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WO2025197925A1 - Information presenting device, information presenting method, and program - Google Patents

Information presenting device, information presenting method, and program

Info

Publication number
WO2025197925A1
WO2025197925A1 PCT/JP2025/010524 JP2025010524W WO2025197925A1 WO 2025197925 A1 WO2025197925 A1 WO 2025197925A1 JP 2025010524 W JP2025010524 W JP 2025010524W WO 2025197925 A1 WO2025197925 A1 WO 2025197925A1
Authority
WO
WIPO (PCT)
Prior art keywords
waveform
measurement
line
information presentation
presentation device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/JP2025/010524
Other languages
French (fr)
Japanese (ja)
Inventor
健悟 大西
智英 浅井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sekisui Medical Co Ltd
Original Assignee
Sekisui Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Medical Co Ltd filed Critical Sekisui Medical Co Ltd
Publication of WO2025197925A1 publication Critical patent/WO2025197925A1/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01Input arrangements or combined input and output arrangements for interaction between user and computer
    • G06F3/048Interaction techniques based on graphical user interfaces [GUI]
    • G06F3/0481Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
    • G06F3/0482Interaction with lists of selectable items, e.g. menus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the present invention relates to an information presentation device, an information presentation method, and a program.
  • This application claims priority from Japanese Patent Application No. 2024-044009, filed on March 19, 2024, the contents of which are incorporated herein by reference.
  • a technology is known in which, on a screen that has a sample list display area and a measurement result display area, when an operation is performed to select one list item from the sample list display area, the measurement results corresponding to the sample corresponding to the selected list item are displayed in the measurement result display area (see, for example, Patent Document 1).
  • Patent Document 1 when presenting measurement results corresponding to samples displayed as list items in a sample list display, it is necessary to perform an operation to select the list item corresponding to the target sample. Considering the need to eliminate the need for such an operation, it is preferable to also appropriately present information about the measurement results at the stage when the sample list is displayed on the screen.
  • the present invention aims to ensure that the measurement results for each sample are properly displayed on the screen that displays the sample list.
  • an information presentation device that includes a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays, corresponding to each sample, measured values that indicate the measurement results for each of the multiple measurement items, as well as one or more symbols that represent information based on the measurement results.
  • One aspect of the present invention is an information presentation method for an information presentation device, which includes a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays, corresponding to each sample, measured values indicating the measurement results for each of the multiple measurement items, as well as one or more symbols representing information based on the measurement results.
  • One aspect of the present invention is a program that causes a computer serving as an information presentation device to function as a display control unit that displays, based on the measurement results obtained by measuring multiple measurement items for one or more samples, one or more symbols that represent information based on the measurement results, along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.
  • the measurement results for each sample are properly presented on the screen that displays the sample list.
  • FIG. 2 is a diagram illustrating an example of the functional configuration of the blood coagulation test apparatus according to the first embodiment.
  • FIG. 2 is a diagram illustrating an example of the functional configuration of measurement result information in the first embodiment.
  • FIG. 10 is a diagram showing an example of a measurement result screen in the first embodiment.
  • FIG. 3 is a diagram showing an example of a measurement waveform (clotting waveform) in the first embodiment.
  • FIG. 10 is a diagram showing an example of a measured waveform (initial reaction abnormality) in the first embodiment.
  • FIG. 4 is a diagram showing an example of a measured waveform (differential waveform) in the first embodiment.
  • FIG. 4 is a diagram showing an example of a measured waveform (corrected waveform) in the first embodiment.
  • 10A to 10C are diagrams illustrating examples of abnormalities in the measured waveform (clotting waveform) in the first embodiment.
  • 10A to 10C are diagrams illustrating examples of abnormalities in the measured waveform (clotting waveform) in the first embodiment.
  • 10A to 10C are diagrams illustrating examples of abnormalities in a measured waveform (differential waveform) in the first embodiment.
  • 10A to 10C are diagrams illustrating examples of abnormalities in a measured waveform (differential waveform) in the first embodiment.
  • 10 is a diagram showing an example of a processing procedure executed by the blood coagulation test apparatus in the first embodiment in response to display of a measurement result screen.
  • FIG. FIG. 10 is a diagram showing an example of a simplified waveform in the second embodiment.
  • FIG. 10A and 10B are diagrams showing examples of display modes of a standard waveform and a simplified waveform in the second embodiment.
  • FIG. 10 is a diagram showing an example of the relationship between the shape of a standard waveform and diseases in the first modified example.
  • FIG. 10 is a diagram showing an example of the relationship between the shape of the standard waveform and drug administration in the second modified example.
  • FIG. 11 is a diagram showing the measurement results of a sample by colorimetric analysis in the third modified example.
  • FIG. 2 is a diagram illustrating an example of the hardware configuration of a blood coagulation test apparatus according to each embodiment.
  • the information presentation device, information presentation method, and program of this embodiment will be described below using a blood coagulation testing device as an example.
  • the blood coagulation test device of this embodiment is a device for performing blood coagulation tests. Under normal conditions, blood circulates without clotting within blood vessels and clots outside of blood vessels. On the other hand, in cases such as thrombosis, blood tends to clot within blood vessels, and in cases such as hemophilia, abnormalities occur in which blood tends to clot less even when it is extravascularly.
  • the blood coagulation test apparatus of this embodiment performs measurements on samples to test the degree of abnormality related to blood coagulation for each sample (blood coagulation test).
  • Measurement items in the blood coagulation test of this embodiment include, for example, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fbg), lupus anticoagulant (LA), and diluted Russell's viper venom time (dRVVT).
  • PT prothrombin time
  • APTT activated partial thromboplastin time
  • Fbg fibrinogen
  • LA lupus anticoagulant
  • dRVVT diluted Russell's viper venom time
  • the blood coagulation test device corresponds to the scattered light method, which is an optical detection method.
  • the scattered light method light is irradiated onto a reaction vessel into which a sample and a reagent have been dispensed.
  • a coagulation reaction occurs in the reaction vessel as the sample and the reagent are mixed, and as the coagulation reaction progresses, the turbidity of the mixture increases.
  • the blood coagulation test device measures the change in the amount of scattered light over measurement time.
  • Absorbance spectroscopy is also known as an optical detection method.
  • Absorbance spectroscopy is a detection method in which a change in the amount of transmitted light irradiated onto a reaction vessel into which a sample and a reagent have been dispensed is measured over a measurement period.
  • the blood coagulation test apparatus of this embodiment may be adapted to perform tests using such absorbance spectroscopy.
  • the blood coagulation test apparatus of this embodiment is configured to perform measurements using scattered light spectroscopy.
  • the blood coagulation test apparatus 100 may be configured to include, as hardware, a CPU (Central Processing Unit), ROM (Read Only Memory), RAM (Random Access Memory), and storage devices such as HDDs (Hard Disk Drives) and SSDs (Solid State Drives).
  • the functions of the blood coagulation test apparatus 100 shown in the figure are realized by the CPU included in the blood coagulation test apparatus 100 executing a program.
  • the blood coagulation test apparatus 100 in the figure includes a measurement unit 101 , a control unit 102 , a storage unit 103 , an operation unit 104 , and a display unit 105 .
  • the measurement unit 101 is a part that measures samples corresponding to blood coagulation tests.
  • the measurement unit 101 can store a predetermined number of reaction vessels into which samples have been dispensed.
  • the measurement unit 101 dispenses reagents into the stored reaction vessels and irradiates light from a light source onto the reaction vessels containing the mixture of sample and reagent.
  • the measurement unit 101 measures the amount of scattered light at measurement times (for example, approximately 0.1 seconds) corresponding to each predetermined measurement item.
  • the measurement unit 101 outputs measurement result information related to the measurement results to the control unit 102.
  • the control unit 102 executes various controls in the blood coagulation test apparatus 100 .
  • the control unit 102 controls the measurement operation of the measurement unit 101 .
  • the control unit 102 acquires the measurement result information for each sample output from the measurement unit 101 , and stores the acquired measurement result information in the measurement result information storage unit 131 .
  • the control unit 102 uses the measurement result information for each sample stored in the measurement result information storage unit 131 to cause the display unit 105 to display a measurement result screen that presents the measurement results for each sample.
  • the control unit 102 includes a measurement result acquisition unit 121 and a display control unit 122.
  • the additional item estimation unit 123 corresponds to a modified example, and therefore its description will be omitted here.
  • the measurement result acquisition unit 121 acquires measurement result information indicating the measurement results obtained by measuring a sample using the measurement unit 101.
  • the measurement result information corresponding to a sample includes the measurement values for each measurement item.
  • the measurement result acquisition unit 121 stores the acquired measurement result information in the measurement result information storage unit 131.
  • the display control unit 122 controls the display on the display unit 105.
  • the display control unit 122 uses the measurement result information stored in the measurement result information storage unit 131 to cause the display unit 105 to display a measurement result screen showing the measurement results for each sample.
  • the storage unit 103 stores various types of information corresponding to the blood coagulation test apparatus 100.
  • the storage unit 103 includes a measurement result information storage unit 131.
  • the measurement result information storage unit 131 stores the measurement result information for each sample.
  • the simplified waveform data storage unit 132 corresponds to the second embodiment, and therefore its description will be omitted here. In the first embodiment, the simplified waveform data storage unit 132 may be omitted.
  • the measurement result information in the figure includes fields for the sample ID, measurement date and time, measurement result, and additional information.
  • the sample ID field stores a sample ID that uniquely identifies the corresponding sample.
  • the measurement date and time field stores the date and time (measurement date and time) when the corresponding sample was tested (measured) by the blood coagulation test apparatus 100.
  • the measurement result field stores the measurement results for the corresponding sample.
  • the measurement result field stores the measurement values for each of a plurality of measurement items (1 to n).
  • the incidental information field stores information (incidental information) associated with the measurement of the corresponding sample.
  • the incidental information may include, for example, information regarding the occurrence of an abnormality related to the hardware of the blood coagulation test apparatus 100 (such as an emergency shutdown or a decrease in the light intensity of the light source lamp) or information regarding the occurrence of an error related to the measurement (such as a deviation of the measurement value from the reference range).
  • the operation unit 104 includes various operators and input devices included in the blood coagulation test apparatus 100.
  • the operation unit 104 may also include an input device connected to the blood coagulation test apparatus 100.
  • the operation unit 104 outputs operation signals corresponding to operations performed on the various operators and input devices to the control unit 102.
  • the control unit 102 executes processing corresponding to the input operation signals.
  • the display unit 105 displays images according to the control of the control unit 102.
  • the blood coagulation test apparatus 100 of this embodiment can display a measurement result screen on the display unit 105 using the measurement result information for each sample stored in the measurement result information storage unit 131 ( FIG. 2 ).
  • sample unit areas AR1 corresponding to each measured sample are arranged vertically.
  • a specimen area and areas for a plurality of measurement items are arranged in the horizontal direction.
  • a sample ID that uniquely identifies the corresponding sample is displayed.
  • Each measurement item area shows the measurement results for the corresponding measurement item. Specifically, in one measurement item area, a measurement value area AR11, a waveform area AR12, and a flag area AR14 are arranged.
  • the measurement value area AR11 shows the measurement value of the corresponding measurement item.
  • the measurement values shown in the measurement value area AR11 include the coagulation time.
  • the waveform area AR12 is an area where a waveform (measured waveform) based on the measurement results of the corresponding measurement item is displayed.
  • the waveform in the waveform area AR12 may be a waveform obtained based on measurements obtained by measuring the amount of scattered light over a measurement time (e.g., every 0.1 seconds) in a coordinate space with time on the horizontal axis and the amount of scattered light on the vertical axis.
  • the figure shows an example in which a clot waveform is displayed as the measured waveform in the waveform area AR12.
  • the flag area AR14 is an area where an analysis flag is displayed.
  • the analysis flag indicates the analysis result of the measurement result.
  • the analysis flag may include information estimated regarding the condition of the sample or drug administration based on the analysis of the measurement result, such as the analysis of the waveform shown in the waveform area AR12.
  • One of the sample conditions indicated by the analysis flags is a deficiency of coagulation factor VIII.
  • Coagulation factor VIII is known as the deficient factor in hemophilia A, a bleeding disorder, and a deficiency of coagulation factor VIII results in a significant bleeding tendency.
  • the "GES (GEntle Slope)" shown in flag area AR14 of Figure 3 suggests a deficiency of coagulation factor VIII as a sample condition.
  • Another sample condition is a thrombotic disorder.
  • the anticoagulant argatroban is sometimes administered to treat a thrombotic disorder.
  • the "NSM (Non-SigMoid)" shown in flag area AR14 of Figure 3 suggests that argatroban is being administered to a patient with a thrombotic disorder.
  • multiple analysis results are obtained for a corresponding measurement item, multiple analysis flags corresponding to the respective analysis results may be displayed in flag area AR14.
  • the analysis flag may be, for example, a character string that simplifies the corresponding information (such as an abbreviation or contraction), or it may be a symbol (mark or indication) that indicates the corresponding information.
  • the figure shows an example in which the analysis flag is displayed as a character string.
  • Measurement waveform The measurement waveform (an example of a symbol) displayed in the waveform area AR12 of the measurement result screen will be described with reference to FIGS.
  • the clot waveform in the figure is a waveform represented by a line (an example of a first line) formed as a locus obtained by plotting measured values obtained by measuring the amount of scattered light of light irradiated onto a sample at measurement time intervals (e.g., approximately 0.1 seconds) over time.
  • the clot waveform may be a waveform represented by a line (an example of a first line) formed as a locus of plotting the measured value (vertical axis) for each measurement point (horizontal axis).
  • i may be 1, 2, 3, ... (increasing by 1) or i may be 5, 10, 15, ... (increasing by 5), and the increment may be set arbitrarily.
  • a line L1 is shown which corresponds to the case where the specimen is normal
  • lines L2 and L3 are shown which correspond to the case where the specimen is not normal.
  • the clot waveform exhibits a sigmoid shape like line L1.
  • the sample is abnormal or the initial reaction is abnormal
  • the waveform exhibits a different shape from line L1.
  • Lines L2 and L3 in the figure indicate abnormal conditions in which the clotting time is delayed compared to line L1.
  • the clotting time is the time it takes for a sample to clot due to the clotting reaction.
  • the clotting time may be measured, for example, as the time it takes for the amount of scattered light to reach a predetermined ratio relative to the amount of scattered light determined as the end point of clotting.
  • Figure 5 shows an example of a clot waveform that focuses on early reaction abnormalities.
  • line L31 does not indicate an early reaction abnormality
  • lines L32 and L33 indicate an early reaction abnormality.
  • the measurement waveform displayed in the waveform area AR12 may be a waveform (differentiated waveform: an example of a third line figure) based on a line (an example of a third line) representing a differentiated value of the coagulation waveform as shown in Figure 6.
  • 6 shows an example of a differential waveform as a measured waveform.
  • the differential waveform in this figure is a waveform obtained by first-order differentiation of the clot waveform.
  • the order of differentiation of the differential waveform as a measured waveform is not particularly limited, and the differential waveform may be obtained by second-order or third-order differentiation of the clot waveform.
  • the measurement waveform displayed in the waveform area AR12 may be a waveform (corrected waveform: an example of a fourth line figure) based on a line (an example of a fourth line) that has been corrected to normalize so that the minimum and maximum values of the scattered light intensity (an example of a matching criterion) corresponding to the vertical axis of the coagulation waveform as shown in Figure 4 are equal (match).
  • 7 shows an example of a corrected waveform as a measured waveform.
  • lines L21, L22, and L23 are shown as corrected waveforms. Lines L21, L22, and L23 are corrected waveforms obtained by correcting lines L1, L2, and L3 of the coagulation waveform in FIG. 4, respectively.
  • the form of the corrected waveform is not limited to the normalized waveform shown in FIG. 7, in which the maximum values of the scattered light amounts corresponding to the vertical axis of the coagulation waveform are equal.
  • the clot waveforms may be corrected to align the rising edge times (an example of a matching criterion).
  • normalization may be performed to align the maximum values of the scattered light intensity corresponding to the vertical axis of the clot waveform, as shown in Figure 7.
  • the time when the amount of scattered light reaches a predetermined height may be used as a reference point, and the clot waveform may be corrected to align on the time axis so that this reference point coincides.
  • the "predetermined height" may be, for example, the amount of scattered light at the end point of coagulation, or half the amount of scattered light at the end point of coagulation.
  • normalization may also be performed by equating the maximum values of the amount of scattered light corresponding to the vertical axis of the clot waveform, as shown in Figure 7.
  • the measured waveform's shape characteristics can be used as a reference for estimating the nature and degree of abnormality in the sample.
  • the measurement result may show that the clotting time is normal, but based on the shape of the measured waveform, findings and analysis results may indicate an abnormality.
  • the shape of the measured waveform reflects whether the specimen is normal or abnormal.
  • Figure 8(A) shows a clot waveform corresponding to a normal sample.
  • the clot waveform in Figure 8(B) shows an abnormal state in which the clotting time is normal but the initial reaction is large in the area surrounded by the characteristic indicator frame FL.
  • the clot waveform in Figure 8(C) shows an abnormal state in which the clotting time is normal but the waveform rises earlier than normal after the start of measurement, as shown in the area surrounded by the characteristic indicator frame FL.
  • Figures 9(A), 9(B), and 9(C) each show examples of clot waveforms where the clotting time is abnormal.
  • the clot waveform in Figure 9(A) has a sigmoid shape, but the rise time is slow.
  • Figure 9(B) shows an example where the rise time of the waveform is slow and the sigmoid shape is not obtained.
  • Figure 9(C) shows an example where the clotting reaction is still in progress at the time when the end point of clotting would normally be reached.
  • FIG. 10A shows an example of a differential waveform corresponding to a normal specimen for comparison.
  • Figure 10(B) shows an example where an abnormality is indicated by two peaks (bimodal) in the differentiated waveform.
  • a normal differentiated waveform has a single peak, as shown in Figure 10(A).
  • FIG. 10C shows an example in which an abnormality is indicated by a small peak appearing before the main waveform peak, as shown in the area surrounded by the feature indicating frame FL.
  • FIG. 11A), 11(B), and 11(C) show examples of differential waveforms corresponding to abnormalities in clotting time.
  • FIG. 11A shows an example in which the differential waveform itself is close to normal, but the rise time is slower than normal, indicating an abnormality.
  • FIG. 11(B) is an example in which an abnormality is indicated by a delayed rise in the differentiated waveform and a gentler slope of the waveform after the peak, as shown in the area surrounded by the feature indication frame FL.
  • FIG. 11C shows an example in which an abnormality is indicated by the peak of the differential waveform being not steep and being highly flat, as shown in the area surrounded by the feature indicating frame FL.
  • each measurement item area on the measurement result screen displays a measurement value area AR11 showing the measurement value and a waveform area AR12 showing the measurement waveform.
  • the user can check the numerical measurement values and measurement waveforms on the measurement result screen, which is a list of the measurement results for the sample. That is, in this embodiment, the measurement results for each sample are appropriately presented on the measurement result screen. Therefore, the user can accurately understand the measurement results from the numerical values and waveforms, without having to perform an operation such as switching to a screen presenting more detailed information.
  • the user can determine with a certain degree of confidence whether the sample is normal or abnormal and estimate the cause of the abnormality, simply by looking at the measurement result screen as a list of the measurement results, without having to perform an operation to switch to a screen that presents detailed information about the measurement results.
  • the measurement result screen simultaneously displays, for each measurement item, measurement values that are expressed as specific numerical values and measurement waveforms that allow the user to intuitively grasp the measurement results. This type of display increases the likelihood that the user will be able to quickly recognize the degree, severity, urgency, etc. of any abnormality. In addition, for example, there may be cases where the measured values are within the normal range but the measured waveform indicates an abnormality.
  • the user is more likely to notice the abnormality by checking not only the measured values but also the measured waveform on the same screen. If the user notices an abnormality on the measurement result screen, the user can check the measurement waveform in more detail as necessary, or request a retest of the sample.
  • the measurement waveforms displayed in the waveform area AR12 for each measurement item on the measurement result screen include, as types, a clot waveform, a differential waveform, and a corrected waveform.
  • the measurement waveform displayed in the waveform area AR12 may be any of a clot waveform, a differential waveform, and a corrected waveform.
  • the type of measurement waveform to be displayed in the waveform area AR12 may be selectable, for example, in response to a user operation. For example, the user may be able to set the measurement waveform to be displayed in the waveform area AR12 by default when the measurement result screen is initially displayed.
  • the measurement waveform displayed in the waveform area AR12 may be switchable in response to a user operation.
  • the measurement waveform may be switchable uniformly for all waveform areas AR12 on the measurement result screen.
  • the measurement waveform may be switchable on a specimen-by-specimen basis (in specimen unit area AR1 units).
  • the measurement waveform may be switchable on a measurement item-by-measurement item basis for all specimens.
  • the measurement waveform may be switchable for a measurement item of a specified specimen in response to a user operation.
  • a feature indication frame FL (an example of a feature indication section) indicating a characteristic portion in some of the measurement waveforms in Figures 8 to 11 may be displayed as appropriate by being added to the measurement waveform in the waveform area AR12 on the measurement result screen.
  • the feature indication frame FL may be configured to be switchable between display and non-display in response to a predetermined operation by the user.
  • the aspect of the characteristic indication frame FL may change depending on the level of the characteristic of the response, such as, for example, an initial reaction, etc.
  • the frame portions of the characteristic indication frame FL may change so that multiple frames are displayed overlapping each other, the color or thickness of the frame portions may change, or the color inside the frame portions may change.
  • one measurement waveform is displayed in the waveform area AR12 corresponding to one measurement item.
  • multiple measurement waveforms of different types e.g., coagulation waveform, differential waveform, corrected waveform
  • the number of types of measurement waveforms displayed in the waveform area AR12 may be changeable in response to a user operation.
  • the measurement waveform displayed in the operated waveform area AR12 may be enlarged.
  • the coordinate scale values may be omitted for the measurement waveform in waveform area AR12, and the coordinate scale values may be displayed for the enlarged measurement waveform.
  • the feature indication frame FL may be maintained in the enlarged measurement waveform as well.
  • multiple types of measured waveforms may be displayed depending on the enlargement.
  • Step S100 In the blood coagulation test apparatus 100, the display control unit 122 accepts the generation of a display trigger that instructs the display of a measurement result screen.
