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WO2024201300A1 - Composition de précurseur d'aérosol comprenant un ester de monomenthyle - Google Patents

Composition de précurseur d'aérosol comprenant un ester de monomenthyle Download PDF

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Publication number
WO2024201300A1
WO2024201300A1 PCT/IB2024/052899 IB2024052899W WO2024201300A1 WO 2024201300 A1 WO2024201300 A1 WO 2024201300A1 IB 2024052899 W IB2024052899 W IB 2024052899W WO 2024201300 A1 WO2024201300 A1 WO 2024201300A1
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WO
WIPO (PCT)
Prior art keywords
aerosol
precursor composition
acid
aerosol precursor
delivery device
Prior art date
Application number
PCT/IB2024/052899
Other languages
English (en)
Inventor
Michael F. Davis
Jr. John W. Caraway
Sawyer Hubbard
Michael Andrew Zawadzki
Steven Lee ALDERMAN
Original Assignee
Rai Strategic Holdings, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rai Strategic Holdings, Inc. filed Critical Rai Strategic Holdings, Inc.
Publication of WO2024201300A1 publication Critical patent/WO2024201300A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

Definitions

  • the present disclosure relates to aerosol provision systems such as smoking articles designed to deliver at least one substance to a user, and to formulations for use therein.
  • aerosol provision systems and in particular non-combustible aerosol provision systems have been proposed through the years as improvements upon, or alternatives to, smoking products that require combusting tobacco for use. These systems are generally designed to deliver at least one substance to a user, such as to satisfy a particular "consumer moment."
  • the substance may include constituents that impart a physiological effect on the user, a sensorial effect on the user, or both.
  • the substance may be generally present in an aerosol-generating material that may contain one or more constituents of a range of constituents, such as active substances, flavors, aerosol-former materials and other functional materials like fillers.
  • Aerosol provision systems include, for example, vapor products commonly known as “electronic cigarettes,” “e-cigarettes” or electronic nicotine delivery systems (ENDS), as well as heat-not- bum products including tobacco heating products (THPs) and carbon-tipped tobacco heating products (CTHPs).
  • vapor products commonly known as "electronic cigarettes,” “e-cigarettes” or electronic nicotine delivery systems (ENDS)
  • heat-not- bum products including tobacco heating products (THPs) and carbon-tipped tobacco heating products (CTHPs).
  • THPs tobacco heating products
  • CHPs carbon-tipped tobacco heating products
  • Many of these products take the form of a system including a device and a consumable, and it is the consumable that includes the material from which the substance to be delivered originates.
  • the device is reusable, and the consumable is single use (although some consumables are refillable). Therefore, in many cases, the consumable is sold separately from the device, and often in a multipack.
  • the present disclosure is generally directed to aerosol precursor compositions for use in an aerosol delivery device.
  • the presence of the sensory (e.g., cooling) effects of menthol in an aerosol generated in such aerosol generating devices may provide a more desirable experience to the consumer.
  • menthol is poorly soluble in certain aerosol precursor compositions, such as those having a high water content. It has surprisingly been found according to the present disclosure that certain monomenthyl esters provide menthol sensory characteristics to aerosols generated from aerosol precursor compositions including them.
  • the disclosure provides a liquid aerosol precursor composition adapted for use in an aerosol delivery device, the liquid aerosol precursor composition comprising: an aerosol former; nicotine; and an organic acid component comprising a monomenthyl ester of a dicarboxylic acid.
  • the dicarboxylic acid is malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, maleic acid, or a combination thereof. In some embodiments, the dicarboxylic acid is succinic acid, fumaric acid, glutaric acid, or a combination thereof. In some embodiments, the dicarboxylic acid is succinic acid.
  • the organic acid component and the nicotine are present in a molar ratio in a range from about 0.1 to about 1.5:1.
  • the organic acid component comprises at least about 75% by weight of the monomenthyl ester, based on the total weight of the organic acid component.
  • the organic acid component further comprises up to about 25% by weight of an organic acid selected from the group consisting of benzoic acid, lactic acid, levulinic acid, nicotinic acid, and combinations thereof.
  • the nicotine is present in liquid aerosol precursor composition in an amount of up to about 5% by weight, based on the total weight of the liquid aerosol precursor composition.
  • the monomenthyl ester is present in the liquid aerosol precursor composition in an amount by weight from about 1 to about 10%, based on the total weight of the aerosol forming composition.
  • the aerosol former comprises one or more polyhydric alcohols, water, or a combination thereof.
  • the one or more polyhydric alcohols is selected from the group consisting of glycerol, propylene glycol, 1,3 -propanediol, diethylene glycol, triethylene glycol, a polyethylene glycol, and combinations thereof.
