WO2025014444A1 - Argon and/or helium cold plasma device for treating skin and mucous membranes, nails, hair, teeth and gums - Google Patents
Argon and/or helium cold plasma device for treating skin and mucous membranes, nails, hair, teeth and gums Download PDFInfo
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- WO2025014444A1 WO2025014444A1 PCT/TR2024/050740 TR2024050740W WO2025014444A1 WO 2025014444 A1 WO2025014444 A1 WO 2025014444A1 TR 2024050740 W TR2024050740 W TR 2024050740W WO 2025014444 A1 WO2025014444 A1 WO 2025014444A1
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- Prior art keywords
- probe
- argon
- cold plasma
- needle
- plastic pen
- Prior art date
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 title claims abstract description 88
- 230000005495 cold plasma Effects 0.000 title claims abstract description 68
- 229910052786 argon Inorganic materials 0.000 title claims abstract description 44
- 210000004209 hair Anatomy 0.000 title claims abstract description 30
- 210000004400 mucous membrane Anatomy 0.000 title claims abstract description 17
- 239000001307 helium Substances 0.000 title claims description 43
- 229910052734 helium Inorganic materials 0.000 title claims description 43
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 title claims description 43
- 239000000523 sample Substances 0.000 claims abstract description 72
- 210000003491 skin Anatomy 0.000 claims abstract description 36
- 210000000282 nail Anatomy 0.000 claims abstract description 33
- 210000000515 tooth Anatomy 0.000 claims abstract description 17
- 239000007789 gas Substances 0.000 claims description 37
- 238000011282 treatment Methods 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 210000001519 tissue Anatomy 0.000 claims description 6
- 210000004262 dental pulp cavity Anatomy 0.000 claims description 5
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 12
- 210000004761 scalp Anatomy 0.000 description 12
- 229910052757 nitrogen Inorganic materials 0.000 description 11
- 210000002381 plasma Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 7
- 230000003779 hair growth Effects 0.000 description 5
- 208000010195 Onychomycosis Diseases 0.000 description 4
- 239000004053 dental implant Substances 0.000 description 4
- 241001480043 Arthrodermataceae Species 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000893966 Trichophyton verrucosum Species 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 3
- 230000037304 dermatophytes Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 230000011759 adipose tissue development Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 201000005882 tinea unguium Diseases 0.000 description 2
- 229940055035 trichophyton verrucosum Drugs 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 102100032912 CD44 antigen Human genes 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 208000007163 Dermatomycoses Diseases 0.000 description 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 102000013814 Wnt Human genes 0.000 description 1
- 208000035472 Zoonoses Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000003778 catagen phase Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 201000003929 dermatomycosis Diseases 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00321—Head or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
- A61B2018/00583—Coblation, i.e. ablation using a cold plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
- A61B2018/1432—Needle curved
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H2240/00—Testing
- H05H2240/20—Non-thermal plasma
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H2245/00—Applications of plasma devices
- H05H2245/30—Medical applications
- H05H2245/34—Skin treatments, e.g. disinfection or wound treatment
Definitions
- the present invention relates to a cold plasma device using argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums.
- Cold plasma combines reactive species such as nitrogen, oxygen, ozone, nitric oxide, ozone, nitric oxide, which inactivate bacteria, viruses and fungi.
- Devices in the known state of the art use ambient gases to generate a cold plasma for treating said nails, hair, skin and mucous membranes, teeth and gums, and aim to treat said nails, hair, skin and mucous membranes, teeth and gums with said plasma.
- all these methods do not have the ability to penetrate the nails, hair, skin and mucous membranes, teeth and gums because they do not use any conductive gas in the system and do not have a manipulator to effectively treat the nails, hair, skin and mucous membranes, teeth and gums with the cold plasma produced with these gases.
- Patent application CN105339048A discloses “Cosmetic Use of Cold Plasma”.
- the invention mentioned in the state of art relates to the cosmetic use of cold atmospheric pressure plasma for the prevention and/or treatment of scalp disorders, in particular aesthetic disorders of the scalp.
- the invention utilizes cold atmospheric plasma for the prevention and/or treatment of aesthetic disorders of the healthy scalp, in particular dandruff of the healthy scalp.
- gases such as air, helium, oxygen, etc. can be used in the cold atmospheric plasma of the invention.
