WO2024250533A1 - Sample processing system - Google Patents
Sample processing system Download PDFInfo
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- WO2024250533A1 WO2024250533A1 PCT/CN2023/127737 CN2023127737W WO2024250533A1 WO 2024250533 A1 WO2024250533 A1 WO 2024250533A1 CN 2023127737 W CN2023127737 W CN 2023127737W WO 2024250533 A1 WO2024250533 A1 WO 2024250533A1
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- WIPO (PCT)
- Prior art keywords
- module
- platform
- powder
- manipulator
- processing system
- Prior art date
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- 238000012545 processing Methods 0.000 title claims abstract description 52
- 239000000843 powder Substances 0.000 claims abstract description 165
- 238000006243 chemical reaction Methods 0.000 claims abstract description 120
- 238000002474 experimental method Methods 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims description 146
- 238000005070 sampling Methods 0.000 claims description 51
- 238000003756 stirring Methods 0.000 claims description 49
- 238000004140 cleaning Methods 0.000 claims description 45
- 238000011068 loading method Methods 0.000 claims description 42
- 239000002699 waste material Substances 0.000 claims description 37
- 238000004458 analytical method Methods 0.000 claims description 33
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- 238000003786 synthesis reaction Methods 0.000 abstract description 4
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- 101100012902 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FIG2 gene Proteins 0.000 description 1
- 101100233916 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR5 gene Proteins 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
Definitions
- the present application relates to the technical field of experimental equipment, and in particular to a sample processing system.
- the purpose of this application is to provide a sample processing system to solve the problems of low automation level, high labor cost, low efficiency and large experimental error in manual operation.
- the present application provides a sample processing system, including a reaction station, which includes: a first machine station, having a first platform; a loading rack, arranged on the first platform, for placing containers; a first manipulator, arranged on the first platform; a switch cover module, arranged on the first platform, for separating or capping the bottle body and bottle cap of the container moved by the first manipulator; a powder adding module, arranged on the first platform, for adding powder to the bottle body after the bottle cap is separated and moved by the first manipulator; a liquid adding module, arranged on the first platform, for adding solution to the bottle body after the powder is added; and a reaction module, arranged on the first platform, for performing a reaction experiment on the solution in the capped container moved by the first manipulator.
- the switch cover module includes a bottle body clamping assembly, a bottle cap clamping assembly and a first driving member, the bottle body clamping assembly is arranged on the first platform, the bottle cap clamping assembly is arranged on the side of the bottle body clamping assembly facing away from the first platform, the bottle body clamping assembly is used to clamp and fix the bottle body, the bottle cap clamping assembly is used to clamp and fix the bottle cap, and the first driving member is used to drive the bottle body clamping assembly and/or the bottle cap clamping assembly to rotate so as to separate or cover the bottle body and the bottle cap; the bottle body clamping assembly and the bottle cap clamping assembly can move relative to each other in relative directions.
- the liquid adding module further includes a cleaning member, which is arranged on the first platform, and the cleaning member is provided with a first accommodating channel and a first waste liquid flow channel, the first accommodating channel is opened from the surface of the cleaning member facing away from the first platform to the interior of the cleaning member, the first accommodating channel is used to accommodate the needle body of the liquid adding needle, the first waste liquid flow channel is opened from the side of the cleaning member to communicate with the first accommodating channel, and with the first platform as a reference, the opening of the first waste liquid flow channel on the surface of the cleaning member is higher than the bottom wall of the first accommodating channel; the cleaning member is also provided with a second accommodating channel and a second waste liquid flow channel, the second accommodating channel is opened from the surface of the cleaning member facing away from the first platform to the interior of the cleaning member, the second accommodating channel and the first accommodating channel are spaced, the second accommodating channel is used to accommodate the needle body of the liquid adding needle, the second waste liquid flow channel is opened from the side of the cleaning member to communicate with the bottom of the second accommodating channel, and
- the liquid adding module includes a pipette, which is detachably connected to the first manipulator.
- the first manipulator is used to move the pipette to the Tip head placement position so that the pipette is connected to the Tip head.
- the pipette is used to automatically aspirate or spit liquid through the Tip head and automatically retract the Tip head.
- the reaction module includes at least one of a first stirring component, a second stirring component and an oscillation component, the first stirring component is used to stir the solution and provide a first temperature range, the second stirring component is used to stir the solution and provide a second temperature range, the first temperature range and the second temperature range are different, and the oscillation component is used to oscillate the solution and provide a third temperature range.
- the reaction station further includes a cache rack, which is disposed on the first platform.
- the loading rack and the cache rack are both provided with a plurality of tray placement positions, the tray placement positions are used to place and limit trays, and the containers are used to be placed on the trays.
- the reaction station further includes a tray clamp and a container clamp
- the first manipulator is detachably connected to the tray clamp and the container clamp
- the tray clamp is used to clamp the tray
- the container clamp is used to clamp the container in the tray.
- the reaction station further includes a barcode scanning module, which is disposed on the first platform.
- a barcode is disposed on the tray and/or container, and the barcode scanning module is used to scan and identify the barcode.
- the reaction station also includes a powder barrel rack, which is arranged on the first platform, and the powder barrel rack is provided with a plurality of powder barrel placement positions, the powder barrel placement positions are used to place and limit the powder barrels, and the powder barrels are used to hold powder; the first manipulator is used to move the powder barrel to the powder adding module, and the powder adding module is used to add the powder in the powder barrel to the bottle body.
- the reaction station further includes a visual module, which is disposed on the first platform.
- the first manipulator is used to move the container after the reaction module performs a reaction experiment to the visual module, and the visual module is used to take a photo of the container.
- the visual module includes a surface light source, an annular light source, a first camera and a second camera, the light emitting surface of the surface light source is located in the vertical direction, the optical axis of the first camera is perpendicular to the light emitting surface of the surface light source, the central axis of the annular light source is located in the vertical direction, and the second camera is located between the annular light source and the first platform; the first camera is used to take a side photo of the container, and the second camera is used to take a bottom photo of the container; the optical axis of the first camera does not intersect with the optical axis of the second camera.
- a calibration plate is further provided on the side of the surface light source facing the first camera, the calibration plate is light-transmissive, parallel to the light-emitting surface of the surface light source, and can move in a direction parallel to the light-emitting surface.
- the optical axis of the second camera coincides with the central axis of the annular light source, or an optical reflector is provided between the annular light source and the first platform, and the optical reflector is used to reflect the light of the central axis of the annular light source to coincide with the optical axis of the second camera.
- the first manipulator is located in the middle position of the first platform, and the loading rack, the switch cover module, the powder adding module, the liquid adding module and the reaction module are arranged around the first manipulator; wherein, one side of the switch cover module is adjacent to the powder adding module, the other side of the switch cover module is adjacent to the reaction module, the side of the powder adding module away from the switch cover module is adjacent to the liquid adding module, and the side of the reaction module away from the switch cover module is adjacent to the loading rack.
- the sample processing system also includes an analysis station, which includes: a second machine having a second platform; a second manipulator disposed on the second platform; an analyzer disposed on the second platform, and the second manipulator is used to place the solution that has completed the reaction in the reaction station and transported to the analysis station into the analyzer for analysis.
- an analysis station which includes: a second machine having a second platform; a second manipulator disposed on the second platform; an analyzer disposed on the second platform, and the second manipulator is used to place the solution that has completed the reaction in the reaction station and transported to the analysis station into the analyzer for analysis.
- the sample processing system also includes a transfer module, which connects the first platform and the second platform and is used to transport the solution that has completed the reaction in the reaction station to the analysis station;
- the transfer module includes a transmission component and a carrying component arranged on the transmission component, the transmission component is used to drive the carrying component to move, and the carrying component is used to place a container.
- the reaction station further includes an air blowing module, which is disposed on the first platform and is used to blow inert gas into the solution before the reaction and/or blow inert gas into the solution to be transported to the analysis station; the air blowing module is disposed close to the switch cover module.
- the inflation module includes a first support seat, an inflation member, a third driving member, a first lifting and rotating assembly and a first head withdrawal mechanism
- the first support seat is arranged on the first platform
- the inflation member, the third driving member and the first lifting and rotating assembly are arranged on the first support seat
- the third driving member is connected to the first lifting and rotating assembly to drive the first lifting and rotating assembly to perform lifting and rotating movements
- the first lifting and rotating assembly is used to connect to the inflation head
- the inflation member is connected to the inflation head for inflating air into the inflation head
- the first head withdrawal mechanism is used to separate the inflation head from the first lifting and rotating assembly.
- the reaction station also includes a sampling module, which is arranged on the first platform.
- the sampling module is provided with a sampling bottle.
- the sampling module is used to absorb the solution from the container after the reaction and transfer it to the sampling bottle to complete the sampling of the solution; the sampling module is arranged close to the switch cover module.
- the sampling module includes a second support seat, a second drive pump, a fourth drive member, a second lifting and rotating assembly and a second head withdrawal mechanism
- the second support seat is arranged on the first platform
- the second drive pump, the fourth drive member and the second lifting and rotating assembly are arranged on the second support seat
- the fourth drive member is connected to the second lifting and rotating assembly to drive the second lifting and rotating assembly to perform lifting and rotating movements
- the second lifting and rotating assembly is used to connect with the Tip head
- the second drive pump is connected to the Tip head
- the second drive pump is used to provide positive pressure or negative pressure to the Tip head so that the Tip head absorbs or spits liquid
- the second head withdrawal mechanism is used to separate the Tip head from the second lifting and rotating assembly.
- the reaction station further includes a filtration module, which is disposed on the first platform and is used to absorb and filter the solution in the sampling bottle.
- the analysis station further includes a mobile module, the mobile module is disposed on the second platform, the second manipulator is disposed on the mobile module, and the mobile module is used to drive the second manipulator to move so as to increase the range of movement of the second manipulator.
- the analysis station further comprises a recovery module
- the recovery module comprises a recovery pipe and a recovery box
- the second platform is provided with a floor drain hole
- the recovery box is arranged below the second platform
- the recovery pipe is passed through the floor drain hole
- the recovery box is arranged below the floor drain hole.
- the leakage hole is connected to the recovery box.
- the sample processing system further includes a mobile robot, and the mobile robot is used to pick up and place containers on the loading rack.
- the sample processing system provided in the present application is provided with a reaction station, and the reaction station includes a first machine, a loading rack, a first manipulator, a cover opening and closing module, a powder adding module, a liquid adding module and a reaction module.
- the first manipulator moves the container to realize the cover opening and closing operations, and the first manipulator moves the bottle body to realize the powder adding operation and the liquid adding operation, and transfers the obtained mixed solution to the reaction module for a reaction experiment, thereby realizing the synthesis reaction of the powder and the solution.
- the entire experiment can be realized in an automated operation, which improves the automation level, reduces the labor cost of manual operation, improves the experimental efficiency, and can reduce the experimental error.
- FIG1 is a perspective view of a sample processing system according to an embodiment
- FIG2 is a perspective view of a partial structure of a sample processing system according to an embodiment
- FIG3 is a plan view of a partial structure of a sample processing system according to an embodiment
- FIG4 is a perspective view of a switch cover module according to an embodiment
- FIG5 is a perspective view of a liquid adding module according to an embodiment
- FIG6 is a perspective view of a liquid adding needle according to an embodiment
- FIG7 is a perspective view of a cleaning member according to an embodiment
- FIG8 is a perspective view of a visual module according to an embodiment
- FIG9 is a perspective view of a visual module according to another embodiment.
- FIG10 is a perspective view of an air blowing module according to an embodiment
- FIG. 11 is a three-dimensional diagram of a sampling module according to an embodiment.
- a component when a component is said to be “fixed to” another component, it can be directly on the other component or there can be a central component.
- a component When a component is said to be “connected to” another component, it can be directly connected to the other component or there can be a central component at the same time.
- An embodiment of the present application provides a sample processing system 1000, including a reaction station 100, which includes a first machine 110, a loading rack 121, a first robot 130, a switch cover module 140, a powder adding module 151, a liquid adding module 160 and a reaction module.
- the first machine 110 is generally a frame structure, which can be a structure constructed by a plurality of horizontal beams, vertical beams, etc., and the horizontal beams and vertical beams are connected by plates; the first machine 110 can also be a structure directly constructed by a plurality of plates.
- the first machine 110 encloses a receiving cavity, which can accommodate various experimental equipment, instruments, power supply and electronic control equipment, experimental consumables, etc.
- the first machine 110 has a first platform 111.
- the first platform 111 has a plane that is roughly parallel to the horizontal plane. The plane is used to place other components. In the following text, when a component is placed on the first platform 111, unless otherwise specified, it means that it is placed on the plane.
- the first platform 111 can be located in the middle of the first machine 110 and can be composed of a plate. Various installation and fixing positions can be set on the first platform 111, which can be holes, grooves, protrusions, etc., without limitation.
- the first platform 111 divides the accommodating chamber in the first machine 110 into two upper and lower chambers.
- the upper chamber is used to accommodate experimental instruments and tools
- the lower chamber can be used to accommodate power supply and electronic control equipment, waste consumables, etc.
- At least one plate around the first machine 110 can be set as a closable door 112, and the door 112 can be a rotating door or a sliding door.
- a handle can be set on the door 112 to facilitate the experimenter to open and close the door 112.
- the door 112 can have a door closing detection function. When the door 112 is not closed in place, an alarm can be sounded to facilitate the experimenter to close the door in place.
- the door 112 can also have a function that requires permission to open, so as to facilitate the permission management of the experimenter and protect the safety of the equipment.
- the functions implemented by the above-mentioned door 112 can be implemented by any feasible solution without limitation.
- the panels around the first machine 110 may be at least partially transparent structures, so that the experimenter or the monitoring camera can observe the situation inside the first machine 110 through the transparent structures.
- a monitoring screen 113 may be provided on the periphery of the first machine 110.
- the monitoring screen 113 is used to display information related to the experiment.
- the experimenter can view the working status of each device through the monitoring screen 113 and/or input instructions to control the operation of the device.
- An exhaust port 114 may also be provided on the top of the first machine 110 to connect with the exhaust device to dehumidify the interior of the first machine 110. Exhaust, etc.
- the loading rack 121 is arranged on the first platform 111, and is used to place the container 510.
- the structure of the loading rack 121 may be a frame structure, and a plate placed approximately horizontally may be provided on the frame, and the container 510 may be placed on the plate.
- the loading rack 121 may be placed on the first platform 111, and may also be fixed to the first platform 111 by a fastening structure such as screws.
- the loading rack 121 may be provided with multiple layers of plates, and each layer of plates may carry the container 510.
- the loading rack 121 may be arranged close to the door 112 of the first machine 110, so that the experimenter or the mobile robot can place the container 510 on the loading rack 121 when the door 112 is opened.
- the container 510 may specifically be a test tube, a reagent bottle, a beaker, a flask, etc., without limitation.
- the container 510 has a bottle body 511 and a bottle cap 512. When no material is loaded in the container 510, the bottle cap 512 is covered on the bottle body 511.
- the bottle cap 512 can be connected to the bottle body 511 by a thread or by a plug, and the specific details are not limited.
- the container 510 can be placed directly on the loading rack 121, or it can be placed on the tray 101 first, and then the tray 101 is placed on the loading rack 121, that is, the container 510 is placed on the loading rack 121 through the tray 101.
- the loading rack 121 can also be used to place various consumables required for experiments, such as Tip heads, filter heads, syringes, etc., and various consumables can be placed on the loading rack 121 through the tray.
- the first manipulator 130 is arranged on the first platform 111.
- the first manipulator 130 can be fixed on the first platform 111, and the end of the first manipulator 130 away from the first platform 111 can be used to grab the container 510 or parts, without limitation.
- the first manipulator 130 can be a manipulator with three-axis, four-axis, or six-axis movement, without limitation.
- the driving structure on the first manipulator 130 is also not limited, as long as the first manipulator 130 can move in multiple directions in the chamber above the first platform 111 of the first machine 110 to achieve functions such as transportation.
- a male connector can be provided at one end of the first manipulator 130 away from the first platform 111.
- the male connector When connecting with other parts (such as various types of grippers), the male connector can be quickly installed and disassembled with the female connector on other parts, that is, the male connector and the female connector are universal parts, so that the first manipulator 130 can quickly connect with other parts and switch different parts.
- the switch cover module 140 is disposed on the first platform 111, and is used to separate or cover the bottle body 511 and the bottle cap 512 of the container 510 moved by the first robot 130.
- the specific structure of the switch cover module 140 is not limited, and its function is to open or close the cover.
- the powder adding module 151 is disposed on the first platform 111, and is used to add powder into the bottle body 511 after the bottle cap 512 is separated and moved by the first manipulator 130.
- the specific structure of the powder adding module 151 is not limited, and its function is to be able to perform the powder adding operation.
- the powder can be set as needed, and the specific composition of the powder is not limited.
- the reaction module is disposed on the first platform 111. After the bottle cap 512 and the bottle body 511 are covered to form a container 510 by the switch cover module 140, the reaction module is used to perform a reaction experiment on the solution in the container 510 moved by the first manipulator 130.
- the specific structure of the reaction module is not limited. The function of the reaction module is to mix the solution with the powder and then stir, oscillate, etc., so that the powder and the solution can react fully.
- the first manipulator 130 is located in the middle of the first platform 111, and the loading rack 121, the switch cover module 140, the powder adding module 151, the liquid adding module 160 and the reaction module are arranged around the first manipulator 130; wherein one side of the switch cover module 140 is adjacent to the powder adding module 151, the other side of the switch cover module 140 is adjacent to the reaction module, the side of the powder adding module 151 away from the switch cover module 140 is adjacent to the liquid adding module 160, and the side of the reaction module away from the switch cover module 140 is adjacent to the loading rack 121.
- multiple modules are arranged with the first manipulator 130 as the center, so that the first manipulator 130 can move between multiple modules and realize the required functions; in addition, the arrangement of the positions between modules can save the time required for the first manipulator 130 to transfer samples between modules, which is conducive to improving the experimental efficiency.
- the sample processing system 1000 of the embodiment of the present application wherein the workflow of the reaction station 100 is as follows: the experimenter opens the door 112 of the first machine 110, manually places the empty container 510 on the loading rack 121, and closes the door 112; the first manipulator 130 moves the container 510 to the switch cover module 140 to separate the bottle cap 512 of the container 510 from the bottle body 511, and the bottle cap 512 can remain at the switch cover module 140; the first manipulator 130 moves the bottle body 511 to the powder adding module 151 for adding powder; the first manipulator 130 moves the bottle body 511 to the liquid adding module 160 for adding liquid; the first manipulator 130 moves the bottle body 511 to the switch cover module 140 to cover the bottle cover 512 on the bottle body 511, so that the powder and solution in the container 510 are in a closed space; the first manipulator 130 moves the container 510 to the reaction module, and the reaction module mixes the powder and solution in the container 510 to accelerate the reaction, thereby completing the reaction process of the sample.
- the sample processing system 1000 provided in the embodiment of the present application is provided with a reaction station 100, and the reaction station 100 includes a first machine 110, a loading rack 121, a first manipulator 130, a cover opening and closing module 140, a powder adding module 151, a liquid adding module 160 and a reaction module.
- the first manipulator 130 moves the container 510 to realize the cover opening and closing operations
- the first manipulator 130 moves the bottle body 511 to realize the powder adding operation and the liquid adding operation.
- the container 510 realizes the mixing operation at the reaction module, so that the synthesis reaction of the powder and the solution can be realized.
- the whole process can be realized by automated operation, which improves the automation level, reduces the labor cost of manual operation, improves the experimental efficiency, and can reduce the experimental error.
- both the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 may have a movable clamping head, which can expand outward or retract inward.
- a movable clamping head which can expand outward or retract inward.
- the clamping head expands outward, it encloses a larger space for placing or removing the object to be clamped (i.e., the bottle body 511 or the bottle cap 512); when the clamping head retracts inward, it encloses a smaller space for clamping the object to be clamped.
- the movement of the clamping head can be achieved by structures such as motors, without limitation. There are no excessive restrictions on the specific structures of the bottle body clamping assembly 141 and the bottle cap clamping assembly 142, as long as the clamping and loosening actions can be achieved.
- the switch cover module 140 may include a switch cover bracket 144, which is disposed on the first platform 111, and the bottle body clamping assembly 141 is disposed on the switch cover bracket 144, that is, the bottle body clamping assembly 141 is disposed on the first platform 111 through the switch cover bracket 144.
- the bottle body clamping assembly 141 may also be directly disposed on the first platform 111.
- the bottle cap clamping assembly 142 may also be disposed on the cover switch bracket 144.
- the bottle cap clamping assembly 142 may be disposed at other positions of the first platform 111, and moved to the side of the bottle body clamping assembly 141 facing away from the first platform 111 when the cover needs to be opened and closed.
- the first driving member 143 can be a stepper motor or other driving structure, without limitation.
- the present embodiment is described for the bottle body 511 and the bottle cap 512 to be screwed together.
- the first driving member 143 can be arranged in the bottle body clamping assembly 141, for driving the bottle body 511 clamped by the bottle body clamping assembly 141 to rotate, and the bottle cap clamping assembly 142 can only do the action of clamping the bottle cap 512, then the bottle body 511 rotates the bottle cap 512 to fix it, and the bottle cap 512 can be separated from the bottle body 511 to realize the uncapping operation.
- the above-mentioned opening action is reversed, and the bottle body 511 and the bottle cap 512 move in the opposite direction relative to the moving direction of opening the cap, that is, the bottle body 511 and the bottle cap 512 move in a direction close to each other, and the cap can be closed.
- the specific structure and implementation method of the first driving member 143 driving the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 to open and close the cap are not specifically limited, and any feasible structure and implementation method can be used.
- the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 By providing the bottle body clamping assembly 141 and the bottle cap clamping assembly 142, the bottle body 511 and the bottle cap 512 can be clamped and loosened, and then through the driving action of the first driving member 143, the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 drive the bottle body 511 and the bottle cap 512 to rotate or move relative to each other, thereby realizing the operation of opening and closing the cap.
- the structure is simple and easy to implement.
- the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 can move relative to each other in opposite directions.
- the bottle cap 512 when opening the cover, gradually withdraws from the bottle mouth during the process from being screwed on the bottle body 511 to being loosened, that is, the bottle cap 512 and the bottle body 511 are displaced in the direction away from each other; when closing the cover, the bottle cap 512 and the bottle body 511 are displaced in the direction of approaching each other during the process from being in contact with the bottle body 511 to being gradually screwed on.
- the plug-type cover opening and closing method during the process of opening and closing the cover, the bottle cap 512 and the bottle body 511 need to move in the direction away from each other to open the cover, and move in the direction of approaching each other to close the cover.
- the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 by setting the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 to be relatively movable in relative directions, power for relative movement of the bottle cap 512 and the bottle body 511 can be provided, or the freedom for relative movement of the bottle cap 512 and the bottle body 511 can be provided.
- a corresponding power mechanism is provided on the corresponding bottle body clamping assembly 141 and/or the bottle cap clamping assembly 142 to drive the clamping head that clamps the bottle body 511 and the bottle cap 512 to move.
- a corresponding guide mechanism, a buffer mechanism, etc. are provided on the corresponding bottle body clamping assembly 141 and/or the bottle cap clamping assembly 142 to provide a guide or buffering effect when the clamping head that clamps the bottle body 511 and the bottle cap 512 moves.
- the relative movement of the bottle cap 512 and the bottle body 511 can be achieved by fixing one of the bottle cap 512 and the bottle body 511 in relative directions and moving the other in relative directions, or by moving both the bottle cap 512 and the bottle body 511 in relative directions.