  • the polyhydric alcohol is selected from the group consisting of glycerol, propylene glycol, and mixtures thereof.
  • the aerosol former comprises water and glycerol.
  • the liquid aerosol precursor composition is substantially free of propylene glycol.
  • a ratio by weight of water to polyhydric alcohol is from about 1:9 to about 9:1. In some embodiments, the ratio by weight of water to poly hydric alcohol is from about 1:1 to about 9:1.
  • the aerosol former comprises about 50% by weight or more of water, based on the total weight of the aerosol former. In some embodiments, the aerosol former comprises from about 10 to about 50% by weight of glycerol, and from about 50 to about 90% by weight of water, based on the total weight of the aerosol former.
  • an aerosol generating material in the form of a substrate adapted for use in an aerosol delivery device, the aerosol generating material comprising a support impregnated with the liquid aerosol precursor composition as described herein.
  • the support comprises tobacco-derived fibers, wood-derived fibers, plant or plant-derived fibers, synthetic fibers, or a combination thereof, and one or more binders.
  • an aerosol delivery device comprising: a housing enclosing a chamber containing the liquid aerosol precursor composition as disclosed herein; a heat source in fluid communication with the chamber and configured to heat the liquid aerosol precursor composition to form an aerosol; and an aerosol pathway positioned to carry the aerosol to a mouth-end of the aerosol delivery device.
  • the heat source comprises an electrically powered heating element
  • the aerosol delivery device further comprises a power source electronically connected to the heating element.
  • the aerosol delivery device further comprises a controller configured to control the power transmitted by the power source to the heating element.
  • an aerosol delivery device comprising: the aerosol generating material as disclosed herein; a heat source configured to heat the aerosol generating material to form an aerosol; and an aerosol pathway extending from the aerosol generating material to a mouth-end of the aerosol delivery device.
  • the heat source comprises either an electrically powered heating element or a combustible ignition source.
  • the heat source is a combustible ignition source comprising a carbon-based material.
  • the heat source is an electrically powered heating element.
  • the aerosol delivery device further comprises a power source electronically connected to the heating element.
  • the aerosol delivery device further comprises a controller configured to control the power transmitted by the power source to the heating element.
  • Embodiment 1 A liquid aerosol precursor composition adapted for use in an aerosol delivery device, the liquid aerosol precursor composition comprising: an aerosol former; nicotine; and an organic acid component comprising a monomenthyl ester of a dicarboxylic acid.
  • Embodiment 2 The liquid aerosol precursor composition of embodiment 1, wherein the dicarboxylic acid is malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, maleic acid, or a combination thereof.
  • the dicarboxylic acid is malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, maleic acid, or a combination thereof.
  • Embodiment 3 The liquid aerosol precursor composition of embodiment 1 or 2, wherein the dicarboxylic acid is succinic acid, fumaric acid, glutaric acid, or a combination thereof.
  • Embodiment 4 The liquid aerosol precursor composition of any one of embodiments 1-3, wherein the dicarboxylic acid is succinic acid.
  • Embodiment 5 The liquid aerosol precursor composition of any one of embodiments 1-4, wherein the organic acid component and the nicotine are present in a molar ratio in a range from about 0.1 to about 1.5:1.
  • Embodiment 6 The liquid aerosol precursor composition of any one of embodiments 1-5, wherein the organic acid component comprises at least about 75% by weight of the monomenthyl ester, based on the total weight of the organic acid component.
  • Embodiment 7 The liquid aerosol precursor composition of any one of embodiments 1-6, wherein the organic acid component further comprises up to about 25% by weight of an organic acid selected from the group consisting of benzoic acid, lactic acid, levulinic acid, nicotinic acid, and combinations thereof.
  • Embodiment 8 The liquid aerosol precursor composition of any one of embodiments 1-7, wherein the nicotine is present in liquid aerosol precursor composition in an amount of up to about 5% by weight, based on the total weight of the liquid aerosol precursor composition.
  • Embodiment 9 The liquid aerosol precursor composition of any one of embodiments 1-8, wherein the monomenthyl ester is present in the liquid aerosol precursor composition in an amount by weight from about 1 to about 10%, based on the total weight of the aerosol forming composition.
  • Embodiment 10 The liquid aerosol precursor composition of any one of embodiments 1-9, wherein the aerosol former comprises one or more polyhydric alcohols, water, or a combination thereof.
  • Embodiment 11 The liquid aerosol precursor composition of embodiment 10, wherein the one or more poly hydric alcohols is selected from the group consisting of glycerol, propylene glycol, 1,3- propanediol, diethylene glycol, triethylene glycol, a polyethylene glycol, and combinations thereof.