  • the display trigger may be generated, for example, in response to a user operation instructing the display of a measurement result screen.
  • the display trigger may also be generated in response to the measurement unit 101 completing measurement of a predetermined group of samples.
  • Step S102 The display control unit 122 selects one sample (target sample) from the samples displayed on the measurement result screen to be used for generating a standard waveform.
  • Step S104 The display control unit 122 acquires the measurement result information associated with the sample ID of the target sample selected in step S102 from the measurement result information storage unit 131.
  • Step S106 The display control unit 122 generates a measurement waveform to be displayed in the waveform area AR12 using the measurement result information acquired in step S104. Specifically, in correspondence with Fig. 3, the display control unit 122 may generate a coagulation waveform as the measurement waveform. In addition, in step S106, the display control unit 122 may generate a coagulation waveform, a differential waveform, and a corrected waveform as the measurement waveforms. The generated measurement waveform may be associated with the specimen and the measurement item and stored in the storage unit 103. By storing the measurement waveform in this way, when displaying the measurement result screen from the second time onwards, it is only necessary to acquire the stored measurement waveform in step S106, and it is not necessary to generate a measurement waveform.
  • Step S108 The display control unit 122 determines whether measurement waveform generation has been completed for all samples currently being displayed on the measurement result screen. If there are still samples for which measurement waveform generation has not been completed, processing returns to step S102, and measurement waveform generation is performed for the next sample.
  • Step S110 When measurement waveform generation for all samples is completed in step S108, the display control unit 122 generates a measurement result screen and displays the generated measurement result screen.
  • the display control unit 122 displays an enlarged image of the target measurement waveform.
  • the display control unit 122 may display the enlarged image of the measurement waveform, for example, as a pop-up window superimposed on the measurement result screen.
  • the display control unit 122 controls so that the measured waveform of the new type is displayed.
  • the display control unit 122 may generate the differential waveform or corrected waveform from the coagulation waveform and switch to displaying the generated differential waveform or corrected waveform.
  • the display control unit 122 may generate a coagulation waveform, then generate a differential waveform and a correction waveform from the coagulation waveform, and display the generated coagulation waveform, differential waveform, and correction waveform.
  • the line diagram as the measured waveform displayed in the waveform area AR12 was a clot waveform formed by plotting measured values on a coordinate system, a differentiated waveform of the clot waveform, or a corrected waveform obtained by correcting the amount of scattered light from the clot waveform.
  • the line diagram as the measured waveform displayed in the waveform area AR12 was a waveform (standard waveform) that faithfully reflected the measured values.
  • a line diagram (simplified waveform: an example of a third line diagram) is displayed using a line (an example of a second line) that is a simplified version of the standard waveform.
  • simplification of the standard waveform may be, for example, processing that emphasizes and represents parts of the standard waveform that are considered to be characteristic and attract attention, and simplifies or omits parts that attract less attention.
  • FIGS. 13(A) to 13(H) show examples of simplified waveforms displayed in the waveform area AR12 of this embodiment.
  • the simplified waveforms shown in FIG. 13(A) to 13(H) each show a shape pattern corresponding to a standard waveform indicating a certain abnormal state.
  • Figures 13(A) and 13(B) are simplified waveforms obtained by simplifying the shapes of different clot waveforms.
  • Figure 13(A) is a simplified version of a non-sigmoid clot waveform.
  • Figure 13(B) is a simplified version of a clot waveform with a gentler slope than normal due to an extended clotting time.
  • the simplified waveform in FIG. 13C is a simplified derivative waveform having a rise that is steeper than normal.
  • the simplified waveform in FIG. 13(D) is a simplified derivative waveform having a peak width wider than normal.
  • the simplified waveform of FIG. 13(E) is a simplified version of a differential waveform having a bimodal shape.
  • the simplified waveform in FIG. 13(F) is a simplified derivative waveform that is symmetrical about the peak timing.
  • the simplified waveform of FIG. 13(G) is a simplified derivative waveform in which the width after the peak is wider than before the peak.
  • the simplified waveform of FIG. 13(H) is a simplified derivative waveform in which the width after the peak is wider than the width before the peak as compared with FIG. 13(G).
  • the standard waveform is highly reliable in that it faithfully reflects the measured value.
  • the waveform area AR12 does not occupy much space on the measurement result screen. For this reason, if the standard waveform is displayed in the waveform area AR12, it may be difficult for the user to grasp, for example, the characteristics corresponding to an abnormality. Therefore, as in this embodiment, if a simplified waveform is displayed in the waveform area AR12 so as to represent the characteristic portions, the user can easily grasp the characteristics of the measured waveform.
  • the blood coagulation test apparatus 100 of this embodiment may be provided with a simple waveform data storage unit 132 (FIG. 1) to display the simple waveform in the waveform area AR12.
  • the simplified waveform data storage unit 132 stores simplified waveforms corresponding to each typical pattern of possible standard waveform shapes.
  • the simplified waveform data storage unit 132 may store multiple simplified waveform data corresponding to one typical pattern. In this case, the multiple simplified waveform data may be simplified so as to represent each of multiple characteristic parts indicated by the corresponding typical pattern.
  • the display control unit 122 of the blood coagulation test apparatus 100 generates a corresponding standard waveform when displaying a simplified waveform in the waveform area AR12 of the measurement result screen.
  • the display control unit 122 acquires corresponding measurement values from the measurement result information storage unit 131 and generates a clot waveform by plotting the acquired measurement values on a coordinate system.
  • the display control unit 122 determines the typical pattern of the generated clot waveform.
  • the display control unit 122 acquires simple waveform data associated with the determined typical pattern from the simple waveform data storage unit 132.
  • the display control unit 122 displays a line diagram as a simplified waveform drawn based on the acquired simple waveform data in the corresponding waveform area AR12.
  • the display control unit 122 when displaying a simplified waveform based on a differentiated waveform or a corrected waveform in the waveform area AR12, the display control unit 122 generates a differentiated waveform or a corrected waveform from the clot waveform generated as described above, and determines a typical pattern of the generated differentiated waveform or corrected waveform.
  • the display control unit 122 acquires simplified waveform data associated with the determined typical pattern from the simplified waveform data storage unit 132, and displays a line figure as a simplified waveform drawn based on the acquired simplified waveform data in the corresponding waveform area AR12.
  • the display control unit 122 may perform pattern matching to determine the typical pattern of the generated standard waveforms (clotting waveform, differential waveform, corrected waveform).
  • the display control unit 122 may use a trained model that has been trained to estimate a typical pattern in response to an input of the shape of the standard waveform.
  • the simplified waveforms PW may be arranged in the waveform area AR12 so as to be superimposed on the standard waveform, as illustrated in Figure 14.
  • the standard waveform is a differentiated waveform, and has two characteristics: it is bimodal and the width after the peak is wider than before the peak.
  • an example is given showing two simplified waveforms: a simplified waveform PW-1 that shows bimodal characteristics and a simplified waveform PW-2 that has a wider width after the peak than before.
  • the two simplified waveforms PW-1 and PW-2 are obtained by dividing a single original differential waveform into two line components for each of the two features, based on the two features that the original differential waveform has.
  • this method of dividing and presenting (displaying) a waveform according to multiple shape characteristics is not limited to simple waveforms, and may also be performed on standard waveforms, for example.
  • the corresponding standard waveform may be enlarged and displayed instead of the simplified waveform.
  • a simplified waveform a simplified waveform divided into multiple parts may be displayed
  • a standard waveform is displayed in the waveform area AR12, and an operation to enlarge the waveform area AR12 is performed
  • one or more simplified waveforms PW may be displayed together with the enlarged standard waveform, as in the manner shown in Figure 14.
  • a simplified waveform (which may be divided into multiple parts) is displayed in the waveform area AR12 and an operation to enlarge the waveform area AR12 is performed
  • an explanation of the simplified waveform may be displayed.
  • the explanation of the simplified waveform may be, for example, an explanation of the characteristic parts of the simplified waveform, an explanation of whether or not there is an abnormality, and if there is an abnormality, a specific explanation of the abnormality.
  • the display of two or more predetermined waveforms from among the simplified waveform and the standard waveform (clotting waveform, differential waveform, corrected waveform) may be switchable in response to an operation.
  • analysis flag may be displayed in response to a specified operation being performed on the flag area AR14.
  • the display unit 105 may be capable of displaying a search screen presenting a list of simple waveforms stored in advance in the simple waveform data storage unit 132.
  • the list of simple waveforms on the search screen may be, for example, a list of simple waveforms arranged side by side, such as those shown in Figures 13(A) to 13(H).
  • each simple waveform arranged on the search screen may be accompanied by a comment explaining the characteristics of the waveform. The user can select at least one of the simplified waveforms arranged on the search screen and perform an operation to instruct execution of a search (search instruction operation).
  • a search result screen may be displayed on the display unit 105, which presents a list of samples having standard waveforms corresponding to the same simplified waveform selected on the search screen as search results.
  • the measurement results may be presented in a predetermined format, for example, together with the sample ID.
  • the measurement results may include a measured value including the clotting time and a standard waveform.
  • the measurement results may include the clotting time, the standard waveform, and a simplified waveform.
  • the measurement results may include the standard waveform and the simplified waveform.
  • the measurement results may include the standard waveform without the simplified waveform.
  • the blood coagulation test apparatus 100 of this modified example may include an additional item estimation unit 123 ( FIG. 1 ) that estimates additional items related to the medical treatment of the sample in the control unit 102.
  • the additional item estimation unit 123 of this modified example estimates a disease of the sample as an additional item related to the medical treatment of the sample.
  • 15A and 15B show examples of the relationship between the shape of the standard waveform and diseases, in which Fig. 15A shows a clot waveform corresponding to a normal state and a differential waveform for comparison. 15(B) shows the clot waveform and differential waveform corresponding to hemophilia A (factor VIII deficiency).
  • hemophilia A factor VIII deficiency
  • the clot waveform has a slower rise time and a gentler slope than normal.
  • the differential waveform is highly flat and bimodal, but there is no significant difference in height between the primary peak (the earlier of the two peaks) and the secondary peak (the later of the two peaks).
  • 15(C) shows the clot waveform and differential waveform corresponding to hemophilia B (factor IX deficiency).
  • hemophilia B factor IX deficiency
  • the clot waveform has a slower rise time and a gentler slope than normal.
  • the differential waveform has a highly flattened shape with a bimodal shape in which the secondary peak is significantly higher than the primary peak.
  • 15(D) shows the clot waveform and differential waveform corresponding to LA.
  • the clot waveform has a shape that rises slower than normal.
  • the differential waveform has a high degree of flatness and a gentle shape near the peak, as shown by the characteristic indication frame FL.
  • Figure 15(E) shows the clot waveform and differential waveform corresponding to factor II deficiency.
  • the clot waveform rises slightly slower than normal and has a slightly gentler shape than normal.
  • the differential waveform has a long tail after the peak, as shown by the characteristic indicator frame FL.
  • the additional item estimation unit 123 can estimate the disease of the specimen based on the shape of the measurement waveform that is characteristic of the disease as described above.
  • the additional item estimation unit 123 may, for example, categorize (classify) the shape of the measurement waveform and identify the disease corresponding to the categorized measurement waveform.
  • the blood coagulation test apparatus 100 may store disease waveform correspondence data in which a type pattern of the shape of the measured waveform is associated with each disease in the storage unit 103.
  • the additional item estimation unit 123 may identify the disease associated with the identified type of the measured waveform from the disease waveform correspondence data.
  • the additional item estimation unit 123 may estimate the disease corresponding to the shape of the measured waveform, for example, by using a trained model that has been trained to estimate the corresponding disease in response to an input of the measured waveform.
  • the display control unit 122 may display information about the estimated disease on the measurement result screen. There are no particular limitations on the location where the information about the disease is displayed on the measurement result screen, but as an example, it may be displayed in the flag area AR14 as an element of the analysis flag. In this case, since the flag area AR14 is provided corresponding to each measurement item, the measurement result screen can display each estimated disease individually according to the measurement results for each measurement item.
  • the additional item estimation unit 123 of this modified example may estimate drug administration as an additional item related to the medical treatment of the specimen.
  • 16A and 16B show examples of the relationship between the shape of the standard waveform and drug administration, with Fig. 16A showing a normal clot waveform and a differential waveform for comparison.
  • 16(B) shows the clot waveform and the differential waveform corresponding to the administration of DOAC (direct oral anticoagulant).
  • DOAC direct oral anticoagulant
  • the clot waveform has a delayed onset compared to normal.
  • the differential waveform has a shape in which the onset of the waveform is delayed but the angle after the onset is steep.
  • 16(C) shows the clot waveform and differential waveform corresponding to heparin administration.
  • the clot waveform has a slow rise time, a gradual rise, and a gradual curve as it reaches its maximum value.
  • the differential waveform has a highly symmetrical shape around the peak, as shown by the characteristic indicator frame FL.
  • 16(D) shows the clot waveform and differential waveform corresponding to the administration of argatroban.
  • argatroban is administered, the clot waveform becomes non-sigmoidal.
  • the differential waveform has a small peak level and gradually decays after the peak.
  • drug administration that can be estimated from the measured waveforms (clotting waveform, differential waveform) is not limited to the examples shown in Figures 16(B), 16(C), and 16(D) above, and includes, for example, emicizumab.
  • the additional item estimation unit 123 can estimate the drug administration for the sample based on the shape of the measurement waveform that is characteristic of drug administration. Specifically, the additional item estimation unit 123 can estimate the presence (necessity) of drug administration to the patient corresponding to the sample and the concentration of the administered drug, as the estimation related to drug administration based on the sample, and the estimation result can be used to consider appropriate drug administration for treatment. In this modified example, the additional item estimation unit 123 may also be configured to categorize (classify) the shape of the measured waveform, as in the first modified example, and identify the drug administration corresponding to the categorized measured waveform.
  • the blood coagulation test apparatus 100 may store drug administration waveform correspondence data in the storage unit 103, which associates a typical pattern of the shape of the measured waveform with each drug administration content.
  • the additional item estimation unit 123 may identify the drug administration associated with the identified type of measured waveform from the drug administration waveform correspondence data. Furthermore, the additional item estimation unit 123 may estimate the drug administration corresponding to the shape of the measured waveform, for example, by using a trained model that has been trained to estimate the corresponding drug administration in response to an input of the measured waveform.
  • the additional item estimation unit 123 may also estimate treatment methods other than drug administration based on the shape of the measured waveform, or other necessary test items, as additional items.
  • the display control unit 122 may display information such as the estimated treatment method or test items on the measurement result screen, or may display it in a pop-up window or the like in response to an operation on the measurement result screen.
  • the display configuration of the measurement result screen described above may also be applied to tests other than blood coagulation tests.
  • Tests other than blood coagulation tests are not particularly limited, but one example is colorimetric analysis (absorbance analysis).
  • Figure 17 shows the measurement results of a sample by colorimetric analysis.
  • Curves L41 and L42 in the figure were formed by plotting the measured values of absorbance (vertical axis) for each photometric point (horizontal axis).
  • Curve L41 corresponds to the prozone state
  • curve L42 corresponds to the nonspecific agglutination state.
  • the curve shown in Figure 17 may be displayed for each specimen unit area on the colorimetric analysis measurement result screen. Also, in this modified example, as in the second embodiment, a simplified curve that is a simplification of the curve shown in Figure 17 may be displayed.
  • the blood coagulation testing device 100 may be configured to function by distributing the functions among multiple devices, each of which is given a specific function, and then connecting them to each other so that they can communicate with each other and work together to execute processing.
  • the blood coagulation test apparatus 100 in the figure includes a measurement unit 1001, a user interface 1003, a communication device 1004, a ROM 1005, a RAM 1006, a storage 1007, a CPU 1008, and a GPU 1009.
  • the measurement unit 1001 , user interface 1003 , communication device 1004 , ROM 1005 , RAM 1006 , storage 1007 , CPU 1008 , and GPU 1009 are connected by a bus 1010 .
  • the measuring unit 1001 is a portion where the sample is measured, and corresponds to the measuring unit 101 in FIG.
  • the user interface 1003 includes hardware corresponding to the user interface.
  • the user interface 1003 may include an input device (keys, buttons, a touch panel, a mouse, a keyboard, etc.) that is provided in the blood coagulation test apparatus 100 or connected to the blood coagulation test apparatus 100.
  • the user interface 1003 may also include a display device, an audio output device, etc. that is provided in the blood coagulation test apparatus 100 or connected to the blood coagulation test apparatus 100.
  • the communication device 1004 is a device that supports communication via a network.
  • the ROM 1005 stores non-rewritable data.
  • the RAM 1006 temporarily stores data used in the calculations executed by the CPU 1008 and the GPU 1009 .
  • the storage 1007 is, for example, a hard disk drive (HDD) or a solid state drive (SSD), and stores various types of data, such as program data.
  • the CPU 1008 executes programs stored in the storage 1007 to perform calculations according to various controls and processes.
  • the GPU 1009 executes processes related to image processing. Note that functions equivalent to those of the blood coagulation test apparatus 100 may be obtained by a plurality of network-compatible devices that are distributed so as to be able to execute predetermined processes on a network.
  • a program for realizing the functions of the above-mentioned blood coagulation test apparatus 100 may be recorded on a computer-readable recording medium, and the program recorded on this recording medium may be loaded into a computer system and executed to perform the processing of the above-mentioned blood coagulation test apparatus 100.
  • "loading a program recorded on a recording medium into a computer system and executing it” includes installing the program on a computer system.
  • the term “computer system” here includes hardware such as an OS and peripheral devices.
  • the term “computer system” may also include multiple computer devices connected via a network, including communication lines such as the Internet, WAN, LAN, and dedicated lines.
  • a recording medium storing a program may be a non-transitory recording medium such as a CD-ROM.
  • the recording medium may also include internal or external recording media accessible from a distribution server to distribute the program.
  • the program code stored on the distribution server's recording medium may be different from the program code in a format executable by a terminal device. In other words, the format in which the program is stored on the distribution server does not matter as long as it can be downloaded from the distribution server and installed in a form that is executable on a terminal device.
  • the program may be divided into multiple parts, each downloaded at a different time and then combined on the terminal device, or each part may be distributed by a different distribution server.
  • the term "computer-readable recording medium” also includes a storage medium that stores a program for a certain period of time, such as volatile memory (RAM) within a computer system that acts as a server or client when a program is transmitted over a network.
  • the program may also be a program that realizes some of the functions described above.
  • the program may be a so-called differential file (differential program) that can realize the functions described above in combination with a program already stored on the computer system.
  • One aspect of this embodiment is an information presentation device that includes a display control unit that displays, based on measurement results obtained by measuring multiple measurement items for one or more samples, one or more representations that represent information based on the measurement results, along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.
  • One aspect of this embodiment is the information presentation device described in (1), in which the representation may be a character string or a symbol as a sign that simplifies and displays information based on the measurement results of the corresponding measurement item.
  • One aspect of this embodiment is the information presentation device described in (1), in which the representation may be a linear figure showing a line formed based on the correspondence measurement results.
  • One aspect of this embodiment is the information presentation device described in (3), wherein the representation may be a first linear figure showing a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (4), wherein the representation may be a second linear figure showing a second line that is a simplified version of a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (5), wherein the representation may be a third line figure that indicates a third line differentiated with respect to a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to predetermined parameters.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (6), wherein the representation may be a fourth line figure showing a fourth line corrected for a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to predetermined parameters.
  • One aspect of this embodiment is the information presentation device described in (1), wherein the display control unit may simultaneously display, as a representation corresponding to one measurement item, a line figure showing a line formed based on the corresponding measurement result, and a character string or symbol as a sign that simplifies information based on the measurement value of the corresponding measurement item.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (8), wherein the display control unit may add and display a feature indication section that indicates a portion of the line shape that has a characteristic feature.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (9), wherein the display control unit may divide a line represented by one of the line figures into multiple line components based on the characteristics of the line, and display a line figure for each of the divided line components.
  • One aspect of this embodiment is the information presentation device described in (3), wherein the measurement results are obtained by measuring the blood clotting time, and the line diagram may be a clotting waveform.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (11), wherein the display control unit may enlarge and display the linear graphic representation in response to an operation.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (12), wherein the display control unit may switch between displaying two or more predetermined linear figures in response to an operation: a first linear figure showing a first line formed by plotting measurement values indicated by corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters; a third linear figure showing a third line obtained by differentiating the first line; a fourth linear figure showing a fourth line obtained by correcting the first line; and a second linear figure showing a second line obtained by simplifying the first line.
  • One aspect of this embodiment is the information presentation device described in any one of (3) to (13), which may further include an additional item estimation unit that estimates predetermined items related to the medical treatment of the subject based on the linear representation of the representation.
  • One aspect of this embodiment is an information presentation method for an information presentation device, which includes a display control unit that, based on measurement results obtained by measuring multiple measurement items for one or more samples, displays, for each sample, measurement values indicating the measurement results for each of the multiple measurement items, as well as one or more symbols representing information based on the measurement results.
  • One aspect of this embodiment is a program that causes a computer serving as an information presentation device to function as a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays one or more symbols representing information based on the measurement results, along with measurement values indicating the measurement results for each of the multiple measurement items, corresponding to each sample.