- the first manipulator 130 is further used to move the bottle cap clamping assembly 142 to align with the bottle body clamping assembly 141 , and the first driving member 143 is disposed on the bottle body clamping assembly 141 to drive the bottle body clamping assembly 141 to rotate relative to the bottle cap clamping assembly 142 .
- the bottle body clamping assembly 141 is fixed to the first platform 111, the male connector of the first manipulator 130 is connected to the female connector on the bottle cap clamping assembly 142, and the bottle cap clamping assembly 142 is moved from its placement position to align with the bottle body clamping assembly 141.
- the bottle cap clamping assembly 142 remains fixed, and the first driving member 143 on the bottle body clamping assembly 141 is actuated to drive the bottle body 511 to rotate relative to the bottle cap 512, so as to realize the opening and closing of the cover.
- the size of the bottle body 511 is larger than the bottle cap 512, which is more convenient to operate.
- a tool rack 123 may be provided on the first platform 111, and the tool rack 123 is used to place various tools.
- the bottle cap clamping assembly 142 can be placed on the tool rack 123 as a cap opening and closing tool, and then removed from the tool rack 123 by the first manipulator 130 when needed, and then placed back on the tool rack 123 after use.
- the tool rack 123 may also be a frame structure, and various placement positions may be provided on the tool rack 123 to facilitate the placement of various tools.
- Various tools are placed on the placement positions on the tool rack 123, and the placement positions can limit the tools to ensure stable support.
- Various tools have female connectors to facilitate quick connection and disassembly with the male connector of the first manipulator 130.
- the tool rack 123 can be directly set on the first platform 111, or it can be It is mounted on the top of the loading rack 121, which is not limited here.
- the powder adding module 151 includes a powder adding component and a weighing component.
- the weighing component is arranged on the first platform 111 and is used to place the bottle body 511 after the bottle cap 512 is separated.
- the powder adding component is used to add powder into the bottle body 511 and determine the amount of powder added according to the weighing result of the weighing component.
- the specific structures of the powder adding component and the weighing component are not limited.
- the powder adding component can add powder into the bottle body 511, and the weighing component can weigh the added powder to achieve quantitative addition of the powder.
- the weight of the added powder can be preset. When the powder adding component adds the powder, the weighing component feeds back the weight of the powder in real time. When the weight of the added powder reaches the preset weight of the powder, the powder adding component stops the powder adding operation.
- the powder adding module 151 may also include a protective cover 1511.
- the powder adding component and the weighing component may be covered by the protective cover 1511 and arranged inside.
- the protective cover 1511 is used to block the interference of the external wind and static electricity on the powder adding component and the weighing component, so as to prevent the wind or static electricity from blowing away the powder or static electricity from adsorbing it to other positions instead of falling into the bottle body 511, thereby improving the powder adding accuracy.
- the side of the protective cover 1511 facing the first manipulator 130 is set as an openable and closable structure.
- the opening and closing method may be lifting and lowering, translating and opening and closing, or rotating and opening and closing, etc., without limitation.
- the side of the protective cover 1511 may be opened by the openable and closable structure, so that the first manipulator 130 can move the bottle body 511 to the internal weighing component, and remove the bottle body 511 after adding the powder.
- the reaction station 100 further includes a powder barrel rack 124, which is provided with a plurality of powder barrel placement positions, which are used to place and limit powder barrels, and the powder barrels are used to contain powder; the first manipulator 130 is used to move the powder barrel to the powder adding module 151, and the powder adding module 151 is used to add the powder in the powder barrel to the bottle body 511.
- the powder barrel rack 124 is arranged on the first platform 111.
- the first manipulator 130 is used to move the powder barrel from the powder barrel rack 124 to the powder adding assembly, and the powder adding assembly is used to add the powder stored in the powder barrel to the bottle body 511.
- the powder barrel also has an opening that can be opened and closed.
- the powder adding assembly When the powder adding assembly adds powder, the powder adding assembly opens the opening of the powder barrel, and the powder leaks from the powder barrel into the bottle body 511 through the opening.
- the powder barrel can be placed on the powder barrel tray 102 first, and then the powder barrel tray 102 is placed at the powder barrel placement position of the powder barrel rack 124.
- the first manipulator 130 is used to move the powder barrel tray 102.
- the structure of the powder barrel tray 102 is not limited.
- the powder barrel placement position of the powder barrel rack 124 can limit the powder barrel tray 102 so that the powder barrel tray 102 is stably placed on the powder barrel rack 124.
- the powder barrel tray 102 can also limit the powder barrel so that the powder barrel is stably placed on the powder barrel tray 102.
- the structure of the powder barrel rack 124 can be the same as or similar to that of the loading rack 121.
- the powder barrel rack 124 can be arranged side by side with the loading rack 121 on the first platform 111, and both are arranged close to the warehouse door 112, so that it is convenient for the experimenter or the mobile robot to load and unload on the powder barrel rack 124 and the loading rack 121.
- the weighing assembly is movable on the first platform 111.
- the weighing assembly moves on the plane of the first platform 111, which can be conveniently aligned with the powder adding assembly, so that the bottle mouth of the bottle body 511 is aligned with the position where the powder leaks out.
- the weighing assembly can be moved to the opened side, so that the first manipulator 130 can place the bottle body 511 on the weighing assembly.
- the weighing assembly can also be moved to the opened side, so that the first manipulator 130 can take away the bottle body 511.
- the powder adding assembly is movable in a direction perpendicular to the first platform 111 , so that the bottle body 511 and the powder barrel can be moved closer to or farther away from each other to facilitate powder adding and weighing operations.
- the liquid adding module 160 includes a first driving pump, a first valve and a liquid adding needle 163, the first driving pump is used to extract solution from the solution bottle 520, the first valve connects the first driving pump and the liquid adding needle 163, and is used to control whether the solution extracted by the first driving pump flows into the liquid adding needle 163, the first manipulator 130 is also used to move the liquid adding needle 163, and the liquid adding needle 163 is used to add solution to the bottle body 511.
- the liquid adding module 160 may include a mounting bracket 161 and a pipeline stopper 162.
- the mounting bracket 161 is disposed on the first platform 111.
- the mounting bracket 161 may be provided with various mounting positions and pipeline perforations.
- the first driving pump and the first valve may be mounted on the mounting bracket 161. At the corresponding installation position on the frame 161, the first driving pump and the first valve can be connected through a pipeline, and the first valve and the liquid adding needle 163 can also be connected through a pipeline.
- the first driving pump can also extend into the solution bottle 520 through a pipeline.
- the solution bottle 520 contains the solution required for the reaction, so that the first driving pump can extract the solution in the solution bottle 520 and can be transported to the liquid adding needle 163 through the control of the first valve to add the solution to the bottle body 511, thereby completing the liquid adding operation.
- the pipeline between the first valve and the liquid adding needle 163 can be limited by the pipeline limiter 162 to prevent multiple pipelines from being entangled with each other and affecting the movement and liquid addition of the liquid adding needle 163.
- the liquid adding module 160 also includes a support bracket 164, which is arranged on the first platform 111, and the support bracket 164 is arranged adjacent to the mounting bracket 161, and the support bracket 164 is used to place the liquid adding needle 163.
- the number of the liquid adding needle 163 can be multiple, and the number of the solution bottle 520 is also multiple, each solution bottle 520 carries different solutions, and the multiple liquid adding needles 163 correspond to the multiple solution bottles 520 one by one.
- the first driving pump can be one or more, and the first valve can be one or more.
- the first valve can be one, and it is a multi-way multi-pass valve, so that different solutions are switched through the switches of different valve ports of the first valve to be delivered to the corresponding liquid adding needle 163; when the first driving pump is multiple, the first valve can also be multiple, and the number can be the same as the number of the liquid adding needle 163, so that the first driving pump, the first valve and the liquid adding needle 163 correspond to each other.
- the first valve has multiple interfaces, and the multiple interfaces are respectively connected to the solution bottle 520, the liquid adding needle 163 and the first driving pump.
- the first driving pump may be one of a plunger pump, a syringe pump, a diaphragm pump, a peristaltic pump, etc.
- the first valve may be one of an electric valve, a pneumatic valve, a hydraulic valve, etc.
- the first valve is a solenoid valve.
- the liquid adding needle 163 may include a substrate 1631, a needle body 1632, a liquid adding pipe joint 1633 and a handling head 1635.
- the substrate 1631 is used as a structural foundation. When placed on the support bracket 164, the substrate 1631 contacts the support bracket 164, and the support bracket 164 limits the substrate 1631.
- the needle body 1632 is connected to one side surface of the substrate 1631, and the side surface of the substrate 1631 facing away from the needle body 1632 is connected to the liquid adding pipe joint 1633 and the handling head 1635.
- the interface 1634 of the liquid adding pipe joint 1633 is connected to the first valve through a pipeline, and the interface 1634 is connected to the needle body 1632.
- the first manipulator 130 can clamp and move the handling head 1635, so that the first manipulator 130 can drive the liquid adding needle 163 to move.
- the first platform 111 may be provided with a plurality of bosses and other placement positions for placing the bottle body 511 or the tray 101, etc. After the first manipulator 130 takes the bottle body 511 from the powder adding module 151, it may be placed at the placement position on the first platform 111, and then the first manipulator 130 may move the liquid adding needle 163 to the position where the bottle body 511 is placed, insert the needle into the bottle mouth, and open the first driving pump and the first valve to inject the solution into the bottle body 511. According to the type and volume of the solution to be reacted, one or more liquid adding needles 163 may be selected to perform one or more liquid adding operations.
- the liquid adding module 160 also includes a cleaning part 165, the cleaning part 165 is arranged on the first platform 111, and the cleaning part 165 is provided with a first accommodating channel 166 and a first waste liquid flow channel 167, the first accommodating channel 166 is opened from the surface of the cleaning part 165 facing away from the first platform 111 to the inside of the cleaning part 165, the first accommodating channel 166 is used to accommodate the needle body 1632 of the liquid adding needle 163, the first waste liquid flow channel 167 is opened from the side of the cleaning part 165 to be connected with the first accommodating channel 166, and with the first platform 111 as a reference, the opening of the first waste liquid flow channel 167 on the surface of the cleaning part 165 is higher than the bottom wall of the first accommodating channel 166.
- the adding needle 163 When adding liquid, it is usually necessary to replace one solution with another one. In order to avoid contamination of the adding needle 163, the adding needle 163 needs to be cleaned before adding liquid again.
- the first manipulator 130 drives the needle body 1632 of the adding needle 163 to insert into the first receiving channel 166, and the first driving pump switches to pumping another solution. The other solution flows to the needle body 1632 to clean the inner wall of the needle body 1632.
- the other solution flowing out of the needle body 1632 gradually fills the first receiving channel 166 until the liquid level reaches the first waste liquid flow channel 167, that is, the other solution in the first receiving channel 166 has a higher liquid level height, and the needle body 1632 is immersed in the other solution, which can clean the outer wall of the needle body 1632.
- the first waste liquid flow channel 167 can be connected to the waste liquid bottle through a pipeline, and the liquid flowing from the first waste liquid flow channel 167 can be cleaned by the needle body 1632.
- the solution flows into the waste bottle for storage.
- the cleaning member 165 is further provided with a second accommodating channel 168 and a second waste liquid flow channel 169
- the second accommodating channel 168 is opened from the surface of the cleaning member facing away from the first platform 111 to the interior of the cleaning member 165
- the second accommodating channel 168 and the first accommodating channel 166 are spaced apart
- the second accommodating channel 168 is used to accommodate the needle body 1632 of the liquid adding needle 163
- the second waste liquid flow channel 169 is opened from the side of the cleaning member 165 to be connected with the bottom of the second accommodating channel 168, and with the first platform 111 as a reference
- the opening of the second waste liquid flow channel 169 on the surface of the cleaning member 165 is not higher than the position where the second accommodating channel 168 and the second waste liquid flow channel 169 are connected.
- the needle body 1632 can be inserted into the second accommodating channel 168. After the solution flows out of the needle body 1632, it directly flows into the waste liquid bottle from the second waste liquid channel 169 without accumulating in the second accommodating channel 168, thereby not contaminating the outer wall of the needle body 1632.
- the needle body 1632 can be first inserted into the second accommodating channel 168 to clean the inner wall, and then inserted into the first accommodating channel 166 to clean the inner wall and the outer wall, so that the cleaning effect is better.
- a support platform 400 may be further provided outside the first machine 110, and the support platform 400 is used to place various solution bottles 520, and the pipeline connected to the first valve may extend from the first machine 110 and extend into each solution bottle 520. In this way, the space inside the first machine 110 can be saved.
- one of the solution bottles 520 may contain a cleaning solution. After the addition operation of all the solutions is completed, the cleaning solution may be transported to the cleaning part 165 to clean the needle body 1632 of the addition needle 163. The addition operation of the addition needle 163 is then stopped until the next experiment.
- liquid adding module 160 By setting up the liquid adding module 160, the liquid adding operation and the operation of cleaning the needle body 1632 of the liquid adding needle 163 can be automatically realized. Liquid adding and cleaning can be realized with one set of structure, which saves parts, makes the equipment structure more compact and occupies less space.
- the liquid adding module 160 includes a pipette, which is detachably connected to the first manipulator 130.
- the first manipulator 130 is used to move the pipette to the Tip head placement position so that the pipette is connected to the Tip head 530 (pipette tip, sampling head).
- the pipette is used to automatically aspirate or spit liquid through the Tip head 530, and automatically retract the Tip head 530.
- the structure of the pipette is not limited.
- the pipette also has a female connector for quick connection and disassembly with the male connector of the first manipulator 130.
- the pipette can be placed on the aforementioned tool rack 123, and the first platform 111 can also be provided with a Tip head rack, and the Tip head rack is provided with a Tip head 530.
- the pipette can be provided with a second drive member and a piston, and the second drive member can drive the piston to perform telescopic movement.
- the first manipulator 130 is connected with the pipette and drives the pipette to move.
- the pipette moves to the solution bottle 520, and the Tip head 530 is inserted into the solution bottle 520, and the second drive member drives the piston to retract, so that the Tip head 530 absorbs liquid, and then the pipette moves to the bottle body 511 and the Tip head 530 is inserted into the bottle mouth of the bottle body 511, and the second drive member drives the piston to extend, so that the Tip head 530 spits liquid, and completes a pipetting operation.
- the Tip head 530 used for the last liquid aspiration needs to be withdrawn and replaced with a new Tip head 530, and the pipette automatically withdraws the Tip head 530 through its own withdrawing mechanism, and the specific structure of the withdrawing mechanism is not limited.
- the above process is then repeated to complete the liquid adding operation, and the first manipulator 130 moves the pipette back to the tool rack 123 for storage until the next liquid adding operation is required.
- the tip head 530 of the present embodiment is disposable, and no cleaning operation is required.
- the tip head 530 after use can be discarded into the waste box.
- a liquid adding module 160 with a liquid adding needle 163 and a liquid adding module 160 with a pipette can be set at the same time, and a suitable liquid adding module 160 is selected according to the capacity of the added solution.
- the capacity of the tip head 530 is limited, for example, 1ml-5ml, and only a small amount of solution can be added each time.
- the liquid adding module 160 with the liquid adding needle 163 can be used for continuous liquid addition. If the amount of each solution added is small, the liquid adding module 160 with a pipette can be selected to reduce the steps of cleaning, and the process is simpler.
- the pipette also includes a first detection member and a second detection member, the first detection member is used to detect whether the Tip head 530 is installed in place, and the second detection member is used to obtain the liquid level of the solution in the Tip head 530 or the bottle body 511.
- the first detection member and the second detection member can be any feasible sensor without limitation. By detecting whether the Tip head 530 is installed in place, it is convenient to determine whether the pipette can perform the pipetting operation to ensure reliability. By detecting the liquid level of the solution in the Tip head 530 or the bottle body 511, it is convenient to determine whether the liquid addition has reached the required amount of liquid addition. By setting the first detection member and the second detection member, the control of the liquid addition operation can be facilitated, and the automation level of the equipment can be improved.
- the reaction module includes at least one of a first stirring component 154, a second stirring component 155 and an oscillation component, the first stirring component 154 is used to stir the solution and provide a first temperature range, the second stirring component 155 is used to stir the solution and provide a second temperature range, the first temperature range and the second temperature range are different, and the oscillation component is used to oscillate the solution and provide a third temperature range.
- the specific structures of the first stirring component 154, the second stirring component 155 and the oscillation component are not limited.
- the stirring function of the first stirring component 154 and the second stirring component 155 can be realized in various possible ways, such as magnetically driving the magnet to move in the bottle body 511, extending the stirring rod into the bottle body 511 for stirring, etc., without limitation.
- the oscillation function of the oscillation component can be realized by clamping the container to drive its swinging oscillation or rotating the eccentric shaft.
- the reaction temperatures required for different powders and solutions are different during the reaction.
- At least one of the first stirring component 154, the second stirring component 155 and the oscillation component is set to provide different temperature ranges while providing the mixing function. According to the temperature required for different reactions, one of the suitable components can be selected for mixing, thereby improving the scope of application of the experiment.
- the first stirring component 154 is a high-temperature magnetic stirrer, which has a temperature controller and a resistance wire, and the temperature controller drives the resistance wire to heat to control the first temperature range to be room temperature-150°C.
- Room temperature is the ambient temperature during the experiment, such as 20°C, 25°C, 30°C, etc., without limitation.
- the first stirring component 154 can accurately control the specific temperature value, and the temperature accuracy can be 1°C, that is, the temperature can be increased or decreased by 1°C within the first temperature range.
- the temperature values that can be accurately controlled are, for example, room temperature, 40°C, 60°C, 80°C, 100°C, 120°C, 140°C, 150°C, etc., and of course, other temperature values can also be used.
- the resistance wire can be coated with a silicone heating film to improve safety.
- the first stirring component 154 has stirring and heating functions, and can fully stir and heat the powder and solution in the bottle body 511 to a suitable reaction temperature.
- the second stirring component 155 is a temperature-controlled electromagnetic stirrer, which has a TEC controller and a semiconductor refrigeration element (Peltier element).
- the TEC controller uses the semiconductor temperature control principle to control the semiconductor element to cool or heat, so as to control the second temperature range to be 0°C-90°C.
- the temperature accuracy of the second stirring component 155 of this embodiment can be 1°C.
- the temperature values that can be accurately controlled are, for example, 0°C, 10°C, 20°C, 30°C, 40°C, 50°C, 60°C, 70°C, 80°C, 90°C, etc., and of course, other temperature values can also be used.
- the second stirring component 155 has stirring, cooling and heating functions, can provide a reaction temperature lower than normal temperature, can fully stir the powder and solution in the bottle 511, and cool or heat to a suitable reaction temperature.
- the third temperature range provided by the oscillation component is room temperature - 150°C, and reference may be made to the manner in which the first stirring component 154 provides the first temperature range, which will not be described in detail.
- first stirring component 154 can be set, one or more second stirring components 155 can be set, and one or more oscillating components can be set.
- Multiple first stirring components 154, multiple second stirring components 155, and multiple oscillating components can simultaneously perform stirring and oscillating operations on multiple bottles 511 to achieve batch experimental operations.
- the reaction station 100 further includes a buffer rack 122, which is disposed on the first platform 111.
- the structure of the buffer rack 122 may be similar to the aforementioned loading rack 121, and can be used as a reference.
- the buffer rack 122 can be set at any position on the first platform 111, and does not need to be set close to the door 112 of the first machine 110.
- the loading rack 121 and the buffer rack 122 are both provided with a plurality of tray placement positions, the tray placement positions are used to place and limit the tray 101, and the container 510 is used to be placed on the tray 101.
- the tray placement positions may be provided with structures such as pins, protrusions, magnetic suction parts, etc., to adapt to the corresponding alignment structure on the tray 101, so that the tray 101 can be limited when placed in the tray placement position, so that the tray 101 can be stably placed on the loading rack 121 or the buffer rack 122.
- the tray 101 may also be provided with a relevant limiting structure, so that the container 510 is limited when placed on the tray 101, ensuring the stability of the container 510.
- the first manipulator 130 can move the tray 101 to drive the container 510 on the tray 101 to move together.
- the first manipulator 130 can also only move the container 510 and leave the tray 101 on the loading rack 121 or the buffer rack 122.
- the reaction station 100 further includes a tray clamp and a container clamp.
- the first manipulator 130 is detachably connected to the tray clamp and the container clamp.
- the tray clamp is used to clamp the tray 101
- the container clamp is used to clamp the container 510 in the tray 101.
- the tray clamp and the container clamp may be provided with the aforementioned female connector for quick installation and removal with the male connector of the first manipulator 130.
- the tray clamp and the container clamp may also be placed on the aforementioned tool rack 123 and limited by the tool rack 123 to stabilize the structure.
- the first manipulator 130 is connected to the tray clamp and the container clamp, and then drives the tray clamp and the container clamp to move from the tool rack 123 to the loading rack 121 or the buffer rack 122.
- the tray clamp clamps the tray 101, and the container clamp clamps the container, so that the first manipulator 130 can drive the tray 101 and the container 510 to move through the tray clamp and the container clamp.
- the specific structures of the tray clamp and the container clamp are not limited, the specific structure of the tray clamp holding the tray 101 is not limited, and the specific structure of the container clamp holding the container is not limited.
- the reaction station 100 further includes a barcode scanning module 152, which is disposed on the first platform 111, and a barcode is disposed on the tray 101 and/or the container 510, and the barcode scanning module 152 is used to scan and identify the barcode.
- the barcode scanning module 152 may include a scanning head, etc., which can scan and identify the barcode.
- the barcode may be a barcode, a two-dimensional code, etc., and the barcode may include relevant information of the tray 101 and/or the container 510, such as the number, type, size, etc.
- the barcode may be set only on the container 510; for the embodiment in which the first manipulator 130 moves the tray 101, the barcode may be set on both the tray 101 and the container 510, or the barcode may be set only on the tray 101.
- the code scanning module 152 scans the barcode, it identifies the relevant information in the barcode and can determine whether the required container 510 has been taken, or whether the required reactant (for example, a container 510 containing powder or a container 510 containing powder and solution placed on the cache rack 122) has been taken.
- the tray 101 and/or the container 510 can be identified, and the input of information during the experiment can be realized to facilitate the exchange of information.
- the code scanning module 152 can be set close to the loading rack 121, so that the first manipulator 130 can move the tray 101 and/or the container 510 placed in the loading rack 121 to the code scanning module 152 for scanning and identification in time.
- the reaction station 100 also includes a visual module 170, the visual module 170 is arranged on the first platform 111, the first robot 130 is used to move the container 510 after the reaction module performs a reaction experiment to the visual module 170, and the visual module 170 is used to take pictures of the container 510.
- the specific structure of the visual module 170 is not limited.
- the visual module 170 is used to take pictures to obtain a picture of the container 510 .
- the progress of the reaction can be determined based on the picture of the container 510 .
- the visual module 170 includes a surface light source 171, an annular light source 172, a first camera 173, and a second camera 174.
- the optical axes of the first camera 173 and the second camera 174 do not intersect.
- the light emitting surface of the surface light source 171 is approximately located in the vertical direction, and the optical axis of the first camera 173 is perpendicular to the light emitting surface of the surface light source 171.
- the central axis of the annular light source 172 is located in the vertical direction, and the second camera 174 is located between the annular light source 172 and the first platform 111.
- the first The camera 173 is used to take a side photo of the container 510
- the second camera 174 is used to take a bottom photo of the container 510 .