  • the one or more poly hydric alcohols is selected from the group consisting of glycerol, propylene glycol, 1,3- propanediol, diethylene glycol, triethylene glycol, a polyethylene glycol, and combinations thereof.
  • Embodiment 12 The liquid aerosol precursor composition of embodiment 10 or 11, wherein the polyhydric alcohol is selected from the group consisting of glycerol, propylene glycol, and mixtures thereof.
  • Embodiment 13 The liquid aerosol precursor composition of any one of embodiments 1-12, wherein the aerosol former comprises water and glycerol.
  • Embodiment 14 The liquid aerosol precursor composition of any one of embodiments 1-10, wherein the liquid aerosol precursor composition is substantially free of propylene glycol.
  • Embodiment 15 The liquid aerosol precursor composition of any one of embodiments 1-14, wherein a ratio by weight of water to poly hydric alcohol is from about 1 : 9 to about 9:1.
  • Embodiment 16 The liquid aerosol precursor composition of any one of embodiments 1-15, wherein the ratio by weight of water to poly hydric alcohol is from about 1 : 1 to about 9:1.
  • Embodiment 17 The liquid aerosol precursor composition of any one of embodiments 1-16, wherein the aerosol former comprises about 50% by weight or more of water, based on the total weight of the aerosol former.
  • Embodiment 18 The liquid aerosol precursor composition of any one of embodiments 1-17, wherein the aerosol former comprises from about 10 to about 50% by weight of glycerol, and from about 50 to about 90% by weight of water, based on the total weight of the aerosol former.
  • Embodiment 19 An aerosol generating material in the form of a substrate adapted for use in an aerosol delivery device, the aerosol generating material comprising a support impregnated with the liquid aerosol precursor composition of any one of embodiments 1-18.
  • Embodiment 20 The aerosol generating component of embodiment 19, wherein the support comprises tobacco-derived fibers, wood-derived fibers, plant or plant-derived fibers, synthetic fibers, or a combination thereof, and one or more binders.
  • Embodiment 21 An aerosol delivery device comprising: a housing enclosing a chamber containing the liquid aerosol precursor composition of any one of embodiments 1 to 18; a heat source in fluid communication with the chamber and configured to heat the liquid aerosol precursor composition to form an aerosol; and an aerosol pathway positioned to carry the aerosol to a mouth-end of the aerosol delivery device.
  • Embodiment 22 The aerosol delivery device of embodiment 21, wherein the heat source comprises an electrically powered heating element, and the aerosol delivery device further comprises a power source electronically connected to the heating element.
  • Embodiment 23 The aerosol delivery device of embodiment 22, further comprising a controller configured to control the power transmitted by the power source to the heating element.
  • Embodiment 24 An aerosol delivery device comprising: the aerosol generating material of embodiment 19 or 20; a heat source configured to heat the aerosol generating material to form an aerosol; and an aerosol pathway extending from the aerosol generating material to a mouth-end of the aerosol delivery device.
  • Embodiment 25 The aerosol delivery device of embodiment 24, wherein the heat source comprises either an electrically powered heating element or a combustible ignition source.
  • Embodiment 26 The aerosol delivery device of embodiment, wherein the heat source is a combustible ignition source comprising a carbon-based material.
  • Embodiment 27 The aerosol delivery device of embodiment 25, wherein the heat source is an electrically powered heating element.
  • Embodiment 28 The aerosol delivery device of embodiment 27, further comprising a power source electronically connected to the heating element.
  • Embodiment 29 The aerosol delivery device of embodiment 28, further comprising a controller configured to control the power transmitted by the power source to the heating element.
  • FIG. 1 is a block diagram of an aerosol provision system according to some example implementations of the present disclosure
  • FIGS. 2 and 3 illustrate an aerosol provision system in the form of a vapor product, according to some example implementations
  • FIG. 4 illustrates a nebulizer that may be used to implement an aerosol generator of an aerosol provision system, according to some example implementations
  • FIGS. 5, 6 and 7 illustrate an aerosol provision system in the form of a tobacco heating product (THP), according to some example implementations.
  • FIG. 8 is a graphical depiction of aerosol formed versus puff count for a liquid aerosol forming composition according to an example embodiment of the disclosure as compared to a conventional liquid aerosol precursor composition.
  • the present disclosure is generally directed to aerosol precursor compositions for use in an aerosol delivery device, and to various aerosol delivery devices comprising such aerosol precursor compositions.
  • the aerosol precursor compositions are capable of generating aerosol, for example when heated, irradiated, or energized in any suitable manner.
  • the disclosure provides aerosol precursor compositions (also referred to herein as "aerosol generating materials") adapted for use in an aerosol delivery device.