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Abstract

This information presentation device is constituted by including a display control unit that, on the basis of measurement results obtained by measuring a plurality of measurement items for each of one or more specimens, displays one or more representational bodies in association with each specimen that represent information based on the measurement results, together with a measurement value indicating a measurement result for each of the plurality of measurement items.

Description

情報提示装置、情報提示方法、およびプログラムInformation presentation device, information presentation method, and program

 本発明は、情報提示装置、情報提示方法、およびプログラムに関する。
 本願は、2024年3月19日に日本に出願された特願2024-044009号について優先権を主張し、その内容をここに援用する。
The present invention relates to an information presentation device, an information presentation method, and a program.
This application claims priority from Japanese Patent Application No. 2024-044009, filed on March 19, 2024, the contents of which are incorporated herein by reference.

 検体一覧表示領域と測定結果表示領域とが配置される画面に対して、検体一覧表示領域から1つのリスト項目を選択する操作が行われたことに応じて、選択されたリスト項目に対応する検体に対応する測定結果を測定結果表示領域に表示する技術が知られている(例えば、特許文献1参照)。 A technology is known in which, on a screen that has a sample list display area and a measurement result display area, when an operation is performed to select one list item from the sample list display area, the measurement results corresponding to the sample corresponding to the selected list item are displayed in the measurement result display area (see, for example, Patent Document 1).

特開2020-56623号公報Japanese Patent Application Laid-Open No. 2020-56623

 特許文献1に記載の技術では、検体一覧表示にてリスト項目として提示されている検体に対応する測定結果を提示するにあたり、対象の検体に対応するリスト項目を選択する操作を行う必要がある。このような操作の手間を省くことを考慮すると、画面において検体一覧が提示される段階で測定結果に関する情報も適切に提示されるようにすることが好ましい。 In the technology described in Patent Document 1, when presenting measurement results corresponding to samples displayed as list items in a sample list display, it is necessary to perform an operation to select the list item corresponding to the target sample. Considering the need to eliminate the need for such an operation, it is preferable to also appropriately present information about the measurement results at the stage when the sample list is displayed on the screen.

 本発明は、検体一覧が提示される画面において、検体ごとの測定結果が適切に提示されるようにすることを目的とする。 The present invention aims to ensure that the measurement results for each sample are properly displayed on the screen that displays the sample list.

 上述した課題を解決する本発明の一態様は、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部を備える情報提示装置である。 One aspect of the present invention that solves the above-mentioned problems is an information presentation device that includes a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays, corresponding to each sample, measured values that indicate the measurement results for each of the multiple measurement items, as well as one or more symbols that represent information based on the measurement results.

 本発明の一態様は、情報提示装置における情報提示方法であって、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部を含む情報提示方法である。 One aspect of the present invention is an information presentation method for an information presentation device, which includes a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays, corresponding to each sample, measured values indicating the measurement results for each of the multiple measurement items, as well as one or more symbols representing information based on the measurement results.

 本発明の一態様は、情報提示装置としてのコンピュータを、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部として機能させるためのプログラムである。 One aspect of the present invention is a program that causes a computer serving as an information presentation device to function as a display control unit that displays, based on the measurement results obtained by measuring multiple measurement items for one or more samples, one or more symbols that represent information based on the measurement results, along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.

 本発明によれば、検体一覧が提示される画面において、検体ごとの測定結果が適切に提示されるようになる。 According to the present invention, the measurement results for each sample are properly presented on the screen that displays the sample list.

第1実施形態における血液凝固検査装置の機能構成例を示す図である。FIG. 2 is a diagram illustrating an example of the functional configuration of the blood coagulation test apparatus according to the first embodiment. 第1実施形態における測定結果情報の機能構成例を示す図である。FIG. 2 is a diagram illustrating an example of the functional configuration of measurement result information in the first embodiment. 第1実施形態における測定結果画面の一例を示す図である。FIG. 10 is a diagram showing an example of a measurement result screen in the first embodiment. 第1実施形態における測定波形(凝固波形)の例を示す図である。FIG. 3 is a diagram showing an example of a measurement waveform (clotting waveform) in the first embodiment. 第1実施形態における測定波形(初期反応異常)の例を示す図である。FIG. 10 is a diagram showing an example of a measured waveform (initial reaction abnormality) in the first embodiment. 第1実施形態における測定波形(微分波形)の例を示す図である。FIG. 4 is a diagram showing an example of a measured waveform (differential waveform) in the first embodiment. 第1実施形態における測定波形(補正波形)の例を示す図である。FIG. 4 is a diagram showing an example of a measured waveform (corrected waveform) in the first embodiment. 第1実施形態における測定波形(凝固波形)を対象に異常の事例を説明する図である。10A to 10C are diagrams illustrating examples of abnormalities in the measured waveform (clotting waveform) in the first embodiment. 第1実施形態における測定波形(凝固波形)を対象に異常の事例を説明する図である。10A to 10C are diagrams illustrating examples of abnormalities in the measured waveform (clotting waveform) in the first embodiment. 第1実施形態における測定波形(微分波形)を対象に異常の事例を説明する図である。10A to 10C are diagrams illustrating examples of abnormalities in a measured waveform (differential waveform) in the first embodiment. 第1実施形態における測定波形(微分波形)を対象に異常の事例を説明する図である。10A to 10C are diagrams illustrating examples of abnormalities in a measured waveform (differential waveform) in the first embodiment. 第1実施形態における血液凝固検査装置が測定結果画面の表示に対応して実行する処理手順例を示す図である。10 is a diagram showing an example of a processing procedure executed by the blood coagulation test apparatus in the first embodiment in response to display of a measurement result screen. FIG. 第2実施形態における簡易波形の例を示す図である。FIG. 10 is a diagram showing an example of a simplified waveform in the second embodiment. 第2実施形態における標準波形と簡易波形との表示態様例を示す図である。10A and 10B are diagrams showing examples of display modes of a standard waveform and a simplified waveform in the second embodiment. 第1変形例における標準波形の形状と疾患との関係例を示す図である。FIG. 10 is a diagram showing an example of the relationship between the shape of a standard waveform and diseases in the first modified example. 第2変形例における標準波形の形状と薬剤投与との関係例を示す図である。FIG. 10 is a diagram showing an example of the relationship between the shape of the standard waveform and drug administration in the second modified example. 第3変形例における比色分析による検体の測定結果を示す図である。FIG. 11 is a diagram showing the measurement results of a sample by colorimetric analysis in the third modified example. 各実施形態における血液凝固検査装置のハードウェア構成例を示す図である。FIG. 2 is a diagram illustrating an example of the hardware configuration of a blood coagulation test apparatus according to each embodiment.

 <第1実施形態>
 [概要]
 以下、血液凝固検査装置を例に、本実施形態の情報提示装置、情報提示方法、およびプログラムについて説明する。
 本実施形態の血液凝固検査装置は、血液凝固検査を行う装置である。血液は、正常な状態では、血管内では凝固せずに循環し血管外では凝固する。一方で、血栓症などの場合には、血液が血管内で凝固する傾向となったり、血友病などの場合には血管外に出血しても凝固しにくい傾向となる異常が生じる。
 本実施形態の血液凝固検査装置は、検体について測定を行うことで、検体ごとの血液凝固に関する異常程度の検査(血液凝固検査)を行う。
First Embodiment
[overview]
The information presentation device, information presentation method, and program of this embodiment will be described below using a blood coagulation testing device as an example.
The blood coagulation test device of this embodiment is a device for performing blood coagulation tests. Under normal conditions, blood circulates without clotting within blood vessels and clots outside of blood vessels. On the other hand, in cases such as thrombosis, blood tends to clot within blood vessels, and in cases such as hemophilia, abnormalities occur in which blood tends to clot less even when it is extravascularly.
The blood coagulation test apparatus of this embodiment performs measurements on samples to test the degree of abnormality related to blood coagulation for each sample (blood coagulation test).

 本実施形態の血液凝固検査における測定項目としては、例えばプロトロンビン時間(PT)、活性化部分トロンボプラスチン時間(APTT)、フィブリノゲン(Fbg)、ループスアンチコアグラント(LA)、希釈ラッセル蛇毒時間(dRVVT)などを挙げることができる。本実施形態の血液凝固検査では、例えば上記の測定項目のうちから所定の複数の測定項目を対象に測定を行うようにされる。対象とする複数の測定項目の選定については特に限定されない。 Measurement items in the blood coagulation test of this embodiment include, for example, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fbg), lupus anticoagulant (LA), and diluted Russell's viper venom time (dRVVT). In the blood coagulation test of this embodiment, measurements are performed on a predetermined number of measurement items selected from the above measurement items. There are no particular limitations on the number of measurement items selected.

 血液凝固検査装置は、光学的検出法における散乱光度法に対応する。散乱光度法は、検体と試薬とを分注した反応容器に光を照射する。反応容器内では検体と試薬とが混合されることに応じて凝固反応が生じ、凝固反応の進行に伴い、混合液の濁度が増加していく。混合液の濁度の増加に応じて、照射された光の散乱光量が増加するように変化する。血液凝固検査装置は、測定時間に対する散乱光量の変化を測定する。
 また、光学的検出法として吸光度法も知られている。吸光度法は、検体と試薬とが分注された反応容器に照射した光の透過光量の測定時間に応じた変化を測定する検出法である。本実施形態の血液凝固検査装置は、このような吸光度法に対応して検査可能とされてもよい。以下の説明においては、本実施形態の血液凝固検査装置が散乱光度法により測定を行うようにされている場合を例に挙げる。
The blood coagulation test device corresponds to the scattered light method, which is an optical detection method. In the scattered light method, light is irradiated onto a reaction vessel into which a sample and a reagent have been dispensed. A coagulation reaction occurs in the reaction vessel as the sample and the reagent are mixed, and as the coagulation reaction progresses, the turbidity of the mixture increases. As the turbidity of the mixture increases, the amount of scattered light of the irradiated light increases. The blood coagulation test device measures the change in the amount of scattered light over measurement time.
Absorbance spectroscopy is also known as an optical detection method. Absorbance spectroscopy is a detection method in which a change in the amount of transmitted light irradiated onto a reaction vessel into which a sample and a reagent have been dispensed is measured over a measurement period. The blood coagulation test apparatus of this embodiment may be adapted to perform tests using such absorbance spectroscopy. In the following description, an example will be given in which the blood coagulation test apparatus of this embodiment is configured to perform measurements using scattered light spectroscopy.

 [血液凝固検査装置の機能構成例]
 図1は、本実施形態の血液凝固検査装置100の機能構成例を示している。血液凝固検査装置100は、ハードウェアとして、CPU(Central Processing Unit)、ROM(Read Only Memory)、RAM(Random Access Memory)、HDD(Hard Disk Drive)やSSD(Solid State Drive)等のストレージデバイス等を備えて構成されてよい。同図に示される血液凝固検査装置100としての機能は、血液凝固検査装置100において備えられるCPUがプログラムを実行することにより実現される。
 同図の血液凝固検査装置100は、測定部101、制御部102、記憶部103、操作部104、および表示部105を備える。
[Example of functional configuration of blood coagulation testing device]
1 shows an example of the functional configuration of a blood coagulation test apparatus 100 according to this embodiment. The blood coagulation test apparatus 100 may be configured to include, as hardware, a CPU (Central Processing Unit), ROM (Read Only Memory), RAM (Random Access Memory), and storage devices such as HDDs (Hard Disk Drives) and SSDs (Solid State Drives). The functions of the blood coagulation test apparatus 100 shown in the figure are realized by the CPU included in the blood coagulation test apparatus 100 executing a program.
The blood coagulation test apparatus 100 in the figure includes a measurement unit 101 , a control unit 102 , a storage unit 103 , an operation unit 104 , and a display unit 105 .

