other suitable power source. The battery 106 may be configured to provide power to the controller 110 and/or the sensor 112 wirelessly or using a wired connection, according to various embodiments. It should be appreciated that the temperature-controlled container 100 may include more than one power source and power transfer mechanism, as determined by a skilled artisan.

[0051] Any suitable sensor 112 capable of accurately detecting and/or measuring measurable outputs such as temperature within one or more of the main housing 102, the storage cavity 126, the heat absorption element 108, and the thermoelectric device 104 may be utilized, such as a thermistor, a thermocouple, and a resistance temperature detector, as examples. In certain embodiments, a plurality of sensors 112 may be employed. One or more sensors 112 may be disposed in or coupled to the storage cavity 126, the main housing 102, the heat absorption element 108, and/or the thermoelectric device 104, as determined by a skilled artisan. In certain embodiments, one or more sensors 112 may be embedded in the PCM cartridge 154. Additional sensors 112 may include humidity sensors and pressure sensors, as examples. Sensors 112 may be configured to detect when a material is removed from the storage cavity 126 and what material is removed. In certain embodiments, the sensors 112 may be in communication, such as near field communication, with one or more transmitters 114.

[0052] It should be further appreciated that any suitable transmitter 114 or plurality of transmitters 114 capable of transmitting data from the sensor 112 to the controller 110 may be employed. At least one transmitter 114 may be disposed in the main housing 102, the storage cavity 126, the heat absorption element 108, and/or the thermoelectric device 104, as examples, as determined by one of skill in the art. In certain embodiments, the transmitter 114 may be a near field communication (NFC) chip disposed in the PCM cartridge 154.

[0053] Referring now to FIGS. 5-11, the temperature-controlled container 100 may include a climate control assembly 186 including the thermoelectric device 104 and the heat absorption element 108, and a control system 188 including the battery 106 and the controller 110. In certain embodiments, the top portion 116 of the main housing 102 may include the climate control assembly 186 and may be configured to be the lid 132. The connecting mechanism 134 and/or the locking mechanism 136 may be employed to couple and secure the top portion 116 of the temperature-controlled container 100 to the outer housing 120 of the temperature-controlled container 100. It should be appreciated that any suitable connecting mechanism 134 and/or locking mechanism 136 may be employed to removably couple and secure the top portion 116 to the outer housing 120 such as a friction fit, a clasp, a latch, a hinge, and a threaded fit, as examples.

[0054] As shown in FIG. 8, the outer housing 120 may have a first end 190 adjacent the top portion 116 of the temperature-controlled container 100 and a second end 192 adjacent the bottom portion 118. The outer housing 120 may have an interior surface 194 and an exterior surface 196. The interior surface 194 may extend from the first end 190 of the outer housing 120 to the second end 192 of the outer housing 120. The interior surface 194 may define an inner bore 198 extending from a top edge 200 to a bottom edge 202. The interior surface 194 may include an upper flange 204 positioned at the first end 190 of the outer housing 120 and a central flange 206 positioned between the first end 190 and the second end 192 of the outer housing 120. A first thickness 208 of the outer housing 120 extending from the second end 192 of the outer housing 120 to the central flange 206 may be less than a second thickness 210 of the outer housing 120 extending from the central flange 206 to the upper flange 204. The central flange 206 may be adjacent a base 212 of a chamber 214 (storage cavity) disposed in the outer housing 120, according to certain embodiments. The top edge 200 may define a top opening 216 and the bottom edge 202 may define a bottom opening 218. The outer housing 120 between the top opening 216 and the bottom opening 218 may have any suitable configuration, such as a cylindrical configuration, as determined by a skilled artisan. The outer housing 120 may be fabricated using any suitable material or combination of materials such as plastic, carbon fiber, stainless steel, or aluminum, as examples.