  • aerosol precursor compositions also referred to herein as "aerosol generating materials”
  • aerosol precursor compositions and aerosol delivery devices comprising them are described further herein below.
  • Aerosol precursor compositions as disclosed herein comprise an aerosol former, nicotine, and an organic acid component comprising a monomenthyl ester of a dicarboxylic acid. Each of these components is described further herein below.
  • Aerosol precursor compositions as disclosed herein comprise an aerosol former.
  • the aerosol former includes one or more constituents capable of forming an aerosol, for example, by thermal or mechanical vaporization.
  • suitable classes of aerosol formers include water, polyhydric alcohols, polysorbates, sorbitan esters, fatty acids, fatty acid esters, triacetin, waxes, sugar alcohols, and combinations thereof.
  • the particular choice of aerosol former(s) may depend on factors such as the method of aerosol formation, the appearance and volume of the aerosol, the desired density of the aerosol, and the like.
  • the aerosol former may include one or more polyhydric alcohols.
  • poly hydric alcohols include glycerol, propylene glycol, and other glycols such as 1,3- propanediol, diethylene glycol, triethylene glycol, and polyethylene glycols (e.g., PEG molecules with weight average molecular weight range of about 200 to about 2,000 Da).
  • the aerosol former comprises one or more polyhydric alcohols.
  • the one or more polyhydric alcohols are selected from the group consisting of glycerol, propylene glycol, 1,3 -propanediol, diethylene glycol, triethylene glycol, a polyethylene glycol, and combinations thereof.
  • the poly hydric alcohol is selected from the group consisting of glycerol, propylene glycol, and mixtures thereof.
  • the aerosol forming composition is substantially free of propylene glycol.
  • the aerosol former comprises water. In some embodiments, the aerosol former comprises water and one or more polyhydric alcohols. In some embodiments, the aerosol former comprises water and a polyhydric alcohol selected from the group consisting of glycerol, propylene glycol, and mixtures thereof. In some embodiments, the aerosol former comprises water and glycerol. [0066] In embodiments where the aerosol former comprises water and a polyhydric alcohol, the ratio of water to poly hydric alcohol may vary.
  • the ratio of water to poly hydric alcohol may be from about 1:10 to about 10:1 by weight, such as about 1:10, 1:9, about 1:8, about 1:7, about 1:6, about 1:5, about 1:4, about 1:3, about 1:2, about 1:1, about 2:1, about 3:1, about 4:1, about 5:1, about 6:1, about 7:1, about 8:1, about 9:1, or about 10:1.
  • ratio by weight of water to polyhydric alcohol is from about 1:9 to about 9:1.
  • ratio by weight of water to poly hydric alcohol is from about 1:1 to about 9:1.
  • the aerosol former comprises about 50% by weight or more of water, based on the total weight of the aerosol former, such as about 50%, about 60%, about 70%, about 80%, or about 90% by weight of water. In some embodiments, the aerosol former comprises from about 10 to about 50% by weight of glycerol, and from about 50 to about 90% by weight of water, based on the total weight of the aerosol former.
  • the aerosol former further comprises one or more polysorbates, one or more sorbitan esters, one or more fatty acids, one or more fatty acid esters, triacetin, one or more waxes, one or more sugar alcohols, or combinations thereof.
  • polysorbates include, but are not limited to, Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate, Tween 60) and Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate, Tween 80).
  • sorbitan esters include, but are not limited to, sorbitan monolaurate, sorbitan monostearate (Span 60), sorbitan monooleate (Span 20), and sorbitan tristearate (Span 65).
  • fatty acids include, but are not limited to, butyric, propionic, valeric, oleic, linoleic, stearic, myristic, and palmitic acids.
  • fatty acid esters include, but are not limited to, alkyl esters, monoglycerides, diglycerides, and triglycerides. Examples of monoglycerides include monolaurin and glycerol monostearate.
  • triglycerides include triolein, tripalmitin, tristearate, glycerol tributyrate, and glycerol trihexanoate.
  • waxes include, but are not limited to, carnauba, beeswax, candellila.
  • sugar alcohols include, but are not limited to, sorbitol, erythritol, mannitol, maltitol, isomalt, and xylitol.
  • the aerosol former further comprises erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, propylene carbonate, or combinations thereof.
  • Aerosol precursor compositions as disclosed herein comprise nicotine.
  • nicotine is meant any suitable form of nicotine (e.g., free base or salt) for providing systemic absorption of at least a portion of the nicotine present.
  • the source of the nicotine may vary, and may be natural or synthetic. Most preferably, the nicotine is naturally occurring and obtained as an extract from a Nicotiana species (e.g., tobacco).