 測定部101は、血液凝固検査に対応する検体の測定を行う部位である。測定部101は検体が分注された所定数の反応容器を格納可能とされる。測定部101は、格納された反応容器に試薬を分注し、検体と試薬との混合液が入った反応容器に対して光源により光を照射する。測定部101は、所定の測定項目ごとに対応して計測時間(例えば0.1秒程度)ごとに散乱光量を測定する。測定部101は、測定結果に関連する測定結果情報を制御部102に出力する。 The measurement unit 101 is a part that measures samples corresponding to blood coagulation tests. The measurement unit 101 can store a predetermined number of reaction vessels into which samples have been dispensed. The measurement unit 101 dispenses reagents into the stored reaction vessels and irradiates light from a light source onto the reaction vessels containing the mixture of sample and reagent. The measurement unit 101 measures the amount of scattered light at measurement times (for example, approximately 0.1 seconds) corresponding to each predetermined measurement item. The measurement unit 101 outputs measurement result information related to the measurement results to the control unit 102.

 制御部102は、血液凝固検査装置100における各種の制御を実行する。
 制御部102は、測定部101の測定の動作に関する制御を行う。
 また、制御部102は、測定部101から出力される検体ごとの測定結果情報を取得し、取得した測定結果情報を測定結果情報記憶部131に記憶させる。
 また、制御部102は、測定結果情報記憶部131に記憶された検体ごとの測定結果情報を利用して、検体単位で測定結果を提示する測定結果画面を表示部105に表示させる。
The control unit 102 executes various controls in the blood coagulation test apparatus 100 .
The control unit 102 controls the measurement operation of the measurement unit 101 .
Furthermore, the control unit 102 acquires the measurement result information for each sample output from the measurement unit 101 , and stores the acquired measurement result information in the measurement result information storage unit 131 .
Furthermore, the control unit 102 uses the measurement result information for each sample stored in the measurement result information storage unit 131 to cause the display unit 105 to display a measurement result screen that presents the measurement results for each sample.

 制御部102は、測定結果取得部121と表示制御部122とを備える。なお、付加項目推定部123は、変形例に対応する部位であることから、ここでの説明を省略する。 The control unit 102 includes a measurement result acquisition unit 121 and a display control unit 122. Note that the additional item estimation unit 123 corresponds to a modified example, and therefore its description will be omitted here.

 測定結果取得部121は、測定部101により検体を測定して得られた測定結果を示す測定結果情報を取得する。検体に対応する測定結果情報は、測定項目ごとの測定値を含む。測定結果取得部121は、取得した測定結果情報を測定結果情報記憶部131に記憶させる。 The measurement result acquisition unit 121 acquires measurement result information indicating the measurement results obtained by measuring a sample using the measurement unit 101. The measurement result information corresponding to a sample includes the measurement values for each measurement item. The measurement result acquisition unit 121 stores the acquired measurement result information in the measurement result information storage unit 131.

 表示制御部122は、表示部105における表示を制御する。表示制御部122は、測定結果情報記憶部131が記憶する測定結果情報を利用して、検体ごとの測定結果を示す測定結果画面を表示部105に表示させる。 The display control unit 122 controls the display on the display unit 105. The display control unit 122 uses the measurement result information stored in the measurement result information storage unit 131 to cause the display unit 105 to display a measurement result screen showing the measurement results for each sample.

 記憶部103は、血液凝固検査装置100に対応する各種の情報を記憶する。記憶部103は、測定結果情報記憶部131を備える。
 測定結果情報記憶部131は、検体ごとの測定結果情報を記憶する。
The storage unit 103 stores various types of information corresponding to the blood coagulation test apparatus 100. The storage unit 103 includes a measurement result information storage unit 131.
The measurement result information storage unit 131 stores the measurement result information for each sample.

 なお、簡易波形データ記憶部132は、第2実施形態に対応することから、ここでの説明を省略する。第1実施形態において、簡易波形データ記憶部132は省略されてよい。 Note that the simplified waveform data storage unit 132 corresponds to the second embodiment, and therefore its description will be omitted here. In the first embodiment, the simplified waveform data storage unit 132 may be omitted.

 図2は、測定結果情報記憶部131が記憶する測定結果情報として、1つの検体に対応する測定結果情報の一例を示している。同図の測定結果情報は、検体ID、測定日時、測定結果、付帯情報の各フィールドを備える。
 検体IDのフィールドは、対応の検体を一意に示す検体IDを格納する。
 測定日時のフィールドは、対応の検体が血液凝固検査装置100により検査(測定)された日時(測定日時)を格納する。
 測定結果のフィールドは、対応の検体についての測定結果を格納する。測定結果のフィールドは、複数の測定項目(1~n)ごとの測定値を格納する。
 付帯情報のフィールドは、対応の検体の測定に対応して付帯された情報(付帯情報)を格納する。付帯情報には、例えば血液凝固検査装置100としてのハードウェアに関する異常の発生(緊急停止、光源ランプの光量低下など)に関する情報や、測定に関するエラーの発生(測定値の基準域からの逸脱など)などの情報が含まれてよい。
2 shows an example of measurement result information corresponding to one sample stored in the measurement result information storage unit 131. The measurement result information in the figure includes fields for the sample ID, measurement date and time, measurement result, and additional information.
The sample ID field stores a sample ID that uniquely identifies the corresponding sample.
The measurement date and time field stores the date and time (measurement date and time) when the corresponding sample was tested (measured) by the blood coagulation test apparatus 100.
The measurement result field stores the measurement results for the corresponding sample. The measurement result field stores the measurement values for each of a plurality of measurement items (1 to n).
The incidental information field stores information (incidental information) associated with the measurement of the corresponding sample. The incidental information may include, for example, information regarding the occurrence of an abnormality related to the hardware of the blood coagulation test apparatus 100 (such as an emergency shutdown or a decrease in the light intensity of the light source lamp) or information regarding the occurrence of an error related to the measurement (such as a deviation of the measurement value from the reference range).

 説明を図1に戻す。
 操作部104は、血液凝固検査装置100が備える各種操作子や入力デバイスを含む。また、操作部104は、血液凝固検査装置100に接続された入力デバイスも含まれてよい。操作部104は、各種操作子や入力デバイスに対して行われた操作に応じた操作信号を制御部102に出力する。制御部102は、入力された操作信号に応じた処理を実行する。
Returning to FIG.
The operation unit 104 includes various operators and input devices included in the blood coagulation test apparatus 100. The operation unit 104 may also include an input device connected to the blood coagulation test apparatus 100. The operation unit 104 outputs operation signals corresponding to operations performed on the various operators and input devices to the control unit 102. The control unit 102 executes processing corresponding to the input operation signals.

 表示部105は、制御部102の制御に応じて画像を表示する。 The display unit 105 displays images according to the control of the control unit 102.

 [測定結果画面について]
 本実施形態の血液凝固検査装置100は、測定結果情報記憶部131が記憶する検体ごとの測定結果情報(図2)を利用して、表示部105に測定結果画面を表示させることができる。
[About the measurement results screen]
The blood coagulation test apparatus 100 of this embodiment can display a measurement result screen on the display unit 105 using the measurement result information for each sample stored in the measurement result information storage unit 131 ( FIG. 2 ).

 図3は、測定結果画面の一例を示している。同図の測定結果画面は、測定された検体ごとに対応する検体単位領域AR1が上下方向に配列される。
 1つの検体単位領域は、横方向において検体の領域と複数の測定項目(PT、APTT、Fbg、AT・・・)ごとの領域とが配置される。
3 shows an example of the measurement result screen, in which sample unit areas AR1 corresponding to each measured sample are arranged vertically.
In one specimen unit area, a specimen area and areas for a plurality of measurement items (PT, APTT, Fbg, AT, etc.) are arranged in the horizontal direction.

 検体の領域においては、対応の検体を一意に示す検体IDが示される。 In the sample area, a sample ID that uniquely identifies the corresponding sample is displayed.

 測定項目の領域のそれぞれにおいては、対応の測定項目についての測定結果が示される。具体的に1つの測定項目の領域においては、計測値エリアAR11、波形エリアAR12、およびフラグエリアAR14が配置される。 Each measurement item area shows the measurement results for the corresponding measurement item. Specifically, in one measurement item area, a measurement value area AR11, a waveform area AR12, and a flag area AR14 are arranged.

 計測値エリアAR11は、対応の測定項目の測定値を示す。計測値エリアAR11において示される測定値には凝固時間が含まれる。
 波形エリアAR12は、対応の測定項目の測定結果に基づく波形(測定波形)が表示されるエリアである。具体的に、波形エリアAR12における波形は、例えば横軸を時間とし縦軸を散乱光量とする座標空間にて、測定時間(例えば0.1秒ごと)に散乱光量を測定して得られた測定値に基づいて得られる波形であってよい。同図においては、波形エリアAR12において測定波形として凝固波形を表示した例が示されている。
 フラグエリアAR14は、解析フラグが示されるエリアである。解析フラグ(表象体の一例)は、測定結果についての解析結果を示す。解析フラグには、例えば波形エリアAR12に示される波形の解析などの測定結果を解析したことで検体の状況や薬剤投与に関して推定した情報が含まれてよい。
 解析フラグにより示される検体の状況の1つとして、凝固第VIII因子の欠乏を挙げることができる。凝固第VIII因子は出血性疾患の血友病Aの欠損因子として知られており、凝固第VIII因子の欠乏は著明な出血傾向をきたす。図3のフラグエリアAR14において示されている「GES(GEntle Slope)」は、検体の状況として、凝固第VIII因子の欠乏を示唆するものとなる。また、他の検体の状況の1つとして、血栓性疾患を挙げることができる。血栓性疾患を治療する際には抗凝固薬であるアルガトロバンを投与することがある。図3のフラグエリアAR14において示されている「NSM(Non-SigMoid)」は、血栓性疾患の患者にアルガトロバンを投与していることを示唆するものとなる。
 また、対応の測定項目に関して複数の解析結果が得られる場合には、フラグエリアAR14において解析結果ごとに応じた複数の解析フラグが示されてよい。
The measurement value area AR11 shows the measurement value of the corresponding measurement item. The measurement values shown in the measurement value area AR11 include the coagulation time.
The waveform area AR12 is an area where a waveform (measured waveform) based on the measurement results of the corresponding measurement item is displayed. Specifically, the waveform in the waveform area AR12 may be a waveform obtained based on measurements obtained by measuring the amount of scattered light over a measurement time (e.g., every 0.1 seconds) in a coordinate space with time on the horizontal axis and the amount of scattered light on the vertical axis. The figure shows an example in which a clot waveform is displayed as the measured waveform in the waveform area AR12.
The flag area AR14 is an area where an analysis flag is displayed. The analysis flag (an example of a symbol) indicates the analysis result of the measurement result. The analysis flag may include information estimated regarding the condition of the sample or drug administration based on the analysis of the measurement result, such as the analysis of the waveform shown in the waveform area AR12.
One of the sample conditions indicated by the analysis flags is a deficiency of coagulation factor VIII. Coagulation factor VIII is known as the deficient factor in hemophilia A, a bleeding disorder, and a deficiency of coagulation factor VIII results in a significant bleeding tendency. The "GES (GEntle Slope)" shown in flag area AR14 of Figure 3 suggests a deficiency of coagulation factor VIII as a sample condition. Another sample condition is a thrombotic disorder. The anticoagulant argatroban is sometimes administered to treat a thrombotic disorder. The "NSM (Non-SigMoid)" shown in flag area AR14 of Figure 3 suggests that argatroban is being administered to a patient with a thrombotic disorder.
Furthermore, if multiple analysis results are obtained for a corresponding measurement item, multiple analysis flags corresponding to the respective analysis results may be displayed in flag area AR14.

 解析フラグは、例えば対応の情報を簡易化して表記した文字列(例えば略語や短縮語)であってもよいし、対応の情報を示すシンボル(マーク・標示)であってもよい。同図においては、解析フラグが文字列として標示されている例を示している。 The analysis flag may be, for example, a character string that simplifies the corresponding information (such as an abbreviation or contraction), or it may be a symbol (mark or indication) that indicates the corresponding information. The figure shows an example in which the analysis flag is displayed as a character string.

 [測定波形について]
 図4~図7を参照して、測定結果画面の波形エリアAR12において表示される測定波形(表象体の一例)について説明する。
[Measurement waveform]
The measurement waveform (an example of a symbol) displayed in the waveform area AR12 of the measurement result screen will be described with reference to FIGS.

 図4は、波形エリアAR12において表示される測定波形としての凝固波形(凝固反応曲線:第1の線図形の一例)を示す。同図の凝固波形は、測定時間(例えば0.1秒程度)ごとに検体に照射した光の散乱光量を測定して得られた測定値を時間経過に応じてプロットした軌跡として形成される線(第1の線の一例)により表される波形である。
 なお、凝固波形は、計測点数(横軸)ごとに測定値(縦軸)をプロットした軌跡として形成される線(第1の線の一例)により表される波形であってもよい。計測点数(i)は、例えば、測定時間が0.1秒ごとであれば、測定開始からの時間=0.1×iで表される点数である。このとき、i=1、2、3、・・・(1ずつ増加)であっても、i=5、10、15、・・・(5ずつ増加)であってもよく、増加する数は任意に設定されてよい。
4 shows a clot waveform (clotting reaction curve: an example of a first line figure) as a measured waveform displayed in the waveform area AR12. The clot waveform in the figure is a waveform represented by a line (an example of a first line) formed as a locus obtained by plotting measured values obtained by measuring the amount of scattered light of light irradiated onto a sample at measurement time intervals (e.g., approximately 0.1 seconds) over time.
The clot waveform may be a waveform represented by a line (an example of a first line) formed as a locus of plotting the measured value (vertical axis) for each measurement point (horizontal axis). The number of measurement points (i) is, for example, if the measurement time is every 0.1 seconds, the number of measurement points is represented by the time from the start of measurement = 0.1 × i. In this case, i may be 1, 2, 3, ... (increasing by 1) or i may be 5, 10, 15, ... (increasing by 5), and the increment may be set arbitrarily.

 図4においては検体が正常である場合に対応する線L1と、検体が正常でない場合に対応する線L2、L3が示されている。
 検体が正常である場合には、凝固波形は線L1のようなシグモイド形状を示す。一方、検体が異常であったり初期反応異常であったりするような場合には、線L1とは異なる形状となる。同図の、線L2、L3は、線L1に対して凝固時間が遅延する異常の状態が示されている。
 凝固時間は、検体が凝固反応により凝固した時間である。凝固時間は、例えば凝固終末点として定められた散乱光量に対する所定割合の散乱光量に至ったときの時間として測定されてよい。
In FIG. 4, a line L1 is shown which corresponds to the case where the specimen is normal, and lines L2 and L3 are shown which correspond to the case where the specimen is not normal.
When the sample is normal, the clot waveform exhibits a sigmoid shape like line L1. On the other hand, when the sample is abnormal or the initial reaction is abnormal, the waveform exhibits a different shape from line L1. Lines L2 and L3 in the figure indicate abnormal conditions in which the clotting time is delayed compared to line L1.
The clotting time is the time it takes for a sample to clot due to the clotting reaction. The clotting time may be measured, for example, as the time it takes for the amount of scattered light to reach a predetermined ratio relative to the amount of scattered light determined as the end point of clotting.

 図5は、初期反応異常について着目した凝固波形の例を示している。同図に示される線L31、L32、L33のうち、線L31は初期反応異常を示していないものであり、線L32、L33が初期反応異常を示すものとなる。 Figure 5 shows an example of a clot waveform that focuses on early reaction abnormalities. Of the lines L31, L32, and L33 shown in the figure, line L31 does not indicate an early reaction abnormality, while lines L32 and L33 indicate an early reaction abnormality.

 また、波形エリアAR12において表示される測定波形は、図6のような凝固波形について微分した値を表す線(第3の線の一例)による波形(微分波形:第3の線図形の一例)であってもよい。
 図6は、測定波形としての微分波形の一例を示している。同図の微分波形は、凝固波形について一次微分を行って求められた波形である。測定波形としての微分波形の微分の次数については特に限定されるものではなく、凝固波形を二次微分あるいは三次微分することにより微分波形が求められてもよい。
 図6においては検体が正常である場合に対応する線L11と、検体が正常でない場合に対応する線L12、L13が示されている。
 検体が正常である場合には、微分波形は線L11のように或る標準的な時間にて立ち上がる形状を示す。一方、検体が異常であるような場合には、例えば線L12のように波形が立ち上がりはするものの、立ち上がり時間の遅延や波形のピークがなだらかになったりする。また、線L13では、立ち上がりの遅延があり、ピークが2つある。
In addition, the measurement waveform displayed in the waveform area AR12 may be a waveform (differentiated waveform: an example of a third line figure) based on a line (an example of a third line) representing a differentiated value of the coagulation waveform as shown in Figure 6.
6 shows an example of a differential waveform as a measured waveform. The differential waveform in this figure is a waveform obtained by first-order differentiation of the clot waveform. The order of differentiation of the differential waveform as a measured waveform is not particularly limited, and the differential waveform may be obtained by second-order or third-order differentiation of the clot waveform.
In FIG. 6, a line L11 corresponding to the case where the sample is normal, and lines L12 and L13 corresponding to the case where the sample is not normal are shown.
If the specimen is normal, the differential waveform will rise at a standard time, as shown by line L11. On the other hand, if the specimen is abnormal, the waveform will rise, as shown by line L12, but the rise time will be delayed and the waveform peak will be gentle. Furthermore, line L13 will have a delayed rise and two peaks.