- Patent application US20210401480A1 discloses “Devices and Methods for Treating Skin Tissue Using Cold Plasma”.
- the invention relates to devices and methods for treating dermatologic diseases and disorders, including skin and nail conditions, using cold plasma.
- the tube comprising the invention may contain an inert gas (such as neon or argon) and/or air at sub-atmospheric pressures of at least about 2 kPa or higher.
- Patent application US20190105506A1 discloses “Cold Plasma Device for Skin Treatment”.
- the cold plasma device comprises a cold plasma generator configured to generate cold plasma that produces reactive species for treating the skin, and a manipulator configured to manipulate the skin to increase exposure of bacteria on the skin to said reactive species during use of the device.
- the present invention is a cold plasma device powered by argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums.
- the present invention is a new device that it has structural features that allow for more effective shooting or application during applications such as skin, skin and mucous membranes, teeth and gums, dermaroller, hair and nails in manipulators integrated in cold plasma devices using argon and/or helium gas.
- the invention comprises an argon cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating hair and scalp, and a manipulator adapted to manipulate hair and scalp while exposing said hair and scalp to said reactive species, ozone, nitrogen, nitric oxide gases during use of the device.
- Said manipulator comprises a cold plasma hand probe and a needle electrode at the end of the cold plasma probe designed to contact the scalp during the use of the argon cold plasma device, and a needle electrode at the end of the cold plasma probe designed to trap the argon gas therein while maintaining a balance of ambient gas and argon to treat the hair and scalp without causing damage.
- Argon-generated cold atmospheric plasma has no cytotoxicity in human skin cells and promotes hair growth by increasing capillary formation, cellular proliferation and protein expression associated with hair/angiogenesis, blood oxygenation and regional blood supply.
- argon cold plasma application promotes hair growth through adipogenesis and activation of CD34+CD44+ stem cells and improves the follicular macroenvironment through increased perifollicular vascularity in the hair follicle.
- SF hair follicle
- catagen telogen ratio by increasing the stem cell activity of (SF).
- Activation of perifollicular adipose tissue and angiogenesis occurs as a result of upregulation of Wnt/p-catenin signaling and SF regeneration.
- argon cold plasma can enhance cellular activities of human skin cells and endothelial cells in vitro and stem cells. Thus, it can enhance angiogenesis, adipogenesis and hair growth in the dermis of the skin.
- inventive device may be a highly effective alternative in regenerative medicine to increase hair growth thanks to the effective application of the argon cold plasma manipulator.
- Another manipulator of the invention is an argon cold plasma device for treating foot and nail fungus, which is connected to an argon cold plasma generator. It comprises an argon cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating the nail and foot skin, and a manipulator adapted to manipulate the nail and foot skin while exposing said nail and foot skin to said reactive species, ozone, nitrogen, nitric oxide gases during use of the device.
- Anthropophilic dermatophytes are more common than zoophilic fungi as etiologic factors of onychomycoses. In the case of the latter, reverse zoonoses are possible, posing a threat to the persistence of dermatophytes in the environment.
- both types of tinea unguium can lead to complete nail plate destruction and secondary mixed infections with fungi and bacteria.
- Trichophyton verrucosum One of the zoophilic dermatophytes causing onychomycosis is Trichophyton verrucosum, whose prevalence has increased in recent years. Such infections are usually treated with allylamines and/or azoles. However, such conventional treatment of infections caused by T. verrucosum often fails or is discontinued by patients.
- Another manipulator of the invention is a helium cold plasma operated dermaroller manipulator. It comprises a helium cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating hair and scalp, and a manipulator adapted to manipulate hair and scalp while exposing said hair and scalp to said reactive species, ozone nitrogen nitric oxide gases during use of the device.
- Said manipulator operates using a cold plasma hand probe and a dermaroller manipulator at the end of the cold plasma probe designed to contact the scalp during use of the helium cold plasma device and helium gas.
- the helium cold plasma produced passes through the gaps on the dermaroller and reaches the titanium needles of the dermaroller manipulator, so that the helium cold plasma energy can reach deeper into the skin during the procedure, providing more effective application option.