  • the nicotine can have the enantiomeric form S(-)-nicotine, R(+)-nicotine, or a mixture of S(-)- nicotine and R(+)-nicotine.
  • the nicotine is in the form of S(-)-nicotine (e.g., in a form that is virtually all S(-)-nicotine) or a racemic mixture composed primarily or predominantly of S(-)-nicotine (e.g., a mixture composed of about 95 weight parts S(-)-nicotine and about 5 weight parts R(+)-nicotine).
  • S(-)-nicotine e.g., in a form that is virtually all S(-)-nicotine
  • a racemic mixture composed primarily or predominantly of S(-)-nicotine e.g., a mixture composed of about 95 weight parts S(-)-nicotine and about 5 weight parts R(+)-nicotine.
  • the nicotine is employed in virtually pure form or in an essentially pure form. Highly preferred nicotine that is employed has a purity of greater than about 95 percent, more preferably greater than about 98 percent, and most preferably greater than about 99 percent, on a weight basis.
  • the nicotine is selected from the group consisting of nicotine free base and a nicotine salt.
  • nicotine is in its free base form.
  • Nicotine may be tobacco-derived (e.g., a tobacco extract) or non-tobacco derived (e.g., synthetic or otherwise obtained).
  • the nicotine (calculated as the free base) is present in the aerosol precursor composition in a concentration of at least about 0.001% by weight of the aerosol precursor composition, such as in a range from about 0.001% to about 10%.
  • the nicotine is present in the nicotine is present in the aerosol precursor composition in an amount of up to about 5% by weight, based on the total weight of the aerosol precursor composition, such as, e.g., from about 0.1% w/w, about 0.2%, about 0.3%, about 0.4%, about 0.5% about 0.6%, about 0.7%, about 0.8%, or about 0.9%, to about 1%, about 2%, about 3%, about 4%, or about 5% by weight, calculated as the free base and based on the total weight of the aerosol precursor composition.
  • the aerosol precursor composition as disclosed herein comprises an organic acid component comprising a monomenthyl ester of a dicarboxylic acid (i.e., a monoester of menthol and a dicarboxylic acid).
  • Menthol is a monoterpenoid with the ability to activate the cold-sensitive Transient Receptor Potential Melastatin-8 (TRPM8) receptor, providing a cooling sensation when inhaled, eaten, or applied to the skin.
  • TRPM8 Transient Receptor Potential Melastatin-8
  • Menthol ((lR,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexan-l-ol; (-)-menthol), is a naturally occurring compound which may be obtained from the oils of spearmint, peppermint, and other members of the mint family of plants, or may be obtained synthetically. It has surprisingly been found according to the present disclosure that certain monomenthyl dicarboxylic acid esters provide menthol sensory characteristics to aerosols generated from aerosol precursor compositions including them. The presence of the sensory (e.g., cooling) effects of menthol in aerosol generating devices may provide a more desirable experience to the consumer.
  • menthol is poorly soluble in certain aerosol precursor compositions, such as those having a high water content. Further, it has been found according to the present disclosure that combining nicotine with such a monomenthyl ester, which is otherwise poorly water soluble, enhances the aqueous solubility of the monomenthyl ester in aerosol precursor compositions having a high water content.
  • Suitable dicarboxylic acids from which the monomenthyl ester may be derived include, but are not limited to, malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, and maleic acid.
  • the dicarboxylic acid is malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, maleic acid, or a combination thereof.
  • the dicarboxylic acid is succinic acid, fumaric acid, glutaric acid, or a combination thereof.
  • the dicarboxylic acid is succinic acid.
  • the amount of the monomenthyl ester present in the aerosol precursor composition may vary based on the water content of the aerosol former and the nicotine concentration of the aerosol precursor composition.
  • monomenthyl dicarboxylate esters generally have low aqueous solubility, but the solubility may be enhanced by the presence of nicotine and/or the presence of varying amounts of non-aqueous (e.g., polyhdric alcohol) components in the aerosol former or the overall aerosol precursor composition.
  • the monomenthyl ester is present in the aerosol precursor composition in an amount by weight from about 1 to about 10%, based on the total weight of the aerosol precursor composition.
  • the monomenthyl ester may be present in an amount by weight of about 1, about 2, about 3, about 4, about 5, about 6, about 7, about 8, about 9, or about 10% by weight, based on the total weight of the aerosol precursor composition.
  • the amount of the total organic acid component present may be expressed relative to the concentration of nicotine.
  • the organic acid component and the nicotine are present in a molar ratio in a range from about 0.1:1 to about 1.5:1, such as from about 0.1:1, or about 0.5:1, to about 1:1, or about 1.5:1.