 また、波形エリアAR12において表示される測定波形は、図4のような凝固波形の縦軸に対応する散乱光量の最小値と最大値(一致化基準の一例)が同等となる(一致する)ように正規化する補正を行った線(第4の線の一例)による波形(補正波形:第4の線図形の一例)であってもよい。
 図7は、測定波形としての補正波形の一例を示している。同図においては、補正波形として、線L21、L22、L23が示されている。線L21、L22、L23は、それぞれ、図4の凝固波形の線L1、L2、L3について補正したものとなる。
Furthermore, the measurement waveform displayed in the waveform area AR12 may be a waveform (corrected waveform: an example of a fourth line figure) based on a line (an example of a fourth line) that has been corrected to normalize so that the minimum and maximum values of the scattered light intensity (an example of a matching criterion) corresponding to the vertical axis of the coagulation waveform as shown in Figure 4 are equal (match).
7 shows an example of a corrected waveform as a measured waveform. In the figure, lines L21, L22, and L23 are shown as corrected waveforms. Lines L21, L22, and L23 are corrected waveforms obtained by correcting lines L1, L2, and L3 of the coagulation waveform in FIG. 4, respectively.

 なお、補正波形の態様は、図7の例のように凝固波形の縦軸に対応する散乱光量の最大値が同等となるように正規化したものに限定されない。
 他の例として、立ち上がり部の時間(一致化基準の一例)を揃えるように凝固波形を補正してもよい。この場合において、図7のように凝固波形の縦軸に対応する散乱光量の最大値を同等とする正規化を組み合わせてよい。
 また、散乱光量が所定の高さに到達したときの時間を基準点にして、その基準点が一致するように時間軸において凝固波形をそろえるように補正してもよい。「所定の高さ」は例えば凝固終末点の散乱光量や、凝固終末点の散乱光量の1/2の値などであってよい。この場合にも、図7のように凝固波形の縦軸に対応する散乱光量の最大値を同等とする正規化を組み合わせてよい。
The form of the corrected waveform is not limited to the normalized waveform shown in FIG. 7, in which the maximum values of the scattered light amounts corresponding to the vertical axis of the coagulation waveform are equal.
As another example, the clot waveforms may be corrected to align the rising edge times (an example of a matching criterion). In this case, normalization may be performed to align the maximum values of the scattered light intensity corresponding to the vertical axis of the clot waveform, as shown in Figure 7.
Alternatively, the time when the amount of scattered light reaches a predetermined height may be used as a reference point, and the clot waveform may be corrected to align on the time axis so that this reference point coincides. The "predetermined height" may be, for example, the amount of scattered light at the end point of coagulation, or half the amount of scattered light at the end point of coagulation. In this case, normalization may also be performed by equating the maximum values of the amount of scattered light corresponding to the vertical axis of the clot waveform, as shown in Figure 7.

 測定波形は、形状の特徴により検体の異常の内容や程度などの推定の参考となり得る。例えば、測定結果として凝固時間は正常であるが、測定波形の形状に基づいた場合には異常との所見・解析結果が得られる場合がある。 The measured waveform's shape characteristics can be used as a reference for estimating the nature and degree of abnormality in the sample. For example, the measurement result may show that the clotting time is normal, but based on the shape of the measured waveform, findings and analysis results may indicate an abnormality.

 測定波形の形状は、検体の正常・異常を反映したものとなる。以下に、異常の事例に応じた測定波形の例を挙げる。
 図8を参照して、凝固時間が正常であっても他の要素により異常と判定される事例について説明する。図8(A)は、正常な検体に対応する凝固波形を示している。一方、図8(B)の凝固波形は、凝固時間については正常であるが、特徴指示枠FLに囲まれた部分において初期反応が大きくなる異常の状態を示している。また、図8(C)の凝固波形は、凝固時間については正常であるが、特徴指示枠FLに囲まれる部分として示すように、測定が開始して波形が立ち上がる時間が正常の場合よりも早くなる異常の状態を示している。
The shape of the measured waveform reflects whether the specimen is normal or abnormal. Below are examples of measured waveforms corresponding to abnormal cases.
Referring to Figure 8, we will explain a case where a normal clotting time is judged to be abnormal based on other factors. Figure 8(A) shows a clot waveform corresponding to a normal sample. On the other hand, the clot waveform in Figure 8(B) shows an abnormal state in which the clotting time is normal but the initial reaction is large in the area surrounded by the characteristic indicator frame FL. Furthermore, the clot waveform in Figure 8(C) shows an abnormal state in which the clotting time is normal but the waveform rises earlier than normal after the start of measurement, as shown in the area surrounded by the characteristic indicator frame FL.

 一方で、凝固時間そのものが異常となる場合もある。図9(A)、図9(B)、図9(C)は、それぞれ凝固時間が異常を示している場合の凝固波形の事例を示している。図9(A)の凝固波形は、シグモイドの形状を有しているものの、立ち上がりの時間が遅い事例である。図9(B)は、波形の立ち上がりの時間が遅く、シグモイドの形状も得られていない事例である。図9(C)は、特徴指示枠FLにより囲んだ部位に示されるように、正常であれば凝固終末点に到達する時間においてまだ凝固反応途中となっている事例である。 On the other hand, there are cases where the clotting time itself is abnormal. Figures 9(A), 9(B), and 9(C) each show examples of clot waveforms where the clotting time is abnormal. The clot waveform in Figure 9(A) has a sigmoid shape, but the rise time is slow. Figure 9(B) shows an example where the rise time of the waveform is slow and the sigmoid shape is not obtained. Figure 9(C), as shown in the area surrounded by the feature indication frame FL, shows an example where the clotting reaction is still in progress at the time when the end point of clotting would normally be reached.

 また、図10を参照して、微分波形としての測定波形について、凝固時間は正常であっても他の要素により異常と判定される事例について説明する。
 図10(A)は、検体が正常な場合に対応する微分波形の例を比較対象として示している。
 図10(B)は、微分波形のピークが2つ(二峰性)であることにより異常が示されている例である。正常な微分波形は、図10(A)のように波形のピークが1つとなる形状である。
 図10(C)は、特徴指示枠FLにより囲んだ部位に示されるように、主たる波形のピークが立ち上がる前に小さなピークが立ち上がることにより異常が示されている例である。
Also, with reference to FIG. 10, a case will be described in which the measured waveform as a differential waveform is determined to be abnormal due to other factors even if the clotting time is normal.
FIG. 10A shows an example of a differential waveform corresponding to a normal specimen for comparison.
Figure 10(B) shows an example where an abnormality is indicated by two peaks (bimodal) in the differentiated waveform. A normal differentiated waveform has a single peak, as shown in Figure 10(A).
FIG. 10C shows an example in which an abnormality is indicated by a small peak appearing before the main waveform peak, as shown in the area surrounded by the feature indicating frame FL.

 また、図11(A)、図11(B)、図11(C)は、凝固時間の異常に対応する微分波形の例を示す。
 図11(A)は、微分波形自体は正常に近い形状であるものの、立ち上がりの時間が正常より遅くなっていることにより異常が示される例である。
 図11(B)は、特徴指示枠FLにより囲んだ部位に示されるように、微分波形の立ち上がりが遅くなっているとともに、ピーク後の波形の傾きが緩やかになっていることにより異常が示される例である。
 図11(C)は、特徴指示枠FLにより囲んだ部位に示されるように、微分波形のピークが急峻でなく扁平度合いが高いことにより異常が示される例である。
11(A), 11(B), and 11(C) show examples of differential waveforms corresponding to abnormalities in clotting time.
FIG. 11A shows an example in which the differential waveform itself is close to normal, but the rise time is slower than normal, indicating an abnormality.
FIG. 11(B) is an example in which an abnormality is indicated by a delayed rise in the differentiated waveform and a gentler slope of the waveform after the peak, as shown in the area surrounded by the feature indication frame FL.
FIG. 11C shows an example in which an abnormality is indicated by the peak of the differential waveform being not steep and being highly flat, as shown in the area surrounded by the feature indicating frame FL.

 これまでの説明から理解できるように、測定結果画面における測定項目の領域のそれぞれには、計測値を示す計測値エリアAR11とともに測定波形を示す波形エリアAR12が表示される。この場合、ユーザは、検体の測定結果の一覧である測定結果画面において、数値による測定値と測定波形とを確認することができる。すなわち、本実施形態においては、測定結果画面により検体ごとの測定結果が適切に提示される。このため、ユーザは、例えば詳細な情報を提示する画面に移行させるような操作を行わなくとも、測定結果を数値と波形とにより的確に把握できる。
 この結果、ユーザは、測定結果の詳細情報を提示する画面に移行させる操作を行わなくとも、測定結果の一覧としての測定結果画面を見た段階で、或る程度の信頼性でもって、検体の正常・異常の判断や、異常の要因の推定などを行える。
 また、測定結果画面においては、測定項目ごとに、具体的数値により測定結果が示される測定値と、直感的に測定結果を把握可能な測定波形とが同時に表示されていることになる。このような表示により、ユーザは、異常の程度、重篤度、緊急性などに関して迅速に気付ける可能性が高くなる。
 また、例えば測定値は正常範囲を示しているが測定波形のほうが異常を示しているような場合がある。このような場合、ユーザは、測定値だけではなく測定波形も同一画面にて確認することで、異常に気付くことができる可能性も高くなる。
 測定結果画面により異常に気付いた場合、ユーザは、必要に応じてさらに詳細な測定波形を確認してみたり、検体の再検査を要請したりすることが可能となる。
As can be understood from the above description, each measurement item area on the measurement result screen displays a measurement value area AR11 showing the measurement value and a waveform area AR12 showing the measurement waveform. In this case, the user can check the numerical measurement values and measurement waveforms on the measurement result screen, which is a list of the measurement results for the sample. That is, in this embodiment, the measurement results for each sample are appropriately presented on the measurement result screen. Therefore, the user can accurately understand the measurement results from the numerical values and waveforms, without having to perform an operation such as switching to a screen presenting more detailed information.
As a result, the user can determine with a certain degree of confidence whether the sample is normal or abnormal and estimate the cause of the abnormality, simply by looking at the measurement result screen as a list of the measurement results, without having to perform an operation to switch to a screen that presents detailed information about the measurement results.
Furthermore, the measurement result screen simultaneously displays, for each measurement item, measurement values that are expressed as specific numerical values and measurement waveforms that allow the user to intuitively grasp the measurement results. This type of display increases the likelihood that the user will be able to quickly recognize the degree, severity, urgency, etc. of any abnormality.
In addition, for example, there may be cases where the measured values are within the normal range but the measured waveform indicates an abnormality. In such cases, the user is more likely to notice the abnormality by checking not only the measured values but also the measured waveform on the same screen.
If the user notices an abnormality on the measurement result screen, the user can check the measurement waveform in more detail as necessary, or request a retest of the sample.

 また、本実施形態においては、測定結果画面における測定項目ごとの波形エリアAR12にて表示される測定波形には、種別として、凝固波形のほか、微分波形や補正波形が含まれる。波形エリアAR12に表示される測定波形は、凝固波形、微分波形、補正波形のいずれであってもよい。
 この場合において、波形エリアAR12に表示する測定波形の種別を、例えばユーザの操作に応じて選択可能とされてよい。例えばユーザの操作によって、測定結果画面が初期表示されるときにデフォルトで波形エリアAR12に表示される測定波形を設定可能とされてよい。
In this embodiment, the measurement waveforms displayed in the waveform area AR12 for each measurement item on the measurement result screen include, as types, a clot waveform, a differential waveform, and a corrected waveform. The measurement waveform displayed in the waveform area AR12 may be any of a clot waveform, a differential waveform, and a corrected waveform.
In this case, the type of measurement waveform to be displayed in the waveform area AR12 may be selectable, for example, in response to a user operation. For example, the user may be able to set the measurement waveform to be displayed in the waveform area AR12 by default when the measurement result screen is initially displayed.

 また、本実施形態において、測定結果画面が表示されている状態において、波形エリアAR12に表示される測定波形を、ユーザの操作に応じて切り替え可能とされてよい。この場合において、測定波形は、測定結果画面における全ての波形エリアAR12を対象に一律に切り替え可能とされてもよい。また、測定波形は、検体単位(検体単位領域AR1単位)で切り替え可能とされてもよい。また、測定波形は、検体に対して共通に測定項目単位で切り替え可能とされてもよい。また、測定波形は、ユーザの操作に応じて指定された検体の測定項目を対象に切り替え可能とされてもよい。 Furthermore, in this embodiment, when the measurement result screen is displayed, the measurement waveform displayed in the waveform area AR12 may be switchable in response to a user operation. In this case, the measurement waveform may be switchable uniformly for all waveform areas AR12 on the measurement result screen. Furthermore, the measurement waveform may be switchable on a specimen-by-specimen basis (in specimen unit area AR1 units). Furthermore, the measurement waveform may be switchable on a measurement item-by-measurement item basis for all specimens. Furthermore, the measurement waveform may be switchable for a measurement item of a specified specimen in response to a user operation.

 また、本実施形態において、図8~図11における一部の測定波形において特徴部位を示す特徴指示枠FL(特徴指示部の一例)は、適宜、測定結果画面における波形エリアAR12の測定波形に付加されるようにして表示されてよい。
 また、特徴指示枠FLは、ユーザの所定操作に応じて、表示・非表示が切り替え可能とされてよい。
 また、特徴指示枠FLは、例えば初期反応などをはじめとする対応の特徴の程度に応じて態様が変化してよい。例えば、特徴の程度に応じて、特徴指示枠FLの枠部が複数に増加して重なって表示されるように変化したり、枠部の色や太さが変化したり、枠部内の色が変化してよい。
In addition, in this embodiment, a feature indication frame FL (an example of a feature indication section) indicating a characteristic portion in some of the measurement waveforms in Figures 8 to 11 may be displayed as appropriate by being added to the measurement waveform in the waveform area AR12 on the measurement result screen.
Furthermore, the feature indication frame FL may be configured to be switchable between display and non-display in response to a predetermined operation by the user.
Furthermore, the aspect of the characteristic indication frame FL may change depending on the level of the characteristic of the response, such as, for example, an initial reaction, etc. For example, depending on the level of the characteristic, the frame portions of the characteristic indication frame FL may change so that multiple frames are displayed overlapping each other, the color or thickness of the frame portions may change, or the color inside the frame portions may change.

 また、図3の例では、1つの測定項目に対応する波形エリアAR12には、1つの測定波形が表示されている。しかしながら、例えば波形エリアAR12において、同じ測定結果に対応する種別(例えば、凝固波形、微分波形、補正波形)の異なる複数の測定波形が表示されるようにしてよい。
 そのうえで、波形エリアAR12において表示される測定波形の種別数をユーザの操作に応じて変更可能とされてもよい。
3, one measurement waveform is displayed in the waveform area AR12 corresponding to one measurement item. However, for example, multiple measurement waveforms of different types (e.g., coagulation waveform, differential waveform, corrected waveform) corresponding to the same measurement result may be displayed in the waveform area AR12.
In addition, the number of types of measurement waveforms displayed in the waveform area AR12 may be changeable in response to a user operation.

 また、本実施形態において、例えば1つの波形エリアAR12を対象とするクリック操作やタップ操作などの所定操作が行われたことに応じて、操作された波形エリアAR12において表示されている測定波形が拡大表示されるようにしてよい。
 例えば、波形エリアAR12の測定波形については座標の目盛の数値の表示は省略し、拡大された測定波形については、座標の目盛の数値が示されるようにしてよい。また、波形エリアAR12の測定波形において特徴指示枠FLが配置されている場合、拡大された測定波形にも同様に特徴指示枠FLが配置された状態が維持されてよい。
 また、波形エリアAR12に1つの所定の種別の測定波形が表示されるようにしている状態であっても、拡大によっては、複数種別の測定波形が表示されるようにしてよい。
In addition, in this embodiment, when a predetermined operation, such as a click operation or a tap operation, is performed on one waveform area AR12, the measurement waveform displayed in the operated waveform area AR12 may be enlarged.
For example, the coordinate scale values may be omitted for the measurement waveform in waveform area AR12, and the coordinate scale values may be displayed for the enlarged measurement waveform. Also, if a feature indication frame FL is placed on the measurement waveform in waveform area AR12, the feature indication frame FL may be maintained in the enlarged measurement waveform as well.
Furthermore, even when one predetermined type of measured waveform is displayed in the waveform area AR12, multiple types of measured waveforms may be displayed depending on the enlargement.

 [処理手順例]
 図12のフローチャートを参照して、本実施形態の血液凝固検査装置100が、図3に例示した態様の測定結果画面の表示に対応して実行する処理手順例について説明する。
[Example of processing procedure]
An example of a processing procedure that the blood coagulation test apparatus 100 of this embodiment executes in response to the display of the measurement result screen in the manner exemplified in FIG. 3 will be described with reference to the flowchart of FIG.

 ステップS100:血液凝固検査装置100において表示制御部122は、測定結果画面の表示を指示する表示トリガの発生を受け付ける。表示トリガは、例えばユーザによる測定結果画面の表示を指示する操作に応じて発生されてよい。また、表示トリガは、測定部101にて所定の検体群の測定を終了したことに応じて発生されてよい。 Step S100: In the blood coagulation test apparatus 100, the display control unit 122 accepts the generation of a display trigger that instructs the display of a measurement result screen. The display trigger may be generated, for example, in response to a user operation instructing the display of a measurement result screen. The display trigger may also be generated in response to the measurement unit 101 completing measurement of a predetermined group of samples.

 ステップS102:表示制御部122は、測定結果画面において表示する検体のうちから、標準波形生成の対象となる1つの検体(対象検体)を選択する。 Step S102: The display control unit 122 selects one sample (target sample) from the samples displayed on the measurement result screen to be used for generating a standard waveform.

 ステップS104:表示制御部122は、ステップS102にて選択した対象検体の検体IDに対応付けられた測定結果情報を測定結果情報記憶部131から取得する。 Step S104: The display control unit 122 acquires the measurement result information associated with the sample ID of the target sample selected in step S102 from the measurement result information storage unit 131.