- the first manipulator 130 moves the container 510 between the first camera 173 and the surface light source 171, the central axis of the container 510 is roughly along the vertical direction, the surface light source 171 illuminates the container 510 from one side of the container 510, and the first camera 173 can take a bright side photo of the container 510. From the side photo of the container 510, it is possible to check the mixing of the powder and the solution in the container 510 after the reaction, the stratification of the liquid, the turbidity of the liquid (clear solution state), etc., and the reaction situation can be judged accordingly.
- the first manipulator 130 moves the container 510 to the side of the annular light source 172 facing away from the first platform 111, and makes the central axis of the container 510 roughly coincide with the central axis of the annular light source 172.
- the annular light source 172 illuminates the container 510 from the bottom side of the container 510, and the second camera 174 can take a bright bottom photo of the container 510. From the bottom photo of the container 510, the condition of the bottom sediment in the container 510 can be checked, and the reaction condition can be judged accordingly.
- the container 510 that has been mixed at the reaction module is generally gradually deposited to the bottom of the container 510 as time goes by. Therefore, the first manipulator 130 generally moves the container 510 between the first camera 173 and the surface light source 171. After the first camera 173 takes a side photo of the container 510, the first manipulator 130 moves the container 510 to the side of the annular light source 172 that is away from the first platform 111, and the second camera 174 takes a bottom photo of the container 510.
- the bottom photo of the container 510 can be taken first, and then the side photo of the container 510 can be taken as needed.
- the shooting can be performed at regular intervals, at regular intervals, or alternately, without any restrictions.
- the visual module 170 may also include a base 175 and various driving structures arranged on the base 175.
- the base 175 is arranged on the first platform 111.
- the various driving structures can be used to control the opening, closing, and brightness of the surface light source 171 and the annular light source 172, as well as driving the surface light source 171, the annular light source 172, the first camera 173, and the second camera 174 to move on the base 175, etc., without any restrictions.
- a calibration plate 176 is further provided on the side of the surface light source 171 facing the first camera 173.
- the calibration plate 176 is made of a transparent material and has light transmittance.
- the calibration plate 176 is parallel to the light emitting surface of the surface light source 171 and can move in a direction parallel to the light emitting surface.
- the calibration plate 176 may be provided with a pattern for calibration, such as a checkerboard or array pattern.
- the calibration plate 176 is used to provide a background for the image captured by the first camera 173, so as to facilitate the inspection of the reaction of the solution in the container 510.
- the driving structure on the base 175 drives one end of the calibration plate 176 and blocks the light-emitting surface of the surface light source 171.
- the light emitted by the surface light source 171 penetrates the calibration plate 176 to illuminate the calibration plate 176.
- the first camera 173 takes a photo of the container 510 and the calibration plate 176.
- the light of the pattern of the calibration plate 176 passes through the solution and enters the first camera 173, and then forms an image in the first camera 173.
- the reaction conditions such as the stratification and mixing conditions in the solution can be judged according to the degree of distortion of the pattern of the calibration plate 176 in the imaged photo.
- the optical axis of the second camera 174 coincides with the central axis of the annular light source 172 . That is, the optical axis of the second camera 174 is substantially vertical, and the second camera 174 is on the side of the annular light source 172 facing the first platform 111 .
- FIG. 9 is basically the same as the embodiment shown in FIG. 8 , except that an optical reflector 177 is provided between the annular light source 172 and the first platform 111 , and the optical reflector 177 is used to reflect the light of the central axis of the annular light source 172 to coincide with the optical axis of the second camera 174.
- the optical reflector 177 may be a plane reflector, a reflective prism, etc., without limitation.
- the optical reflector 177 is replaced by the optical reflector 177, thereby changing the path of the light reflected from the bottom of the container 510, so that the optical axis of the second camera 174 does not need to be provided in the direction of the central axis of the annular light source 172, and the second camera 174 can be provided in a more reasonable position, making the structure more compact.
- the optical axis of the second camera 174 may be parallel to the optical axis of the first camera 173.
- the sample processing system 1000 further includes a mobile robot (not shown in the figure), which is used to pick up and place the container 510 on the loading rack 121.
- the mobile robot can replace the experimenter to load and unload materials, which can reduce labor costs. Realize full automation of the entire experimental process.
- the first manipulator 130 can move the container 510 after the reaction is completed to the loading rack 121 , so that the experimenter or the mobile robot can take the reaction sample from the loading rack 121 .
- the sample processing system 1000 further includes an analysis station 200 , and the analysis station 200 includes a second machine 210 , a second robot 220 , and an analyzer 230 .
- the second machine 210 is arranged at one side of the first machine 110, and the two machines can be arranged close to each other.
- the second machine 210 has a second platform 211, which is similar to the first platform 111 and is also a platform for placing various parts.
- the second platform 211 can be at the same height as the first platform 111.
- the second robot 220 is disposed on the second platform 211.
- the second robot 220 is similar to the first robot 130, and the description of the first robot 130 is referred to above and will not be repeated here.
- the analyzer 230 is disposed on the second platform 211, and the second manipulator 220 is used to place the solution that has completed the reaction in the reaction station 100 and is transported to the analysis station 200 into the analyzer 230 for analysis.
- the analyzer 230 is used to analyze the solution and obtain information such as the components and content of the solution.
- the analyzer 230 can be an LCMS (liquid chromatography-mass spectrometry) analyzer, an HPLC (High Performance Liquid Chromatography) analyzer, an UPLC (Ultra Performance Liquid Chromatography) analyzer, etc.
- the specific structure and principle of the analyzer 230 are not limited, and any feasible one can be used.
- the sample processing system 1000 After the sample processing system 1000 completes the reaction at the reaction station 100, it is sent to the analysis station 200 for analysis, which extends the workflow of the sample processing system 1000, automates the analysis process, and further improves the automation level of the equipment.
- the sample processing system 1000 further includes a transfer module 300 , which connects the first platform 111 and the second platform 211 and is used to transport the solution that has completed the reaction in the reaction station 100 to the analysis station 200 .
- the transfer module 300 may include various conveying devices, such as guide devices, conveyor belt devices, etc., without limitation.
- the transfer module 300 includes a transmission component 310 and a bearing component 320 arranged on the transmission component 310, and the two ends of the transmission component 310 are respectively arranged on the first platform 111 and the second platform 211, and the transmission component 310 is used to drive the bearing component 320 to move on the transmission component 310, so as to move between the first platform 111 and the second platform 211.
- the bearing component 320 is used to place the container 510 or the tray 101 with the container 510, so as to transfer the reacted solution from the reaction station 100 to the analysis station 200.
- the transmission component 310 can be specifically a screw nut transmission mechanism, and the bearing component 320 is arranged on the nut, and the bearing component 320 can be driven to move on the transmission component 310 by a motor or other structures.
- the solution can be transferred so that the analyzer 230 can analyze the solution.
- the reaction station 100 further includes a gas blowing module 180 , which is disposed on the first platform 111 , and is used to blow inert gas into the solution before the reaction, and/or blow inert gas into the solution to be transported to the analysis station.
- the gas blowing module 180 is disposed close to the switch cover module 140 .
- the specific structure of the air-inflating module 180 is not limited. Optionally, please refer to Figures 3 and 10.
- the air-inflating module 180 includes a first support seat 181, an air-inflating member 182, a third driving member 183, a first lifting and rotating assembly 184, etc.
- the first support seat 181 is arranged on the first platform 111, and the air-inflating member 182, the third driving member 183 and the first lifting and rotating assembly 184 are arranged on the first support seat 181.
- the third driving member 183 is, for example, a dual-motion motor.
- the third driving member 183 is connected to the first lifting and rotating assembly 184 to drive the first lifting and rotating assembly 184 to perform lifting and rotating movements.
- the first lifting and rotating assembly 184 is used to connect with the air-inflating head, and the air-inflating member 182 is connected to the air-inflating head for inflating the air-inflating head.
- the air-inflating head can be a Tip head 530 or other structures, without limitation.
- An air-inflating head placement rack can be provided on the first support seat 181, on which a plurality of air-inflating heads can be placed.
- the first manipulator 130 moves the container 510 (i.e., the bottle body 511) to which the powder and solution are added to a position close to the inflation module 180.
- the container 510 i.e., the bottle body 511) to which the powder and solution are added is placed on the switch cover module.
- the switch cover module 140 closes the container 510, and then the first manipulator 130 sends it into the reaction module for reaction experiment.
- the first lifting and rotating assembly 184 of the inflation module 180 performs lifting and/or rotating motion to move to the inflation head placement rack, and is connected to the inflation head, and then performs lifting and/or rotating motion to immerse the inflation head in the solution in the bottle body 511, and then the inflation component 182 inflates the inflation head, and inert gas such as nitrogen or helium is blown into the solution through the inflation head, which can discharge oxygen in the solution to prevent the solution from being oxidized.
- the inflation component 182 may include a gas storage bottle and a control valve, the gas storage bottle is used to store inert gas, one end of the control valve is connected to the gas storage bottle, and the other end is connected to the inflation head, which is used to control the on-off of the gas path between the gas storage bottle and the inflation head.
- the control valve is a solenoid valve.
- the inflation module 180 may also be provided with a first head-retracting mechanism. After completing an inflation operation, the first lifting and rotating assembly 184 may drive the inflation head to move to the first head-retracting mechanism to withdraw the inflation head, that is, the first head-retracting mechanism is used to separate the inflation head from the first lifting and rotating assembly 184. The withdrawn inflation head may be discarded into a waste box. When the inflation operation is performed next time, the first lifting and rotating assembly 184 is reconnected with a new inflation head to avoid contamination of the solution by the inflation head.
- the specific structure of the first head-retracting mechanism is not limited.
- the reaction station 100 further includes a sampling module 190, the sampling module 190 is disposed on the first platform 111, the sampling module 190 is provided with a sampling bottle 540, the sampling module 190 is used to absorb the solution from the container 510 after the reaction and transfer it to the sampling bottle 540 to complete the sampling of the solution, and the sampling module 190 is arranged near the switch cover module 140.
- the sampling bottle 540 may contain a diluent, and the sampling module 190 may simultaneously complete the sampling and dilution of the solution; or, before sampling, the sampling bottle 540 is empty, and after the solution sampling is completed, the diluent may be added to the sampling bottle 540 to dilute the solution.
- the sampling module 190 includes a second support seat 191, a second drive pump 192, a fourth drive member 193, a second lifting and rotating assembly 194, etc.
- the second support seat 191 is arranged on the first platform 111
- the second drive pump 192, the fourth drive member 193 and the second lifting and rotating assembly 194 are arranged on the second support seat 191
- the fourth drive member 193 is, for example, a dual-motion motor
- the fourth drive member 193 is connected to the second lifting and rotating assembly 194 to drive the second lifting and rotating assembly 194 to perform lifting and rotating movements
- the second lifting and rotating assembly 194 is used to connect with the Tip head 530
- the Tip head 530 is connected to the second drive pump 192
- the second drive pump 192 is used to provide positive pressure or negative pressure to the Tip head 530, so that the Tip head 530 can absorb or spit liquid.
- a Tip head placement rack can be set on the second support seat 191,
- the first manipulator 130 moves the container 510 (i.e., the bottle body 511, which contains the solution after the reaction) after the reaction is completed to the switch cover module 140 to open the cover, and then the second lifting and rotating component 194 of the sampling module 190 performs lifting and/or rotating movements to move to the tip head placement rack and connect with the tip head 530, and then performs lifting and/or rotating movements to immerse the tip head 530 in the solution in the bottle body 511, and then the second driving pump 192 provides negative pressure to the tip head 530, so that the tip head 530 absorbs liquid, and then the second lifting and rotating component 194 drives the tip head 530 after the liquid absorption to move to the sampling bottle 540, and the second driving pump 192 provides positive pressure to the tip head 530, so that the tip head 530 spits liquid into the sampling bottle 540, and the solution in the sampling bottle 540 is diluted by the diluent.
- the diluted solution in the sampling bottle 540 can be transferred to the analyzer 230 for
- the sampling module 190 Similar to the aforementioned air blowing module 180, the sampling module 190 also needs to perform a head withdrawal operation, and a new Tip head 530 needs to be replaced each time sampling is performed, that is, the sampling module 190 may also be provided with a second head withdrawal mechanism similar to the aforementioned first head withdrawal mechanism, and the second head withdrawal mechanism is used to separate the Tip head from the second lifting and rotating assembly 194, and the specific structure of the second head withdrawal mechanism is not limited.
- the reaction station 100 further includes a filter module 153 .
- the filter module 153 is disposed on the first platform 111 .
- the filter module 153 is used to absorb and filter the solution in the sampling bottle 540 .
- the specific structure of the filter module 153 is not limited.
- the solution in the sampling bottle 540 has been diluted and can be transferred to the analyzer 230 for analysis after being filtered by the filter module 153.
- the filtered solution can be moved to the air blowing module 180. At the location, the solution is aerated and then sent to the analysis station 200.
- the analysis station 200 is also provided with a mobile module 240, the mobile module 240 is arranged on the second platform 211, the second manipulator 220 is arranged on the mobile module 240, and the mobile module 240 is used to drive the second manipulator 220 to move to increase the range of movement of the second manipulator 220.
- the moving module 240 can drive the second robot 220 to move along at least one direction on the second platform 211 , and the specific structure of the moving module 240 is not limited.
- the analysis station 200 also includes a recycling module 250, and the recycling module 250 includes a recycling pipe and a recycling box.
- the second platform 211 is provided with a floor drain hole, and the recycling box is arranged below the second platform 211.
- the recycling pipe is passed through the floor drain hole and connected to the recycling box.
- the waste after the analysis is completed is discarded into the recycling pipe and collected into the recycling box along the recycling pipe.
- the containers, waste liquids, etc. that have been analyzed can be recycled by simply throwing them into the recycling pipe, and the operation is simple.
- the recycling box can be manually taken out from the analysis station and the waste can be stored and processed at a designated location.
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Abstract
Description
本申请要求于2023年06月09日提交中国专利局、申请号为202310688783.6、申请名称为“样品处理系统”的中国专利申请的优先权,其全部内容通过引用结合在本申请中。This application claims the priority of the Chinese patent application filed with the China Patent Office on June 9, 2023, with application number 202310688783.6 and application name “Sample Processing System”, the entire contents of which are incorporated by reference into this application.
本申请涉及实验设备技术领域,具体涉及一种样品处理系统。The present application relates to the technical field of experimental equipment, and in particular to a sample processing system.
在进行化学试剂配制、药品研发等行业中,通常需要将粉料与溶液进行混合以进行反应。目前的试验过程中主要依赖实验人员手动操作,自动化水平低,且人工成本高,效率低,实验误差也较大。In the chemical reagent preparation, drug research and development and other industries, it is usually necessary to mix powders with solutions for reaction. The current experimental process mainly relies on manual operation by experimenters, with low automation level, high labor costs, low efficiency and large experimental errors.
发明内容Summary of the invention
本申请的目的是提供一种样品处理系统,解决人工操作的自动化水平低,人工成本高,效率低,实验误差大的问题。The purpose of this application is to provide a sample processing system to solve the problems of low automation level, high labor cost, low efficiency and large experimental error in manual operation.
为实现本申请的目的,本申请提供了如下的技术方案:To achieve the purpose of this application, this application provides the following technical solutions:
本申请提供一种样品处理系统,包括反应站,所述反应站包括:第一机台,具有第一平台;上料架,设置于所述第一平台,用于放置容器;第一机械手,设置于所述第一平台;开关盖模组,设置于所述第一平台,用于将所述第一机械手移动过来的容器的瓶身和瓶盖进行分离或盖合;加粉模组,设置于所述第一平台,用于向所述第一机械手移动过来的分离瓶盖后的瓶身内添加粉料;加液模组,设置于所述第一平台,用于向添加粉料后的瓶身内添加溶液;反应模组,设置于所述第一平台,用于对所述第一机械手移动过来的盖合后的容器中的溶液进行反应实验。The present application provides a sample processing system, including a reaction station, which includes: a first machine station, having a first platform; a loading rack, arranged on the first platform, for placing containers; a first manipulator, arranged on the first platform; a switch cover module, arranged on the first platform, for separating or capping the bottle body and bottle cap of the container moved by the first manipulator; a powder adding module, arranged on the first platform, for adding powder to the bottle body after the bottle cap is separated and moved by the first manipulator; a liquid adding module, arranged on the first platform, for adding solution to the bottle body after the powder is added; and a reaction module, arranged on the first platform, for performing a reaction experiment on the solution in the capped container moved by the first manipulator.
一种实施方式中,所述开关盖模组包括瓶身夹持组件、瓶盖夹持组件和第一驱动件,所述瓶身夹持组件设置于所述第一平台,所述瓶盖夹持组件设置在所述瓶身夹持组件背向所述第一平台的一侧,所述瓶身夹持组件用于夹持固定瓶身,所述瓶盖夹持组件用于夹持固定瓶盖,所述第一驱动件用于驱动所述瓶身夹持组件和/或所述瓶盖夹持组件旋转,以使瓶身与瓶盖分离或盖合;所述瓶身夹持组件和所述瓶盖夹持组件在相对的方向上可相对移动。In one embodiment, the switch cover module includes a bottle body clamping assembly, a bottle cap clamping assembly and a first driving member, the bottle body clamping assembly is arranged on the first platform, the bottle cap clamping assembly is arranged on the side of the bottle body clamping assembly facing away from the first platform, the bottle body clamping assembly is used to clamp and fix the bottle body, the bottle cap clamping assembly is used to clamp and fix the bottle cap, and the first driving member is used to drive the bottle body clamping assembly and/or the bottle cap clamping assembly to rotate so as to separate or cover the bottle body and the bottle cap; the bottle body clamping assembly and the bottle cap clamping assembly can move relative to each other in relative directions.
一种实施方式中,所述加粉模组包括加粉组件和称重组件,所述称重组件设置在所述第一平台,并用于放置分离瓶盖后的瓶身,所述加粉组件用于向瓶身内添加粉料,并根据所述称重组件的称重结果确定粉料的添加量;所述称重组件在所述第一平台上可移动,和/或,所述加粉组件在垂直于所述第一平台的方向上可移动;所述加粉模组还包括防护罩,所述加粉组件和所述称重组件被所述防护罩罩设在内部,所述防护罩朝向所述第一机械手的一侧面为可开闭结构。In one embodiment, the powder adding module includes a powder adding component and a weighing component, the weighing component is arranged on the first platform and is used to place the bottle body after the bottle cap is separated, the powder adding component is used to add powder into the bottle body, and determine the amount of powder added according to the weighing result of the weighing component; the weighing component is movable on the first platform, and/or the powder adding component is movable in a direction perpendicular to the first platform; the powder adding module also includes a protective cover, the powder adding component and the weighing component are covered inside by the protective cover, and the side of the protective cover facing the first manipulator is an openable and closable structure.
一种实施方式中,所述加液模组包括第一驱动泵、第一阀门和加液针,所述第一驱动泵用于从溶液瓶中抽取溶液,所述第一阀门连通所述第一驱动泵和所述加液针,用于控制所述第一驱动泵抽取的溶液是否流入所述加液针,所述第一机械手还用于移动所述加液针,所述 加液针用于向瓶身内添加溶液。In one embodiment, the liquid adding module includes a first driving pump, a first valve and a liquid adding needle, wherein the first driving pump is used to extract solution from a solution bottle, the first valve connects the first driving pump and the liquid adding needle and is used to control whether the solution extracted by the first driving pump flows into the liquid adding needle, the first manipulator is also used to move the liquid adding needle, The filling needle is used to add solution into the bottle.
一种实施方式中,所述加液模组还包括清洗件,所述清洗件设置于所述第一平台,所述清洗件开设有第一容置通道和第一废液流道,所述第一容置通道自所述清洗件背向所述第一平台的表面开设至所述清洗件的内部,所述第一容置通道用于容置所述加液针的针体,所述第一废液流道自所述清洗件的侧面开设至与所述第一容置通道连通,且以所述第一平台为基准,所述第一废液流道在所述清洗件的表面的开口比所述第一容置通道的底壁更高;所述清洗件还开设有第二容置通道和第二废液流道,所述第二容置通道自所述清洗件背向所述第一平台的表面开设至所述清洗件的内部,所述第二容置通道与所述第一容置通道具有间隔,所述第二容置通道用于容置所述加液针的针体,所述第二废液流道自所述清洗件的侧面开设至与所述第二容置通道的底部连通,且以所述第一平台为基准,所述第二废液流道在所述清洗件的表面的开口不高于所述第二容置通道与所述第二废液流道连通的位置。In one embodiment, the liquid adding module further includes a cleaning member, which is arranged on the first platform, and the cleaning member is provided with a first accommodating channel and a first waste liquid flow channel, the first accommodating channel is opened from the surface of the cleaning member facing away from the first platform to the interior of the cleaning member, the first accommodating channel is used to accommodate the needle body of the liquid adding needle, the first waste liquid flow channel is opened from the side of the cleaning member to communicate with the first accommodating channel, and with the first platform as a reference, the opening of the first waste liquid flow channel on the surface of the cleaning member is higher than the bottom wall of the first accommodating channel; the cleaning member is also provided with a second accommodating channel and a second waste liquid flow channel, the second accommodating channel is opened from the surface of the cleaning member facing away from the first platform to the interior of the cleaning member, the second accommodating channel and the first accommodating channel are spaced, the second accommodating channel is used to accommodate the needle body of the liquid adding needle, the second waste liquid flow channel is opened from the side of the cleaning member to communicate with the bottom of the second accommodating channel, and with the first platform as a reference, the opening of the second waste liquid flow channel on the surface of the cleaning member is not higher than the position where the second accommodating channel is connected to the second waste liquid flow channel.
一种实施方式中,所述加液模组包括移液器,所述移液器与所述第一机械手可拆卸连接,所述第一机械手用于移动所述移液器至Tip头放置位使所述移液器与Tip头连接,所述移液器用于自动通过Tip头吸液或吐液,以及自动退Tip头。In one embodiment, the liquid adding module includes a pipette, which is detachably connected to the first manipulator. The first manipulator is used to move the pipette to the Tip head placement position so that the pipette is connected to the Tip head. The pipette is used to automatically aspirate or spit liquid through the Tip head and automatically retract the Tip head.
一种实施方式中,所述反应模组包括第一搅拌组件、第二搅拌组件和振荡组件中的至少一个,所述第一搅拌组件用于对溶液进行搅拌并提供第一温度范围,所述第二搅拌组件用于对溶液进行搅拌并提供第二温度范围,所述第一温度范围和所述第二温度范围不同,所述振荡组件用于对溶液进行振荡并提供第三温度范围。In one embodiment, the reaction module includes at least one of a first stirring component, a second stirring component and an oscillation component, the first stirring component is used to stir the solution and provide a first temperature range, the second stirring component is used to stir the solution and provide a second temperature range, the first temperature range and the second temperature range are different, and the oscillation component is used to oscillate the solution and provide a third temperature range.
一种实施方式中,所述反应站还包括缓存架,所述缓存架设置于所述第一平台,所述上料架和所述缓存架均设有多个托盘放置位,所述托盘放置位用于放置托盘并限位,所述容器用于放置在所述托盘上。In one embodiment, the reaction station further includes a cache rack, which is disposed on the first platform. The loading rack and the cache rack are both provided with a plurality of tray placement positions, the tray placement positions are used to place and limit trays, and the containers are used to be placed on the trays.
一种实施方式中,所述反应站还包括托盘夹爪和容器夹爪,所述第一机械手与所述托盘夹爪、所述容器夹爪均可拆卸连接,所述托盘夹爪用于夹持所述托盘,所述容器夹爪用于夹持所述托盘内的容器。In one embodiment, the reaction station further includes a tray clamp and a container clamp, the first manipulator is detachably connected to the tray clamp and the container clamp, the tray clamp is used to clamp the tray, and the container clamp is used to clamp the container in the tray.