[0055] With reference to FIG. 7, the chamber 214 may include the base 212 and a chamber sidewall 220. The base 212 may include a top surface 222 and bottom surface 224. The chamber sidewall 220 may extend upwardly from an outer perimeter 226 of the base 212. The chamber sidewall 220 may have an upper edge 228 that defines a chamber opening 230. The chamber sidewall 220 may have an interior surface 232 and a top surface 234, and the storage cavity 126 may be defined by the top surface 222 of the base 212 and the interior surface 232 of the chamber sidewall 220.

[0056] The chamber 214 may be configured to be housed in the inner bore 198 of the outer housing 120 such that the top surface 234 of the chamber sidewall 220 may interface with a bottom surface 236 of the upper flange 204. It should be appreciated that an exterior surface 238 of the chamber sidewall 220 may be positioned adjacent the interior surface 194 of the outer housing 120 generally between the central flange 206 and the upper flange 204. The base 212 of the chamber 214 may be generally perpendicular to a longitudinal axis of the chamber 214 and the outer housing 120, such that the top surface 222 of the base 212 may be generally parallel to a surface upon which the temperature-controlled container 100 is positioned (e.g., a table, the floor or ground, etc.).

[0057] The chamber 214 may be a single integral component or may be formed from a plurality of components coupled to one another using any suitable process such as molding, forging, and/or stamping, as examples. In certain embodiments, the chamber 214 may have an insulated double wall including insulation, a vacuum, and/or an inert gas. It should be appreciated that the chamber 214 may also be fabricated using a uniform material throughout, according to certain embodiments. The chamber 214 may be integral with the outer housing 120 or removably, semi-permanently, or permanently coupled to the outer housing 120, according to certain embodiments.

[0058] With reference to FIG. 9, a bracing member 240 may include an upper brace element 242, a lower brace element 244, and a battery housing 246, The upper brace element 242, the lower brace element 244, and the battery housing 246 may define a battery storage cavity 248. In certain embodiments, the bracing member 240 may be configured to house and/or couple to the battery 106 and/or the controller 110. The bracing member 240 may be disposed in the inner bore 246 of the outer housing 120 between the bottom edge 202 of the outer housing 120 and the base 212 of the chamber 214. The bracing member 240 may be disposed at a predetermined distance from the base 212 of the chamber 214 such that there is a space 249 between the base 212 of the chamber 214 and the upper brace element 242 of the bracing member 240. Any suitable means for permanently, semi-permanently, or removably securing the bracing member 240 to the outer housing 120 may be employed, such as a screw fit, as one example. Alternatively, the bracing member 240 may be integrally formed with the outer housing 120.

[0059] The upper brace element 242 may have a top surface 250, a bottom surface 252, and sidewall 254. The sidewall 254 of the upper brace element 242 may be configured to abut the interior surface 194 of the outer housing 120 and follow the contours of the interior surface 194 of the outer housing 120. A plurality of openings 256 may be disposed in the upper brace element 242. In certain embodiments, a wire assembly 258 such as a wire harness may extend through one or more of the openings 256 and be coupled to one or more battery terminals 260. In certain embodiments, the one or more battery terminals 260 may extend through one or more of the openings 256 when the battery 106 is properly positioned within the battery storage cavity 248 of the bracing member 240, as shown in FIG. 7.

[0060] The lower brace element 244 may include a top surface 262, a bottom surface 264, and a sidewall 266. In certain embodiments, the sidewall 266 may be configured to abut the interior surface 194 of the outer housing 120 and form a seal with the outer housing 120. The bottom surface 264 of the lower brace element 244 may be flush with the bottom edge 202 of the outer housing 120 or may be recessed with respect to the bottom edge 202 of the outer housing 120, as shown in FIG. 7. A battery opening 268 may be formed in the bottom surface 264 of the lower brace element 244 and may be configured to allow for removal and installation of the battery 106 with respect to the bracing member 240 and the outer housing 120. In certain embodiments, a removable cover (not shown) may be disposed in or coupled to the lower brace element 244 and configured to secure the battery 106 within the battery storage cavity 248 when the removable cover is secured to the lower brace element 244.