- Another manipulator of the invention is a helium cold plasma tooth, root, canal manipulator. It comprises a helium cold plasma generator adapted to generate helium cold plasma producing reactive species, ozone, nitric oxide, nitrogen gases for treating the tooth root and canal, and a manipulator adapted to manipulate the tooth root and canal while exposing said tooth root and canal to said reactive species, ozone, nitrogen, nitric oxide, gases during use of the device. Thanks to this manipulator, helium cold plasma, which previously could not be delivered to the tooth root and canal by any method, is effectively delivered to the tooth root and canal thanks to this manipulator, and it is aimed to combat biofilms in the tooth root and canal more effectively.
- Another manipulator of the invention is a helium cold plasma teeth, gums and dental implant manipulator. It comprises a helium cold plasma generator adapted to generate helium cold plasma producing reactive species, ozone, nitric oxide, nitrogen gases for treating teeth, gums and dental implants, and a manipulator adapted to manipulate teeth, gums and dental implants while exposing said teeth, gums and dental implants to said reactive species, ozone, nitrogen, nitric oxide, gases during use of the device. Thanks to this manipulator, the helium cold plasma generator can be used to treat areas in the mouth that could not be treated with the helium cold plasma generator before, thanks to the ergonomic design and practicality of the manipulator, even the narrowest points can be treated.
- the invention it has become possible to deliver helium cold plasma to every area in the mouth. In this way, procedures such as wound healing, stopping bleeding, teeth whitening, infection removal, increasing the tissue compatibility of implants, increasing the bond strength of adhesives can be performed more effectively.
- Figure 1 The general appearance of the inventive product.
- FIG. 1 Detail view of the probes of the inventive product.
- the invention comprises at least one tank (13) in which argon and/or helium gas is stored, an air hose (12) for conveying argon and/or helium gas contained in the tank (13) by the air connector (11) to the plastic pen probe (6), a needle hub holder (2) associated with the needle electrode (1), hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6), the needle electrode (1) and the probe adapter (15) with a perforated structure that can pass through the needle hub holder (2), the roller application probe (20), which is formed in a form that can be attached and removed from the probe adapter (15) and has rotatable rollers at the end and these rollers are fixed at two points and the plasma energy penetrates the roller tips and then the skin through the airways.
- the invention further comprises a general application probe (16) which is mounted on the needle hub holder (2) in order to deliver cold plasma energy to the target tissue at the required temperature without spreading from a single point, and the end part of which has a gradually narrowing structure towards the part to be applied and the end part to contact the tissue has a flat crosssection so that it is not pointed.
- the invention further comprises a nail application probe (17) having an elliptical shape to create a vacuum effect in different devices and to transmit electric ion currents in the form of wires in the cold plasma device and to increase the effect rate by reducing the gas content in the air. This probe has an elliptical tip for optimum plasma distribution over a large area and optimum delivery to the nail surface.
- the invention further comprises a hair application probe (18) having an expanding tip in the form of a cylindrical form, wherein the tip portion has a structure that gradually or non-gradually expands towards the part to be applied in order to increase the rate of effect on the surface to be applied.
- the invention further comprises a general dental application probe (19) having a curved needle at the end thereof, which is formed in a removable form for attachment to the probe adapter (15) for convenient use of the plasma in the teeth and mouth.
- the invention further comprises a root canal application probe (21) comprising at least two fins, the tip of which has a tapered structure for the use of plasma in root canal treatment in the canal area and in hard-to- reach places in the mouth, formed in a removable form that can be attached to the probe adapter (15).
- a root canal application probe (21) comprising at least two fins, the tip of which has a tapered structure for the use of plasma in root canal treatment in the canal area and in hard-to- reach places in the mouth, formed in a removable form that can be attached to the probe adapter (15).
- the needle distance provides a plasma conduction difference and provides improvement in the region by working at optimal temperatures according to the shape of the ion flow of the cold plasma and the region where it can work.
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention relates to an argon and/or helium-powered cold plasma device for treating nails, hair, skin and mucous membranes, teeth and gums, comprises a general application probe (16), a nail application probe (17), a hair application probe (18), a general dental application probe (19), a roller application probe (20) and a dental canal application probe (21).
Description
ARGON AND/OR HELIUM COLD PLASMA DEVICE FOR TREATING SKIN AND MUCOUS MEMBRANES, NAILS, HAIR, TEETH AND GUMS
Technical Field:
The present invention relates to a cold plasma device using argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums.
Background of the Invention:
Today, the use of cold plasma devices for disinfecting objects or treating skin is well known. Cold plasma combines reactive species such as nitrogen, oxygen, ozone, nitric oxide, ozone, nitric oxide, which inactivate bacteria, viruses and fungi.