一种实施方式中,所述反应站还包括扫码模组,所述扫码模组设置于所述第一平台,所述托盘和/或容器上设有条码,所述扫码模组用于扫描并识别所述条码。In one embodiment, the reaction station further includes a barcode scanning module, which is disposed on the first platform. A barcode is disposed on the tray and/or container, and the barcode scanning module is used to scan and identify the barcode.
一种实施方式中,所述反应站还包括粉桶架,所述粉桶架设置于所述第一平台,所述粉桶架设有多个粉桶放置位,所述粉桶放置位用于放置粉桶并限位,所述粉桶用于盛装粉料;所述第一机械手用于移动所述粉桶至所述加粉模组,所述加粉模组用于将所述粉桶中的粉料添加至瓶身中。In one embodiment, the reaction station also includes a powder barrel rack, which is arranged on the first platform, and the powder barrel rack is provided with a plurality of powder barrel placement positions, the powder barrel placement positions are used to place and limit the powder barrels, and the powder barrels are used to hold powder; the first manipulator is used to move the powder barrel to the powder adding module, and the powder adding module is used to add the powder in the powder barrel to the bottle body.
一种实施方式中,所述反应站还包括视觉模组,所述视觉模组设置于所述第一平台,所述第一机械手用于将所述反应模组进行反应实验后的容器移动至所述视觉模组处,所述视觉模组用于对容器进行拍照。In one embodiment, the reaction station further includes a visual module, which is disposed on the first platform. The first manipulator is used to move the container after the reaction module performs a reaction experiment to the visual module, and the visual module is used to take a photo of the container.
一种实施方式中,所述视觉模组包括面光源、环形光源、第一相机和第二相机,所述面光源的出光面位于竖直方向上,所述第一相机的光轴与所述面光源的出光面垂直,所述环形光源的中心轴位于竖直方向上,所述第二相机位于所述环形光源与第一平台之间的位置;所述第一相机用于拍摄容器的侧面照片,所述第二相机用于拍摄容器的底部照片;所述第一相机的光轴与所述第二相机的光轴不相交。In one embodiment, the visual module includes a surface light source, an annular light source, a first camera and a second camera, the light emitting surface of the surface light source is located in the vertical direction, the optical axis of the first camera is perpendicular to the light emitting surface of the surface light source, the central axis of the annular light source is located in the vertical direction, and the second camera is located between the annular light source and the first platform; the first camera is used to take a side photo of the container, and the second camera is used to take a bottom photo of the container; the optical axis of the first camera does not intersect with the optical axis of the second camera.
一种实施方式中,所述面光源朝向所述第一相机的一侧还设有标定板,所述标定板具有透光性,所述标定板平行于所述面光源的出光面,且所述标定板能够沿平行于所述出光面的方向移动。 In one embodiment, a calibration plate is further provided on the side of the surface light source facing the first camera, the calibration plate is light-transmissive, parallel to the light-emitting surface of the surface light source, and can move in a direction parallel to the light-emitting surface.
一种实施方式中,所述第二相机的光轴与所述环形光源的中心轴重合,或者,所述环形光源与所述第一平台之间的位置设置有光学反射件,所述光学反射件用于将所述环形光源的中心轴的光线反射至与所述第二相机的光轴重合。In one embodiment, the optical axis of the second camera coincides with the central axis of the annular light source, or an optical reflector is provided between the annular light source and the first platform, and the optical reflector is used to reflect the light of the central axis of the annular light source to coincide with the optical axis of the second camera.
一种实施方式中,所述第一机械手位于所述第一平台的中间位置,所述上料架、所述开关盖模组、所述加粉模组、所述加液模组和所述反应模组围绕所述第一机械手设置;其中,所述开关盖模组的一侧与所述加粉模组相邻,所述开关盖模组的另一侧与所述反应模组相邻,所述加粉模组远离所述开关盖模组的一侧与所述加液模组相邻,所述反应模组远离所述开关盖模组的一侧与所述上料架相邻。In one embodiment, the first manipulator is located in the middle position of the first platform, and the loading rack, the switch cover module, the powder adding module, the liquid adding module and the reaction module are arranged around the first manipulator; wherein, one side of the switch cover module is adjacent to the powder adding module, the other side of the switch cover module is adjacent to the reaction module, the side of the powder adding module away from the switch cover module is adjacent to the liquid adding module, and the side of the reaction module away from the switch cover module is adjacent to the loading rack.
一种实施方式中,所述样品处理系统还包括分析站,所述分析站包括:第二机台,具有第二平台;第二机械手,设置于所述第二平台;分析仪,设置于所述第二平台,所述第二机械手用于将从所述反应站中完成反应并输送至所述分析站的溶液放入所述分析仪进行分析。In one embodiment, the sample processing system also includes an analysis station, which includes: a second machine having a second platform; a second manipulator disposed on the second platform; an analyzer disposed on the second platform, and the second manipulator is used to place the solution that has completed the reaction in the reaction station and transported to the analysis station into the analyzer for analysis.
一种实施方式中,所述样品处理系统还包括中转模组,所述中转模组连接所述第一平台和所述第二平台,并用于将所述反应站中完成反应的溶液输送至所述分析站;所述中转模组包括传输组件和设置于所述传输组件上的承载组件,所述传输组件用于带动所述承载组件移动,所述承载组件用于放置容器。In one embodiment, the sample processing system also includes a transfer module, which connects the first platform and the second platform and is used to transport the solution that has completed the reaction in the reaction station to the analysis station; the transfer module includes a transmission component and a carrying component arranged on the transmission component, the transmission component is used to drive the carrying component to move, and the carrying component is used to place a container.
一种实施方式中,所述反应站还包括鼓气模组,所述鼓气模组设置于所述第一平台,所述鼓气模组用于向反应前的溶液中鼓入惰性气体,和/或向待输送至所述分析站的溶液中鼓入惰性气体;所述鼓气模组靠近所述开关盖模组设置。In one embodiment, the reaction station further includes an air blowing module, which is disposed on the first platform and is used to blow inert gas into the solution before the reaction and/or blow inert gas into the solution to be transported to the analysis station; the air blowing module is disposed close to the switch cover module.
一种实施方式中,所述鼓气模组包括第一支撑座、鼓气件、第三驱动件、第一升降旋转组件和第一退头机构,所述第一支撑座设置于所述第一平台,所述鼓气件、所述第三驱动件和所述第一升降旋转组件设置于所述第一支撑座,所述第三驱动件与所述第一升降旋转组件连接,以驱动所述第一升降旋转组件作升降和旋转运动,所述第一升降旋转组件用于与鼓气头连接,所述鼓气件与鼓气头连通,用于向鼓气头鼓气,所述第一退头机构用于将鼓气头与所述第一升降旋转组件分离。In one embodiment, the inflation module includes a first support seat, an inflation member, a third driving member, a first lifting and rotating assembly and a first head withdrawal mechanism, the first support seat is arranged on the first platform, the inflation member, the third driving member and the first lifting and rotating assembly are arranged on the first support seat, the third driving member is connected to the first lifting and rotating assembly to drive the first lifting and rotating assembly to perform lifting and rotating movements, the first lifting and rotating assembly is used to connect to the inflation head, the inflation member is connected to the inflation head for inflating air into the inflation head, and the first head withdrawal mechanism is used to separate the inflation head from the first lifting and rotating assembly.
一种实施方式中,所述反应站还包括取样模组,所述取样模组设置于所述第一平台,所述取样模组设有取样瓶,所述取样模组用于从反应后的容器中吸取溶液并转移到所述取样瓶中,以完成溶液的取样;所述取样模组靠近所述开关盖模组设置。In one embodiment, the reaction station also includes a sampling module, which is arranged on the first platform. The sampling module is provided with a sampling bottle. The sampling module is used to absorb the solution from the container after the reaction and transfer it to the sampling bottle to complete the sampling of the solution; the sampling module is arranged close to the switch cover module.
一种实施方式中,所述取样模组包括第二支撑座、第二驱动泵、第四驱动件、第二升降旋转组件和第二退头机构,所述第二支撑座设置于所述第一平台,所述第二驱动泵、所述第四驱动件和所述第二升降旋转组件设置于所述第二支撑座,所述第四驱动件与所述第二升降旋转组件连接,以驱动所述第二升降旋转组件作升降和旋转运动,所述第二升降旋转组件用于与Tip头连接,所述第二驱动泵与Tip头连通,所述第二驱动泵用于向Tip头提供正压或负压,以使Tip头吸液或吐液,所述第二退头机构用于将Tip头与所述第二升降旋转组件分离。In one embodiment, the sampling module includes a second support seat, a second drive pump, a fourth drive member, a second lifting and rotating assembly and a second head withdrawal mechanism, the second support seat is arranged on the first platform, the second drive pump, the fourth drive member and the second lifting and rotating assembly are arranged on the second support seat, the fourth drive member is connected to the second lifting and rotating assembly to drive the second lifting and rotating assembly to perform lifting and rotating movements, the second lifting and rotating assembly is used to connect with the Tip head, the second drive pump is connected to the Tip head, the second drive pump is used to provide positive pressure or negative pressure to the Tip head so that the Tip head absorbs or spits liquid, and the second head withdrawal mechanism is used to separate the Tip head from the second lifting and rotating assembly.
一种实施方式中,所述反应站还包括过滤模组,所述过滤模组设置于所述第一平台,所述过滤模组用于对所述取样瓶中的溶液吸取并过滤。In one embodiment, the reaction station further includes a filtration module, which is disposed on the first platform and is used to absorb and filter the solution in the sampling bottle.
一种实施方式中,所述分析站还包括移动模组,所述移动模组设置于所述第二平台,所述第二机械手设置于所述移动模组上,所述移动模组用于带动所述第二机械手移动,以增大所述第二机械手的活动范围。In one embodiment, the analysis station further includes a mobile module, the mobile module is disposed on the second platform, the second manipulator is disposed on the mobile module, and the mobile module is used to drive the second manipulator to move so as to increase the range of movement of the second manipulator.
一种实施方式中,所述分析站还包括回收模组,所述回收模组包括回收管和回收箱,所述第二平台开设有地漏孔,所述回收箱设置于所述第二平台下方,所述回收管穿设于所述地 漏孔,且连通至所述回收箱。In one embodiment, the analysis station further comprises a recovery module, the recovery module comprises a recovery pipe and a recovery box, the second platform is provided with a floor drain hole, the recovery box is arranged below the second platform, the recovery pipe is passed through the floor drain hole, and the recovery box is arranged below the floor drain hole. The leakage hole is connected to the recovery box.
一种实施方式中,所述样品处理系统还包括移动机器人,所述移动机器人用于在所述上料架上取放容器。In one embodiment, the sample processing system further includes a mobile robot, and the mobile robot is used to pick up and place containers on the loading rack.
本申请提供的样品处理系统,通过设置反应站,反应站包括第一机台、上料架、第一机械手、开关盖模组、加粉模组、加液模组和反应模组,通过第一机械手移动容器实现开盖和关盖操作,第一机械手移动瓶身实现加粉操作和加液操作,并将得到的混合溶液转移至反应模组处进行反应实验,从而能够实现粉料与溶液的合成反应,整个实验能够实现自动化操作,提升了自动化水平,降低了人工操作的人工成本,提高了实验效率,且能减小实验误差。The sample processing system provided in the present application is provided with a reaction station, and the reaction station includes a first machine, a loading rack, a first manipulator, a cover opening and closing module, a powder adding module, a liquid adding module and a reaction module. The first manipulator moves the container to realize the cover opening and closing operations, and the first manipulator moves the bottle body to realize the powder adding operation and the liquid adding operation, and transfers the obtained mixed solution to the reaction module for a reaction experiment, thereby realizing the synthesis reaction of the powder and the solution. The entire experiment can be realized in an automated operation, which improves the automation level, reduces the labor cost of manual operation, improves the experimental efficiency, and can reduce the experimental error.
为了更清楚地说明本申请实施方式或现有技术中的技术方案,下面将对实施方式或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本申请的一些实施方式,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly illustrate the implementation methods of the present application or the technical solutions in the prior art, the drawings required for use in the implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some implementation methods of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
图1是一种实施例的样品处理系统的立体图;FIG1 is a perspective view of a sample processing system according to an embodiment;
图2是一种实施例的样品处理系统的部分结构的立体图;FIG2 is a perspective view of a partial structure of a sample processing system according to an embodiment;
图3是一种实施例的样品处理系统的部分结构的平面图;FIG3 is a plan view of a partial structure of a sample processing system according to an embodiment;
图4是一种实施例的开关盖模组的立体图;FIG4 is a perspective view of a switch cover module according to an embodiment;
图5是一种实施例的加液模组的立体图;FIG5 is a perspective view of a liquid adding module according to an embodiment;
图6是一种实施例的加液针的立体图;FIG6 is a perspective view of a liquid adding needle according to an embodiment;
图7是一种实施例的清洗件的透视图;FIG7 is a perspective view of a cleaning member according to an embodiment;
图8是一种实施例的视觉模组的立体图;FIG8 is a perspective view of a visual module according to an embodiment;
图9是另一种实施例的视觉模组的立体图;FIG9 is a perspective view of a visual module according to another embodiment;
图10是一种实施例的鼓气模组的立体图;FIG10 is a perspective view of an air blowing module according to an embodiment;
图11是一种实施例的取样模组的立体图。FIG. 11 is a three-dimensional diagram of a sampling module according to an embodiment.
附图标记说明:
1000-样品处理系统;
100-反应站,101-托盘,102-粉桶托盘;110-第一机台,111-第一平台,112-仓门,113-
监视屏,114-排风口,121-上料架,122-缓存架,123-工具架,124-粉桶架;130-第一机械手,140-开关盖模组,141-瓶身夹持组件,142-瓶盖夹持组件,143-第一驱动件,144-开关盖支架,151-加粉模组,1511-防护罩,152-扫码模组,153-过滤模组,154-第一搅拌组件,155-第二搅拌组件,160-加液模组,161-安装支架,162-管路限位件,163-加液针,1631-基板,1632-针体,1633-加液管接头,1634-接口,1635-搬运头,164-支撑支架,165-清洗件,166-第一容置通道,167-第一废液流道,168-第二容置通道,169-第二废液流道;170-视觉模组,171-面光源,172-环形光源,173-第一相机,174-第二相机,175-基座,176-标定板,177-光学反射件,180-鼓气模组,181-第一支撑座,182-鼓气件,183-第三驱动件,184-第一升降旋转组件,190-取样模组,191-第二支撑座,192-第二驱动泵,193-第四驱动件,194-第二升降旋转组件;
200-分析站,210-第二机台,211-第二平台,220-第二机械手,230-分析仪,240-移动
模组,250-回收模组;
300-中转模组,310-传输组件,320-承载组件;
400-支撑台;
510-容器,511-瓶身,512-瓶盖,520-溶液瓶,530-Tip头,540-取样瓶。Description of reference numerals:
1000-sample processing system;
100-reaction station, 101-tray, 102-powder barrel tray; 110-first machine, 111-first platform, 112-door, 113-
Monitoring screen, 114-exhaust vent, 121-loading rack, 122-buffer rack, 123-tool rack, 124-powder barrel rack; 130-first manipulator, 140-switch cover module, 141-bottle body clamping assembly, 142-bottle cap clamping assembly, 143-first driving member, 144-switch cover bracket, 151-powder adding module, 1511-protective cover, 152-code scanning module, 153-filtering module, 154-first stirring assembly, 155-second stirring assembly, 160-liquid adding module, 161-mounting bracket, 162-pipeline limiter, 163-liquid adding needle, 1631-base plate, 1632-needle body, 1633-liquid adding pipe joint, 1634-interface, 163 5-handling head, 164-support bracket, 165-cleaning member, 166-first accommodating channel, 167-first waste liquid flow channel, 168-second accommodating channel, 169-second waste liquid flow channel; 170-visual module, 171-surface light source, 172-annular light source, 173-first camera, 174-second camera, 175-base, 176-calibration plate, 177-optical reflector, 180-air blowing module, 181-first support seat, 182-air blowing member, 183-third driving member, 184-first lifting and rotating assembly, 190-sampling module, 191-second support seat, 192-second driving pump, 193-fourth driving member, 194-second lifting and rotating assembly;
200-analysis station, 210-second machine, 211-second platform, 220-second manipulator, 230-analyzer, 240-mobile module, 250-recovery module;
300-transfer module, 310-transmission component, 320-carrying component;
400-support table;
510- container, 511- bottle body, 512- bottle cap, 520- solution bottle, 530- tip head, 540- sampling bottle.
下面将结合本申请实施方式中的附图,对本申请实施方式中的技术方案进行清楚、完整地描述,显然,所描述的实施方式仅仅是本申请一部分实施方式,而不是全部的实施方式。基于本申请中的实施方式,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施方式,都属于本申请保护的范围。The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.
需要说明的是,当组件被称为“固定于”另一个组件,它可以直接在另一个组件上或者也可以存在居中的组件。当一个组件被认为是“连接”另一个组件,它可以是直接连接到另一个组件或者可能同时存在居中组件。It should be noted that when a component is said to be "fixed to" another component, it can be directly on the other component or there can be a central component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there can be a central component at the same time.
除非另有定义,本申请所使用的所有的技术和科学术语与属于本申请的技术领域的技术人员通常理解的含义相同。本申请中在说明书中所使用的术语只是为了描述具体的实施例的目的,不是旨在于限制本申请。本申请所使用的术语“和/或”包括一个或多个相关的所列项目的任意的和所有的组合。Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used in this application and in the specification are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and/or" used in this application includes any and all combinations of one or more related listed items.
下面结合附图,对本申请的一些实施方式作详细说明。在不冲突的情况下,下述的实施例及实施例中的特征可以相互组合。In conjunction with the accompanying drawings, some embodiments of the present application are described in detail below. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other.
请参考图1至图3,本申请实施例提供一种样品处理系统1000,包括反应站100,该反应站100包括第一机台110、上料架121、第一机械手130、开关盖模组140、加粉模组151、加液模组160和反应模组。Please refer to Figures 1 to 3. An embodiment of the present application provides a sample processing system 1000, including a reaction station 100, which includes a first machine 110, a loading rack 121, a first robot 130, a switch cover module 140, a powder adding module 151, a liquid adding module 160 and a reaction module.
第一机台110大致为框架式结构,可为由多个横梁、竖梁等搭建而成的结构,并在横梁和竖梁之间通过板件连接;第一机台110也可为多个板件直接搭建而成的结构。第一机台110围合了一容纳腔,该容纳腔可收容各实验器材、仪器、电源电控设备、实验耗材等。The first machine 110 is generally a frame structure, which can be a structure constructed by a plurality of horizontal beams, vertical beams, etc., and the horizontal beams and vertical beams are connected by plates; the first machine 110 can also be a structure directly constructed by a plurality of plates. The first machine 110 encloses a receiving cavity, which can accommodate various experimental equipment, instruments, power supply and electronic control equipment, experimental consumables, etc.
第一机台110具有第一平台111,第一平台111具有一大致与水平面平行的平面,该平面用于设置其他的零部件,在后文中的关于某零部件设置于第一平台111,除特殊说明外,均是指设置在该平面上。第一平台111可位于第一机台110的中部,可由板件构成,第一平台111上可设置有各种安装固定位置,具体可为孔、槽、凸起等,不做限制。The first machine 110 has a first platform 111. The first platform 111 has a plane that is roughly parallel to the horizontal plane. The plane is used to place other components. In the following text, when a component is placed on the first platform 111, unless otherwise specified, it means that it is placed on the plane. The first platform 111 can be located in the middle of the first machine 110 and can be composed of a plate. Various installation and fixing positions can be set on the first platform 111, which can be holes, grooves, protrusions, etc., without limitation.
第一平台111将第一机台110内的容纳腔分隔为上下两个腔室,上方腔室用于收容实验用的仪器、工具等,下方腔室可用于收容电源电控设备、废弃耗材等。The first platform 111 divides the accommodating chamber in the first machine 110 into two upper and lower chambers. The upper chamber is used to accommodate experimental instruments and tools, and the lower chamber can be used to accommodate power supply and electronic control equipment, waste consumables, etc.
第一机台110的四周的至少一板件可设置为可开闭的仓门112,仓门112可为转动仓门或滑移仓门,仓门112上可设把手以便于实验人员打开和关闭仓门112。仓门112可为多个,可在第一机台110的四周的至少一侧进行设置,设置多个仓门112可以方便从不同位置打开仓门112,进行实验以及观察、维护等。仓门112可具备关门到位检测功能,当仓门112未关门到位时,可报警以便于实验人员将门关闭到位。仓门112还可具有需要权限才能打开的功能,以便于对实验人员进行权限管理,保护设备安全。上述的仓门112所实现的功能,可采用任意可行的方案实现,不做限定。At least one plate around the first machine 110 can be set as a closable door 112, and the door 112 can be a rotating door or a sliding door. A handle can be set on the door 112 to facilitate the experimenter to open and close the door 112. There can be multiple doors 112, which can be set on at least one side around the first machine 110. The multiple doors 112 can be conveniently opened from different positions to conduct experiments, observations, maintenance, etc. The door 112 can have a door closing detection function. When the door 112 is not closed in place, an alarm can be sounded to facilitate the experimenter to close the door in place. The door 112 can also have a function that requires permission to open, so as to facilitate the permission management of the experimenter and protect the safety of the equipment. The functions implemented by the above-mentioned door 112 can be implemented by any feasible solution without limitation.
第一机台110四周的板件(可为仓门112上)可设至少部分为透明结构,以便于实验人员或监控摄像头透过该透明结构观察第一机台110内部的情况。The panels around the first machine 110 (which may be on the door 112 ) may be at least partially transparent structures, so that the experimenter or the monitoring camera can observe the situation inside the first machine 110 through the transparent structures.
第一机台110的外周还可设置监视屏113,监视屏113用于显示实验相关信息,实验人员可以通过该监视屏113查看各设备的工作状态,和/或输入指令以控制设备的运作。第一机台110的顶部还可设置有排风口114,用于与排风设备连通以对第一机台110内部进行除湿 排气等。A monitoring screen 113 may be provided on the periphery of the first machine 110. The monitoring screen 113 is used to display information related to the experiment. The experimenter can view the working status of each device through the monitoring screen 113 and/or input instructions to control the operation of the device. An exhaust port 114 may also be provided on the top of the first machine 110 to connect with the exhaust device to dehumidify the interior of the first machine 110. Exhaust, etc.