[0061] The battery housing 246 may include a plurality of sidewalls 270 and may have a top end 272 adjacent the upper brace element 242 and a bottom end 274 adjacent the lower brace element 244. An interior surface 276 of the plurality of sidewalls 270, the upper brace element 242, and the lower brace element 244 may define the battery storage cavity 248. In certain embodiments, the battery storage cavity 248 may have a cuboid configuration. It should be appreciated that any suitable configuration capable of supporting and/or housing the battery 106 may be employed. The battery housing 246 of the bracing member 240 may have a recessed portion 278 with respect to the upper brace element 242 and the lower brace element 244 configured to receive the controller 110 and/or the wire assembly 258.

[0062] Referring now to FIGS. 10 and 11, the top portion 116 of the temperature- controlled container 100 may include a lid housing 280 and the climate control assembly 186. The lid housing 280 may be configured to form a seal with the outer housing 120 and the chamber 214. The lid housing 280 may include a lid base 282 and a lid cover 284 defining a climate control cavity 286. The lid base 282 may include an opening 288 through which the thermoelectric device 104 may extend, according to certain embodiments. The lid base 282 may be any suitable size and configuration capable of forming a seal with the outer housing 120 and and/or the chamber 214 when the top portion 116 including the lid housing 280 is in a closed configuration, as shown in FIG. 6. The lid cover 284 may have a top wall 290, an outer depending wall 292, and an inner depending wall 294. The top wall 290 may have a plurality of cooling passages 296 extending therethrough. The outer depending wall 292 may extend from an outer perimeter 298 of the top wall 290 to a bottom edge 300 of the lid cover 284. The bottom edge 300 may be configured to abut the lid base 282. The outer depending wall 292 may have additional cooling passages 296.

[0063] The inner depending wall 294 may extend downwardly from a bottom surface 302 of the lid cover 284 and may be spaced apart from the outer depending wall 292. A portion of the bottom surface 302 of the lid cover 284 and an inner surface 304 of the inner depending wall 294 may define a heat absorbing element housing 306 disposed in the climate control cavity 186. It should be appreciated that the lid housing 280 may be fabricated using any suitable material or materials capable of housing the climate control assembly 228 and sealing the chamber 214, such as plastic, carbon fiber, stainless steel, and/or aluminum, as examples.

[0064] In certain embodiments, the climate control assembly 186 may include the thermoelectric device 104 and the heat absorbing element 108. In certain more particular embodiments, the climate control assembly 186 may include the thermoelectric device 104, a first heat absorption element 308, and a second heat absorption element 310. The first heat absorption element 308 may be disposed at a first end 312 of the thermoelectric device 104 adjacent the outer housing 120 and the second heat absorption element 310 may be disposed at the second end 314 of the thermoelectric device 104 adjacent the top wall 290 of the lid cover 284. It should be appreciated that the climate control assembly 186 or one of more components of the climate control assembly 186 may be housed within the top portion 116 and/or the outer housing 120 of the temperature-controlled container 100. In certain embodiments, the climate control assembly 186 or one or more components of the climate control assembly 186 may be removably coupled to the outer housing 120.

[0065] The first heat absorption element 308 may be directly or indirectly coupled to the first end 312 of the thermoelectric device 104. The first heat absorption element 308 may include at least an interface plate 316 and a heat sink 318. The interface plate 316 may include an upper cradle 320, a lower surface 322, and an outer edge 324. The interface plate 316 may be coupled to the outer housing 120 and the outer edge 324 may abut the upper flange 204 when the temperature-controlled container 100 is in a closed configuration, as shown in FIGS. 6 and 7. In certain embodiments, the upper cradle 320 may be configured to receive the thermoelectric device 104. The second heat absorption element 310 may have a base 326 directly or indirectly coupled to an upper surface 328 of the thermoelectric device 104. It should be appreciated that each of the first heat absorption element 308 and the second heat absorption element 310 may be directly coupled to the thermoelectric device 104 or indirectly coupled to the thermoelectric device 104 using any suitable means such as a conductive paste or a conductive surface, as examples. Any suitable material or combination of materials capable of absorbing and conducting heat may be used to fabricate each of the first and second heat absorption elements 308, 310. It should be appreciated that a skilled artisan may include any additional mechanisms for enhancing thermal energy transfer, such as heat pipes and vapor chambers, as desired.