  • the organic acid component and the nicotine are present in a molar ratio ofabout O.l:!, about 0.2:l, about 0.3:l, about 0.4:l, about 0.5:l, about 0.6:l, about 0.7:1, about 0.8:l, about 0.9:l, about 1:1, about 1.1:1; about 1.2:1, about 1.3:1, about 1.4:1, or about 1.5:1.
  • the ratio is about 1:1.
  • the organic acid component is monomenthyl succinate, fumarate, glutarate, or a combination thereof, and is present in a molar ratio to nicotine from about 0.1:1 to about 1.5:1.
  • the molar ratio of monomenthyl succinate, fumarate, glutarate, or combination thereof to nicotine is from about 0.9:1 to about 1.1:1, or is 1:1.
  • the organic acid component comprises one or more organic acids in addition to the monomenthyl ester.
  • organic acid refers to an organic (i.e., carbonbased) compound that is characterized by acidic properties.
  • organic acids are relatively weak acids (i.e., they do not dissociate completely in the presence of water), such as carboxylic acids (-CO2H) or sulfonic acids (-SO2OH).
  • the organic acid is a carboxylic acid.
  • the carboxylic acid further comprises an alpha-hydroxy group.
  • the carboxylic acid further comprises a keto group.
  • the carboxylic acid is selected from the group consisting of succinic acid, lactic acid, benzoic acid, citric acid, tartaric acid, fumaric acid, levulinic acid, acetic acid, malic acid, formic acid, sorbic acid, benzoic acid, propanoic acid, pyruvic acid, and combinations thereof.
  • the carboxylic acid is benzoic acid, lactic acid, levulinic acid, nicotinic acid, ora combination thereof.
  • the carboxylic acid is lactic acid.
  • the carboxylic acid is benzoic acid.
  • the amount of additional organic acid component present, beyond the monomenthyl ester may vary.
  • the organic acid component comprises up to about 25% by weight of a further organic acid.
  • the organic acid component comprises up to about 25% by weight of a further organic acid selected from the group consisting of benzoic acid, lactic acid, levulinic acid, nicotinic acid, and combinations thereof.
  • the organic acid component comprises at least about 75% by weight of the monomenthyl ester, based on the total weight of the organic acid component, such as about 75, about 80, about 85, about 90, about 95, about 99, or even 100% by weight of the monomenthyl ester, based on the total weight of the organic acid component.
  • the pH of the aerosol precursor composition can vary and canbe dependent, e.g., on the content and composition of the organic acid component.
  • the pH of the aerosol precursor composition is from about 4 to about 7.5, e.g., about 5 to about 7.5, or about 5.5 to about 7.5.
  • the aerosol precursor composition comprises one or more further components, such as active ingredient, a flavorant, or other functional materials.
  • further components such as active ingredient, a flavorant, or other functional materials.
  • the aerosol precursor composition comprises an active ingredient, including, but not limited to, botanical materials, cannabinoids, terpenes, tobacco extract, or combinations thereof.
  • the active ingredient comprises one or more non-tobacco botanicals.
  • the term "botanical ingredient” or “botanical” refers to any plant material or fungal-derived material, including plant material in its natural form and plant material derived from natural plant materials, such as extracts or isolates from plant materials or treated plant materials (e.g., plant materials subjected to heat treatment, fermentation, or other treatment processes capable of altering the chemical nature of the material).
  • a “botanical material” includes but is not limited to "herbal materials,” which refer to seed-producing plants that do not develop persistent woody tissue and are often valued for their medicinal or sensory characteristics (e.g., teas or tisanes).
  • botanical material is intended to exclude tobacco materials (i.e., does not include any Nicotiana species).
  • the botanical materials used in the present invention may comprise, without limitation, any of the compounds and sources set forth herein, including mixtures thereof. Certain botanical materials of this type are sometimes referred to as dietary supplements, nutraceuticals, "phytochemicals” or "functional foods.”
  • Non-limiting examples of botanical materials include without limitation acai berry, alfalfa, allspice, annatto seed, apricot oil, ashwagandha, bacopa monniera, baobab, basil, bee balm, beet root, wild bergamot, black pepper, blueberries, borage seed oil, bugleweed, cacao, calamus root, catnip, catuaba, cayenne pepper, Centella asiatica, chaga mushroom, Chai-hu, chamomile, cherry blossom, chervil, chlorophyll, cinnamon, dark chocolate, citrus, cocoa, comfrey leaf and root, gingko biloba, ginseng, goji berries, grape seed, green tea, black tea, black cohosh, cayenne, chamomile, cloves, cocoa powder, cordyceps, cranberry, curcumin, damiana, dandelion, Dorstenia arifolia, Dorstenia odor
  • a botanical is typically at a concentration of from about 0.01% w/w to about 10% by weight, such as, e.g., from about 0.01% w/w, about 0.05%, about 0.1%, or about 0.5%, to about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, or about 10%, about 11%, about 12%, about 13%, about 14%, or about 15% by weight, based on the total weight of the aerosol precursor composition.