上料架121设置于第一平台111,用于放置容器510。上料架121的结构可为框架式结构,框架上可设有大致水平放置的板件,容器510可放置在该板件上。上料架121可放置到第一平台111上,也可通过如螺钉等紧固结构固定到第一平台111上。上料架121可设置有多层板件,每层板件均可承载容器510。上料架121可靠近第一机台110的仓门112设置,以便于实验人员或移动机器人在仓门112打开时即可将容器510放置到上料架121上。容器510具体可为试管、试剂瓶、烧杯、烧瓶等,不做限制。容器510为具有瓶身511和瓶盖512的结构,在容器510内未承载有物料时,瓶盖512盖设于瓶身511,瓶盖512具体可为通过螺纹与瓶身511连接而实现盖合,也可为通过插塞方式与瓶身511连接而实现盖合,具体不做限定。容器510可直接放置到上料架121上,也可先放置到托盘101上,再将托盘101放置到上料架121上,即容器510通过托盘101放置到上料架121上。此外,上料架121也可以用于放置各类实验所需耗材,如Tip头、过滤头、注射器等,各类耗材均可通过托盘放置到上料架121上。The loading rack 121 is arranged on the first platform 111, and is used to place the container 510. The structure of the loading rack 121 may be a frame structure, and a plate placed approximately horizontally may be provided on the frame, and the container 510 may be placed on the plate. The loading rack 121 may be placed on the first platform 111, and may also be fixed to the first platform 111 by a fastening structure such as screws. The loading rack 121 may be provided with multiple layers of plates, and each layer of plates may carry the container 510. The loading rack 121 may be arranged close to the door 112 of the first machine 110, so that the experimenter or the mobile robot can place the container 510 on the loading rack 121 when the door 112 is opened. The container 510 may specifically be a test tube, a reagent bottle, a beaker, a flask, etc., without limitation. The container 510 has a bottle body 511 and a bottle cap 512. When no material is loaded in the container 510, the bottle cap 512 is covered on the bottle body 511. The bottle cap 512 can be connected to the bottle body 511 by a thread or by a plug, and the specific details are not limited. The container 510 can be placed directly on the loading rack 121, or it can be placed on the tray 101 first, and then the tray 101 is placed on the loading rack 121, that is, the container 510 is placed on the loading rack 121 through the tray 101. In addition, the loading rack 121 can also be used to place various consumables required for experiments, such as Tip heads, filter heads, syringes, etc., and various consumables can be placed on the loading rack 121 through the tray.
第一机械手130设置于第一平台111。第一机械手130可固定在第一平台111上,第一机械手130远离第一平台111的一端可用于抓取容器510或零部件,不做限制。第一机械手130可为三轴、四轴、六轴移动的机械手,不做限定。第一机械手130上的驱动结构也不做限定,只要第一机械手130能够在第一机台110的第一平台111的上方的腔室进行多个方向的移动,以实现搬运等功能即可。可选的,第一机械手130远离第一平台111的一端可设置有公连接头,在与其他零部件(如各类夹爪)进行连接时,该公连接头可与其他零部件上的母连接头实现快速安装和拆卸,即公连接头和母连接头为通用的零部件,以便于第一机械手130能够快速与其他零部件进行连接并切换不同的零部件。The first manipulator 130 is arranged on the first platform 111. The first manipulator 130 can be fixed on the first platform 111, and the end of the first manipulator 130 away from the first platform 111 can be used to grab the container 510 or parts, without limitation. The first manipulator 130 can be a manipulator with three-axis, four-axis, or six-axis movement, without limitation. The driving structure on the first manipulator 130 is also not limited, as long as the first manipulator 130 can move in multiple directions in the chamber above the first platform 111 of the first machine 110 to achieve functions such as transportation. Optionally, a male connector can be provided at one end of the first manipulator 130 away from the first platform 111. When connecting with other parts (such as various types of grippers), the male connector can be quickly installed and disassembled with the female connector on other parts, that is, the male connector and the female connector are universal parts, so that the first manipulator 130 can quickly connect with other parts and switch different parts.
开关盖模组140设置于第一平台111,用于将第一机械手130移动过来的容器510的瓶身511和瓶盖512进行分离或盖合。开关盖模组140的具体结构不做限定,其功能在于能够进行开盖或关盖。The switch cover module 140 is disposed on the first platform 111, and is used to separate or cover the bottle body 511 and the bottle cap 512 of the container 510 moved by the first robot 130. The specific structure of the switch cover module 140 is not limited, and its function is to open or close the cover.
加粉模组151设置于第一平台111,用于向第一机械手130移动过来的分离瓶盖512后的瓶身511内添加粉料。加粉模组151的具体结构不做限定,其功能在于能够进行加粉操作。粉料可根据需要设置,粉料的具体成分不做限制。The powder adding module 151 is disposed on the first platform 111, and is used to add powder into the bottle body 511 after the bottle cap 512 is separated and moved by the first manipulator 130. The specific structure of the powder adding module 151 is not limited, and its function is to be able to perform the powder adding operation. The powder can be set as needed, and the specific composition of the powder is not limited.
加液模组160设置于第一平台111,用于向添加粉料后的瓶身511内添加溶液。加液模组160的具体结构不做限定,其功能在于能够进行加液操作。溶液可根据需要设置,溶液的具体成分不做限制。The liquid adding module 160 is disposed on the first platform 111, and is used to add solution to the bottle body 511 after the powder is added. The specific structure of the liquid adding module 160 is not limited, and its function is to be able to perform liquid adding operation. The solution can be set as needed, and the specific composition of the solution is not limited.
反应模组设置于第一平台111,通过开关盖模组140将瓶盖512与瓶身511盖合为容器510后,反应模组用于对第一机械手130移动过来的容器510中的溶液进行反应实验。反应模组的具体结构不做限定,反应模组的功能在于能够将溶液与粉料混合后进行搅拌、振荡等,以使粉料和溶液进行充分反应。The reaction module is disposed on the first platform 111. After the bottle cap 512 and the bottle body 511 are covered to form a container 510 by the switch cover module 140, the reaction module is used to perform a reaction experiment on the solution in the container 510 moved by the first manipulator 130. The specific structure of the reaction module is not limited. The function of the reaction module is to mix the solution with the powder and then stir, oscillate, etc., so that the powder and the solution can react fully.
可选的,第一机械手130位于第一平台111的中间位置,上料架121、开关盖模组140、加粉模组151、加液模组160和反应模组围绕第一机械手130设置;其中,开关盖模组140的一侧与加粉模组151相邻,开关盖模组140的另一侧与反应模组相邻,加粉模组151远离开关盖模组140的一侧与加液模组160相邻,反应模组远离开关盖模组140的一侧与上料架121相邻。如此,以第一机械手130为中心布置了多个模组,方便第一机械手130在多个模组之间活动,便于实现所需的功能;此外,模组与模组之间位置的排布,能够节省第一机械手130在模组间进行样品转移所需的时间,有利于提高实验效率。 Optionally, the first manipulator 130 is located in the middle of the first platform 111, and the loading rack 121, the switch cover module 140, the powder adding module 151, the liquid adding module 160 and the reaction module are arranged around the first manipulator 130; wherein one side of the switch cover module 140 is adjacent to the powder adding module 151, the other side of the switch cover module 140 is adjacent to the reaction module, the side of the powder adding module 151 away from the switch cover module 140 is adjacent to the liquid adding module 160, and the side of the reaction module away from the switch cover module 140 is adjacent to the loading rack 121. In this way, multiple modules are arranged with the first manipulator 130 as the center, so that the first manipulator 130 can move between multiple modules and realize the required functions; in addition, the arrangement of the positions between modules can save the time required for the first manipulator 130 to transfer samples between modules, which is conducive to improving the experimental efficiency.
本申请实施例的样品处理系统1000,其中反应站100的工作流程为:实验人员打开第一机台110的仓门112,人工将空的容器510放置到上料架121上,将仓门112关闭;第一机械手130将容器510移动到开关盖模组140处将容器510的瓶盖512与瓶身511分离,瓶盖512可留在开关盖模组140处;第一机械手130将瓶身511移动到加粉模组151处进行加粉操作;第一机械手130将瓶身511移动到加液模组160处进行加液操作;第一机械手130将瓶身511移动到开关盖模组140处将瓶盖512盖设到瓶身511上,以使容器510内的粉料和溶液处于封闭空间中;第一机械手130将容器510移动到反应模组处,反应模组将容器510内的粉料和溶液进行混匀,加快反应,从而完成样品的反应的过程。The sample processing system 1000 of the embodiment of the present application, wherein the workflow of the reaction station 100 is as follows: the experimenter opens the door 112 of the first machine 110, manually places the empty container 510 on the loading rack 121, and closes the door 112; the first manipulator 130 moves the container 510 to the switch cover module 140 to separate the bottle cap 512 of the container 510 from the bottle body 511, and the bottle cap 512 can remain at the switch cover module 140; the first manipulator 130 moves the bottle body 511 to the powder adding module 151 for adding powder; the first manipulator 130 moves the bottle body 511 to the liquid adding module 160 for adding liquid; the first manipulator 130 moves the bottle body 511 to the switch cover module 140 to cover the bottle cover 512 on the bottle body 511, so that the powder and solution in the container 510 are in a closed space; the first manipulator 130 moves the container 510 to the reaction module, and the reaction module mixes the powder and solution in the container 510 to accelerate the reaction, thereby completing the reaction process of the sample.
本申请实施例提供的样品处理系统1000,通过设置反应站100,反应站100包括第一机台110、上料架121、第一机械手130、开关盖模组140、加粉模组151、加液模组160和反应模组,通过第一机械手130移动容器510实现开盖和关盖操作,第一机械手130移动瓶身511实现加粉操作和加液操作,容器510在反应模组处实现混匀操作,从而能够实现粉料与溶液的合成反应,整个过程能够实现自动化操作,提升了自动化水平,降低了人工操作的人工成本,提高了实验效率,且能减小实验误差。The sample processing system 1000 provided in the embodiment of the present application is provided with a reaction station 100, and the reaction station 100 includes a first machine 110, a loading rack 121, a first manipulator 130, a cover opening and closing module 140, a powder adding module 151, a liquid adding module 160 and a reaction module. The first manipulator 130 moves the container 510 to realize the cover opening and closing operations, and the first manipulator 130 moves the bottle body 511 to realize the powder adding operation and the liquid adding operation. The container 510 realizes the mixing operation at the reaction module, so that the synthesis reaction of the powder and the solution can be realized. The whole process can be realized by automated operation, which improves the automation level, reduces the labor cost of manual operation, improves the experimental efficiency, and can reduce the experimental error.
一种实施例中,请参考图2至图4,开关盖模组140包括瓶身夹持组件141、瓶盖夹持组件142和第一驱动件143。瓶身夹持组件141设置于第一平台111,瓶盖夹持组件142设置在瓶身夹持组件141背向第一平台111的一侧,瓶身夹持组件141用于夹持固定瓶身511,瓶盖夹持组件142用于夹持固定瓶盖512。第一驱动件143用于驱动瓶身夹持组件141和/或瓶盖夹持组件142旋转,以使瓶身511与瓶盖512分离或盖合。In one embodiment, please refer to Figures 2 to 4, the switch cover module 140 includes a bottle body clamping assembly 141, a bottle cap clamping assembly 142 and a first driving member 143. The bottle body clamping assembly 141 is disposed on the first platform 111, and the bottle cap clamping assembly 142 is disposed on the side of the bottle body clamping assembly 141 facing away from the first platform 111. The bottle body clamping assembly 141 is used to clamp and fix the bottle body 511, and the bottle cap clamping assembly 142 is used to clamp and fix the bottle cap 512. The first driving member 143 is used to drive the bottle body clamping assembly 141 and/or the bottle cap clamping assembly 142 to rotate, so that the bottle body 511 and the bottle cap 512 are separated or covered.
可选的,瓶身夹持组件141和瓶盖夹持组件142均可具有可移动的夹持头,夹持头可外扩或内收。夹持头外扩时围合了较大的空间,以用于放入或取出待夹持的物体(即瓶身511或瓶盖512);夹持头内收时围合了较小的空间,以用于夹紧待夹持的物体。夹持头的移动可通过如电机等结构实现,不做限制。瓶身夹持组件141和瓶盖夹持组件142的具体结构不做过多限制,只要能够实现夹紧和松开的动作即可。Optionally, both the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 may have a movable clamping head, which can expand outward or retract inward. When the clamping head expands outward, it encloses a larger space for placing or removing the object to be clamped (i.e., the bottle body 511 or the bottle cap 512); when the clamping head retracts inward, it encloses a smaller space for clamping the object to be clamped. The movement of the clamping head can be achieved by structures such as motors, without limitation. There are no excessive restrictions on the specific structures of the bottle body clamping assembly 141 and the bottle cap clamping assembly 142, as long as the clamping and loosening actions can be achieved.
可选的,开关盖模组140可包括开关盖支架144,开关盖支架144设置在第一平台111上,瓶身夹持组件141设置在开关盖支架144上,即瓶身夹持组件141通过开关盖支架144设置在第一平台111上。其他可选的,瓶身夹持组件141也可直接设置在第一平台111上。Optionally, the switch cover module 140 may include a switch cover bracket 144, which is disposed on the first platform 111, and the bottle body clamping assembly 141 is disposed on the switch cover bracket 144, that is, the bottle body clamping assembly 141 is disposed on the first platform 111 through the switch cover bracket 144. Alternatively, the bottle body clamping assembly 141 may also be directly disposed on the first platform 111.
可选的,瓶盖夹持组件142也可设置在开关盖支架144上。其他可选的,瓶盖夹持组件142可设置在第一平台111的其他位置,当需要进行开关盖时再移动到瓶身夹持组件141背向第一平台111的一侧。Optionally, the bottle cap clamping assembly 142 may also be disposed on the cover switch bracket 144. Alternatively, the bottle cap clamping assembly 142 may be disposed at other positions of the first platform 111, and moved to the side of the bottle body clamping assembly 141 facing away from the first platform 111 when the cover needs to be opened and closed.
第一驱动件143可为步进电机或其他驱动结构,不做限制。本实施例针对瓶身511和瓶盖512为螺接的方式盖合而进行说明。可选的,第一驱动件143可设置在瓶身夹持组件141,用于驱动瓶身夹持组件141夹紧的瓶身511旋转,瓶盖夹持组件142可仅做夹紧瓶盖512的动作,则瓶身511转动瓶盖512固定,能够将瓶盖512与瓶身511分离实现开盖操作。可选的,第一驱动件143也可设置在瓶盖夹持组件142,用于驱动瓶盖夹持组件142夹紧的瓶盖512旋转,瓶身夹持组件141可仅做夹紧瓶身511的动作,则瓶盖512转动瓶身511固定,能够将瓶盖512与瓶身511分离实现开盖操作。可选的,瓶身夹持组件141和瓶盖夹持组件142可均设有第一驱动件143,并分别用于驱动瓶身511和瓶盖512反向旋转,也能够将瓶盖512与瓶身511分离实现开盖操作。关盖时,将上述开盖的动作反向操作,即瓶身511和瓶盖512相对开盖的旋转方向反向旋转,即可实现关盖。The first driving member 143 can be a stepper motor or other driving structure, without limitation. The present embodiment is described for the bottle body 511 and the bottle cap 512 to be screwed together. Optionally, the first driving member 143 can be arranged in the bottle body clamping assembly 141, for driving the bottle body 511 clamped by the bottle body clamping assembly 141 to rotate, and the bottle cap clamping assembly 142 can only do the action of clamping the bottle cap 512, then the bottle body 511 rotates the bottle cap 512 to fix it, and the bottle cap 512 can be separated from the bottle body 511 to realize the uncapping operation. Optionally, the first driving member 143 can also be arranged in the bottle cap clamping assembly 142, for driving the bottle cap 512 clamped by the bottle cap clamping assembly 142 to rotate, and the bottle body clamping assembly 141 can only do the action of clamping the bottle body 511, then the bottle cap 512 rotates the bottle body 511 to fix it, and the bottle cap 512 can be separated from the bottle body 511 to realize the uncapping operation. Optionally, the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 may both be provided with a first driving member 143, and respectively used to drive the bottle body 511 and the bottle cap 512 to rotate in the opposite direction, and also to separate the bottle cap 512 from the bottle body 511 to realize the opening operation. When closing the cover, the above-mentioned opening action is reversed, that is, the bottle body 511 and the bottle cap 512 rotate in the opposite direction relative to the rotation direction of opening the cover, and the cover can be closed.
其他实施例中,对于瓶身511和瓶盖512为插塞的方式盖合时,则瓶身夹持组件141和 瓶盖夹持组件142可在夹紧瓶身511和瓶盖512后,第一驱动件143可将瓶身511和/或瓶盖512沿瓶身511的轴线在相反的方向上拉动,以将瓶身511和瓶盖512拉开而实现开盖操作。关盖时,将上述开盖的动作反向操作,瓶身511和瓶盖512相对开盖的移动方向反向移动,即瓶身511和瓶盖512朝相互靠近的方向移动,即可实现关盖。In other embodiments, when the bottle body 511 and the bottle cap 512 are plugged together, the bottle body clamping assembly 141 and After the bottle cap clamping assembly 142 clamps the bottle body 511 and the bottle cap 512, the first driving member 143 can pull the bottle body 511 and/or the bottle cap 512 in opposite directions along the axis of the bottle body 511 to pull the bottle body 511 and the bottle cap 512 apart to achieve the opening operation. When closing the cap, the above-mentioned opening action is reversed, and the bottle body 511 and the bottle cap 512 move in the opposite direction relative to the moving direction of opening the cap, that is, the bottle body 511 and the bottle cap 512 move in a direction close to each other, and the cap can be closed.
第一驱动件143驱动瓶身夹持组件141和瓶盖夹持组件142实现开盖和关盖的具体结构和实现方式不做具体限定,任意可行的结构和实现方式均可。The specific structure and implementation method of the first driving member 143 driving the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 to open and close the cap are not specifically limited, and any feasible structure and implementation method can be used.
通过设置瓶身夹持组件141和瓶盖夹持组件142,能够实现夹紧和松开瓶身511和瓶盖512,再通过第一驱动件143的驱动作用,使得瓶身夹持组件141和瓶盖夹持组件142带动瓶身511和瓶盖512相对旋转或相对移动,便可实现开盖和关盖的操作,结构简单,容易实现。By providing the bottle body clamping assembly 141 and the bottle cap clamping assembly 142, the bottle body 511 and the bottle cap 512 can be clamped and loosened, and then through the driving action of the first driving member 143, the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 drive the bottle body 511 and the bottle cap 512 to rotate or move relative to each other, thereby realizing the operation of opening and closing the cap. The structure is simple and easy to implement.
可选的,瓶身夹持组件141和瓶盖夹持组件142在相对的方向上可相对移动。Optionally, the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 can move relative to each other in opposite directions.
对于旋转式开关盖的方式,在开盖时,瓶盖512从与瓶身511旋紧到松开的过程中,瓶盖512逐步退出瓶口,即瓶盖512和瓶身511之间在相互远离的方向上产生位移;在关盖时,瓶盖512从与瓶身511接触到逐渐旋紧的过程中,瓶盖512和瓶身511之间在相互靠近的方向上产生位移。对于插塞方式开关盖的方式,在开关盖的过程中,需要瓶盖512和瓶身511在相互远离的方向上移动以开盖,在相互靠近的方向上移动以关盖。因此,在瓶盖512和瓶身511进行开关盖过程中,为了使得瓶盖512与瓶身511盖合或瓶盖512退出瓶口,都需要瓶盖512和瓶身511之间产生相对移动。For the rotary cover opening and closing method, when opening the cover, the bottle cap 512 gradually withdraws from the bottle mouth during the process from being screwed on the bottle body 511 to being loosened, that is, the bottle cap 512 and the bottle body 511 are displaced in the direction away from each other; when closing the cover, the bottle cap 512 and the bottle body 511 are displaced in the direction of approaching each other during the process from being in contact with the bottle body 511 to being gradually screwed on. For the plug-type cover opening and closing method, during the process of opening and closing the cover, the bottle cap 512 and the bottle body 511 need to move in the direction away from each other to open the cover, and move in the direction of approaching each other to close the cover. Therefore, during the process of opening and closing the bottle cap 512 and the bottle body 511, in order to make the bottle cap 512 cover the bottle body 511 or the bottle cap 512 withdraw from the bottle mouth, relative movement between the bottle cap 512 and the bottle body 511 is required.
本实施例中,通过设置瓶身夹持组件141和瓶盖夹持组件142在相对的方向上可相对移动,可以提供给瓶盖512和瓶身511相对移动的动力,或者提供给瓶盖512和瓶身511相对移动的自由度。对于提供动力的情况,根据需要移动的瓶身511和/或瓶盖512,在对应的瓶身夹持组件141和/或瓶盖夹持组件142上设置相应的动力机构,以带动夹紧瓶身511和瓶盖512的夹持头移动。对于提供自由度的情况,根据需要移动的瓶身511和/或瓶盖512,在对应的瓶身夹持组件141和/或瓶盖夹持组件142上设置相应的导向机构、缓冲机构等,以在夹紧瓶身511和瓶盖512的夹持头移动时提供导向或缓冲作用。In this embodiment, by setting the bottle body clamping assembly 141 and the bottle cap clamping assembly 142 to be relatively movable in relative directions, power for relative movement of the bottle cap 512 and the bottle body 511 can be provided, or the freedom for relative movement of the bottle cap 512 and the bottle body 511 can be provided. In the case of providing power, according to the bottle body 511 and/or the bottle cap 512 to be moved as needed, a corresponding power mechanism is provided on the corresponding bottle body clamping assembly 141 and/or the bottle cap clamping assembly 142 to drive the clamping head that clamps the bottle body 511 and the bottle cap 512 to move. In the case of providing freedom, according to the bottle body 511 and/or the bottle cap 512 to be moved as needed, a corresponding guide mechanism, a buffer mechanism, etc. are provided on the corresponding bottle body clamping assembly 141 and/or the bottle cap clamping assembly 142 to provide a guide or buffering effect when the clamping head that clamps the bottle body 511 and the bottle cap 512 moves.
应当理解,瓶盖512和瓶身511相对移动,可由瓶盖512和瓶身511的其中一者在相对的方向上固定,另一者在相对的方向上移动而实现,也可由瓶盖512和瓶身511两者都在相对的方向上移动而实现。It should be understood that the relative movement of the bottle cap 512 and the bottle body 511 can be achieved by fixing one of the bottle cap 512 and the bottle body 511 in relative directions and moving the other in relative directions, or by moving both the bottle cap 512 and the bottle body 511 in relative directions.
可选的,第一机械手130还用于移动瓶盖夹持组件142至与瓶身夹持组件141对位,第一驱动件143设置在瓶身夹持组件141,用于驱动瓶身夹持组件141相对瓶盖夹持组件142旋转。Optionally, the first manipulator 130 is further used to move the bottle cap clamping assembly 142 to align with the bottle body clamping assembly 141 , and the first driving member 143 is disposed on the bottle body clamping assembly 141 to drive the bottle body clamping assembly 141 to rotate relative to the bottle cap clamping assembly 142 .
本实施例中,瓶身夹持组件141固定在第一平台111,第一机械手130的公连接头和瓶盖夹持组件142上的母连接头连接,将瓶盖夹持组件142从其放置处移动至与瓶身夹持组件141对位,两者分别将瓶身511和瓶盖512夹紧后,瓶盖夹持组件142保持固定不动,瓶身夹持组件141上的第一驱动件143动作而带动瓶身511相对瓶盖512旋转,实现开关盖。采用瓶盖512固定瓶身511旋转的方式,瓶身511的尺寸比瓶盖512更大,更便于操作。In this embodiment, the bottle body clamping assembly 141 is fixed to the first platform 111, the male connector of the first manipulator 130 is connected to the female connector on the bottle cap clamping assembly 142, and the bottle cap clamping assembly 142 is moved from its placement position to align with the bottle body clamping assembly 141. After the two clamp the bottle body 511 and the bottle cap 512 respectively, the bottle cap clamping assembly 142 remains fixed, and the first driving member 143 on the bottle body clamping assembly 141 is actuated to drive the bottle body 511 to rotate relative to the bottle cap 512, so as to realize the opening and closing of the cover. By adopting the method of fixing the bottle body 511 to rotate with the bottle cap 512, the size of the bottle body 511 is larger than the bottle cap 512, which is more convenient to operate.