[0066] In certain embodiments, each of the first and second heat absorption elements 308, 310 may be PCM cartridges 154. In certain embodiments, each PCM cartridge 154 may be a removable PCM cartridge 154. A first removable PCM cartridge 330 may be removably coupled to the first end 312 of the thermoelectric device 104. In certain embodiments, the interface plate 316 may be coupled to or integral with the first removable PCM cartridge 330 and adapted to removably engage with the thermoelectric device 104 during installation and removal of the first removable PCM cartridge 330. The temperature-controlled container 100 may include a coupling mechanism and/or a locking mechanism such as a sliding mechanism or snap fit, as examples, configured to secure the first removable PCM cartridge 330 to the thermoelectric device 104 and/or the lid cover 284. In certain embodiments, the first removable PCM cartridge 330 may be secured in the desired position by one or more of the thermoelectric device 104, the lid base 282, and the outer housing 120. It should be appreciated that any suitable coupling mechanism and/or locking mechanism configured to removably couple and secure the first removable PCM cartridge 330 directly or indirectly to the thermoelectric device 104 may be employed, as determined by one of skill in the art.

[0067] A second removable PCM cartridge 332 may be disposed in or coupled to the lid cover 284 and directly or indirectly coupled to the second end 314 of the thermoelectric device 104. Any suitable coupling mechanism and/or locking mechanism may be employed to secure the second removable PCM cartridge 332 directly or indirectly to the thermoelectric device 104 and/or the lid cover 284, such as a snap fit or a friction fit, as examples. In certain embodiments, the second removable PCM cartridge 332 may be secured in the desired position by one or more of the thermoelectric device 104 and the lid cover 284. The second removable PCM cartridge 332 may be accessed by removing the lid cover 284 from the lid base 282, removing the top portion 116 from the outer housing 120, and/or by removing the climate control assembly 186 from the lid 232.

[0068] It should be appreciated that a plurality of PCM cartridges 154 may be utilized with the temperature-controlled container 100. According to certain embodiments, each PCM cartridge 154 may be adapted to maintain a desired temperature over a predetermined period of time. As examples, the plurality of PCM cartridges 154 may include one or more PCM cartridges 154 adapted to maintain a storage temperature of 4 degrees Celsius and one or more PCM cartridges 154 adapted to maintain a storage temperature of 12 degrees Celsius. It should be further appreciated that, according to certain embodiments, PCM cartridges 154 may be fixed or removable with respect to the temperature-controlled container 100.

[0069] In certain embodiments, the climate control assembly 186 may include a fan 334 disposed between the second heat absorption element 310 and the lid cover 284 such that the fan 334 is adjacent the cooling passages 296 disposed in lid cover 284. Any suitable fan 334 may be utilized, such as a multi-blade DC fan, as one example. It should be appreciated that, in certain embodiments, the temperature-controlled container 100 may not include a fan 334. [0070] In certain embodiments, as shown in FIG. 7, a hinge mechanism 336 may be configured to couple the outer housing 120 to the lid 232. The hinge mechanism 336 may provide between 75 degrees of rotation and 180 degrees of rotation or more between the closed configuration and an open configuration (not shown). It should be appreciated that in the closed configuration, a seal is formed between the outer housing 120 and the lid 232 and between the chamber 214 and the lid 232. In the open configuration, a user may access the chamber 214 and one or more components of the climate control assembly 186. Any suitable locking mechanism 338 may be employed to releasably engage and secure the lid 232 with respect to the outer housing 120.

[0071] As shown in FIG. 12, a system 400 for monitoring and controlling the temperature of a temperature-sensitive material during storage and transport may include a temperature- controlled container 100 and a user device 402 in wireless communication with the temperature- controlled container 100 for monitoring and/or controlling the storage cavity 126, the thermoelectric device 104, the heat absorption element 108, the battery 106, and/or the controller 110 of the temperature-controlled container 100. The user device 402 may be in communication with the temperature-controlled container 100 through a network 404 including a system server 406 through which the temperature-controlled container 100 and the user device 126 may communicate. The network 404 may be a radio access network, such as LTE or 5G, a local area network (LAN), a wide area network (WAN) such as the Internet, or wireless LAN (WLAN), as examples. The temperature-controlled container 100, the user device 402, and the system server 406 may be configured to communicate with the network 404 via wireless or wired connections.