 ステップS106:表示制御部122は、ステップS104により取得した測定結果情報を利用して、波形エリアAR12に表示させる測定波形を生成する。具体的に、図3との対応では、表示制御部122は、測定波形として凝固波形を生成してよい。
 また、表示制御部122は、当該ステップS106において、測定波形として凝固波形、微分波形、および補正波形を生成してよい。
 また、生成された測定波形は、検体および測定項目に対応付けて記憶部103に記憶させてもよい。このように測定波形を記憶させることで、2回目以降の測定結果画面の表示に際しては、当該ステップS106において、記憶された測定波形を取得すればよく、測定波形を生成しなくともよい。
Step S106: The display control unit 122 generates a measurement waveform to be displayed in the waveform area AR12 using the measurement result information acquired in step S104. Specifically, in correspondence with Fig. 3, the display control unit 122 may generate a coagulation waveform as the measurement waveform.
In addition, in step S106, the display control unit 122 may generate a coagulation waveform, a differential waveform, and a corrected waveform as the measurement waveforms.
The generated measurement waveform may be associated with the specimen and the measurement item and stored in the storage unit 103. By storing the measurement waveform in this way, when displaying the measurement result screen from the second time onwards, it is only necessary to acquire the stored measurement waveform in step S106, and it is not necessary to generate a measurement waveform.

 ステップS108:表示制御部122は、現段階において測定結果画面に提示する全ての検体を対象として測定波形の生成が完了したか否かを判定する。まだ測定波形の生成が完了していない検体が残っている場合には、ステップS102に処理が戻されることで、次の検体を新たに対象として測定波形の生成が行われる。 Step S108: The display control unit 122 determines whether measurement waveform generation has been completed for all samples currently being displayed on the measurement result screen. If there are still samples for which measurement waveform generation has not been completed, processing returns to step S102, and measurement waveform generation is performed for the next sample.

 ステップS110:ステップS108にて全ての検体を対象として測定波形の生成が完了した場合、表示制御部122は、測定結果画面を生成し、生成した測定結果画面を表示する。 Step S110: When measurement waveform generation for all samples is completed in step S108, the display control unit 122 generates a measurement result screen and displays the generated measurement result screen.

 測定結果画面が表示された状態において、波形エリアAR12に表示されている測定波形の拡大を指示する操作が行われた場合、表示制御部122は、対象の測定波形を拡大した画像を表示させる。表示制御部122は、測定波形を拡大した画像を、例えば測定結果画面上に重畳させたポップアップウィンドウとして表示させてよい。
 また、表示制御部122は、例えば波形エリアAR12に表示されている測定波形の種別の変更を指示する操作が行われたことに応じて、変更先の種別の測定波形が表示されるように制御する。この際、例えば凝固波形から微分波形もしくは補正波形への変更が指示された場合において、未だ微分波形もしくは補正波形を生成していない場合には、凝固波形から微分波形もしくは補正波形を生成し、生成した微分波形もしくは補正波形の表示に切り替えるようにしてよい。
 また、表示制御部122は、測定結果画面や測定波形を拡大した画面などにおいて複数種別の測定波形を表示させる場合には、凝固波形を生成したうえで、凝固波形から微分波形と補正波形とを生成し、生成した凝固波形、微分波形、および補正波形を表示してよい。
When the measurement result screen is displayed and an operation is performed to instruct enlargement of the measurement waveform displayed in the waveform area AR12, the display control unit 122 displays an enlarged image of the target measurement waveform. The display control unit 122 may display the enlarged image of the measurement waveform, for example, as a pop-up window superimposed on the measurement result screen.
Furthermore, in response to an operation to instruct a change in the type of the measured waveform displayed in the waveform area AR12, the display control unit 122 controls so that the measured waveform of the new type is displayed. At this time, for example, when an instruction is given to change from a coagulation waveform to a differential waveform or a corrected waveform, if the differential waveform or corrected waveform has not yet been generated, the display control unit 122 may generate the differential waveform or corrected waveform from the coagulation waveform and switch to displaying the generated differential waveform or corrected waveform.
In addition, when displaying multiple types of measurement waveforms on a measurement result screen or a screen showing an enlarged measurement waveform, the display control unit 122 may generate a coagulation waveform, then generate a differential waveform and a correction waveform from the coagulation waveform, and display the generated coagulation waveform, differential waveform, and correction waveform.

 <第2実施形態>
 [簡易波形について]
 続いて、第2実施形態について説明する。上記の第1実施形態において波形エリアAR12に表示される測定波形としての線図形は、座標上に測定値をプロットして形成される凝固波形、もしくは凝固波形の微分波形、もしくは凝固波形の散乱光量を補正した補正波形であった。つまり、第1実施形態において波形エリアAR12に表示される測定波形としての線図形は、測定値を忠実に反映した波形(標準波形)とされていた。
 これに対して、本実施形態における波形エリアAR12においては、上記の標準波形に代えて、標準波形を簡易化した線(第2の線の一例)による線図形(簡易波形:第3の線図形の一例)が表示される。本実施形態において、標準波形の簡易化とは、例えば、標準波形において特徴的とされ注目度が高いとされる部位を強調、表象化し、注目度が低いような部位については単純化や省略などをする処理であってよい。
Second Embodiment
[About simple waveforms]
Next, a second embodiment will be described. In the first embodiment, the line diagram as the measured waveform displayed in the waveform area AR12 was a clot waveform formed by plotting measured values on a coordinate system, a differentiated waveform of the clot waveform, or a corrected waveform obtained by correcting the amount of scattered light from the clot waveform. In other words, in the first embodiment, the line diagram as the measured waveform displayed in the waveform area AR12 was a waveform (standard waveform) that faithfully reflected the measured values.
In contrast, in the waveform area AR12 of this embodiment, instead of the above-mentioned standard waveform, a line diagram (simplified waveform: an example of a third line diagram) is displayed using a line (an example of a second line) that is a simplified version of the standard waveform. In this embodiment, simplification of the standard waveform may be, for example, processing that emphasizes and represents parts of the standard waveform that are considered to be characteristic and attract attention, and simplifies or omits parts that attract less attention.

 図13(A)~図13(H)は、本実施形態の波形エリアAR12にて表示される簡易波形の例を示している。図13(A)~図13(H)に示される簡易波形は、それぞれ或る異常の状態を示す標準波形に対応した形状パターンを示している。 FIGS. 13(A) to 13(H) show examples of simplified waveforms displayed in the waveform area AR12 of this embodiment. The simplified waveforms shown in FIG. 13(A) to 13(H) each show a shape pattern corresponding to a standard waveform indicating a certain abnormal state.

 図13(A)、図13(B)は、それぞれ異なる凝固波形の形状を簡易化することにより得られた簡易波形である。図13(A)は、非シグモイド形状の凝固波形を簡易化したものとなる。図13(B)は、凝固時間が延長することで平常よりも傾斜が緩やかな形状の凝固波形を簡易化したものとなる。 Figures 13(A) and 13(B) are simplified waveforms obtained by simplifying the shapes of different clot waveforms. Figure 13(A) is a simplified version of a non-sigmoid clot waveform. Figure 13(B) is a simplified version of a clot waveform with a gentler slope than normal due to an extended clotting time.

 図13(C)~図13(H)は、それぞれ異なる微分波形の形状を簡易化することにより得られた簡易波形である。
 図13(C)の簡易波形は、立ち上がりが平常よりも急峻な形状の微分波形を簡易化したものである。
 図13(D)の簡易波形は、平常よりもピークの幅が広い形状の微分波形を簡易化したものである。
 図13(E)の簡易波形は、二峰性を有する形状の微分波形を簡易化したものである。
 図13(F)の簡易波形は、ピークタイミングを中心として対称となっている形状の微分波形を簡易化したものである。
 図13(G)の簡易波形は、ピーク前に対してピーク後の幅が平常より広い形状の微分波形を簡易化したものである。
 図13(H)の簡易波形は、ピーク前に対してピーク後の幅が図13(G)よりさらに広い形状の微分波形を簡易化したものである。
13(C) to 13(H) show simplified waveforms obtained by simplifying the shapes of different differential waveforms.
The simplified waveform in FIG. 13C is a simplified derivative waveform having a rise that is steeper than normal.
The simplified waveform in FIG. 13(D) is a simplified derivative waveform having a peak width wider than normal.
The simplified waveform of FIG. 13(E) is a simplified version of a differential waveform having a bimodal shape.
The simplified waveform in FIG. 13(F) is a simplified derivative waveform that is symmetrical about the peak timing.
The simplified waveform of FIG. 13(G) is a simplified derivative waveform in which the width after the peak is wider than before the peak.
The simplified waveform of FIG. 13(H) is a simplified derivative waveform in which the width after the peak is wider than the width before the peak as compared with FIG. 13(G).

 標準波形は、測定値を忠実に反映したものであるという点で信頼性は高い。しかしながら、測定結果画面において波形エリアAR12が占有できるスペースはさほど大きくない。このため、波形エリアAR12において標準波形を表示した場合には、ユーザは、例えば異常に対応する特徴を把握しにくくなる場合がある。
 そこで、本実施形態のように、波形エリアAR12において特徴部位を表象するように簡易化された簡易波形を表示するようにすれば、ユーザも測定波形としての特徴を容易に把握できるようになる。
The standard waveform is highly reliable in that it faithfully reflects the measured value. However, the waveform area AR12 does not occupy much space on the measurement result screen. For this reason, if the standard waveform is displayed in the waveform area AR12, it may be difficult for the user to grasp, for example, the characteristics corresponding to an abnormality.
Therefore, as in this embodiment, if a simplified waveform is displayed in the waveform area AR12 so as to represent the characteristic portions, the user can easily grasp the characteristics of the measured waveform.

 [簡易波形表示に対応する構成例]
 本実施形態の血液凝固検査装置100は、波形エリアAR12にて簡易波形を表示するにあたり、簡易波形データ記憶部132(図1)を備えてよい。
 簡易波形データ記憶部132は、想定し得る標準波形の形状の類型パターンごとに対応する簡易波形を記憶する。簡易波形データ記憶部132は、1つの類型パターンに対応させて複数の簡易波形データを記憶してよい。この場合において、複数の簡易波形データは、対応の類型パターンが示す複数の特徴部位のそれぞれを表象するように簡易化したものであってよい。
[Configuration example for simple waveform display]
The blood coagulation test apparatus 100 of this embodiment may be provided with a simple waveform data storage unit 132 (FIG. 1) to display the simple waveform in the waveform area AR12.
The simplified waveform data storage unit 132 stores simplified waveforms corresponding to each typical pattern of possible standard waveform shapes. The simplified waveform data storage unit 132 may store multiple simplified waveform data corresponding to one typical pattern. In this case, the multiple simplified waveform data may be simplified so as to represent each of multiple characteristic parts indicated by the corresponding typical pattern.

 本実施形態において、血液凝固検査装置100の表示制御部122は、測定結果画面の波形エリアAR12にて簡易波形を表示するにあたり、対応の標準波形を生成する。表示制御部122は、測定結果情報記憶部131から対応の測定値を取得し、取得した測定値を座標上にプロットすることにより凝固波形を生成する。表示制御部122は、例えば生成した凝固波形の類型パターンを判定する。表示制御部122は、判定した類型パターンに対応付けられている簡易波形データを簡易波形データ記憶部132から取得する。表示制御部122は、取得した簡易波形データに基づいて描画した簡易波形としての線図形を、対応の波形エリアAR12にて表示させる。 In this embodiment, the display control unit 122 of the blood coagulation test apparatus 100 generates a corresponding standard waveform when displaying a simplified waveform in the waveform area AR12 of the measurement result screen. The display control unit 122 acquires corresponding measurement values from the measurement result information storage unit 131 and generates a clot waveform by plotting the acquired measurement values on a coordinate system. The display control unit 122, for example, determines the typical pattern of the generated clot waveform. The display control unit 122 acquires simple waveform data associated with the determined typical pattern from the simple waveform data storage unit 132. The display control unit 122 displays a line diagram as a simplified waveform drawn based on the acquired simple waveform data in the corresponding waveform area AR12.

 また、表示制御部122は、微分波形もしくは補正波形を基とする簡易波形を波形エリアAR12にて表示させる場合には、上記のように生成した凝固波形から微分波形もしくは補正波形を生成し、生成した微分波形もしくは補正波形の類型パターンを判定する。表示制御部122は、判定した類型パターンに対応付けられている簡易波形データを簡易波形データ記憶部132から取得し、取得した簡易波形データに基づいて描画した簡易波形としての線図形を、対応の波形エリアAR12にて表示させる。
 表示制御部122は、生成した標準波形(凝固波形、微分波形、補正波形)の類型パターンを判定するにあたり、パターンマッチングによる処理を行ってよい。また、パターンマッチングにあたり、表示制御部122は、標準波形の形状の入力に応じて類型パターンを推定するように学習した学習済みモデルを利用してよい。
Furthermore, when displaying a simplified waveform based on a differentiated waveform or a corrected waveform in the waveform area AR12, the display control unit 122 generates a differentiated waveform or a corrected waveform from the clot waveform generated as described above, and determines a typical pattern of the generated differentiated waveform or corrected waveform. The display control unit 122 acquires simplified waveform data associated with the determined typical pattern from the simplified waveform data storage unit 132, and displays a line figure as a simplified waveform drawn based on the acquired simplified waveform data in the corresponding waveform area AR12.
The display control unit 122 may perform pattern matching to determine the typical pattern of the generated standard waveforms (clotting waveform, differential waveform, corrected waveform). In addition, for pattern matching, the display control unit 122 may use a trained model that has been trained to estimate a typical pattern in response to an input of the shape of the standard waveform.

 また、例えば表示部105の画面サイズが大きいことなどにより、測定結果画面の波形エリアAR12におけるサイズを比較的大きくすることができるような場合には、波形エリアAR12において、図14に例示するように、標準波形に重畳させるようにして、簡易波形PW(PW-1、PW-2)を配置してもよい。
 同図では、標準波形が微分波形であり、二峰性を有するとともにピーク前に対してピーク後の幅が平常より広い形状となる2つの特徴を有している。そこで、この場合には、二峰性を示す簡易波形PW-1とピーク後の幅が平常より広い形状となっている簡易波形PW-2との2つの簡易波形を示した例を挙げている。
 つまり、2つの簡易波形PW-1、PW-2は、基となる1つの微分波形が有する2つの特徴に基づいて、2つの特徴ごとに2つの線の成分に分割したものとされる。
In addition, if the size of the waveform area AR12 on the measurement result screen can be made relatively large, for example because the screen size of the display unit 105 is large, the simplified waveforms PW (PW-1, PW-2) may be arranged in the waveform area AR12 so as to be superimposed on the standard waveform, as illustrated in Figure 14.
In the figure, the standard waveform is a differentiated waveform, and has two characteristics: it is bimodal and the width after the peak is wider than before the peak. In this case, an example is given showing two simplified waveforms: a simplified waveform PW-1 that shows bimodal characteristics and a simplified waveform PW-2 that has a wider width after the peak than before.
In other words, the two simplified waveforms PW-1 and PW-2 are obtained by dividing a single original differential waveform into two line components for each of the two features, based on the two features that the original differential waveform has.

 なお、このように波形の形状における複数の形状の特徴に応じて波形を分割して提示(表示)する態様は、簡易波形に限定されず、例えば標準波形についても行うようにされてよい。 Note that this method of dividing and presenting (displaying) a waveform according to multiple shape characteristics is not limited to simple waveforms, and may also be performed on standard waveforms, for example.

 また、例えば波形エリアAR12において簡易波形を表示したうえで、波形エリアAR12に対する拡大の操作が行われた場合には、簡易波形に代えて対応の標準波形が拡大して表示されるようにしてよい。
 また、例えば波形エリアAR12において簡易波形(複数に分割された簡易波形が標示されてよい)または標準波形を表示している状態のもとで、波形エリアAR12に対する拡大の操作が行われた場合には、図14の態様のようにして、拡大した標準波形とともに1以上の簡易波形PWを表示してもよい。
 また、例えば波形エリアAR12において簡易波形(複数に分割された簡易波形が標示されてよい)を表示している状態のもとで、波形エリアAR12に対する拡大の操作が行われた場合には、簡易波形に関する説明が表示されるようにしてよい。簡易波形に関する説明としては、例えば簡易波形が有する特徴部分に関する説明、異常の有無に関する説明、異常有りの場合には異常に関する具体的な説明などであってよい。
 また、波形エリアAR12において、簡易波形と標準波形(凝固波形、微分波形、補正波形)のうちの所定の2以上の波形の表示を、操作に応じて切替可能とされてよい。
Furthermore, for example, when a simplified waveform is displayed in the waveform area AR12 and then an operation to enlarge the waveform area AR12 is performed, the corresponding standard waveform may be enlarged and displayed instead of the simplified waveform.
Furthermore, for example, when a simplified waveform (a simplified waveform divided into multiple parts may be displayed) or a standard waveform is displayed in the waveform area AR12, and an operation to enlarge the waveform area AR12 is performed, one or more simplified waveforms PW may be displayed together with the enlarged standard waveform, as in the manner shown in Figure 14.
Furthermore, for example, when a simplified waveform (which may be divided into multiple parts) is displayed in the waveform area AR12 and an operation to enlarge the waveform area AR12 is performed, an explanation of the simplified waveform may be displayed. The explanation of the simplified waveform may be, for example, an explanation of the characteristic parts of the simplified waveform, an explanation of whether or not there is an abnormality, and if there is an abnormality, a specific explanation of the abnormality.
In addition, in the waveform area AR12, the display of two or more predetermined waveforms from among the simplified waveform and the standard waveform (clotting waveform, differential waveform, corrected waveform) may be switchable in response to an operation.

 また、フラグエリアAR14を対象とする所定操作が行われたことに応じて、解析フラグに関する詳細な情報が表示されるようにしてよい。 Furthermore, detailed information regarding the analysis flag may be displayed in response to a specified operation being performed on the flag area AR14.