其中,第一平台111上可设有工具架123,工具架123上用于放置各类工具,瓶盖夹持组件142可作为开关盖工具放置在工具架123上,在需要使用时再由第一机械手130从工具架123上移走,使用完毕后再放回工具架123。工具架123也可为框架式结构,工具架123上可设有各类放置位,以便于放置各类工具,各类工具放置在工具架123上的放置位上,放置位能够对工具进行限位,保证稳定支撑。各类工具均具有母连接头,以便于与第一机械手130的公连接头进行快速连接与拆卸。工具架123可以直接设置在第一平台111上,也可以 架设在上料架121的顶部,这里不作限定。Among them, a tool rack 123 may be provided on the first platform 111, and the tool rack 123 is used to place various tools. The bottle cap clamping assembly 142 can be placed on the tool rack 123 as a cap opening and closing tool, and then removed from the tool rack 123 by the first manipulator 130 when needed, and then placed back on the tool rack 123 after use. The tool rack 123 may also be a frame structure, and various placement positions may be provided on the tool rack 123 to facilitate the placement of various tools. Various tools are placed on the placement positions on the tool rack 123, and the placement positions can limit the tools to ensure stable support. Various tools have female connectors to facilitate quick connection and disassembly with the male connector of the first manipulator 130. The tool rack 123 can be directly set on the first platform 111, or it can be It is mounted on the top of the loading rack 121, which is not limited here.
一种实施例中,请参考图2和图3,加粉模组151包括加粉组件和称重组件,称重组件设置在第一平台111,并用于放置分离瓶盖512后的瓶身511,加粉组件用于向瓶身511内添加粉料,并根据称重组件的称重结果确定粉料的添加量。In one embodiment, please refer to Figures 2 and 3, the powder adding module 151 includes a powder adding component and a weighing component. The weighing component is arranged on the first platform 111 and is used to place the bottle body 511 after the bottle cap 512 is separated. The powder adding component is used to add powder into the bottle body 511 and determine the amount of powder added according to the weighing result of the weighing component.
加粉组件和称重组件的具体结构不做限定,加粉组件能够将粉料添加到瓶身511内,称重组件能够对添加的粉料进行称重,以实现粉料的定量添加。其中,添加的粉料的重量可预先设定,加粉组件添加粉料的同时,称重组件实时反馈粉料的重量,当添加的粉料的重量达到预先设定的粉料的重量时,加粉组件停止加粉操作。The specific structures of the powder adding component and the weighing component are not limited. The powder adding component can add powder into the bottle body 511, and the weighing component can weigh the added powder to achieve quantitative addition of the powder. The weight of the added powder can be preset. When the powder adding component adds the powder, the weighing component feeds back the weight of the powder in real time. When the weight of the added powder reaches the preset weight of the powder, the powder adding component stops the powder adding operation.
加粉模组151还可包括防护罩1511,加粉组件和称重组件可被防护罩1511罩设在内部,防护罩1511用于阻挡外界的风和静电等对加粉组件和称重组件的干扰,避免风或静电将粉料吹跑或静电吸附到其他位置而未落入瓶身511内,从而能提高加粉精度。防护罩1511朝向第一机械手130的一侧面设置为可开闭的结构,可开闭的方式可以为上下升降开闭、左右平移开闭或旋转开闭等,不做限制,可通过该可开闭的结构打开防护罩1511的侧面,以使得第一机械手130可以将瓶身511移动到内部的称重组件上,并将添加粉料完毕的瓶身511移出。The powder adding module 151 may also include a protective cover 1511. The powder adding component and the weighing component may be covered by the protective cover 1511 and arranged inside. The protective cover 1511 is used to block the interference of the external wind and static electricity on the powder adding component and the weighing component, so as to prevent the wind or static electricity from blowing away the powder or static electricity from adsorbing it to other positions instead of falling into the bottle body 511, thereby improving the powder adding accuracy. The side of the protective cover 1511 facing the first manipulator 130 is set as an openable and closable structure. The opening and closing method may be lifting and lowering, translating and opening and closing, or rotating and opening and closing, etc., without limitation. The side of the protective cover 1511 may be opened by the openable and closable structure, so that the first manipulator 130 can move the bottle body 511 to the internal weighing component, and remove the bottle body 511 after adding the powder.
可选的,反应站100还包括粉桶架124,粉桶架124设有多个粉桶放置位,粉桶放置位用于放置粉桶并限位,粉桶用于盛装粉料;第一机械手130用于移动粉桶至加粉模组151,加粉模组151用于将粉桶中的粉料添加至瓶身511中。粉桶架124设置在第一平台111上。第一机械手130用于将粉桶从粉桶架124移动到加粉组件处,加粉组件用于将粉桶中储存的粉料添加到瓶身511内。粉桶还具有可开闭的开口,加粉组件加粉时,加粉组件将粉桶的开口打开,粉料从粉桶内通过该开口漏出至瓶身511内。粉桶可先放置在粉桶托盘102上,再将粉桶托盘102放置在粉桶架124的粉桶放置位处,第一机械手130用于移动该粉桶托盘102。粉桶托盘102的结构不做限定,粉桶架124的粉桶放置位可对粉桶托盘102进行限位,以使得粉桶托盘102稳定的放置在粉桶架124上。粉桶托盘102也可对粉桶进行限位,以使粉桶稳定的放置在粉桶托盘102上。粉桶架124的结构可以与上料架121的结构相同或近似,粉桶架124可以与上料架121并排设置在第一平台111上,且均靠近仓门112设置,从而便于实验人员或移动机器人在粉桶架124和上料架121上进行上下料。Optionally, the reaction station 100 further includes a powder barrel rack 124, which is provided with a plurality of powder barrel placement positions, which are used to place and limit powder barrels, and the powder barrels are used to contain powder; the first manipulator 130 is used to move the powder barrel to the powder adding module 151, and the powder adding module 151 is used to add the powder in the powder barrel to the bottle body 511. The powder barrel rack 124 is arranged on the first platform 111. The first manipulator 130 is used to move the powder barrel from the powder barrel rack 124 to the powder adding assembly, and the powder adding assembly is used to add the powder stored in the powder barrel to the bottle body 511. The powder barrel also has an opening that can be opened and closed. When the powder adding assembly adds powder, the powder adding assembly opens the opening of the powder barrel, and the powder leaks from the powder barrel into the bottle body 511 through the opening. The powder barrel can be placed on the powder barrel tray 102 first, and then the powder barrel tray 102 is placed at the powder barrel placement position of the powder barrel rack 124. The first manipulator 130 is used to move the powder barrel tray 102. The structure of the powder barrel tray 102 is not limited. The powder barrel placement position of the powder barrel rack 124 can limit the powder barrel tray 102 so that the powder barrel tray 102 is stably placed on the powder barrel rack 124. The powder barrel tray 102 can also limit the powder barrel so that the powder barrel is stably placed on the powder barrel tray 102. The structure of the powder barrel rack 124 can be the same as or similar to that of the loading rack 121. The powder barrel rack 124 can be arranged side by side with the loading rack 121 on the first platform 111, and both are arranged close to the warehouse door 112, so that it is convenient for the experimenter or the mobile robot to load and unload on the powder barrel rack 124 and the loading rack 121.
可选的,称重组件在第一平台111上可移动。称重组件在第一平台111的平面上移动,可以方便与加粉组件对位,使得瓶身511的瓶口与粉料漏下位置对位。另外,在防护罩1511的一侧面打开时,称重组件可移动至该打开的侧面处,便于第一机械手130将瓶身511放置到称重组件上,当加料完毕时,称重组件也可移动至打开的侧面处,以便于第一机械手130将瓶身511取走。Optionally, the weighing assembly is movable on the first platform 111. The weighing assembly moves on the plane of the first platform 111, which can be conveniently aligned with the powder adding assembly, so that the bottle mouth of the bottle body 511 is aligned with the position where the powder leaks out. In addition, when one side of the protective cover 1511 is opened, the weighing assembly can be moved to the opened side, so that the first manipulator 130 can place the bottle body 511 on the weighing assembly. When the feeding is completed, the weighing assembly can also be moved to the opened side, so that the first manipulator 130 can take away the bottle body 511.
可选的,加粉组件在垂直于第一平台111的方向上可移动,可以方便瓶身511与粉桶相互靠近或远离,以便进行加粉、称重操作。Optionally, the powder adding assembly is movable in a direction perpendicular to the first platform 111 , so that the bottle body 511 and the powder barrel can be moved closer to or farther away from each other to facilitate powder adding and weighing operations.
一种实施例中,请参考图2、图3和图5、图6,加液模组160包括第一驱动泵、第一阀门和加液针163,第一驱动泵用于从溶液瓶520中抽取溶液,第一阀门连通第一驱动泵和加液针163,用于控制第一驱动泵抽取的溶液是否流入加液针163,第一机械手130还用于移动加液针163,加液针163用于向瓶身511内添加溶液。In one embodiment, please refer to Figures 2, 3, 5 and 6, the liquid adding module 160 includes a first driving pump, a first valve and a liquid adding needle 163, the first driving pump is used to extract solution from the solution bottle 520, the first valve connects the first driving pump and the liquid adding needle 163, and is used to control whether the solution extracted by the first driving pump flows into the liquid adding needle 163, the first manipulator 130 is also used to move the liquid adding needle 163, and the liquid adding needle 163 is used to add solution to the bottle body 511.
加液模组160可包括安装支架161和管路限位件162,安装支架161设置在第一平台111上。安装支架161上可设有各种安装位和管道穿孔,第一驱动泵和第一阀门可安装在安装支 架161上的对应的安装位上,第一驱动泵与第一阀门之间可通过管路连通,第一阀门和加液针163之间也可通过管路连通,第一驱动泵还可通过管道伸入到溶液瓶520内,溶液瓶520内盛装有反应所需的溶液,如此第一驱动泵可抽取溶液瓶520内的溶液,并通过第一阀门的控制,能够输送至加液针163,以向瓶身511内添加溶液,从而完成加液操作。第一阀门与加液针163之间的管路可通过管路限位件162进行限位,避免多个管路相互缠绕,影响加液针163的移动和加液。The liquid adding module 160 may include a mounting bracket 161 and a pipeline stopper 162. The mounting bracket 161 is disposed on the first platform 111. The mounting bracket 161 may be provided with various mounting positions and pipeline perforations. The first driving pump and the first valve may be mounted on the mounting bracket 161. At the corresponding installation position on the frame 161, the first driving pump and the first valve can be connected through a pipeline, and the first valve and the liquid adding needle 163 can also be connected through a pipeline. The first driving pump can also extend into the solution bottle 520 through a pipeline. The solution bottle 520 contains the solution required for the reaction, so that the first driving pump can extract the solution in the solution bottle 520 and can be transported to the liquid adding needle 163 through the control of the first valve to add the solution to the bottle body 511, thereby completing the liquid adding operation. The pipeline between the first valve and the liquid adding needle 163 can be limited by the pipeline limiter 162 to prevent multiple pipelines from being entangled with each other and affecting the movement and liquid addition of the liquid adding needle 163.
加液模组160还包括支撑支架164,支撑支架164设置在第一平台111,且支撑支架164与安装支架161相邻设置,支撑支架164用于放置加液针163。加液针163的数量可为多个,溶液瓶520的数量也为多个,每个溶液瓶520承载的溶液不同,多个加液针163与多个溶液瓶520一一对应。第一驱动泵可为一个或多个,第一阀门可为一个或多个,第一驱动泵为一个时,第一阀门可为一个,且为多路多通型阀门,以通过第一阀门的不同阀口的开关切换不同的溶液输送至对应的加液针163;第一驱动泵为多个时,第一阀门也可为多个,数量与加液针163的数量可相同,使得第一驱动泵、第一阀门和加液针163一一对应。一种具体的实施例中,第一阀门具有多个接口,多个接口分别与溶液瓶520、加液针163和第一驱动泵连通。第一驱动泵可以为柱塞泵、注射泵、隔膜泵、蠕动泵等中的其中一种。第一阀门可以为电动阀、气动阀、液压阀等中的其中一种,优选的,第一阀门为电磁阀。The liquid adding module 160 also includes a support bracket 164, which is arranged on the first platform 111, and the support bracket 164 is arranged adjacent to the mounting bracket 161, and the support bracket 164 is used to place the liquid adding needle 163. The number of the liquid adding needle 163 can be multiple, and the number of the solution bottle 520 is also multiple, each solution bottle 520 carries different solutions, and the multiple liquid adding needles 163 correspond to the multiple solution bottles 520 one by one. The first driving pump can be one or more, and the first valve can be one or more. When the first driving pump is one, the first valve can be one, and it is a multi-way multi-pass valve, so that different solutions are switched through the switches of different valve ports of the first valve to be delivered to the corresponding liquid adding needle 163; when the first driving pump is multiple, the first valve can also be multiple, and the number can be the same as the number of the liquid adding needle 163, so that the first driving pump, the first valve and the liquid adding needle 163 correspond to each other. In a specific embodiment, the first valve has multiple interfaces, and the multiple interfaces are respectively connected to the solution bottle 520, the liquid adding needle 163 and the first driving pump. The first driving pump may be one of a plunger pump, a syringe pump, a diaphragm pump, a peristaltic pump, etc. The first valve may be one of an electric valve, a pneumatic valve, a hydraulic valve, etc. Preferably, the first valve is a solenoid valve.
加液针163的结构不做限定。可选的,参考图5和图6,加液针163可包括基板1631、针体1632、加液管接头1633和搬运头1635,基板1631用作结构基础,放置在支撑支架164上时,基板1631与支撑支架164接触,且支撑支架164对基板1631构成限位作用。基板1631的其中一侧表面连接有针体1632,基板1631背向针体1632的一侧表面连接有加液管接头1633和搬运头1635,加液管接头1633的接口1634通过管路与第一阀门连通,且该接口1634与针体1632连通,第一机械手130可夹持并移动搬运头1635,使得第一机械手130可带动加液针163移动。The structure of the liquid adding needle 163 is not limited. Optionally, referring to FIG. 5 and FIG. 6 , the liquid adding needle 163 may include a substrate 1631, a needle body 1632, a liquid adding pipe joint 1633 and a handling head 1635. The substrate 1631 is used as a structural foundation. When placed on the support bracket 164, the substrate 1631 contacts the support bracket 164, and the support bracket 164 limits the substrate 1631. The needle body 1632 is connected to one side surface of the substrate 1631, and the side surface of the substrate 1631 facing away from the needle body 1632 is connected to the liquid adding pipe joint 1633 and the handling head 1635. The interface 1634 of the liquid adding pipe joint 1633 is connected to the first valve through a pipeline, and the interface 1634 is connected to the needle body 1632. The first manipulator 130 can clamp and move the handling head 1635, so that the first manipulator 130 can drive the liquid adding needle 163 to move.
第一平台111上可设有若干凸台等放置位置,用于放置瓶身511或托盘101等,第一机械手130将瓶身511从加粉模组151取走后,可放置在第一平台111上的放置位置处,之后第一机械手130可移动加液针163至瓶身511放置的位置,将针头伸入到瓶口内,第一驱动泵和第一阀门打开,以将溶液注入瓶身511。根据所需反应的溶液的种类和容量,可选择一个或多个加液针163进行一次或多次加液操作。The first platform 111 may be provided with a plurality of bosses and other placement positions for placing the bottle body 511 or the tray 101, etc. After the first manipulator 130 takes the bottle body 511 from the powder adding module 151, it may be placed at the placement position on the first platform 111, and then the first manipulator 130 may move the liquid adding needle 163 to the position where the bottle body 511 is placed, insert the needle into the bottle mouth, and open the first driving pump and the first valve to inject the solution into the bottle body 511. According to the type and volume of the solution to be reacted, one or more liquid adding needles 163 may be selected to perform one or more liquid adding operations.
一种实施例中,请参考图5至图7,加液模组160还包括清洗件165,清洗件165设置于第一平台111,清洗件165开设有第一容置通道166和第一废液流道167,第一容置通道166自清洗件165背向第一平台111的表面开设至清洗件165的内部,第一容置通道166用于容置加液针163的针体1632,第一废液流道167自清洗件165的侧面开设至与第一容置通道166连通,且以第一平台111为基准,第一废液流道167在清洗件165的表面的开口比第一容置通道166的底壁更高。In one embodiment, please refer to Figures 5 to 7, the liquid adding module 160 also includes a cleaning part 165, the cleaning part 165 is arranged on the first platform 111, and the cleaning part 165 is provided with a first accommodating channel 166 and a first waste liquid flow channel 167, the first accommodating channel 166 is opened from the surface of the cleaning part 165 facing away from the first platform 111 to the inside of the cleaning part 165, the first accommodating channel 166 is used to accommodate the needle body 1632 of the liquid adding needle 163, the first waste liquid flow channel 167 is opened from the side of the cleaning part 165 to be connected with the first accommodating channel 166, and with the first platform 111 as a reference, the opening of the first waste liquid flow channel 167 on the surface of the cleaning part 165 is higher than the bottom wall of the first accommodating channel 166.
在加液时,通常加完一种溶液需要更换另外一种溶液,为了避免加液针163的污染,则加液针163需要进行清洗才能再次加液。本实施例中,第一驱动泵泵送的一种溶液完毕后,第一机械手130带动加液针163的针体1632插入第一容置通道166,第一驱动泵切换至泵送另一种溶液,该另一种溶液流到针体1632对针体1632的内壁进行清洗,从针体1632流出的该另一种溶液逐渐填充第一容置通道166直至液面到达第一废液流道167处,即第一容置通道166内的该另一种溶液具有较高的液面高度,针体1632浸入该另一种溶液中,能够对针体1632的外壁进行清洗。第一废液流道167可通过管道与废液瓶连通,从第一废液流道167流 出的溶液流入废液瓶中储存。When adding liquid, it is usually necessary to replace one solution with another one. In order to avoid contamination of the adding needle 163, the adding needle 163 needs to be cleaned before adding liquid again. In this embodiment, after the first driving pump finishes pumping one solution, the first manipulator 130 drives the needle body 1632 of the adding needle 163 to insert into the first receiving channel 166, and the first driving pump switches to pumping another solution. The other solution flows to the needle body 1632 to clean the inner wall of the needle body 1632. The other solution flowing out of the needle body 1632 gradually fills the first receiving channel 166 until the liquid level reaches the first waste liquid flow channel 167, that is, the other solution in the first receiving channel 166 has a higher liquid level height, and the needle body 1632 is immersed in the other solution, which can clean the outer wall of the needle body 1632. The first waste liquid flow channel 167 can be connected to the waste liquid bottle through a pipeline, and the liquid flowing from the first waste liquid flow channel 167 can be cleaned by the needle body 1632. The solution flows into the waste bottle for storage.
可选的,请参考图5至图7,清洗件165还开设有第二容置通道168和第二废液流道169,第二容置通道168自清洗件背向第一平台111的表面开设至清洗件165的内部,第二容置通道168与第一容置通道166具有间隔,第二容置通道168用于容置加液针163的针体1632,第二废液流道169自清洗件165的侧面开设至与第二容置通道168的底部连通,且以第一平台111为基准,第二废液流道169在清洗件165的表面的开口不高于第二容置通道168与第二废液流道169连通的位置。Optionally, please refer to Figures 5 to 7, the cleaning member 165 is further provided with a second accommodating channel 168 and a second waste liquid flow channel 169, the second accommodating channel 168 is opened from the surface of the cleaning member facing away from the first platform 111 to the interior of the cleaning member 165, the second accommodating channel 168 and the first accommodating channel 166 are spaced apart, the second accommodating channel 168 is used to accommodate the needle body 1632 of the liquid adding needle 163, the second waste liquid flow channel 169 is opened from the side of the cleaning member 165 to be connected with the bottom of the second accommodating channel 168, and with the first platform 111 as a reference, the opening of the second waste liquid flow channel 169 on the surface of the cleaning member 165 is not higher than the position where the second accommodating channel 168 and the second waste liquid flow channel 169 are connected.
在仅需要清洗加液针163的针体1632的内壁的情况下,可将针体1632插入第二容置通道168,溶液从针体1632内流出后直接从第二废液流道169流入废液瓶中,不会在第二容置通道168中积存,从而不会对针体1632的外壁产生污染。When only the inner wall of the needle body 1632 of the liquid-filling needle 163 needs to be cleaned, the needle body 1632 can be inserted into the second accommodating channel 168. After the solution flows out of the needle body 1632, it directly flows into the waste liquid bottle from the second waste liquid channel 169 without accumulating in the second accommodating channel 168, thereby not contaminating the outer wall of the needle body 1632.
可选的,针体1632可先插入第二容置通道168对内壁清洗,再插入第一容置通道166对内壁和外壁进行清洗,清洗效果更佳。Optionally, the needle body 1632 can be first inserted into the second accommodating channel 168 to clean the inner wall, and then inserted into the first accommodating channel 166 to clean the inner wall and the outer wall, so that the cleaning effect is better.
参考图1、图2和图3,第一机台110外侧还可设置有支撑台400,支撑台400用于放置各种不同的溶液瓶520,与第一阀门连接的管路可从第一机台110伸出并伸入各溶液瓶520中。如此,可节约第一机台110内的空间。1, 2 and 3, a support platform 400 may be further provided outside the first machine 110, and the support platform 400 is used to place various solution bottles 520, and the pipeline connected to the first valve may extend from the first machine 110 and extend into each solution bottle 520. In this way, the space inside the first machine 110 can be saved.
可选的,其中一种溶液瓶520中可盛装有清洗液,当完成全部的溶液的加液操作后,可将该清洗液输送到清洗件165对加液针163的针体1632进行清洗,之后加液针163停止加液操作,直至下一次实验时进行加液操作。Optionally, one of the solution bottles 520 may contain a cleaning solution. After the addition operation of all the solutions is completed, the cleaning solution may be transported to the cleaning part 165 to clean the needle body 1632 of the addition needle 163. The addition operation of the addition needle 163 is then stopped until the next experiment.
通过设置加液模组160,能够自动化实现加液操作和清洗加液针163的针体1632的操作,使用一套结构即可实现加液和清洗,节约了零部件,使得设备结构更为紧凑,空间占用小。By setting up the liquid adding module 160, the liquid adding operation and the operation of cleaning the needle body 1632 of the liquid adding needle 163 can be automatically realized. Liquid adding and cleaning can be realized with one set of structure, which saves parts, makes the equipment structure more compact and occupies less space.
另一种实施例中,加液模组160包括移液器,移液器与第一机械手130可拆卸连接,第一机械手130用于移动移液器至Tip头放置位使移液器与Tip头530(吸头、取样头)连接,移液器用于自动通过Tip头530吸液或吐液,以及自动退Tip头530。In another embodiment, the liquid adding module 160 includes a pipette, which is detachably connected to the first manipulator 130. The first manipulator 130 is used to move the pipette to the Tip head placement position so that the pipette is connected to the Tip head 530 (pipette tip, sampling head). The pipette is used to automatically aspirate or spit liquid through the Tip head 530, and automatically retract the Tip head 530.