[0072] According to certain embodiments, the system server 406 may be implemented in or function as a base station (which may also be referred to as Node Bs or evolved Node Bs (eNBs)), and/or the system server 406 may include web servers, mail servers, application servers, etc. The system server 406 may be a standalone server, a networked server, or an array of servers. It should be appreciated that there may be multiple user devices 402 configured for communication with the temperature-controlled container 100 and/or with one another via wireless or wired connections. Examples of user devices 402 may include smartphones, wearable devices, tablets, laptop computers, desktop computers, Internet of Things (loT) devices, or other mobile or stationary devices. [0073] In certain embodiments, the system server 406 and/or the controller 110 may be configured by machine-readable instructions 408. The machine-readable instructions 408 may include modules 410. The modules 410 may be implemented as one or more of functional logic, hardware logic, electronic circuitry, software modules, and the like. As examples, the modules 410 may include one or more of a temperature measurement module, a temperature adjustment module, a temperature alert module, and an artificial intelligence module.

[0074] The user device 402 of the system 400 may be configured to allow the user to monitor the temperature-controlled container 100 and make adjustments relating to the conditions within the temperature-controlled container 100, as needed, based on predetermined parameters and/or real-time instructions, thereby allowing for continuous remote monitoring and management of conditions within the temperature-controlled container 100 such as temperature and humidity. The user device 402 may be configured to receive alerts when the temperature within the storage cavity 126, the thermoelectric device 104, and/or the heat absorption element 108 deviates from a predetermined range or other threshold parameter.

[0075] Additionally, a downloadable application on the user device 402 may provide a user interface 412 configured to display real-time data such as temperature, humidity levels, and pressure readings collected from the sensors 112 within the temperature-controlled container 100 and allow a user to adjust the conditions within the temperature-controlled container 100 remotely. As such, a user may be able to adjust the settings and conditions relating to the temperature-controlled container 100 based on developing or anticipated changes in conditions within the temperature-controlled container 100 and the environment outside of the container.

[0076] The system server 406 may be configured to aggregate data from one or more sensors 112 and/or containers 100 and provide analytics with respect to the performance, reliability, and efficiency, as examples. The system server 406 may be configured to store and provide access to historical and real-time data, enabling long-term monitoring and analysis of data including temperature control trends and deviations. As such, the user may assess the effectiveness of various temperature control strategies and make adjustments to improve future performance. In certain embodiments, the artificial intelligence module may be configured to use historical and real-time data combined with predictive modeling to initiate adjustments with respect to conditions such as temperature within the temperature-controlled container 100. As examples, the controller 110, the system server 406, the user interface 412, the modules 410 such as the artificial intelligence module, and/or the user may initiate an adjustment with respect to the current flowing through the thermoelectric device 104 and/or the flow of thermal energy through the heat absorption element 108 based on historical and/or real-time data.

[0077] As shown in FIG. 13, a method 500 of using the temperature-controlled container 100 for maintaining the temperature of the temperature-sensitive material during storage and/or transport of the temperature-sensitive material may include a first step 502 of providing the temperature-controlled container 100. A second step 504 may include inserting the temperaturesensitive material into the storage cavity 126 of the temperature-controlled container 100, and a third step 506 may include determining a desired temperature of the storage cavity 126 of the temperature-controlled container 100. A fourth step 508 may include arranging the temperature- controlled container 100 such that the desired temperature may be reached and maintained over a predetermined period of time. In a fifth step 510, the temperature-sensitive material may be secured within the storage cavity 126 of the temperature-controlled container 100.