 また、表示部105において、例えば簡易波形データ記憶部132に予め記憶されている簡易波形の一覧を提示した検索画面を表示可能とされてよい。具体的に、検索画面における簡易波形の一覧は、例えば図13(A)~図13(H)に示されるような各簡易波形を並べて配置したようなものであってよい。そのうえで、検索画面にて配置される各簡易波形には、波形の特徴を説明するようなコメントが付されてもよい。
 ユーザは、検索画面にて配置される簡易波形のうちの少なくとも1つを選択して検索の実行を指示する操作(検索指示操作)を行うことができる。検索指示操作に応じて、表示部105には、検索画面にて選択されたのと同じ簡易波形に対応する標準波形を有する検体のリストを検索結果として提示する検索結果画面が表示されてよい。
 検索結果画面においては、検体のリスト項目ごとにおいて、例えば検体IDとともに測定結果が所定の態様で提示されてよい。この場合、測定結果としては、例えば凝固時間を含む測定値と標準波形とが提示されてよい。また、測定結果として、凝固時間と標準波形と簡易波形とが提示されてよい。また、測定結果として、標準波形と簡易波形とが提示されてよい。また、測定結果として、簡易波形を提示せずに標準波形が提示されてもよい。
 このような検索機能を有することで、ユーザは、簡易波形の特徴に対応する異常の類型に応じた検体を検索することが可能となる。
Furthermore, the display unit 105 may be capable of displaying a search screen presenting a list of simple waveforms stored in advance in the simple waveform data storage unit 132. Specifically, the list of simple waveforms on the search screen may be, for example, a list of simple waveforms arranged side by side, such as those shown in Figures 13(A) to 13(H). In addition, each simple waveform arranged on the search screen may be accompanied by a comment explaining the characteristics of the waveform.
The user can select at least one of the simplified waveforms arranged on the search screen and perform an operation to instruct execution of a search (search instruction operation). In response to the search instruction operation, a search result screen may be displayed on the display unit 105, which presents a list of samples having standard waveforms corresponding to the same simplified waveform selected on the search screen as search results.
On the search result screen, for each list item of samples, the measurement results may be presented in a predetermined format, for example, together with the sample ID. In this case, for example, the measurement results may include a measured value including the clotting time and a standard waveform. Alternatively, the measurement results may include the clotting time, the standard waveform, and a simplified waveform. Alternatively, the measurement results may include the standard waveform and the simplified waveform. Alternatively, the measurement results may include the standard waveform without the simplified waveform.
Such a search function allows the user to search for specimens according to the type of abnormality that corresponds to the characteristics of the simplified waveform.

 <変形例>
 以下、上記各実施形態における変形例について説明する。
 [第1変形例]
 本変形例の血液凝固検査装置100は、制御部102において検体の診療に関する付加的な項目に関する推定を行う付加項目推定部123(図1)を備えてよい。本変形例の付加項目推定部123は、検体の診療に関する付加項目として、検体の疾患を推定する。
<Modification>
Modifications of the above embodiments will be described below.
[First Modification]
The blood coagulation test apparatus 100 of this modified example may include an additional item estimation unit 123 ( FIG. 1 ) that estimates additional items related to the medical treatment of the sample in the control unit 102. The additional item estimation unit 123 of this modified example estimates a disease of the sample as an additional item related to the medical treatment of the sample.

 図15は、標準波形の形状と疾患との関係例を示している。図15(A)は、比較対象として正常に対応する凝固波形と微分波形とを示している。
 図15(B)は、血友病A(第VIII因子欠乏)に対応する凝固波形と微分波形とを示している。血友病A(第VIII因子欠乏)の場合、凝固波形は、正常よりも立ち上がりが遅く、傾斜も緩やかな形状となっている。また、微分波形は、特徴指示枠FLとして示すように、扁平度が高く、二峰性を有するが一次ピーク(2つのピークのうち出現時間が先のピーク)と二次ピーク(2つのピークのうち出現時間が後のピーク)の高さに顕著な差がない形状となる。
 図15(C)は、血友病B(第IX因子欠乏)に対応する凝固波形と微分波形とを示している。血友病B(第IX因子欠乏)の場合、凝固波形は、正常よりも立ち上がりが遅く、傾斜も緩やかな形状となっている。また、微分波形は、特徴指示枠FLとして示すように、扁平度が高く、二次ピークのほうが一次ピークよりも顕著に高い二峰性を有する形状となる。
 図15(D)は、LAに対応する凝固波形と微分波形とを示している。LAの場合、凝固波形は、正常よりも立ち上がりが遅い形状となっている。微分波形は、特徴指示枠FLとして示すように、扁平度が高く、ピーク付近がなだらかな形状となる。
 図15(E)は、第II因子欠乏に対応する凝固波形と微分波形とを示している。第II因子欠乏の場合、凝固波形は、立ち上がりが正常よりも若干遅く、正常よりも若干緩やかな形状となっている。微分波形は、特徴指示枠FLとして示すように、ピーク後の裾部が長い形状となっている。
15A and 15B show examples of the relationship between the shape of the standard waveform and diseases, in which Fig. 15A shows a clot waveform corresponding to a normal state and a differential waveform for comparison.
15(B) shows the clot waveform and differential waveform corresponding to hemophilia A (factor VIII deficiency). In the case of hemophilia A (factor VIII deficiency), the clot waveform has a slower rise time and a gentler slope than normal. Furthermore, as shown by the characteristic indicator frame FL, the differential waveform is highly flat and bimodal, but there is no significant difference in height between the primary peak (the earlier of the two peaks) and the secondary peak (the later of the two peaks).
15(C) shows the clot waveform and differential waveform corresponding to hemophilia B (factor IX deficiency). In the case of hemophilia B (factor IX deficiency), the clot waveform has a slower rise time and a gentler slope than normal. Furthermore, as shown by the characteristic indicator frame FL, the differential waveform has a highly flattened shape with a bimodal shape in which the secondary peak is significantly higher than the primary peak.
15(D) shows the clot waveform and differential waveform corresponding to LA. In the case of LA, the clot waveform has a shape that rises slower than normal. The differential waveform has a high degree of flatness and a gentle shape near the peak, as shown by the characteristic indication frame FL.
Figure 15(E) shows the clot waveform and differential waveform corresponding to factor II deficiency. In the case of factor II deficiency, the clot waveform rises slightly slower than normal and has a slightly gentler shape than normal. The differential waveform has a long tail after the peak, as shown by the characteristic indicator frame FL.

 付加項目推定部123は、上記のような疾患に対応して特徴的となる測定波形の形状に基づいて、検体の疾患を推定することができる。付加項目推定部123は、例えば測定波形の形状について類型化(分類)し、類型化した測定波形に該当する疾患を特定するようにされてよい。
 この際、血液凝固検査装置100は、疾患ごとに測定波形の形状の類型パターンを対応付けた疾患波形対応データを記憶部103に記憶させてよい。この場合、付加項目推定部123は、特定した測定波形の類型に対応付けられた疾患を疾患波形対応データから特定するようにされてよい。また、付加項目推定部123は、例えば測定波形の入力に応じて該当の疾患を推定するように学習した学習済みモデルを利用して、測定波形の形状に対応する疾患を推定してよい。
The additional item estimation unit 123 can estimate the disease of the specimen based on the shape of the measurement waveform that is characteristic of the disease as described above. The additional item estimation unit 123 may, for example, categorize (classify) the shape of the measurement waveform and identify the disease corresponding to the categorized measurement waveform.
In this case, the blood coagulation test apparatus 100 may store disease waveform correspondence data in which a type pattern of the shape of the measured waveform is associated with each disease in the storage unit 103. In this case, the additional item estimation unit 123 may identify the disease associated with the identified type of the measured waveform from the disease waveform correspondence data. Furthermore, the additional item estimation unit 123 may estimate the disease corresponding to the shape of the measured waveform, for example, by using a trained model that has been trained to estimate the corresponding disease in response to an input of the measured waveform.

 表示制御部122は、推定された疾患に関する情報を測定結果画面にて表示してよい。測定結果画面において疾患に関する情報が表示される位置は特に限定されないが、一例として、解析フラグの要素としてフラグエリアAR14にて表示されるようにしてもよい。この場合、フラグエリアAR14は測定項目ごとに対応して設けられていることから、測定結果画面においては、測定項目ごとの測定結果に応じてそれぞれ個別に推定された疾患を表示することができる。 The display control unit 122 may display information about the estimated disease on the measurement result screen. There are no particular limitations on the location where the information about the disease is displayed on the measurement result screen, but as an example, it may be displayed in the flag area AR14 as an element of the analysis flag. In this case, since the flag area AR14 is provided corresponding to each measurement item, the measurement result screen can display each estimated disease individually according to the measurement results for each measurement item.

 [第2変形例]
 本変形例の付加項目推定部123は、検体の診療に関する付加項目の推定として、薬剤投与に関する推定を行ってよい。
[Second Modification]
The additional item estimation unit 123 of this modified example may estimate drug administration as an additional item related to the medical treatment of the specimen.

 図16は、標準波形の形状と薬剤投与との関係例を示している。図16(A)は、比較対象として正常に対応する凝固波形と微分波形とを示している。
 図16(B)は、DOAC(直接経口抗凝固薬)投与に対応する凝固波形と微分波形とを示している。DOAC投与の場合、凝固波形は、正常よりも立ち上がりが遅延している。微分波形は、特徴指示枠FLとして示すように、波形の立ち上がりは遅延しているが、立ち上がり後の角度が急峻となる形状を有する。
 図16(C)は、ヘパリン投与に対応する凝固波形と微分波形とを示している。ヘパリン投与の場合、凝固波形は、立ち上がり時間が遅く、立ち上がり時が緩やかで、最大値に至る際の曲線も緩やかとなる形状を有する。微分波形は、特徴指示枠FLとして示すように、ピークを中心とする対称性が高い形状となる。
 図16(D)は、アルガトロバン投与に対応する凝固波形と微分波形とを示している。アルガトロバン投与の場合、凝固波形は、非シグモイド形状となる。微分波形は、ピークレベルが小さく、ピーク後においてなだらかに減衰していくような形状となる。
 なお、測定波形(凝固波形、微分波形)により推定可能な薬剤投与は、例えばエミシズマブなどをはじめ、上記の図16(B)、図16(C)、図16(D)に示した例に限定されない。
16A and 16B show examples of the relationship between the shape of the standard waveform and drug administration, with Fig. 16A showing a normal clot waveform and a differential waveform for comparison.
16(B) shows the clot waveform and the differential waveform corresponding to the administration of DOAC (direct oral anticoagulant). In the case of DOAC administration, the clot waveform has a delayed onset compared to normal. As shown by the characteristic indication frame FL, the differential waveform has a shape in which the onset of the waveform is delayed but the angle after the onset is steep.
16(C) shows the clot waveform and differential waveform corresponding to heparin administration. In the case of heparin administration, the clot waveform has a slow rise time, a gradual rise, and a gradual curve as it reaches its maximum value. The differential waveform has a highly symmetrical shape around the peak, as shown by the characteristic indicator frame FL.
16(D) shows the clot waveform and differential waveform corresponding to the administration of argatroban. When argatroban is administered, the clot waveform becomes non-sigmoidal. The differential waveform has a small peak level and gradually decays after the peak.
Note that drug administration that can be estimated from the measured waveforms (clotting waveform, differential waveform) is not limited to the examples shown in Figures 16(B), 16(C), and 16(D) above, and includes, for example, emicizumab.

 付加項目推定部123は、このように薬剤投与に対応して特徴的となる測定波形の形状に基づいて、検体についての薬剤投与に関する推定を行うことができる。具体的に、付加項目推定部123は、検体に基づく薬剤投与に関する推定として、検体に対応する患者への薬剤投与の有無(要否)や投与された薬剤の濃度を推定することが可能となり、推定結果を治療のための適切な薬剤投与の検討に用いることができる。
 本変形例においても、付加項目推定部123は、第1変形例と同様に、例えば測定波形の形状について類型化(分類)し、類型化した測定波形に該当する薬剤投与を特定するようにされてよい。
 この際、血液凝固検査装置100は、薬剤投与の内容ごとに測定波形の形状の類型パターンを対応付けた薬剤投与波形対応データを記憶部103に記憶させてよい。この場合の付加項目推定部123は、特定した測定波形の類型に対応付けられた薬剤投与を薬剤投与波形対応データから特定するようにされてよい。また、付加項目推定部123は、例えば測定波形の入力に応じて該当の薬剤投与を推定するように学習した学習済みモデルを利用して、測定波形の形状に対応する薬剤投与を推定してよい。
The additional item estimation unit 123 can estimate the drug administration for the sample based on the shape of the measurement waveform that is characteristic of drug administration. Specifically, the additional item estimation unit 123 can estimate the presence (necessity) of drug administration to the patient corresponding to the sample and the concentration of the administered drug, as the estimation related to drug administration based on the sample, and the estimation result can be used to consider appropriate drug administration for treatment.
In this modified example, the additional item estimation unit 123 may also be configured to categorize (classify) the shape of the measured waveform, as in the first modified example, and identify the drug administration corresponding to the categorized measured waveform.
In this case, the blood coagulation test apparatus 100 may store drug administration waveform correspondence data in the storage unit 103, which associates a typical pattern of the shape of the measured waveform with each drug administration content. In this case, the additional item estimation unit 123 may identify the drug administration associated with the identified type of measured waveform from the drug administration waveform correspondence data. Furthermore, the additional item estimation unit 123 may estimate the drug administration corresponding to the shape of the measured waveform, for example, by using a trained model that has been trained to estimate the corresponding drug administration in response to an input of the measured waveform.

 なお、付加項目推定部123は、付加項目として、測定波形の形状に基づいて薬剤投与以外の治療方法の推定や、他の必要な検査項目の推定なども行うようにされてよい。表示制御部122は、推定された治療方法や検査項目などの情報を測定結果画面に表示する、もしくは測定結果画面に対する操作によってポップアップウィンドウなどにより表示するようにされてよい。 The additional item estimation unit 123 may also estimate treatment methods other than drug administration based on the shape of the measured waveform, or other necessary test items, as additional items. The display control unit 122 may display information such as the estimated treatment method or test items on the measurement result screen, or may display it in a pop-up window or the like in response to an operation on the measurement result screen.

 [第3変形例]
 これまでに説明した測定結果画面の表示の構成は、血液凝固検査以外の検査にも適用されてよい。血液凝固検査以外の検査としては特に限定されないが、一例として、比色分析(吸光度分析)を挙げることができる。
[Third Modification]
The display configuration of the measurement result screen described above may also be applied to tests other than blood coagulation tests. Tests other than blood coagulation tests are not particularly limited, but one example is colorimetric analysis (absorbance analysis).

 図17は、比色分析による検体の測定結果を示している。同図の曲線L41、L42は測光ポイント(横軸)ごとに吸光度(縦軸)の測定値をプロットすることにより形成されたものである。曲線L41はプロゾーンの状態に対応し、曲線L42は非特異凝集の状態に対応する。 Figure 17 shows the measurement results of a sample by colorimetric analysis. Curves L41 and L42 in the figure were formed by plotting the measured values of absorbance (vertical axis) for each photometric point (horizontal axis). Curve L41 corresponds to the prozone state, and curve L42 corresponds to the nonspecific agglutination state.

 例えば比色分析の測定結果画面において、検体単位領域ごとに、図17に示した曲線を表示するようにされてよい。また、本変形例においても、第2実施形態のように、図17に示した曲線を簡易化した簡易化曲線を表示するようにされてよい。 For example, the curve shown in Figure 17 may be displayed for each specimen unit area on the colorimetric analysis measurement result screen. Also, in this modified example, as in the second embodiment, a simplified curve that is a simplification of the curve shown in Figure 17 may be displayed.

 [第4変形例]
 なお、それぞれ所定の機能が与えられた複数の装置に分散されたうえで、相互が通信可能に接続されて連携して処理を実行することで、血液凝固検査装置100としての機能が実現されるように構成されてよい。
[Fourth Modification]
In addition, the blood coagulation testing device 100 may be configured to function by distributing the functions among multiple devices, each of which is given a specific function, and then connecting them to each other so that they can communicate with each other and work together to execute processing.

 <血液凝固検査装置のハードウェア構成例について>
 図18は、上記各実施形態に対応する血液凝固検査装置100のハードウェア構成例を示している。同図の血液凝固検査装置100は、測定部1001、ユーザインターフェース1003、通信デバイス1004、ROM1005、RAM1006、ストレージ1007、CPU1008、およびGPU1009を備える。
 測定部1001、ユーザインターフェース1003、通信デバイス1004、ROM1005、RAM1006、ストレージ1007、CPU1008、およびGPU1009は、バス1010により接続されている。
<Example of hardware configuration for blood coagulation testing equipment>
18 shows an example of the hardware configuration of a blood coagulation test apparatus 100 corresponding to each of the above embodiments. The blood coagulation test apparatus 100 in the figure includes a measurement unit 1001, a user interface 1003, a communication device 1004, a ROM 1005, a RAM 1006, a storage 1007, a CPU 1008, and a GPU 1009.
The measurement unit 1001 , user interface 1003 , communication device 1004 , ROM 1005 , RAM 1006 , storage 1007 , CPU 1008 , and GPU 1009 are connected by a bus 1010 .

 測定部1001は、試料の測定を行う部位であり、図1の測定部101に対応する。
 ユーザインターフェース1003は、ユーザインターフェースに対応するハードウェアを含む。具体的に、ユーザインターフェース1003は、血液凝固検査装置100に備えられる、あるいは血液凝固検査装置100に接続される入力デバイス(キー、ボタン、タッチパネル、マウス、キーボード等)を含んでよい。また、ユーザインターフェース1003は、血液凝固検査装置100に備えられる、あるいは血液凝固検査装置100に接続されるディスプレイデバイス、音声出力デバイスなどを含んでよい。
The measuring unit 1001 is a portion where the sample is measured, and corresponds to the measuring unit 101 in FIG.
The user interface 1003 includes hardware corresponding to the user interface. Specifically, the user interface 1003 may include an input device (keys, buttons, a touch panel, a mouse, a keyboard, etc.) that is provided in the blood coagulation test apparatus 100 or connected to the blood coagulation test apparatus 100. The user interface 1003 may also include a display device, an audio output device, etc. that is provided in the blood coagulation test apparatus 100 or connected to the blood coagulation test apparatus 100.