Devices in the known state of the art use ambient gases to generate a cold plasma for treating said nails, hair, skin and mucous membranes, teeth and gums, and aim to treat said nails, hair, skin and mucous membranes, teeth and gums with said plasma. However, all these methods do not have the ability to penetrate the nails, hair, skin and mucous membranes, teeth and gums because they do not use any conductive gas in the system and do not have a manipulator to effectively treat the nails, hair, skin and mucous membranes, teeth and gums with the cold plasma produced with these gases. Some of the inventions related to cold plasmas are given below.
Patent application CN105339048A discloses “Cosmetic Use of Cold Plasma”. The invention mentioned in the state of art relates to the cosmetic use of cold atmospheric pressure plasma for the prevention and/or treatment of scalp disorders, in particular aesthetic disorders of the scalp. The invention utilizes cold atmospheric plasma for the prevention and/or treatment of aesthetic disorders of the healthy scalp, in particular dandruff of the healthy scalp. Various gases such as air, helium, oxygen, etc. can be used in the cold atmospheric plasma of the invention.
Patent application US20210401480A1 discloses “Devices and Methods for Treating Skin Tissue Using Cold Plasma”. The invention relates to devices and methods for treating dermatologic diseases and disorders, including skin and nail conditions, using cold plasma. The tube comprising the invention may contain an inert gas (such as neon or argon) and/or air at sub-atmospheric pressures of at least about 2 kPa or higher.
Patent application US20190105506A1 discloses “Cold Plasma Device for Skin Treatment”. The cold plasma device comprises a cold plasma generator configured to generate cold plasma that produces reactive species for treating the skin, and a manipulator configured to manipulate the skin to increase exposure of bacteria on the skin to said reactive species during use of the device.
Cold plasma devices are described in the patent applications mentioned above. However, when the manipulators discussed in the relevant patent applications are examined structurally, they are insufficient for applications such as skin and mucosa, teeth and gums, dermaroller, hair and nails.
As a result, there is a need for a new device with structural features that can overcome the disadvantages mentioned above and allow more effective shooting or application during applications such as skin, skin and mucous membranes, teeth and gums, dermaroller, hair and nails in manipulators integrated into cold plasma devices using argon and/or helium gas.
Summary of the Invention:
The present invention is a cold plasma device powered by argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums. The present invention is a new device that it has structural features that allow for more effective shooting or application during applications such as skin, skin and mucous membranes, teeth and gums, dermaroller, hair and nails in manipulators integrated in cold plasma devices using argon and/or helium gas.
The invention comprises an argon cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating hair and scalp, and a manipulator adapted to manipulate hair and scalp while exposing said hair and scalp to said reactive species, ozone, nitrogen, nitric oxide gases during use of the device. Said manipulator comprises a cold plasma hand probe and a needle electrode at the end of the cold plasma probe designed to contact the scalp during the use of the argon cold plasma device, and a needle electrode at the end of the cold plasma probe designed to trap the argon gas therein while maintaining a balance of ambient gas and argon to treat the hair and scalp without causing damage. Argon-generated cold atmospheric plasma has no cytotoxicity in human skin cells and promotes hair growth by increasing capillary formation, cellular proliferation and protein expression associated with hair/angiogenesis, blood oxygenation and regional blood supply. In addition, argon cold plasma application promotes hair growth through adipogenesis and activation of CD34+CD44+ stem cells and improves the follicular macroenvironment through increased perifollicular vascularity in the hair follicle. Considering the importance of the hair follicle (SF) cycle rate (growth - regression - rest) in the diagnosis of alopecia, argon cold atmospheric plasma treatment improves hair growth by increasing the anagen : catagen : telogen ratio by increasing the stem cell activity of (SF). Activation of perifollicular adipose tissue and angiogenesis occurs as a result of upregulation of Wnt/p-catenin signaling and SF regeneration. Finally, these results suggest that argon cold plasma can enhance cellular activities of human skin cells and endothelial cells in vitro and stem cells. Thus, it can enhance angiogenesis, adipogenesis and hair growth in the dermis of the skin. In addition, the inventive device may be a highly effective alternative in regenerative medicine to increase hair growth thanks to the effective application of the argon cold plasma manipulator.