移液器的结构不做限定。可选的,移液器同样具有母连接头,用于与第一机械手130的公连接头快速连接和拆卸。移液器可放置于前述的工具架123上,第一平台111上还可设有Tip头架,Tip头架放置有Tip头530。移液器上可设有第二驱动件和活塞,第二驱动件可带动活塞作伸缩运动。第一机械手130与移液器连接并带动移液器移动,移液器移动至与Tip头530连接后,移液器移动至溶液瓶520处,并将Tip头530插入溶液瓶520内,第二驱动件驱动活塞缩回,使得Tip头530吸液,之后移液器移动至瓶身511处并将Tip头530插入瓶身511的瓶口内,第二驱动件驱动活塞伸出,使得Tip头530吐液,完成一次移液操作。当需要更换不同的溶液时,需要将上次吸液的Tip头530退出更换为新的Tip头530,则移液器通过自身的退头机构自动将Tip头530退下,退头机构的具体结构无需限定。之后重复上述过程,完成加液操作,第一机械手130将移液器移动回工具架123存放,直至下次需要进行加液操作。The structure of the pipette is not limited. Optionally, the pipette also has a female connector for quick connection and disassembly with the male connector of the first manipulator 130. The pipette can be placed on the aforementioned tool rack 123, and the first platform 111 can also be provided with a Tip head rack, and the Tip head rack is provided with a Tip head 530. The pipette can be provided with a second drive member and a piston, and the second drive member can drive the piston to perform telescopic movement. The first manipulator 130 is connected with the pipette and drives the pipette to move. After the pipette moves to be connected with the Tip head 530, the pipette moves to the solution bottle 520, and the Tip head 530 is inserted into the solution bottle 520, and the second drive member drives the piston to retract, so that the Tip head 530 absorbs liquid, and then the pipette moves to the bottle body 511 and the Tip head 530 is inserted into the bottle mouth of the bottle body 511, and the second drive member drives the piston to extend, so that the Tip head 530 spits liquid, and completes a pipetting operation. When a different solution needs to be replaced, the Tip head 530 used for the last liquid aspiration needs to be withdrawn and replaced with a new Tip head 530, and the pipette automatically withdraws the Tip head 530 through its own withdrawing mechanism, and the specific structure of the withdrawing mechanism is not limited. The above process is then repeated to complete the liquid adding operation, and the first manipulator 130 moves the pipette back to the tool rack 123 for storage until the next liquid adding operation is required.
本实施例与前述的采用加液针163的操作相比,本实施例的Tip头530是一次性使用的,无需清洗操作,使用后的Tip头530丢弃到废品盒即可。在实际应用中,可同时设置带加液针163的加液模组160,以及带移液器的加液模组160,并根据所加溶液的容量选择合适的加液模组160。具体的,由于加液针163是直接与溶液瓶520连通的,可连续不断的进行加液,而Tip头530的容量有限,例如为1ml-5ml,每次只能添加少量的溶液,如需要添加的同一种溶液的量较大时,可使用带加液针163的加液模组160进行连续加液,如每种溶液的添加量都较少时,可选择带移液器的加液模组160,减少清洗的步骤,工艺过程更简单些。 Compared with the operation of the aforementioned liquid adding needle 163, the tip head 530 of the present embodiment is disposable, and no cleaning operation is required. The tip head 530 after use can be discarded into the waste box. In practical applications, a liquid adding module 160 with a liquid adding needle 163 and a liquid adding module 160 with a pipette can be set at the same time, and a suitable liquid adding module 160 is selected according to the capacity of the added solution. Specifically, since the liquid adding needle 163 is directly connected to the solution bottle 520, liquid addition can be continuously performed, and the capacity of the tip head 530 is limited, for example, 1ml-5ml, and only a small amount of solution can be added each time. If the amount of the same solution to be added is large, the liquid adding module 160 with the liquid adding needle 163 can be used for continuous liquid addition. If the amount of each solution added is small, the liquid adding module 160 with a pipette can be selected to reduce the steps of cleaning, and the process is simpler.
进一步的,移液器还包括第一检测件和第二检测件,第一检测件用于检测Tip头530是否安装到位,第二检测件用于获取Tip头530或瓶身511中溶液的液面高度。Furthermore, the pipette also includes a first detection member and a second detection member, the first detection member is used to detect whether the Tip head 530 is installed in place, and the second detection member is used to obtain the liquid level of the solution in the Tip head 530 or the bottle body 511.
第一检测件和第二检测件可为任意可行的传感器,不做限制。通过检测Tip头530是否安装到位,以便于确定移液器是否可以进行移液操作,确保可靠性。通过检测Tip头530或瓶身511中溶液的液面高度,以便于确定加液是否已达到所需加液的量。通过设置第一检测件和第二检测件,能够方便进行加液操作的控制,提升设备自动化水平。The first detection member and the second detection member can be any feasible sensor without limitation. By detecting whether the Tip head 530 is installed in place, it is convenient to determine whether the pipette can perform the pipetting operation to ensure reliability. By detecting the liquid level of the solution in the Tip head 530 or the bottle body 511, it is convenient to determine whether the liquid addition has reached the required amount of liquid addition. By setting the first detection member and the second detection member, the control of the liquid addition operation can be facilitated, and the automation level of the equipment can be improved.
一种实施例中,请参考图2和图3,反应模组包括第一搅拌组件154、第二搅拌组件155和振荡组件中的至少一个,第一搅拌组件154用于对溶液进行搅拌并提供第一温度范围,第二搅拌组件155用于对溶液进行搅拌并提供第二温度范围,第一温度范围和第二温度范围不同,振荡组件用于对溶液进行振荡并提供第三温度范围。In one embodiment, please refer to Figures 2 and 3, the reaction module includes at least one of a first stirring component 154, a second stirring component 155 and an oscillation component, the first stirring component 154 is used to stir the solution and provide a first temperature range, the second stirring component 155 is used to stir the solution and provide a second temperature range, the first temperature range and the second temperature range are different, and the oscillation component is used to oscillate the solution and provide a third temperature range.
第一搅拌组件154、第二搅拌组件155和振荡组件的具体结构均不做限定。第一搅拌组件154、第二搅拌组件155两者搅拌的功能可采用磁力驱动磁石在瓶身511内运动、搅拌杆伸入瓶身511内搅拌等各种可能的实现方式,均不做限定。振荡组件振荡的功能可采用夹持容器带动其摆动振荡或偏心轴旋转等方式实现。在反应时不同粉料和溶液所需的反应温度是不同的,设置第一搅拌组件154、第二搅拌组件155和振荡组件中的至少一个,在提供混匀功能的同时,提供不同温度范围,可根据不同反应所需的温度,选择其中一个合适的组件进行混匀,提高了实验的适用范围。The specific structures of the first stirring component 154, the second stirring component 155 and the oscillation component are not limited. The stirring function of the first stirring component 154 and the second stirring component 155 can be realized in various possible ways, such as magnetically driving the magnet to move in the bottle body 511, extending the stirring rod into the bottle body 511 for stirring, etc., without limitation. The oscillation function of the oscillation component can be realized by clamping the container to drive its swinging oscillation or rotating the eccentric shaft. The reaction temperatures required for different powders and solutions are different during the reaction. At least one of the first stirring component 154, the second stirring component 155 and the oscillation component is set to provide different temperature ranges while providing the mixing function. According to the temperature required for different reactions, one of the suitable components can be selected for mixing, thereby improving the scope of application of the experiment.
可选的,第一搅拌组件154为高温磁力搅拌仪,其内具有温度控制器和电阻丝,温度控制器驱动电阻丝加热,以控制第一温度范围为常温-150℃。常温为实验时的环境温度,例如为20℃、25℃、30℃等,不做限制。在第一温度范围内,第一搅拌组件154可精确控制具体的温度数值,且温度精度可为1℃,即可在第一温度范围内进行升温1℃或降温1℃的控制。可精确控制的温度数值例如常温、40℃、60℃、80℃、100℃、120℃、140℃、150℃等,当然,还可以为其他温度数值。其中,电阻丝可通过硅胶加热膜包覆,以提高安全性。本实施例中,第一搅拌组件154具有搅拌功能和加热功能,能将瓶身511内的粉料和溶液进行充分搅拌以及加热达到合适的反应温度。Optionally, the first stirring component 154 is a high-temperature magnetic stirrer, which has a temperature controller and a resistance wire, and the temperature controller drives the resistance wire to heat to control the first temperature range to be room temperature-150°C. Room temperature is the ambient temperature during the experiment, such as 20°C, 25°C, 30°C, etc., without limitation. Within the first temperature range, the first stirring component 154 can accurately control the specific temperature value, and the temperature accuracy can be 1°C, that is, the temperature can be increased or decreased by 1°C within the first temperature range. The temperature values that can be accurately controlled are, for example, room temperature, 40°C, 60°C, 80°C, 100°C, 120°C, 140°C, 150°C, etc., and of course, other temperature values can also be used. Among them, the resistance wire can be coated with a silicone heating film to improve safety. In this embodiment, the first stirring component 154 has stirring and heating functions, and can fully stir and heat the powder and solution in the bottle body 511 to a suitable reaction temperature.
可选的,第二搅拌组件155为温控电磁搅拌仪,其内具有TEC控制器和半导体制冷元件(帕尔贴元件),TEC控制器采用半导体温控原理控制半导体元件进行制冷或加热,以控制第二温度范围为0℃-90℃。与第一搅拌组件154类似的,本实施例的第二搅拌组件155的温度精度可为1℃。可精确控制的温度数值例如0℃、10℃、20℃、30℃、40℃、50℃、60℃、70℃、80℃、90℃等,当然,还可以为其他温度数值。本实施例中,第二搅拌组件155具有搅拌功能、制冷功能和加热功能,能提供比常温更低的反应温度,能将瓶身511内的粉料和溶液进行充分搅拌以及制冷或加热达到合适的反应温度。Optionally, the second stirring component 155 is a temperature-controlled electromagnetic stirrer, which has a TEC controller and a semiconductor refrigeration element (Peltier element). The TEC controller uses the semiconductor temperature control principle to control the semiconductor element to cool or heat, so as to control the second temperature range to be 0°C-90°C. Similar to the first stirring component 154, the temperature accuracy of the second stirring component 155 of this embodiment can be 1°C. The temperature values that can be accurately controlled are, for example, 0°C, 10°C, 20°C, 30°C, 40°C, 50°C, 60°C, 70°C, 80°C, 90°C, etc., and of course, other temperature values can also be used. In this embodiment, the second stirring component 155 has stirring, cooling and heating functions, can provide a reaction temperature lower than normal temperature, can fully stir the powder and solution in the bottle 511, and cool or heat to a suitable reaction temperature.
可选的,振荡组件提供的第三温度范围为常温-150℃,可参考第一搅拌组件154提供第一温度范围的方式,不再赘述。Optionally, the third temperature range provided by the oscillation component is room temperature - 150°C, and reference may be made to the manner in which the first stirring component 154 provides the first temperature range, which will not be described in detail.
可以理解的是,可根据实验所需的反应温度范围,选择第一搅拌组件154、第二搅拌组件155和振荡组件的其中一种、两种或同时选择三种进行实验,均不做限定。根据实验的需要,第一搅拌组件154可设置一个或多个,第二搅拌组件155也可设置一个或多个,振荡组件也可设置一个或多个,多个第一搅拌组件154、多个第二搅拌组件155、多个振荡组件可同时进行多个瓶身511的搅拌、振荡操作,以实现批量的实验操作。It is understandable that, according to the reaction temperature range required by the experiment, one, two or all three of the first stirring component 154, the second stirring component 155 and the oscillating component can be selected for the experiment, and there is no limitation. According to the needs of the experiment, one or more first stirring components 154 can be set, one or more second stirring components 155 can be set, and one or more oscillating components can be set. Multiple first stirring components 154, multiple second stirring components 155, and multiple oscillating components can simultaneously perform stirring and oscillating operations on multiple bottles 511 to achieve batch experimental operations.
一种实施例中,请参考图2和图3,反应站100还包括缓存架122,缓存架122设置于第一平台111。缓存架122的结构可与前述的上料架121类似,参照即可。在实验过程中,反 应站100内可能同时有多个容器510或瓶身511(即开盖后的容器510),以及在其中一些实验步骤之间,需要将容器510暂时存放,故而设置缓存架122,可以暂时存放容器510。缓存架122的设置位置可在第一平台111上任意位置,并不需要靠近第一机台110的仓门112设置。In one embodiment, please refer to FIG. 2 and FIG. 3 , the reaction station 100 further includes a buffer rack 122, which is disposed on the first platform 111. The structure of the buffer rack 122 may be similar to the aforementioned loading rack 121, and can be used as a reference. There may be multiple containers 510 or bottles 511 (i.e., containers 510 with lids opened) in the test station 100 at the same time, and the containers 510 need to be temporarily stored between some experimental steps, so a buffer rack 122 is provided to temporarily store the containers 510. The buffer rack 122 can be set at any position on the first platform 111, and does not need to be set close to the door 112 of the first machine 110.
可选的,上料架121和缓存架122均设有多个托盘放置位,托盘放置位用于放置托盘101并限位,容器510用于放置在托盘101上。托盘放置位可设置如销钉、凸起、磁吸件等结构,以与托盘101上对应的对位结构适配,使得托盘101放置在托盘放置位时能够被限位,从而使得托盘101稳定的放置在上料架121或缓存架122上。托盘101上亦可设置有相关的限位结构,使得容器510放置在托盘101上时被限位,确保容器510的稳定。在第一机械手130移动容器510时,第一机械手130可移动托盘101,以带动托盘101上的容器510一起移动,当然,第一机械手130也可仅移动容器510,而将托盘101留在上料架121或缓存架122上。Optionally, the loading rack 121 and the buffer rack 122 are both provided with a plurality of tray placement positions, the tray placement positions are used to place and limit the tray 101, and the container 510 is used to be placed on the tray 101. The tray placement positions may be provided with structures such as pins, protrusions, magnetic suction parts, etc., to adapt to the corresponding alignment structure on the tray 101, so that the tray 101 can be limited when placed in the tray placement position, so that the tray 101 can be stably placed on the loading rack 121 or the buffer rack 122. The tray 101 may also be provided with a relevant limiting structure, so that the container 510 is limited when placed on the tray 101, ensuring the stability of the container 510. When the first manipulator 130 moves the container 510, the first manipulator 130 can move the tray 101 to drive the container 510 on the tray 101 to move together. Of course, the first manipulator 130 can also only move the container 510 and leave the tray 101 on the loading rack 121 or the buffer rack 122.
可选的,反应站100还包括托盘夹爪和容器夹爪,第一机械手130与托盘夹爪、容器夹爪均可拆卸连接,托盘夹爪用于夹持托盘101,容器夹爪用于夹持托盘101内的容器510。托盘夹爪、容器夹爪上可设置有前述的母连接头,以用于与第一机械手130的公连接头实现快速安装和拆卸。托盘夹爪、容器夹爪也可放置在前述的工具架123上,并被工具架123限位,以使结构稳定。在使用时第一机械手130与托盘夹爪、容器夹爪连接后带动托盘夹爪、容器夹爪从工具架123处移动至上料架121或缓存架122处,托盘夹爪夹持托盘101、容器夹爪夹持容器,从而第一机械手130可以通过托盘夹爪、容器夹爪带动托盘101、容器510移动。托盘夹爪、容器夹爪的具体结构不做限定,托盘夹爪夹持托盘101的具体结构也不做限定,容器夹爪夹持容器的具体结构也不做限定。Optionally, the reaction station 100 further includes a tray clamp and a container clamp. The first manipulator 130 is detachably connected to the tray clamp and the container clamp. The tray clamp is used to clamp the tray 101, and the container clamp is used to clamp the container 510 in the tray 101. The tray clamp and the container clamp may be provided with the aforementioned female connector for quick installation and removal with the male connector of the first manipulator 130. The tray clamp and the container clamp may also be placed on the aforementioned tool rack 123 and limited by the tool rack 123 to stabilize the structure. When in use, the first manipulator 130 is connected to the tray clamp and the container clamp, and then drives the tray clamp and the container clamp to move from the tool rack 123 to the loading rack 121 or the buffer rack 122. The tray clamp clamps the tray 101, and the container clamp clamps the container, so that the first manipulator 130 can drive the tray 101 and the container 510 to move through the tray clamp and the container clamp. The specific structures of the tray clamp and the container clamp are not limited, the specific structure of the tray clamp holding the tray 101 is not limited, and the specific structure of the container clamp holding the container is not limited.
可选的,请参考图3,反应站100还包括扫码模组152,扫码模组152设置于第一平台111,托盘101和/或容器510上设有条码,扫码模组152用于扫描并识别条码。扫码模组152可包括扫描头等,可对条码进行扫描和识别。条码可为条形码、二维码等,条码中可包含有托盘101和/或容器510的相关信息,例如编号、类型、尺寸等。其中,对于第一机械手130直接移动容器510的实施例,可仅在容器510上设置条码;对于第一机械手130移动托盘101的实施例,可在托盘101和容器510上同时设置条码,也可仅在托盘101上设置条码。扫码模组152扫描条码后,识别条码中的相关信息,能够判断是否取到了所需的容器510,或者,是否取到了所需的反应物(例如缓存架122上放置的盛装有粉料的容器510或者盛装有粉料和溶液的容器510)。通过设置扫码模组152,能够识别托盘101和/或容器510,能够实现实验过程中信息的录入以方便进行信息的交互。扫码模组152可靠近上料架121设置,方便第一机械手130及时将放入上料架121中的托盘101和/或容器510移动至扫码模组152进行扫描和识别。Optionally, please refer to FIG. 3 , the reaction station 100 further includes a barcode scanning module 152, which is disposed on the first platform 111, and a barcode is disposed on the tray 101 and/or the container 510, and the barcode scanning module 152 is used to scan and identify the barcode. The barcode scanning module 152 may include a scanning head, etc., which can scan and identify the barcode. The barcode may be a barcode, a two-dimensional code, etc., and the barcode may include relevant information of the tray 101 and/or the container 510, such as the number, type, size, etc. Among them, for the embodiment in which the first manipulator 130 directly moves the container 510, the barcode may be set only on the container 510; for the embodiment in which the first manipulator 130 moves the tray 101, the barcode may be set on both the tray 101 and the container 510, or the barcode may be set only on the tray 101. After the code scanning module 152 scans the barcode, it identifies the relevant information in the barcode and can determine whether the required container 510 has been taken, or whether the required reactant (for example, a container 510 containing powder or a container 510 containing powder and solution placed on the cache rack 122) has been taken. By setting the code scanning module 152, the tray 101 and/or the container 510 can be identified, and the input of information during the experiment can be realized to facilitate the exchange of information. The code scanning module 152 can be set close to the loading rack 121, so that the first manipulator 130 can move the tray 101 and/or the container 510 placed in the loading rack 121 to the code scanning module 152 for scanning and identification in time.
一种实施例中,请参考图2、图3、图8和图9,反应站100还包括视觉模组170,视觉模组170设置于第一平台111,第一机械手130用于将反应模组进行反应实验后的容器510移动至视觉模组170处,视觉模组170用于对容器510进行拍照。In one embodiment, please refer to Figures 2, 3, 8 and 9, the reaction station 100 also includes a visual module 170, the visual module 170 is arranged on the first platform 111, the first robot 130 is used to move the container 510 after the reaction module performs a reaction experiment to the visual module 170, and the visual module 170 is used to take pictures of the container 510.
视觉模组170的具体结构可不做限定,视觉模组170用于拍照,以获取容器510的图片,根据容器510的图片可判断反应进行的情况。The specific structure of the visual module 170 is not limited. The visual module 170 is used to take pictures to obtain a picture of the container 510 . The progress of the reaction can be determined based on the picture of the container 510 .
可选的,请参考图2、图3、图8,视觉模组170包括面光源171、环形光源172、第一相机173和第二相机174,第一相机173和第二相机174的光轴不相交。面光源171的出光面大致位于竖直方向上,第一相机173的光轴与面光源171的出光面垂直。环形光源172的中心轴位于竖直方向上,第二相机174位于环形光源172与第一平台111之间的位置。第一 相机173用于拍摄容器510的侧面照片,第二相机174用于拍摄容器510的底部照片。Optionally, please refer to Figures 2, 3, and 8. The visual module 170 includes a surface light source 171, an annular light source 172, a first camera 173, and a second camera 174. The optical axes of the first camera 173 and the second camera 174 do not intersect. The light emitting surface of the surface light source 171 is approximately located in the vertical direction, and the optical axis of the first camera 173 is perpendicular to the light emitting surface of the surface light source 171. The central axis of the annular light source 172 is located in the vertical direction, and the second camera 174 is located between the annular light source 172 and the first platform 111. The first The camera 173 is used to take a side photo of the container 510 , and the second camera 174 is used to take a bottom photo of the container 510 .
使用时,第一机械手130将容器510移动到第一相机173与面光源171之间,容器510的中心轴大致沿竖直方向,面光源171从容器510的一侧照亮容器510,第一相机173能够拍摄到明亮的容器510的侧面照片。从容器510的侧面照片可以查看容器510中的粉料和溶液反应后的混匀情况、液体分层的情况、液体浑浊情况(溶清状态)等,便可据此判断反应的情况。When in use, the first manipulator 130 moves the container 510 between the first camera 173 and the surface light source 171, the central axis of the container 510 is roughly along the vertical direction, the surface light source 171 illuminates the container 510 from one side of the container 510, and the first camera 173 can take a bright side photo of the container 510. From the side photo of the container 510, it is possible to check the mixing of the powder and the solution in the container 510 after the reaction, the stratification of the liquid, the turbidity of the liquid (clear solution state), etc., and the reaction situation can be judged accordingly.
使用时,第一机械手130将容器510移动到环形光源172背向第一平台111的一侧,并使得容器510的中心轴大致与环形光源172的中心轴重合,环形光源172从容器510的底部一侧照亮容器510,第二相机174能够拍摄到明亮的容器510的底部照片。从容器510的底部照片可以查看容器510中底部沉积物的情况,便可据此判断反应的情况。When in use, the first manipulator 130 moves the container 510 to the side of the annular light source 172 facing away from the first platform 111, and makes the central axis of the container 510 roughly coincide with the central axis of the annular light source 172. The annular light source 172 illuminates the container 510 from the bottom side of the container 510, and the second camera 174 can take a bright bottom photo of the container 510. From the bottom photo of the container 510, the condition of the bottom sediment in the container 510 can be checked, and the reaction condition can be judged accordingly.
一般而言,在反应模组处完成混匀的容器510,随着时间的推移,一般是逐渐沉积到容器510的底部的,因此,一般是第一机械手130先将容器510移动到第一相机173与面光源171之间,第一相机173拍摄容器510的侧面照片后,第一机械手130再将容器510移动到环形光源172背向第一平台111的一侧,第二相机174拍摄容器510的底部照片。当然,在实际操作过程中,也可根据需要先拍摄容器510的底部照片,再拍摄容器510的侧面照片。可定时进行拍摄,可每隔一定时间进行拍摄,可交替拍摄,均不做限制。Generally speaking, the container 510 that has been mixed at the reaction module is generally gradually deposited to the bottom of the container 510 as time goes by. Therefore, the first manipulator 130 generally moves the container 510 between the first camera 173 and the surface light source 171. After the first camera 173 takes a side photo of the container 510, the first manipulator 130 moves the container 510 to the side of the annular light source 172 that is away from the first platform 111, and the second camera 174 takes a bottom photo of the container 510. Of course, in the actual operation process, the bottom photo of the container 510 can be taken first, and then the side photo of the container 510 can be taken as needed. The shooting can be performed at regular intervals, at regular intervals, or alternately, without any restrictions.
视觉模组170还可包括基座175及基座175上设置的各类驱动结构等,基座175设置于第一平台111,各类驱动结构可用于控制面光源171和环形光源172的开启、关闭、发光亮度以及驱动面光源171、环形光源172、第一相机173和第二相机174等在基座175上移动等,均不做限制。The visual module 170 may also include a base 175 and various driving structures arranged on the base 175. The base 175 is arranged on the first platform 111. The various driving structures can be used to control the opening, closing, and brightness of the surface light source 171 and the annular light source 172, as well as driving the surface light source 171, the annular light source 172, the first camera 173, and the second camera 174 to move on the base 175, etc., without any restrictions.
可选的,面光源171朝向第一相机173的一侧还设有标定板176,标定板176为透明材质而具有透光性,标定板176平行于面光源171的出光面,且标定板176能够沿平行于出光面的方向移动。Optionally, a calibration plate 176 is further provided on the side of the surface light source 171 facing the first camera 173. The calibration plate 176 is made of a transparent material and has light transmittance. The calibration plate 176 is parallel to the light emitting surface of the surface light source 171 and can move in a direction parallel to the light emitting surface.