 通信デバイス1004は、ネットワーク経由での通信に対応するデバイスである。
 ROM1005は、書き換え不可のデータを記憶する。
 RAM1006は、CPU1008やGPU1009が実行する演算に用いるデータを一時的に記憶する。
 ストレージ1007は、例えばHDD(Hard Disc Drive)やSSD(Solid State Drive)であり、例えばプログラムのデータ等をはじめとする各種のデータを記憶する。
 CPU1008は、ストレージ1007に記憶されたプログラムを実行することで各種の制御や処理等に応じた演算を実行する。
 GPU1009は、画像処理に関連する処理を実行する。
 なお、ネットワーク上で所定の処理を実行可能なように分散された複数のネットワーク対応の装置により血液凝固検査装置100と同等の機能が得られるようにされてもよい。
The communication device 1004 is a device that supports communication via a network.
The ROM 1005 stores non-rewritable data.
The RAM 1006 temporarily stores data used in the calculations executed by the CPU 1008 and the GPU 1009 .
The storage 1007 is, for example, a hard disk drive (HDD) or a solid state drive (SSD), and stores various types of data, such as program data.
The CPU 1008 executes programs stored in the storage 1007 to perform calculations according to various controls and processes.
The GPU 1009 executes processes related to image processing.
Note that functions equivalent to those of the blood coagulation test apparatus 100 may be obtained by a plurality of network-compatible devices that are distributed so as to be able to execute predetermined processes on a network.

 なお、上述の血液凝固検査装置100としての機能を実現するためのプログラムをコンピュータ読み取り可能な記録媒体に記録して、この記録媒体に記録されたプログラムをコンピュータシステムに読み込ませ、実行することにより上述の血液凝固検査装置100としての処理を行ってもよい。ここで、「記録媒体に記録されたプログラムをコンピュータシステムに読み込ませ、実行する」とは、コンピュータシステムにプログラムをインストールすることを含む。ここでいう「コンピュータシステム」とは、OSや周辺機器等のハードウェアを含むものとする。また、「コンピュータシステム」は、インターネットやWAN、LAN、専用回線等の通信回線を含むネットワークを介して接続された複数のコンピュータ装置を含んでもよい。また、「コンピュータ読み取り可能な記録媒体」とは、フレキシブルディスク、光磁気ディスク、ROM、CD-ROM等の可搬媒体、コンピュータシステムに内蔵されるハードディスク等の記憶装置のことをいう。このように、プログラムを記憶した記録媒体は、CD-ROM等の非一過性の記録媒体であってもよい。また、記録媒体には、当該プログラムを配信するために配信サーバからアクセス可能な内部または外部に設けられた記録媒体も含まれる。配信サーバの記録媒体に記憶されるプログラムのコードは、端末装置で実行可能な形式のプログラムのコードと異なるものでもよい。すなわち、配信サーバからダウンロードされて端末装置で実行可能な形でインストールができるものであれば、配信サーバで記憶される形式は問わない。なお、プログラムを複数に分割し、それぞれ異なるタイミングでダウンロードした後に端末装置で合体される構成や、分割されたプログラムのそれぞれを配信する配信サーバが異なっていてもよい。さらに「コンピュータ読み取り可能な記録媒体」とは、ネットワークを介してプログラムが送信された場合のサーバやクライアントとなるコンピュータシステム内部の揮発性メモリ(RAM)のように、一定時間プログラムを保持しているものも含むものとする。また、上記プログラムは、上述した機能の一部を実現するためのものであってもよい。さらに、上述した機能をコンピュータシステムにすでに記録されているプログラムとの組み合わせで実現できるもの、いわゆる差分ファイル(差分プログラム)であってもよい。 In addition, a program for realizing the functions of the above-mentioned blood coagulation test apparatus 100 may be recorded on a computer-readable recording medium, and the program recorded on this recording medium may be loaded into a computer system and executed to perform the processing of the above-mentioned blood coagulation test apparatus 100. Here, "loading a program recorded on a recording medium into a computer system and executing it" includes installing the program on a computer system. The term "computer system" here includes hardware such as an OS and peripheral devices. The term "computer system" may also include multiple computer devices connected via a network, including communication lines such as the Internet, WAN, LAN, and dedicated lines. The term "computer-readable recording medium" refers to portable media such as flexible disks, optical magnetic disks, ROMs, and CD-ROMs, as well as storage devices such as hard disks built into a computer system. In this way, a recording medium storing a program may be a non-transitory recording medium such as a CD-ROM. The recording medium may also include internal or external recording media accessible from a distribution server to distribute the program. The program code stored on the distribution server's recording medium may be different from the program code in a format executable by a terminal device. In other words, the format in which the program is stored on the distribution server does not matter as long as it can be downloaded from the distribution server and installed in a form that is executable on a terminal device. The program may be divided into multiple parts, each downloaded at a different time and then combined on the terminal device, or each part may be distributed by a different distribution server. Furthermore, the term "computer-readable recording medium" also includes a storage medium that stores a program for a certain period of time, such as volatile memory (RAM) within a computer system that acts as a server or client when a program is transmitted over a network. The program may also be a program that realizes some of the functions described above. Furthermore, the program may be a so-called differential file (differential program) that can realize the functions described above in combination with a program already stored on the computer system.

 <付記>
 (1)本実施形態の一態様は、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部を備える情報提示装置である。
<Additional Notes>
(1) One aspect of this embodiment is an information presentation device that includes a display control unit that displays, based on measurement results obtained by measuring multiple measurement items for one or more samples, one or more representations that represent information based on the measurement results, along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.

 (2)本実施形態の一態様は、(1)に記載の情報提示装置であって、前記表象体は、対応の測定項目の測定結果に基づく情報を簡易化して表記した文字列または標示としてのシンボルであってよい。 (2) One aspect of this embodiment is the information presentation device described in (1), in which the representation may be a character string or a symbol as a sign that simplifies and displays information based on the measurement results of the corresponding measurement item.

 (3)本実施形態の一態様は、(1)に記載の情報提示装置であって、前記表象体は、対応の測定結果に基づいて形成した線を示す線図形であってよい。 (3) One aspect of this embodiment is the information presentation device described in (1), in which the representation may be a linear figure showing a line formed based on the correspondence measurement results.

 (4)本実施形態の一態様は、(3)に記載の情報提示装置であって、前記表象体は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を示す第1の線図形であってよい。 (4) One aspect of this embodiment is the information presentation device described in (3), wherein the representation may be a first linear figure showing a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters.

 (5)本実施形態の一態様は、(3)から(4)のいずれか1つに記載の情報提示装置であって、前記表象体は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を簡易化した第2の線を示す第2の線図形であってよい。 (5) One aspect of this embodiment is the information presentation device described in any one of (3) to (4), wherein the representation may be a second linear figure showing a second line that is a simplified version of a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters.

 (6)本実施形態の一態様は、(3)から(5)のいずれか1つに記載の情報提示装置であって、前記表象体は、対応の測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線について微分した第3の線を示す第3の線図形であってよい。 (6) One aspect of this embodiment is the information presentation device described in any one of (3) to (5), wherein the representation may be a third line figure that indicates a third line differentiated with respect to a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to predetermined parameters.

 (7)本実施形態の一態様は、(3)から(6)のいずれか1つに記載の情報提示装置であって、前記表象体は、対応の測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線について補正した第4の線を示す第4の線図形であってよい。 (7) One aspect of this embodiment is the information presentation device described in any one of (3) to (6), wherein the representation may be a fourth line figure showing a fourth line corrected for a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to predetermined parameters.

 (8)本実施形態の一態様は、(1)に記載の情報提示装置であって、前記表示制御部は、1つの測定項目に対応する表象体として、対応の測定結果に基づいて形成した線を示す線図形と、対応の測定項目の測定値に基づく情報を簡易化して表記した文字列または標示としてのシンボルとを同時に表示させてよい。 (8) One aspect of this embodiment is the information presentation device described in (1), wherein the display control unit may simultaneously display, as a representation corresponding to one measurement item, a line figure showing a line formed based on the corresponding measurement result, and a character string or symbol as a sign that simplifies information based on the measurement value of the corresponding measurement item.

 (9)本実施形態の一態様は、(3)から(8)のいずれか1つに記載の情報提示装置であって、前記表示制御部は、前記線図形の形状に特徴を有する部位を示す特徴指示部を付加して表示させてよい。 (9) One aspect of this embodiment is the information presentation device described in any one of (3) to (8), wherein the display control unit may add and display a feature indication section that indicates a portion of the line shape that has a characteristic feature.

 (10)本実施形態の一態様は、(3)から(9)のいずれか1つに記載の情報提示装置であって、前記表示制御部は、1つの前記線図形が示す線を当該線の特徴に基づいて複数の線成分に分割し、分割した線成分ごとの線図形を表示させてよい。 (10) One aspect of this embodiment is the information presentation device described in any one of (3) to (9), wherein the display control unit may divide a line represented by one of the line figures into multiple line components based on the characteristics of the line, and display a line figure for each of the divided line components.

 (11)本実施形態の一態様は、(3)に記載の情報提示装置であって、前記測定結果は、血液の凝固時間に関して測定して得られたものであり、前記線図形は、凝固波形であってよい。 (11) One aspect of this embodiment is the information presentation device described in (3), wherein the measurement results are obtained by measuring the blood clotting time, and the line diagram may be a clotting waveform.

 (12)本実施形態の一態様は、(3)から(11)のいずれか1つに記載の情報提示装置であって、前記表示制御部は、前記線図形としての表象体を操作に応じて拡大させて表示してよい。 (12) One aspect of this embodiment is the information presentation device described in any one of (3) to (11), wherein the display control unit may enlarge and display the linear graphic representation in response to an operation.

 (13)本実施形態の一態様は、(3)から(12)のいずれか1つに記載の情報提示装置であって、前記表示制御部は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を示す第1の線図形、前記第1の線について微分した第3の線を示す第3の線図形、前記第1の線について補正した第4の線を示す第4の線図形、および前記第1の線を簡易化した第2の線を示す第2の線図形とのうちの所定の2以上の線図形を、操作に応じて切り替えて表示してよい。 (13) One aspect of this embodiment is the information presentation device described in any one of (3) to (12), wherein the display control unit may switch between displaying two or more predetermined linear figures in response to an operation: a first linear figure showing a first line formed by plotting measurement values indicated by corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters; a third linear figure showing a third line obtained by differentiating the first line; a fourth linear figure showing a fourth line obtained by correcting the first line; and a second linear figure showing a second line obtained by simplifying the first line.

 (14)本実施形態の一態様は、(3)から(13)のいずれか1つに記載の情報提示装置であって、前記表象体の線図形に基づいて、検体の診療に関する所定の項目について推定する付加項目推定部をさらに備えてよい。 (14) One aspect of this embodiment is the information presentation device described in any one of (3) to (13), which may further include an additional item estimation unit that estimates predetermined items related to the medical treatment of the subject based on the linear representation of the representation.

 (15)本実施形態の一態様は、情報提示装置における情報提示方法であって、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部を含む情報提示方法である。 (15) One aspect of this embodiment is an information presentation method for an information presentation device, which includes a display control unit that, based on measurement results obtained by measuring multiple measurement items for one or more samples, displays, for each sample, measurement values indicating the measurement results for each of the multiple measurement items, as well as one or more symbols representing information based on the measurement results.

 (16)本実施形態の一態様は、情報提示装置としてのコンピュータを、1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部として機能させるためのプログラムである。 (16) One aspect of this embodiment is a program that causes a computer serving as an information presentation device to function as a display control unit that, based on the measurement results obtained by measuring multiple measurement items for one or more samples, displays one or more symbols representing information based on the measurement results, along with measurement values indicating the measurement results for each of the multiple measurement items, corresponding to each sample.

100 血液凝固検査装置
101 測定部
102 制御部
103 記憶部
104 操作部
105 表示部
121 測定結果取得部
122 表示制御部
123 付加項目推定部
131 測定結果情報記憶部
132 簡易波形データ記憶部
1001 測定部
1003 ユーザインターフェース
1004 通信デバイス
1005 ROM
1006 RAM
1007 ストレージ
1008 CPU
1009 GPU
1010 バス
100 Blood coagulation test apparatus 101 Measurement unit 102 Control unit 103 Storage unit 104 Operation unit 105 Display unit 121 Measurement result acquisition unit 122 Display control unit 123 Additional item estimation unit 131 Measurement result information storage unit 132 Simplified waveform data storage unit 1001 Measurement unit 1003 User interface 1004 Communication device 1005 ROM
1006 RAM
1007 Storage 1008 CPU
1009 GPU
1010 Bus

Claims (16)

 1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部
 を備える情報提示装置。
An information presentation device comprising: a display control unit that displays, based on measurement results obtained by measuring multiple measurement items for one or more samples, one or more representations that represent information based on the measurement results along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.
 前記表象体は、対応の測定項目の測定結果に基づく情報を簡易化して表記した文字列または標示としてのシンボルである
 請求項1に記載の情報提示装置。
The information presentation device according to claim 1 , wherein the representation is a character string or a symbol as a sign that represents information based on the measurement result of the corresponding measurement item in a simplified form.
 前記表象体は、対応の測定結果に基づいて形成した線を示す線図形である
 請求項1に記載の情報提示装置。
The information presentation device according to claim 1 , wherein the symbol is a linear figure representing a line formed based on a result of measuring the correspondence.
 前記表象体は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を示す第1の線図形である
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the representation is a first linear figure showing a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to the predetermined parameters.
 前記表象体は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を簡易化した第2の線を示す第2の線図形である
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3, wherein the representation is a second linear figure showing a second line that is a simplified version of a first line formed by plotting the measurement values indicated by the corresponding measurement results in a coordinate space with coordinate axes corresponding to the specified parameters.
 前記表象体は、対応の測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線について微分した第3の線を示す第3の線図形である
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the representation is a third line obtained by differentiating a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to the predetermined parameters.
 前記表象体は、対応の測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線について補正した第4の線を示す第4の線図形である
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the representation is a fourth linear figure showing a fourth line corrected for a first line formed by plotting the corresponding measurement values in a coordinate space with coordinate axes corresponding to the predetermined parameters.
 前記表示制御部は、1つの測定項目に対応する表象体として、対応の測定結果に基づいて形成した線を示す線図形と、対応の測定項目の測定値に基づく情報を簡易化して表記した文字列または標示としてのシンボルとを同時に表示させる
 請求項1に記載の情報提示装置。
The information presentation device of claim 1, wherein the display control unit simultaneously displays, as a representation corresponding to one measurement item, a linear figure showing a line formed based on the corresponding measurement result, and a symbol as a character string or sign that simplifies information based on the measurement value of the corresponding measurement item.
 前記表示制御部は、前記線図形の形状に特徴を有する部位を示す特徴指示部を付加して表示させる
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the display control unit displays the line figure by adding a feature indicating portion that indicates a portion having a characteristic shape to the line figure.
 前記表示制御部は、1つの前記線図形が示す線を当該線の特徴に基づいて複数の線成分に分割し、分割した線成分ごとの線図形を表示させる
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the display control unit divides a line indicated by one of the line figures into a plurality of line components based on characteristics of the line, and displays the line figures for each of the divided line components.
 前記測定結果は、血液の凝固時間に関して測定して得られたものであり、前記線図形は、凝固波形である
 請求項3に記載の情報提示装置。
The information display device according to claim 3 , wherein the measurement result is obtained by measuring a blood clotting time, and the line figure is a clot waveform.
 前記表示制御部は、前記線図形としての表象体を操作に応じて拡大させて表示する
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , wherein the display control unit enlarges and displays the representation as the line figure in response to an operation.
 前記表示制御部は、対応の測定結果が示す測定値を所定のパラメータに対応する座標軸による座標空間にプロットして形成された第1の線を示す第1の線図形、前記第1の線について微分した第3の線を示す第3の線図形、前記第1の線について補正した第4の線を示す第4の線図形、および前記第1の線を簡易化した第2の線を示す第2の線図形とのうちの所定の2以上の線図形を、操作に応じて切り替えて表示する
 請求項3に記載の情報提示装置。
4. The information presentation device of claim 3, wherein the display control unit switches between and displays two or more predetermined linear figures among a first linear figure showing a first line formed by plotting measurement values indicated by corresponding measurement results in a coordinate space with coordinate axes corresponding to predetermined parameters, a third linear figure showing a third line differentiated with respect to the first line, a fourth linear figure showing a fourth line corrected with respect to the first line, and a second linear figure showing a second line simplified from the first line, in response to an operation.
 前記表象体の線図形に基づいて、検体の診療に関する所定の項目について推定する付加項目推定部をさらに備える
 請求項3に記載の情報提示装置。
The information presentation device according to claim 3 , further comprising an additional item estimation unit that estimates predetermined items related to medical treatment of the subject based on the linear representation of the representation.
 情報提示装置における情報提示方法であって、
 1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部
 を含む情報提示方法。
An information presentation method in an information presentation device,
An information presentation method including a display control unit that displays, based on measurement results obtained by measuring multiple measurement items for one or more samples, one or more representations that represent information based on the measurement results along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.
 情報提示装置としてのコンピュータを、
 1以上の検体ごとに複数の測定項目を測定して得られた測定結果に基づいて、検体ごとに対応させて、前記複数の測定項目ごとの測定結果を示す測定値とともに当該測定結果に基づく情報を表象する1以上の表象体を表示させる表示制御部
 として機能させるためのプログラム。
Computers as information presentation devices
A program for functioning as a display control unit that displays, based on the measurement results obtained by measuring multiple measurement items for one or more samples, one or more representations that represent information based on the measurement results along with measurement values that indicate the measurement results for each of the multiple measurement items, corresponding to each sample.
PCT/JP2025/010524 2024-03-19 2025-03-18 Information presenting device, information presenting method, and program Pending WO2025197925A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001005880A (en) * 1999-04-20 2001-01-12 Toshiba Corp Care-requiring certification work support system, care-requiring certification processing method, and storage medium
JP2008032751A (en) * 2007-10-22 2008-02-14 Hitachi Ltd Analysis result management method and apparatus
US20120019559A1 (en) * 2010-07-20 2012-01-26 Siler Lucas C Methods and Apparatus for Interactive Display of Images and Measurements

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001005880A (en) * 1999-04-20 2001-01-12 Toshiba Corp Care-requiring certification work support system, care-requiring certification processing method, and storage medium
JP2008032751A (en) * 2007-10-22 2008-02-14 Hitachi Ltd Analysis result management method and apparatus
US20120019559A1 (en) * 2010-07-20 2012-01-26 Siler Lucas C Methods and Apparatus for Interactive Display of Images and Measurements

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