Another manipulator of the invention is an argon cold plasma device for treating foot and nail fungus, which is connected to an argon cold plasma generator. It comprises an argon cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating the nail and foot skin, and a manipulator adapted to manipulate the nail and foot skin while exposing said nail and
foot skin to said reactive species, ozone, nitrogen, nitric oxide gases during use of the device.
Anthropophilic dermatophytes are more common than zoophilic fungi as etiologic factors of onychomycoses. In the case of the latter, reverse zoonoses are possible, posing a threat to the persistence of dermatophytes in the environment. However, without treatment, both types of tinea unguium can lead to complete nail plate destruction and secondary mixed infections with fungi and bacteria. One of the zoophilic dermatophytes causing onychomycosis is Trichophyton verrucosum, whose prevalence has increased in recent years. Such infections are usually treated with allylamines and/or azoles. However, such conventional treatment of infections caused by T. verrucosum often fails or is discontinued by patients. In vitro studies on the direct application of argon cold atmospheric plasma on Trichophyton verrucosum growth, germination and nail adhesion as a new alternative treatment for this type of dermatomycosis are presented here. The manipulator referred to herein, the cold plasma hand probe and the needle electrode at the end of the cold plasma probe designed to contact the nail and foot skin during the use of the argon cold plasma device, and the needle electrode at the end of the cold plasma probe designed to contact the nail and foot skin during the use of the argon cold plasma device, trapping the argon gas inside, while at the same time maintaining the balance of ambient gas and argon, allowing the nail and foot skin to be treated without damaging it. In this way, it is possible to popularize the application of argon cold plasma with the inventive nail manipulator and make such treatments more accessible.
Another manipulator of the invention is a helium cold plasma operated dermaroller manipulator. It comprises a helium cold plasma generator adapted to generate cold plasma generating reactive species, ozone, nitric oxide, nitrogen gases for treating hair and scalp, and a manipulator adapted to manipulate hair and scalp while exposing said hair and scalp to said reactive species, ozone nitrogen nitric oxide gases during use of the device. Said manipulator operates using a cold plasma hand probe and a dermaroller manipulator at the end of the cold plasma probe designed to contact the scalp during use of the helium cold plasma device and helium gas. The helium cold plasma produced
passes through the gaps on the dermaroller and reaches the titanium needles of the dermaroller manipulator, so that the helium cold plasma energy can reach deeper into the skin during the procedure, providing more effective application option.
Another manipulator of the invention is a helium cold plasma tooth, root, canal manipulator. It comprises a helium cold plasma generator adapted to generate helium cold plasma producing reactive species, ozone, nitric oxide, nitrogen gases for treating the tooth root and canal, and a manipulator adapted to manipulate the tooth root and canal while exposing said tooth root and canal to said reactive species, ozone, nitrogen, nitric oxide, gases during use of the device. Thanks to this manipulator, helium cold plasma, which previously could not be delivered to the tooth root and canal by any method, is effectively delivered to the tooth root and canal thanks to this manipulator, and it is aimed to combat biofilms in the tooth root and canal more effectively.
Another manipulator of the invention is a helium cold plasma teeth, gums and dental implant manipulator. It comprises a helium cold plasma generator adapted to generate helium cold plasma producing reactive species, ozone, nitric oxide, nitrogen gases for treating teeth, gums and dental implants, and a manipulator adapted to manipulate teeth, gums and dental implants while exposing said teeth, gums and dental implants to said reactive species, ozone, nitrogen, nitric oxide, gases during use of the device. Thanks to this manipulator, the helium cold plasma generator can be used to treat areas in the mouth that could not be treated with the helium cold plasma generator before, thanks to the ergonomic design and practicality of the manipulator, even the narrowest points can be treated. Thanks to the invention, it has become possible to deliver helium cold plasma to every area in the mouth. In this way, procedures such as wound healing, stopping bleeding, teeth whitening, infection removal, increasing the tissue compatibility of implants, increasing the bond strength of adhesives can be performed more effectively.
The structural and characteristic features and all advantages of the product subject to the invention will be more clearly understood thanks to the figures given below and the
detailed description written by referring to these figures, and therefore, the evaluation should be made by considering these figures and detailed description.