标定板176上可设有棋盘格或阵列图案等用于标定的图案,标定板176用于提供第一相机173拍摄的图像的背景,以便于检查容器510内溶液的反应情况。当需要检查溶液的反应情况时,基座175上的驱动结构带动标定板176一端并遮挡面光源171的出光面,面光源171射出的光穿透标定板176以照亮标定板176。第一相机173拍摄容器510和标定板176的照片,标定板176的图案的光线透过溶液进入第一相机173后在第一相机173内成像,可根据成像的照片中标定板176的图案的畸变程度判断溶液中的分层情况、混匀情况等反应情况。The calibration plate 176 may be provided with a pattern for calibration, such as a checkerboard or array pattern. The calibration plate 176 is used to provide a background for the image captured by the first camera 173, so as to facilitate the inspection of the reaction of the solution in the container 510. When the reaction of the solution needs to be inspected, the driving structure on the base 175 drives one end of the calibration plate 176 and blocks the light-emitting surface of the surface light source 171. The light emitted by the surface light source 171 penetrates the calibration plate 176 to illuminate the calibration plate 176. The first camera 173 takes a photo of the container 510 and the calibration plate 176. The light of the pattern of the calibration plate 176 passes through the solution and enters the first camera 173, and then forms an image in the first camera 173. The reaction conditions such as the stratification and mixing conditions in the solution can be judged according to the degree of distortion of the pattern of the calibration plate 176 in the imaged photo.
一种实施例中,请参考图8,第二相机174的光轴与环形光源172的中心轴重合。即第二相机174的光轴大致为竖直方向,第二相机174在环形光源172朝向第一平台111的一侧。In one embodiment, referring to FIG8 , the optical axis of the second camera 174 coincides with the central axis of the annular light source 172 . That is, the optical axis of the second camera 174 is substantially vertical, and the second camera 174 is on the side of the annular light source 172 facing the first platform 111 .
另一种实施例中,请参考图9,与图8所示的实施例基本相同,区别在于,环形光源172与第一平台111之间的位置设置有光学反射件177,光学反射件177用于将环形光源172的中心轴的光线反射至与第二相机174的光轴重合。光学反射件177可为平面反射镜、反射棱镜等,不做限定。与图8所示实施例相比,本实施例中将图8中的设置第二相机174的位置替换为设置光学反射件177,从而改变容器510底部反射光线的路径,从而可使得第二相机174的光轴不必沿与环形光源172的中心轴的方向设置,能够使得第二相机174设置在更为合理的位置,使得结构更为紧凑。可选的,第二相机174的光轴可以与第一相机173的光轴平行。In another embodiment, please refer to FIG. 9 , which is basically the same as the embodiment shown in FIG. 8 , except that an optical reflector 177 is provided between the annular light source 172 and the first platform 111 , and the optical reflector 177 is used to reflect the light of the central axis of the annular light source 172 to coincide with the optical axis of the second camera 174. The optical reflector 177 may be a plane reflector, a reflective prism, etc., without limitation. Compared with the embodiment shown in FIG. 8 , in this embodiment, the position where the second camera 174 is provided in FIG. 8 is replaced by the optical reflector 177, thereby changing the path of the light reflected from the bottom of the container 510, so that the optical axis of the second camera 174 does not need to be provided in the direction of the central axis of the annular light source 172, and the second camera 174 can be provided in a more reasonable position, making the structure more compact. Optionally, the optical axis of the second camera 174 may be parallel to the optical axis of the first camera 173.
一种实施例中,样品处理系统1000还包括移动机器人(图中未示出),移动机器人用于在上料架121上取放容器510。利于移动机器人取代实验人员上下料,能够降低人工成本, 实现整个实验流程的全自动化。In one embodiment, the sample processing system 1000 further includes a mobile robot (not shown in the figure), which is used to pick up and place the container 510 on the loading rack 121. The mobile robot can replace the experimenter to load and unload materials, which can reduce labor costs. Realize full automation of the entire experimental process.
一种实施例中,反应模组在完成合成反应实验后,第一机械手130可以将反应完成的容器510移动至上料架121,以便于实验人员或移动机器人在上料架121上取走反应样品。In one embodiment, after the reaction module completes the synthesis reaction experiment, the first manipulator 130 can move the container 510 after the reaction is completed to the loading rack 121 , so that the experimenter or the mobile robot can take the reaction sample from the loading rack 121 .
一种实施例中,请参考图1至图3,样品处理系统1000还包括分析站200,分析站200包括第二机台210、第二机械手220和分析仪230。In one embodiment, referring to FIG. 1 to FIG. 3 , the sample processing system 1000 further includes an analysis station 200 , and the analysis station 200 includes a second machine 210 , a second robot 220 , and an analyzer 230 .
第二机台210设置于第一机台110的一侧,两种机台可以紧靠设置。第二机台210具有第二平台211,第二平台211与第一平台111类似,也是用于设置各种零部件的平台。第二平台211可以与第一平台111等高。The second machine 210 is arranged at one side of the first machine 110, and the two machines can be arranged close to each other. The second machine 210 has a second platform 211, which is similar to the first platform 111 and is also a platform for placing various parts. The second platform 211 can be at the same height as the first platform 111.
第二机械手220设置于第二平台211。第二机械手220与第一机械手130类似,参考前述第一机械手130的描述即可,不再赘述。The second robot 220 is disposed on the second platform 211. The second robot 220 is similar to the first robot 130, and the description of the first robot 130 is referred to above and will not be repeated here.
分析仪230设置于第二平台211,第二机械手220用于将从反应站100中完成反应并输送至分析站200的溶液放入分析仪230进行分析。分析仪230用于进行对溶液进行分析,可得到溶液的组分及含量等信息。分析仪230可为LCMS(液质联用)分析仪、HPLC(High Performance Liquid Chromatography,高效液相色谱)分析仪、UPLC(Ultra Performance Liquid Chromatography,超高效液相色谱)分析仪等,分析仪230的具体结构和原理等均不做限制,任意可行的均可。The analyzer 230 is disposed on the second platform 211, and the second manipulator 220 is used to place the solution that has completed the reaction in the reaction station 100 and is transported to the analysis station 200 into the analyzer 230 for analysis. The analyzer 230 is used to analyze the solution and obtain information such as the components and content of the solution. The analyzer 230 can be an LCMS (liquid chromatography-mass spectrometry) analyzer, an HPLC (High Performance Liquid Chromatography) analyzer, an UPLC (Ultra Performance Liquid Chromatography) analyzer, etc. The specific structure and principle of the analyzer 230 are not limited, and any feasible one can be used.
因此,本实施例中,样品处理系统1000在反应站100完成反应后,再送到分析站200进行分析,延长了样品处理系统1000的工作流程,将分析的过程也实现了自动化,进一步提升了设备的自动化水平。Therefore, in this embodiment, after the sample processing system 1000 completes the reaction at the reaction station 100, it is sent to the analysis station 200 for analysis, which extends the workflow of the sample processing system 1000, automates the analysis process, and further improves the automation level of the equipment.
可选的,请参考图2和图3,样品处理系统1000还包括中转模组300,中转模组300连接第一平台111和第二平台211,并用于将反应站100中完成反应的溶液输送至分析站200。Optionally, referring to FIG. 2 and FIG. 3 , the sample processing system 1000 further includes a transfer module 300 , which connects the first platform 111 and the second platform 211 and is used to transport the solution that has completed the reaction in the reaction station 100 to the analysis station 200 .
中转模组300可包括各种输送装置,例如导向装置、传输带装置等,不做限制。示例性的,请参考图3,中转模组300包括传输组件310和设置于传输组件310上的承载组件320,传输组件310的两端分别设置在第一平台111和第二平台211上,传输组件310用于带动承载组件320在传输组件310上移动,以在第一平台111和第二平台211之间移动。承载组件320用于放置容器510或放有容器510的托盘101,从而将反应后的溶液从反应站100转移到分析站200。传输组件310具体可为丝杠螺母传动机构,承载组件320设置在螺母上,通过电机等结构便可驱动承载组件320在传输组件310上移动。The transfer module 300 may include various conveying devices, such as guide devices, conveyor belt devices, etc., without limitation. Exemplarily, please refer to Figure 3, the transfer module 300 includes a transmission component 310 and a bearing component 320 arranged on the transmission component 310, and the two ends of the transmission component 310 are respectively arranged on the first platform 111 and the second platform 211, and the transmission component 310 is used to drive the bearing component 320 to move on the transmission component 310, so as to move between the first platform 111 and the second platform 211. The bearing component 320 is used to place the container 510 or the tray 101 with the container 510, so as to transfer the reacted solution from the reaction station 100 to the analysis station 200. The transmission component 310 can be specifically a screw nut transmission mechanism, and the bearing component 320 is arranged on the nut, and the bearing component 320 can be driven to move on the transmission component 310 by a motor or other structures.
通过设置中转模组300,可以实现溶液的转移,以便于分析仪230对溶液进行分析。By providing the transfer module 300 , the solution can be transferred so that the analyzer 230 can analyze the solution.
一种实施例中,请参考图2、图3和图10,反应站100还包括鼓气模组180,鼓气模组180设置于第一平台111,鼓气模组180用于向反应前的溶液中鼓入惰性气体,和/或向待输送至分析站的溶液中鼓入惰性气体。鼓气模组180靠近开关盖模组140设置。In one embodiment, referring to FIG. 2 , FIG. 3 and FIG. 10 , the reaction station 100 further includes a gas blowing module 180 , which is disposed on the first platform 111 , and is used to blow inert gas into the solution before the reaction, and/or blow inert gas into the solution to be transported to the analysis station. The gas blowing module 180 is disposed close to the switch cover module 140 .
鼓气模组180的具体结构不做限制。可选的,请参考图3和图10,鼓气模组180包括第一支撑座181、鼓气件182、第三驱动件183、第一升降旋转组件184等,第一支撑座181设置于第一平台111,鼓气件182、第三驱动件183和第一升降旋转组件184设置于第一支撑座181,第三驱动件183例如为双运动电机,第三驱动件183与第一升降旋转组件184连接,以驱动第一升降旋转组件184可作升降和旋转运动,第一升降旋转组件184用于与鼓气头连接,鼓气件182与鼓气头连通,用于向鼓气头鼓气。鼓气头可为Tip头530或其他结构,不做限制。第一支撑座181上可以设置鼓气头放置架,其上可放置多个鼓气头。The specific structure of the air-inflating module 180 is not limited. Optionally, please refer to Figures 3 and 10. The air-inflating module 180 includes a first support seat 181, an air-inflating member 182, a third driving member 183, a first lifting and rotating assembly 184, etc. The first support seat 181 is arranged on the first platform 111, and the air-inflating member 182, the third driving member 183 and the first lifting and rotating assembly 184 are arranged on the first support seat 181. The third driving member 183 is, for example, a dual-motion motor. The third driving member 183 is connected to the first lifting and rotating assembly 184 to drive the first lifting and rotating assembly 184 to perform lifting and rotating movements. The first lifting and rotating assembly 184 is used to connect with the air-inflating head, and the air-inflating member 182 is connected to the air-inflating head for inflating the air-inflating head. The air-inflating head can be a Tip head 530 or other structures, without limitation. An air-inflating head placement rack can be provided on the first support seat 181, on which a plurality of air-inflating heads can be placed.
使用时,第一机械手130将添加完粉料和溶液的容器510(即瓶身511)移动到靠近鼓气模组180的位置。或者,将添加完粉料和溶液的容器510(即瓶身511)放置在开关盖模组 140处,鼓气模组180向容器510鼓气完毕后,由开关盖模组140对该容器510进行关盖,之后由第一机械手130送入反应模组中进行反应实验。鼓气模组180的第一升降旋转组件184进行升降和/或旋转运动以移动至鼓气头放置架处,并与鼓气头连接,之后再进行升降和/或旋转运动以使鼓气头浸入到瓶身511内的溶液中,之后鼓气件182向鼓气头鼓气,惰性气体例如氮气或氦气等通过鼓气头鼓入溶液中,能将溶液中的氧气排出,以避免溶液被氧化。鼓气件182可以包括储气瓶和控制阀,储气瓶用于储存惰性气体,控制阀一端与储气瓶连通,另一端与鼓气头连通,用于控制储气瓶与鼓气头之间的气路通断。优选的,控制阀为电磁阀。When in use, the first manipulator 130 moves the container 510 (i.e., the bottle body 511) to which the powder and solution are added to a position close to the inflation module 180. Alternatively, the container 510 (i.e., the bottle body 511) to which the powder and solution are added is placed on the switch cover module. At 140, after the inflation module 180 has finished inflating the container 510, the switch cover module 140 closes the container 510, and then the first manipulator 130 sends it into the reaction module for reaction experiment. The first lifting and rotating assembly 184 of the inflation module 180 performs lifting and/or rotating motion to move to the inflation head placement rack, and is connected to the inflation head, and then performs lifting and/or rotating motion to immerse the inflation head in the solution in the bottle body 511, and then the inflation component 182 inflates the inflation head, and inert gas such as nitrogen or helium is blown into the solution through the inflation head, which can discharge oxygen in the solution to prevent the solution from being oxidized. The inflation component 182 may include a gas storage bottle and a control valve, the gas storage bottle is used to store inert gas, one end of the control valve is connected to the gas storage bottle, and the other end is connected to the inflation head, which is used to control the on-off of the gas path between the gas storage bottle and the inflation head. Preferably, the control valve is a solenoid valve.
鼓气模组180还可设有第一退头机构,在完成一次鼓气动作后,第一升降旋转组件184可带动鼓气头移动到第一退头机构处将鼓气头退出,即第一退头机构用于将鼓气头与第一升降旋转组件184分离,退出的鼓气头可丢弃到废品盒,在下一次进行鼓气操作时,第一升降旋转组件184重新与新的鼓气头连接,以避免鼓气头对溶液的污染。第一退头机构的具体结构不做限定。The inflation module 180 may also be provided with a first head-retracting mechanism. After completing an inflation operation, the first lifting and rotating assembly 184 may drive the inflation head to move to the first head-retracting mechanism to withdraw the inflation head, that is, the first head-retracting mechanism is used to separate the inflation head from the first lifting and rotating assembly 184. The withdrawn inflation head may be discarded into a waste box. When the inflation operation is performed next time, the first lifting and rotating assembly 184 is reconnected with a new inflation head to avoid contamination of the solution by the inflation head. The specific structure of the first head-retracting mechanism is not limited.
可选的,请参考图2、图3和图11,反应站100还包括取样模组190,取样模组190设置于第一平台111,取样模组190设有取样瓶540,取样模组190用于从反应后的容器510中吸取溶液并转移到取样瓶540中,以完成溶液的取样,取样模组190靠近开关盖模组140设置。在取样前,取样瓶540中可以盛装有稀释液,取样模组190可以同时完成溶液的取样和稀释;或者,在取样前,取样瓶540为空,在完成溶液取样后,可以往取样瓶540添加稀释液以对溶液进行稀释。Optionally, please refer to FIG. 2, FIG. 3 and FIG. 11, the reaction station 100 further includes a sampling module 190, the sampling module 190 is disposed on the first platform 111, the sampling module 190 is provided with a sampling bottle 540, the sampling module 190 is used to absorb the solution from the container 510 after the reaction and transfer it to the sampling bottle 540 to complete the sampling of the solution, and the sampling module 190 is arranged near the switch cover module 140. Before sampling, the sampling bottle 540 may contain a diluent, and the sampling module 190 may simultaneously complete the sampling and dilution of the solution; or, before sampling, the sampling bottle 540 is empty, and after the solution sampling is completed, the diluent may be added to the sampling bottle 540 to dilute the solution.
取样模组190的具体结构不做限制。可选的,请参考图3和图11,取样模组190包括第二支撑座191、第二驱动泵192、第四驱动件193、第二升降旋转组件194等,第二支撑座191设置于第一平台111,第二驱动泵192、第四驱动件193和第二升降旋转组件194设置于第二支撑座191,第四驱动件193例如为双运动电机,第四驱动件193与第二升降旋转组件194连接,以驱动第二升降旋转组件194可作升降和旋转运动,第二升降旋转组件194用于与Tip头530连接,Tip头530与第二驱动泵192连通,第二驱动泵192用于向Tip头530提供正压或负压,以使Tip头530吸液或吐液。第二支撑座191上可以设置Tip头放置架,其上可放置多个Tip头530。The specific structure of the sampling module 190 is not limited. Optionally, please refer to Figures 3 and 11, the sampling module 190 includes a second support seat 191, a second drive pump 192, a fourth drive member 193, a second lifting and rotating assembly 194, etc. The second support seat 191 is arranged on the first platform 111, the second drive pump 192, the fourth drive member 193 and the second lifting and rotating assembly 194 are arranged on the second support seat 191, the fourth drive member 193 is, for example, a dual-motion motor, the fourth drive member 193 is connected to the second lifting and rotating assembly 194 to drive the second lifting and rotating assembly 194 to perform lifting and rotating movements, the second lifting and rotating assembly 194 is used to connect with the Tip head 530, the Tip head 530 is connected to the second drive pump 192, and the second drive pump 192 is used to provide positive pressure or negative pressure to the Tip head 530, so that the Tip head 530 can absorb or spit liquid. A Tip head placement rack can be set on the second support seat 191, on which a plurality of Tip heads 530 can be placed.
使用时,第一机械手130将反应完成后的容器510(即瓶身511,内装有反应后的溶液)移动到开关盖模组140上进行开盖,然后取样模组190的第二升降旋转组件194进行升降和/或旋转运动以移动至Tip头放置架处,并与Tip头530连接,之后再进行升降和/或旋转运动以使Tip头530浸入到瓶身511内的溶液中,之后第二驱动泵192提供给Tip头530负压,使得Tip头530吸液,之后第二升降旋转组件194带动吸液后的Tip头530移动到取样瓶540处,第二驱动泵192提供给Tip头530正压,使得Tip头530向取样瓶540中吐液,在取样瓶540中溶液被稀释液稀释。后续可将取样瓶540中的稀释后的溶液转移到分析仪230进行分析。When in use, the first manipulator 130 moves the container 510 (i.e., the bottle body 511, which contains the solution after the reaction) after the reaction is completed to the switch cover module 140 to open the cover, and then the second lifting and rotating component 194 of the sampling module 190 performs lifting and/or rotating movements to move to the tip head placement rack and connect with the tip head 530, and then performs lifting and/or rotating movements to immerse the tip head 530 in the solution in the bottle body 511, and then the second driving pump 192 provides negative pressure to the tip head 530, so that the tip head 530 absorbs liquid, and then the second lifting and rotating component 194 drives the tip head 530 after the liquid absorption to move to the sampling bottle 540, and the second driving pump 192 provides positive pressure to the tip head 530, so that the tip head 530 spits liquid into the sampling bottle 540, and the solution in the sampling bottle 540 is diluted by the diluent. The diluted solution in the sampling bottle 540 can be transferred to the analyzer 230 for analysis later.
与前述的鼓气模组180类似的,取样模组190也需要进行退头操作,每次取样需要更换新的Tip头530,即取样模组190也可设置有类似前述第一退头机构的第二退头机构,第二退头机构用于将Tip头与第二升降旋转组件194分离,第二退头机构的具体结构不做限制。Similar to the aforementioned air blowing module 180, the sampling module 190 also needs to perform a head withdrawal operation, and a new Tip head 530 needs to be replaced each time sampling is performed, that is, the sampling module 190 may also be provided with a second head withdrawal mechanism similar to the aforementioned first head withdrawal mechanism, and the second head withdrawal mechanism is used to separate the Tip head from the second lifting and rotating assembly 194, and the specific structure of the second head withdrawal mechanism is not limited.
一种实施例中,请参考图2和图3,反应站100还包括过滤模组153,过滤模组153设置于第一平台111,过滤模组153用于对取样瓶540中的溶液吸取并过滤。In one embodiment, referring to FIG. 2 and FIG. 3 , the reaction station 100 further includes a filter module 153 . The filter module 153 is disposed on the first platform 111 . The filter module 153 is used to absorb and filter the solution in the sampling bottle 540 .
过滤模组153的具体结构不做限制,取样瓶540中的溶液已稀释,经过过滤模组153的过滤后便可转移至分析仪230进行分析。可选的,可以将过滤得到的溶液移动到鼓气模组180 处,对该溶液完成鼓气操作后再送入分析站200中。The specific structure of the filter module 153 is not limited. The solution in the sampling bottle 540 has been diluted and can be transferred to the analyzer 230 for analysis after being filtered by the filter module 153. Optionally, the filtered solution can be moved to the air blowing module 180. At the location, the solution is aerated and then sent to the analysis station 200.
一种实施例中,请参考图2和图3,分析站200还设有移动模组240,移动模组240设置于第二平台211,第二机械手220设置于移动模组240上,移动模组240用于带动第二机械手220移动,以增大第二机械手220的活动范围。In one embodiment, please refer to Figures 2 and 3, the analysis station 200 is also provided with a mobile module 240, the mobile module 240 is arranged on the second platform 211, the second manipulator 220 is arranged on the mobile module 240, and the mobile module 240 is used to drive the second manipulator 220 to move to increase the range of movement of the second manipulator 220.
移动模组240可带动第二机械手220在第二平台211上沿至少一个方向移动,移动模组240的具体结构不做限定。The moving module 240 can drive the second robot 220 to move along at least one direction on the second platform 211 , and the specific structure of the moving module 240 is not limited.
一种实施例中,请参考图2和图3,分析站200还包括回收模组250,回收模组250包括回收管和回收箱,第二平台211开设有地漏孔,回收箱设置于第二平台211下方,回收管穿设于地漏孔且连通至回收箱,分析完成后的废弃物丢弃到回收管,并顺着回收管而收集到回收箱中。如此,分析完成的容器、废液等通过简单的丢入回收管,便可实现回收,操作简单。待回收箱中的废弃物装满后,可人工手动将回收箱从分析站取出并到指定地点将废弃物进行存放、处理。In one embodiment, please refer to Figures 2 and 3, the analysis station 200 also includes a recycling module 250, and the recycling module 250 includes a recycling pipe and a recycling box. The second platform 211 is provided with a floor drain hole, and the recycling box is arranged below the second platform 211. The recycling pipe is passed through the floor drain hole and connected to the recycling box. The waste after the analysis is completed is discarded into the recycling pipe and collected into the recycling box along the recycling pipe. In this way, the containers, waste liquids, etc. that have been analyzed can be recycled by simply throwing them into the recycling pipe, and the operation is simple. After the waste in the recycling box is full, the recycling box can be manually taken out from the analysis station and the waste can be stored and processed at a designated location.
在本申请实施例的描述中,需要说明的是,术语“中心”、“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指标的方位或位置关系为基于附图所述的方位或位置关系,仅是为了便于描述本申请和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本申请的限制。In the description of the embodiments of the present application, it should be noted that the orientation or positional relationship of terms such as "center", "up", "down", "left", "right", "vertical", "horizontal", "inside" and "outside" are based on the orientation or positional relationship described in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.
以上所揭露的仅为本申请一种较佳实施例而已,当然不能以此来限定本申请之权利范围,本领域普通技术人员可以理解实现上述实施例的全部或部分流程,并依本申请权利要求所作的等同变化,仍属于本申请所涵盖的范围。 What is disclosed above is only a preferred embodiment of the present application, and it certainly cannot be used to limit the scope of rights of the present application. Ordinary technicians in this field can understand that all or part of the processes of implementing the above embodiment and equivalent changes made according to the claims of the present application are still within the scope covered by the present application.
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