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WO2025175304A3 - Process for the preparation of deoxycholic acid - Google Patents

Process for the preparation of deoxycholic acid

Info

Publication number
WO2025175304A3
WO2025175304A3 PCT/US2025/016340 US2025016340W WO2025175304A3 WO 2025175304 A3 WO2025175304 A3 WO 2025175304A3 US 2025016340 W US2025016340 W US 2025016340W WO 2025175304 A3 WO2025175304 A3 WO 2025175304A3
Authority
WO
WIPO (PCT)
Prior art keywords
deoxycholic acid
preparation
compound
formula
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/016340
Other languages
French (fr)
Other versions
WO2025175304A2 (en
Inventor
Hubert Botte
Jean-Pierre Demoute
Bruno DUDOT
Christelle GEOFFROY
Loïc PAQUIN
Artur PINTO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Inc
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Publication of WO2025175304A2 publication Critical patent/WO2025175304A2/en
Publication of WO2025175304A3 publication Critical patent/WO2025175304A3/en
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure relates to a process for preparing a compound of formula (7), comprising the step of reacting a compound of formula (6) with a reducing agent, and to process for preparing deoxycholic acid or a pharmaceutically acceptable salt thereof comprising said step, and to uses of the deoxycholic acid or a pharmaceutically acceptable salt thereof prepared by the process to extract outer membrane vesicles from Gram-negative bacteria.
PCT/US2025/016340 2024-02-16 2025-02-18 Process for the preparation of deoxycholic acid Pending WO2025175304A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP24158094 2024-02-16
EP24158094.3 2024-02-16

Publications (2)

Publication Number Publication Date
WO2025175304A2 WO2025175304A2 (en) 2025-08-21
WO2025175304A3 true WO2025175304A3 (en) 2025-11-06

Family

ID=89983277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/016340 Pending WO2025175304A2 (en) 2024-02-16 2025-02-18 Process for the preparation of deoxycholic acid

Country Status (1)

Country Link
WO (1) WO2025175304A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5511117B2 (en) * 2000-07-27 2014-06-04 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド Vaccine for broad protection against diseases caused by Neisseria meningitidis
EP3138850A1 (en) * 2011-06-16 2017-03-08 Kythera Biopharmaceuticals, Inc. Compositions containing deoxycholic acid and c1-3-alcohols, directed to the purification of deoxycholic acid
WO2018013615A1 (en) * 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
US20180338987A1 (en) * 2007-06-19 2018-11-29 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JP2021167317A (en) * 2015-06-16 2021-10-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695624A (en) 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US5494808A (en) 1994-09-15 1996-02-27 Merck & Co., Inc. Defined medium OMPC fermentation process
NO20002828D0 (en) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinaceous vaccine against Neisseria meningtidis serogroup and method of preparation thereof
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
BRPI0813140C1 (en) 2007-06-19 2021-05-25 Kythera Biopharmaceuticals Inc method for the preparation of deoxycholic acid (dca) or an ester thereof or a pharmaceutically acceptable salt thereof and intermediate compound
CN106146593B (en) 2015-04-14 2021-06-01 南京迈诺威医药科技有限公司 Method for preparing deoxycholic acid
KR102527103B1 (en) 2016-06-06 2023-04-28 크리스탈 파마 에스.에이.유. Process for producing deoxycholic acid and intermediates useful in the production of deoxycholic acid
CN111328332B (en) 2017-08-03 2023-01-24 玫帝托克斯股份有限公司 Method for preparing bile acids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5511117B2 (en) * 2000-07-27 2014-06-04 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド Vaccine for broad protection against diseases caused by Neisseria meningitidis
US20180338987A1 (en) * 2007-06-19 2018-11-29 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
EP3138850A1 (en) * 2011-06-16 2017-03-08 Kythera Biopharmaceuticals, Inc. Compositions containing deoxycholic acid and c1-3-alcohols, directed to the purification of deoxycholic acid
JP2021167317A (en) * 2015-06-16 2021-10-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic compositions
WO2018013615A1 (en) * 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CURSE GEOFFREY J ET AL: "HIV-l recombinant gp160 vaccine induced antibodies in serum and saliva", VACCINE, 1 January 1995 (1995-01-01), pages 209 - 214, XP093316931 *
KATONA BRYSON W. ET AL: "Enantiomeric Deoxycholic Acid:? Total Synthesis, Characterization, and Preliminary Toxicity toward Colon Cancer Cell Lines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 24, 25 October 2007 (2007-10-25), United States, pages 9298 - 9307, XP093189169, ISSN: 0022-3263, DOI: 10.1021/jo701559q *
NODE M ET AL: "HARD ACID AND SOFT NUCLEAR SYSTEMS. 3.1 DEALKYLATION OF ESTERS WITHALUMINUM HALIDE-THIOL AND ALUMINUM HALIDE-SULFIDE SYSTEMS", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, UNITED STATES, vol. 46, no. 10, 8 May 1981 (1981-05-08), pages 1991 - 1993, XP000652782, ISSN: 0022-3263, DOI: 10.1021/JO00323A004 *

Also Published As

Publication number Publication date
WO2025175304A2 (en) 2025-08-21

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