Description of the Figures:
The invention will be described with reference to the accompanying figures, so that the features of the invention will be more clearly understood and appreciated, but the purpose of this is not to limit the invention to these certain regulations. On the contrary, it is intended to cover all alternatives, changes and equivalences that can be included in the area of the invention defined by the accompanying claims. The details shown should be understood that they are shown only for the purpose of describing the preferred embodiments of the present invention and are presented in order to provide the most convenient and easily understandable description of both the shaping of methods and the rules and conceptual features of the invention. In these drawings;
Figure 1 The general appearance of the inventive product.
Figure 2 Detail view of the probes of the inventive product.
The figures to help understand the present invention are numbered as indicated in the attached image and are given below along with their names.
Description of References:
1. Needle electrode
2. Needle hub holder
3. Hub connection point
4. Core connection spring
5. Core coil
6. Plastic pen probe
7. Core coil winding
8. High voltage and core connection point
9. High voltage probe input
10. High voltage cable
11. Air connector
12. Air hose
13. Tank
14. High voltage generator
15. Probe adapter
16. General application probe
17. Nail application probe
18. Hair application probe
19. General dental practice probe
20. Roller application probe
21. Root canal application probe
Detailed Description of the Invention:
The invention comprises at least one tank (13) in which argon and/or helium gas is stored, an air hose (12) for conveying argon and/or helium gas contained in the tank (13) by the air connector (11) to the plastic pen probe (6), a needle hub holder (2) associated with the needle electrode (1), hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6), the needle electrode (1) and the probe adapter (15) with a perforated structure that can pass through the needle hub holder (2), the roller application probe (20), which is formed in a form that can be attached and removed from the probe adapter (15) and has rotatable rollers at the end and these rollers are fixed at two points and the plasma energy penetrates the roller tips and then the skin through the airways.
In addition to the above embodiment, the invention further comprises a general application probe (16) which is mounted on the needle hub holder (2) in order to deliver cold plasma energy to the target tissue at the required temperature without spreading from a single point, and the end part of which has a gradually narrowing structure towards the part to be applied and the end part to contact the tissue has a flat crosssection so that it is not pointed.
In addition to the above embodiment, the invention further comprises a nail application probe (17) having an elliptical shape to create a vacuum effect in different devices and to transmit electric ion currents in the form of wires in the cold plasma device and to increase the effect rate by reducing the gas content in the air. This probe has an elliptical tip for optimum plasma distribution over a large area and optimum delivery to the nail surface.
In addition to the above embodiment, the invention further comprises a hair application probe (18) having an expanding tip in the form of a cylindrical form, wherein the tip portion has a structure that gradually or non-gradually expands towards the part to be applied in order to increase the rate of effect on the surface to be applied.
In addition to the above embodiment, the invention further comprises a general dental application probe (19) having a curved needle at the end thereof, which is formed in a removable form for attachment to the probe adapter (15) for convenient use of the plasma in the teeth and mouth.
In addition to the above embodiment, the invention further comprises a root canal application probe (21) comprising at least two fins, the tip of which has a tapered structure for the use of plasma in root canal treatment in the canal area and in hard-to- reach places in the mouth, formed in a removable form that can be attached to the probe adapter (15).
In all the probes described here, the needle distance provides a plasma conduction difference and provides improvement in the region by working at optimal temperatures according to the shape of the ion flow of the cold plasma and the region where it can work.
Claims
1- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a probe adapter (15) with a perforated structure that pass through the needle electrode (1) and needle hub holder (2),
- a roller application probe (20), which is formed in a form that can be attached to the probe adapter (15) and removable and has rotatable rollers at the end and these rollers are fixed at two points and the plasma energy penetrates the roller tips and then the skin through the airways.
2- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a general application probe (16), which is mounted on the needle hub holder (2) in order to deliver cold plasma energy to the target tissue at the required temperature without spreading from a single point, and which has a gradually narrowing structure towards the part to be applied and has a flat cross-section so that the end part that will contact the tissue is not pointed.
3- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a probe adapter (15) with a perforated structure that pass through the needle electrode (1) and needle hub holder (2),
- a nail application probe (17) with an elliptical shape to create a vacuum effect in different devices and to transmit electric ion currents in the form of wires in the cold plasma device and to increase the effect rate by reducing the gas ratio in the air.
4- The nail application probe (17) according to Claim 3, wherein it has elliptical shape tip.
5- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a probe adapter (15) with a perforated structure that pass through the needle electrode (1) and needle hub holder (2),
- a hair application probe (18) with an expanding tip in the form of a cylindrical form in which the tip has a structure that gradually or non-gradually expands
towards the part to be applied in order to increase the effect rate on the surface to be applied.
6- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a probe adapter (15) with a perforated structure that pass through the needle electrode (1) and needle hub holder (2),
- a general dental application probe (19) with a curved needle at the tip, which is formed in a removable form that can be attached to the probe adapter (15) to ensure comfortable use of plasma in the teeth and mouth.
7- A cold plasma device powered with an argon and/or helium for treating nails, hair, skin and mucous membranes, teeth and gums, comprising;
- at least one tank (13) where argon and/or helium gas is stored,
- an air hose (12) for delivering argon and/or helium gas contained in the tank (13) to the plastic pen probe (6) via the air connector (11),
- a needle hub holder (2) associated to the needle electrode (1),
- a hub connection point (3) positioned on the plastic pen probe (6) for fixing the needle hub holder to plastic pen probe (6),
- a probe adapter (15) with a perforated structure that pass through the needle electrode (1) and needle hub holder (2),
- a root canal application probe (21) with a tapered tip and at least two fins for the use of plasma in root canal treatment in the canal area and hard-to-reach places in the mouth, formed in a removable form that can be attached to the probe adapter (15).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2023008123 | 2023-07-11 | ||
| TR2023/008123 TR2023008123A2 (en) | 2023-07-11 | COLD PLASMA DEVICE WORKING WITH ARGON AND/OR HELIUM TO TREAT SKIN, NAILS, HAIR, SKIN AND MUCOSA, TEETH AND GUMS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2025014444A1 true WO2025014444A1 (en) | 2025-01-16 |
Family
ID=94215764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/TR2024/050740 WO2025014444A1 (en) | 2023-07-11 | 2024-07-01 | Argon and/or helium cold plasma device for treating skin and mucous membranes, nails, hair, teeth and gums |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2025014444A1 (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1340509A (en) * | 1962-11-27 | 1963-10-18 | Siemens Reiniger Werke Ag | Safety device for high frequency surgical devices |
| US4901719A (en) * | 1986-04-08 | 1990-02-20 | C. R. Bard, Inc. | Electrosurgical conductive gas stream equipment |
| US9554843B2 (en) * | 2006-09-01 | 2017-01-31 | Conmed Corporation | Adapter and method for converting gas-enhanced electrosurgical coagulation instrument for cutting |
| US20190105506A1 (en) * | 2016-03-22 | 2019-04-11 | Koninklijke Philips N.V. | Cold plasma device for treating skin |
| US20210401480A1 (en) * | 2020-06-25 | 2021-12-30 | Inbar Medical Ltd. | Devices and methods for treating skin tissue using cold plasma |
| WO2022246070A1 (en) * | 2021-05-20 | 2022-11-24 | Clear Intradermal Technologies, Inc. | Needle adaptor for plasma generating handpiece related application |
| US20230056196A1 (en) * | 2021-08-17 | 2023-02-23 | Feagle Co., Ltd | Dental disease treating device and method for treating dental disease |
-
2024
- 2024-07-01 WO PCT/TR2024/050740 patent/WO2025014444A1/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1340509A (en) * | 1962-11-27 | 1963-10-18 | Siemens Reiniger Werke Ag | Safety device for high frequency surgical devices |
| US4901719A (en) * | 1986-04-08 | 1990-02-20 | C. R. Bard, Inc. | Electrosurgical conductive gas stream equipment |
| US9554843B2 (en) * | 2006-09-01 | 2017-01-31 | Conmed Corporation | Adapter and method for converting gas-enhanced electrosurgical coagulation instrument for cutting |
| US20190105506A1 (en) * | 2016-03-22 | 2019-04-11 | Koninklijke Philips N.V. | Cold plasma device for treating skin |
| US20210401480A1 (en) * | 2020-06-25 | 2021-12-30 | Inbar Medical Ltd. | Devices and methods for treating skin tissue using cold plasma |
| WO2022246070A1 (en) * | 2021-05-20 | 2022-11-24 | Clear Intradermal Technologies, Inc. | Needle adaptor for plasma generating handpiece related application |
| US20230056196A1 (en) * | 2021-08-17 | 2023-02-23 | Feagle Co., Ltd | Dental disease treating device and method for treating dental disease |
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