[0078] It should be appreciated that additional steps relating to the preparation of the temperature-sensitive material and/or preparation of the temperature-controlled container 100 including the storage cavity 126 may be included in the method 500. Additionally, steps relating to determining the desired temperature of the storage cavity 126 may be included such as using a software application on the user device 402 to determine the desired temperature based on a type and weight of the temperature-sensitive material, as one example. The fourth step 508 of arranging the temperature-controlled container 100 such that the desired temperature may be reached and maintained may include steps such as providing data and/or instructions relating to predetermined parameters for storage using the user device 402, providing data and/or instructions relating to predetermined parameters for storage using the controller 110, and installing and/or activating one or more of the thermoelectric device 104 and the heat absorption element 108. The temperature-sensitive material may be secured within the storage cavity 126 by securing the top portion 116 to the sidewall 120 of the temperature-controlled container 100, thereby sealing the storage cavity 126.

[0079] Additional steps may relate to monitoring, maintaining, and adjusting the desired temperature of the storage cavity 126 in the temperature-controlled container 100. As examples, the controller 110 may be configured to collect and process information from the sensor 112 at predetermined intervals. If the temperature of the storage cavity 126 falls below or exceeds the desired temperature, the controller 110 may be configured to alert a user using an audible sound, for example, and/or communicate the alert using the user device 402. Steps relating to initiating a change with respect to the current flowing through the thermoelectric device 104 and/or adjusting a flow of thermal energy through the heat absorption element 108, as examples, based on historical and/or real-time data to maintain or adjust the desired temperature of the storage cavity 126 may also be employed.

[0080] Steps relating to selecting, replacing, recharging, and adjusting the heat absorption element 108 may also be included, as well as steps relating to monitoring, maintaining, and adjusting the temperature of the storage cavity 126, the thermoelectric device 104, and/or the heat absorption element 108. As an example, steps relating to selecting a removable PCM cartridge 154, replacing a removable PCM cartridge 154, and recharging a removable PCM cartridge 154 during and/or after use may be employed, in certain embodiments. It should be appreciated that any steps relating to measuring, monitoring, maintaining, and adjusting various aspects of the environment within the storage cavity such as temperature, humidity, and pressure, as examples, may be employed.

[0081] It should be further appreciated that additional steps may be included in the method 500, as determined by one of skill in the art. Steps may be repeated and/or omitted, as needed. Steps may be performed manually or automatically by the user, the controller 110, the system server 406, the user device 402, the modules 410, and any combination thereof.

[0082] Advantageously, the temperature-controlled container 100 may be configured to maintain a precise temperature of a temperature-sensitive material over a desired period of time during storage and transport. The temperature-controlled container 100 may include the thermoelectric device 104, heat absorption element 108, and insulated double wall to enhance the efficiency and reliability of the temperature-controlled container 100 and militate against thermal exchange with an external environment. The temperature within the storage cavity 126 may be maintained within a predetermined range without excessive energy consumption and detrimental fluctuations in temperature. The temperature-controlled container 100 may be small enough to be easily portable but durable enough for emergency settings. In certain embodiments, the temperature-controlled container 100 may advantageously have GPS capabilities allowing the temperature-controlled container 100 to be located quickly. The temperature-controlled container 100 may be configured to be stackable with similar containers 100 allowing for a large, organized temperature-controlled environment, which may be particularly useful where large volumes of temperature-sensitive materials need to be stored and/or transported together.

[0083] Specific PCM cartridges 154 may be selected based on the temperature-sensitive material to be stored and transported and may be easy to install, replace, and recharge, as needed. The PCM cartridges 154 may facilitate customization of the temperature-controlled container 100 according to specific user needs and variable environmental conditions and may be reused multiple times, thereby enhancing the sustainability and cost-effectiveness of the temperature- controlled container 100. The configuration of the temperature-controlled container 100 including the heat absorption elements 108 on either side of the thermoelectric device 104, the plurality of fins 162 including phase change material 164, the insulated walls, and the use of advanced materials like graphene in PCM cartridges 154 may enhance thermal conductivity, thereby improving the efficiency of heat transfer. It is contemplated that, in addition to graphene in the phase change material 164, other materials or compounds such as surfactants may also be employed to enhance thermal conductivity.