  • the active ingredient comprises one or more cannabinoids.
  • cannabinoid refers to a class of diverse natural or synthetic chemical compounds that acts on cannabinoid receptors (e.g., CB1 and CB2) in cells that alter neurotransmitter release in the brain.
  • Cannabinoids are cyclic molecules exhibiting particular properties such as the ability to easily cross the blood-brain barrier.
  • Cannabinoids may be naturally occurring (Phytocannabinoids) from plants such as cannabis, (endocannabinoids) from animals, or artificially manufactured (synthetic cannabinoids).
  • Cannabis species express at least 85 different phytocannabinoids, and these may be divided into subclasses, including cannabigerols, cannabichromenes, cannabidiols, tetrahydrocannabinols, cannabinols and cannabinodiols, and other cannabinoids, such as cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN) and cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic
  • the cannabinoid is selected from the group consisting of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN) and cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), Cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabmolic acid (THCA), tetrahydrocannabivarinic acid (THCV A), and
  • the cannabinoid is selected from tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, and cannabidiol (CBD), another major constituent of the plant, but which is devoid of psychoactivity. All of the above compounds can be used in the form of an isolate from plant material or synthetically derived. Certain cannabinoids, including but not limited to CBD and THC, may exist in more than one isomeric form, for example A8- and A9-THC. Such isomeric forms may be naturally occurring or may be synthetic. For avoidance of doubt, reference within the present disclosure to a "cannabinoid" is intended to be inclusive of any and all isomeric forms thereof.
  • the cannabinoid comprises at least tetrahydrocannabinol (THC). In some embodiments, the cannabinoid is tetrahydrocannabinol (THC). In some embodiments, the THC is A8- THC. In some embodiments, the THC is A9-THC.
  • the cannabinoid comprises at least cannabidiol (CBD). In some embodiments, the cannabinoid is cannabidiol (CBD). In some embodiments, the CBD is synthetic CBD. In some embodiments, the CBD is A8-CBD. In some embodiments, the CBD is A9-CBD.
  • the cannabinoid e.g., CBD
  • CBD cannabinoid
  • An isolate is an extract from a plant, such as cannabis, where the active material of interest (in this case the cannabinoid, such as CBD) is present in a high degree of purity, for example greater than 95%, greater than 96%, greater than 97%, greater than 98%, or around 99% purity.
  • the cannabinoid is an isolate of CBD in a high degree of purity, and the amount of any other cannabinoid in the substrate is no greater than about 1% by weight of the substrate, such as no greater than about 0.5% by weight of the aerosol precursor composition such as no greater than about 0.1% by weight of the aerosol precursor composition such as no greater than about 0.01% by weight of the aerosol precursor composition.
  • the choice of cannabinoid and the particular percentages thereof which may be present within the aerosol precursor composition will vary depending upon the desired characteristics of the composition.
  • the cannabinoid (such as CBD) is present in the aerosol precursor composition in a concentration of at least about 0.001% by weight of the aerosol precursor composition, such as in a range from about 0.001% to about 2% by weight of the aerosol precursor composition.
  • the cannabinoid (such as CBD) is present in the aerosol precursor composition in a concentration of from about 0.1% to about 1.5% by weight, based on the total weight of the aerosol precursor composition.
  • the cannabinoid (such as CBD) is present in a concentration from about 0.4% to about 1.5% by weight, based on the total weight of the aerosol precursor composition.
  • the active ingredient may include a cannabimimetic, which is a class of compounds derived from plants other than cannabis that have biological effects on the endocannabinoid system similar to cannabinoids.
  • Examples include yangonin, alpha-amyrin or beta-amyrin (also classified as terpenes), cyanidin, curcumin (tumeric), catechin, quercetin, salvinorin A, N-acylethanolamines, and N-alkylamide lipids. Such compounds can be used in the same amounts and ratios noted herein for cannabinoids.
  • Active ingredients suitable for use in the aerosol precursor composition can also be classified as terpenes, many of which are associated with biological effects, such as calming effects.
  • Terpenes are understood to have the general formula of (C5H 8 ) n and include monoterpenes, sesquiterpenes, and diterpenes.
  • Terpenes can be acyclic, monocyclic or bicyclic in structure. Some terpenes provide an entourage effect when used in combination with cannabinoids or cannabimimetics.