[0084] Advantageously, the transmitters 114 such as integrated NFC chips and sensors 112 enable real-time monitoring and dynamic adjustment of the internal conditions of the storage cavity 126, the thermoelectric device 104, and/or the heat absorption elements 108. As such, a user may immediately respond to temperature fluctuations, thereby ensuring that temperaturesensitive materials such as pharmaceuticals and biological samples may be maintained within predetermined temperature ranges. Additionally, the inclusion of wireless communication capabilities allows for remote monitoring and control of the environment within the temperature- controlled container 100 when the temperature-controlled container 100 is otherwise inaccessible, such as in transit or in remote storage locations. The communication of real-time data and alerts to the user may allow for prompt adjustments, as needed, and the data storage and artificial intelligence module may allow for data analysis that may be used to optimize conditions for the transfer and storage of temperature-sensitive materials.

EXAMPLE

[0085] Pharmaceutical Transport

[0086] In certain embodiments, a temperature-controlled container 100 may be utilized for transport of pharmaceuticals that require precise temperature regulation. The temperature- controlled container 100 may include removable PCM cartridges 154 adapted to maintain a precise internal temperature such as 4°C, ideal for many temperature-sensitive drugs. The temperature-controlled container 100 may include one or more sensors 112 and transmitters 114 such as NFC chips in communication with a controller 110 having a processor 180 to ensure that the temperature remains constant throughout the transport process. The controller 110 may be configured to maintain and/or adjust a temperature of the temperature-controlled container 100 based on the data received from the sensors 112.

[0087] The embedded sensors 112 may be disposed in the PCM cartridges 154 and may provide real-time data with respect to the internal conditions of the PCM cartridges 154 and/or a storage cavity 126 of the temperature-controlled container 100. The transmitters may be disposed in the PCM cartridges 154 and configured to facilitate communication between the sensors 112 and the processor 180. The temperature-controlled container 100 may be in network communication with a system server 406 and a user device 402.

[0088] During transport, the sensors 112 may continuously monitor the internal temperature, humidity, and pressure of the storage cavity 126 and/or the PCM cartridges 154. Deviations from predetermined parameters may be communicated to a remote user in the form of an alert displayed by the user device 402. Upon receiving the alert, the remote user may adjust various settings relating to temperature, for example, and/or replace or recharge the PCM cartridges 154, as needed, and ensure that the pharmaceuticals remain within a predetermined temperature range.

[0089] Example embodiments are provided so that this disclosure will be thorough, and will fully convey the scope to those who are skilled in the art. Numerous specific details are set forth such as examples of specific components, devices, and methods, to provide a thorough understanding of embodiments of the present disclosure. It will be apparent to those skilled in the art that specific details need not be employed, that example embodiments may be embodied in many different forms, and that neither should be construed to limit the scope of the disclosure. In some example embodiments, well-known processes, well-known device structures, and well- known technologies are not described in detail. Equivalent changes, modifications and variations of some embodiments, materials, compositions and methods can be made within the scope of the present technology, with substantially similar results.

Claims

CLAIMS What is claimed is:

1. A temperature-controlled container, comprising: a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface; a storage cavity disposed in the main housing; a lid coupled to the main housing and configured to seal the storage cavity; a thermoelectric device; a battery in electrical communication with the thermoelectric device; a first heat absorption element coupled to the main housing and adjacent to a first end of the thermoelectric device, the first heat absorption element in thermal communication with the thermoelectric device; and a second heat absorption element coupled to the main housing and adjacent to a second end of the thermoelectric device, the second heat absorption element in thermal communication with the thermoelectric device; a transmitter; a sensor; and a controller in communication with the sensor through the transmitter.

2. The temperature-controlled container of claim 1, wherein a first heat absorption element may be disposed at a first end of the thermoelectric device and a second heat absorption element may be disposed at a second end of the thermoelectric device.

3. The temperature-controlled container of claim 2, wherein the first heat absorption element is housed in the storage cavity and the second heat absorption element is disposed in a recess formed in the sidewall of the container.

4. The temperature-controlled container of claim 2, wherein at least one of the first heat absorption element and the second heat absorption element is directly coupled to the thermoelectric device.

5. The temperature-controlled container of claim 1, wherein the heat absorption element includes a removable phase change material (PCM) cartridge.

6. The temperature-controlled container of claim 1, wherein the PCM cartridge includes graphene.

7. The temperature-controlled container of claim 5, wherein a first removable PCM cartridge is removably disposed in the storage cavity of the container adjacent a first end of the thermoelectric device.

8. The temperature-controlled container of claim 7, wherein a second removable PCM cartridge is coupled to the main housing adjacent a second end of the thermoelectric device.

9. The temperature-controlled container of claim 1, wherein the sensor is disposed in the heat absorption element.

10. The temperature-controlled container of claim 1, wherein the transmitter is a near field communication chip.

11. The temperature-controlled container of claim 1 , wherein the top portion of the container includes a lid housing and a climate control assembly including the thermoelectric device, a first heat absorption element is disposed at a first end of the thermoelectric device, and a second heat absorption element is disposed at a second end of the thermoelectric device.

12. The temperature-controlled container of claim 11, wherein the lid housing has a plurality of cooling passages disposed adjacent to the second heat absorption element.

13. The temperature-controlled container of claim 11, wherein at least one of the first heat absorption element and the second heat absorption element is a removable PCM cartridge.

14. The temperature-controlled container of claim 1, wherein the temperature-controlled container is vacuum insulated.

15. A system for monitoring and controlling the temperature of a temperature-sensitive material, comprising: a temperature-controlled container, having: a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface; a storage cavity disposed in the main housing; a lid coupled to the main housing and configured to seal the storage cavity; a thermoelectric device; a battery in electrical communication with the thermoelectric device; a first heat absorption element coupled to the main housing and adjacent to a first end of the thermoelectric device, the first heat absorption element in thermal communication with the thermoelectric device; and a second heat absorption element coupled to the main housing and adjacent to a second end of the thermoelectric device, the second heat absorption element in thermal communication with the thermoelectric device; a transmitter; a sensor; and a controller in communication with the sensor through the transmitter; a network; and a user device in communication with the temperature-controlled container through the network.

16. The system of claim 15, wherein the user device is configured to receive an alert when a temperature within at least one of the storage cavity, the thermoelectric device, and the heat absorption element deviates from a predetermined temperature range.

17. The system of claim 15, wherein the network includes a system server configured by machine-readable instructions and the machine-readable instructions include an artificial intelligence module.

18. A method of using a temperature-controlled container for maintaining a desired temperature of a temperature sensitive material, the method comprising steps of: providing a temperature-controlled container having: a main housing having a top portion, a bottom portion, a sidewall, an interior surface, and an exterior surface; a storage cavity disposed in the main housing; a lid coupled to the main housing and configured to seal the storage cavity; a thermoelectric device; a battery in electrical communication with the thermoelectric device; a first heat absorption element coupled to the main housing and adjacent to a first end of the thermoelectric device, the first heat absorption element in thermal communication with the thermoelectric device; and a second heat absorption element coupled to the main housing and adjacent to a second end of the thermoelectric device, the second heat absorption element in thermal communication with the thermoelectric device; a transmitter; a sensor; and a controller in communication with the sensor through the transmitter; inserting the temperature-sensitive material into the storage cavity of the temperature- controlled container; determining the desired temperature of the temperature-sensitive material; arranging the temperature-controlled container such that the desired temperature may be reached and maintained over a predetermined period of time; and securing the temperature-sensitive material within the storage cavity of the temperature- controlled container.

19. The method of claim 18, wherein the step of arranging the temperature-controlled container such that the desired temperature may be reached and maintained over a predetermined period of time includes selecting and installing a PCM cartridge.

20. The method of claim 19, wherein a step of maintaining the desired temperature over a predetermined period of time includes at least one of recharging and replacing the PCM cartridge.