  • Examples include betacaryophyllene, linalool, limonene, beta-citronellol, linalyl acetate, pinene (alpha or beta), geraniol, carvone, eucalyptol, menthone, iso-menthone, piperitone, myrcene, beta-bourbonene, and germacrene, which may be used singly or in combination.
  • the terpene is a terpene derivable from a phytocannabinoid producing plant, such as a plant from the stain of the cannabis sativa species, such as hemp.
  • Suitable terpenes in this regard include so-called “CIO” terpenes, which are those terpenes comprising 10 carbon atoms, and so- called “C15" terpenes, which are those terpenes comprising 15 carbon atoms.
  • the active ingredient comprises more than one terpene.
  • the active ingredient may comprise one, two, three, four, five, six, seven, eight, nine, ten or more terpenes as defined herein.
  • the terpene is selected from pinene (alpha and beta), geraniol, linalool, limonene, carvone, eucalyptol, menthone, iso-menthone, piperitone, myrcene, beta-bourbonene, germacrene and mixtures thereof.
  • Terpenes and/or cannabinoids may be present as an active ingredient, as an aerosol former, or as a flavorant.
  • the amount of terpenes and/or cannabinoids present may vary accordingly based on their intended purpose.
  • the active ingredient comprises a tobacco extract.
  • tobacco extract refers to the isolated components of a tobacco material that are extracted from solid tobacco pulp by a solvent (e.g., water) that is brought into contact with the tobacco material in an extraction process. While a tobacco extract may comprise nicotine, reference to a tobacco extract herein is distinct and different from nicotine, which may also be obtained, e.g., by extraction from tobacco material. In various embodiments, a tobacco material can be treated to extract soluble components of the tobacco material therefrom. Various extraction techniques of tobacco materials can be used to provide a tobacco extract and tobacco solid material. See, for example, the extraction processes described in US Pat. Appl. Pub. No.
  • Typical inclusion ranges for tobacco extract can vary depending on the nature and type of the tobacco extract and intended use of the aerosol precursor composition.
  • the aerosol precursor composition comprises a tobacco extract, in aqueous or dry powder form, in an amount of from about 1 to about 5% by weight, based on the total weight of the aerosol precursor composition.
  • the aerosol precursor composition can be characterized as completely free or substantially free of tobacco extract (other than purified nicotine as an active ingredient). For example, certain embodiments can be characterized as having less than 1% by weight, or less than 0.5% by weight, or less than 0.1%, or less than 0.01% by weight of tobacco extract, or even 0% by weight of tobacco extract.
  • the aerosol precursor composition may also include a flavorant.
  • a flavorant refers to compounds or components that can be aerosolized and delivered to a user and which impart a sensory experience in terms of taste and/or aroma. Flavorants may be natural or synthetic, and the character of the flavors imparted thereby may be described, without limitation, as fresh, sweet, herbal, confectionary, floral, fruity, or spicy.
  • flavorants include, but are not limited to, vanillin, ethyl vanillin, cream, tea, coffee, fruit (e.g., apple, cherry, strawberry, peach and citrus flavors, including lime, orange, and lemon), maple, menthol, eucalyptus, mint, peppermint, spearmint, Wintergreen, cascarilla, nutmeg, clove, lavender, cardamom, ginger, honey, anise, sage, rosemary, hibiscus, rose hip, yerba mate, guayusa, honeybush, rooibos, yerba santa, bacopa monniera, gingko biloba, withania somnifera, cinnamon, sandalwood, jasmine, cascarilla, cocoa, licorice, trigeminal sensates, terpenes, and any combinations thereof.
  • trigeminal sensate refers to a flavoring agent which has an effect on the trigeminal nerve, producing sensations including heating, cooling, tingling, and the like.
  • Nonlimiting examples of trigeminal sensate flavoring agents include capsaicin, citric acid, menthol, Sichuan buttons, erythritol, and cubebol.
  • Further non-limiting examples include flavorings and flavor packages of the type and character traditionally used for the flavoring of cigarette, cigar, and pipe tobaccos. See also, Leffingwell et al., Tobacco Flavoring for Smoking Products, R. J. Reynolds Tobacco Company (1972), which is incorporated herein by reference.
  • Flavoring agents may comprise components such as terpenes, terpenoids, aldehydes, ketones, esters, and the like. Syrups, such as high fructose com syrup, also can be employed. Some examples of plant-derived compositions that may be suitable are disclosed in U.S. Pat. No. 9,107,453 and U.S. Pat. App. Pub. No. 2012/0152265 both to Dube et al., the disclosures of which are incorporated herein by reference in their entireties. The selection of such further components is variable based upon factors such as the sensory characteristics that are desired for the smoking article, their affinity for the substrate material, their solubility, and other physiochemical properties.
  • the present disclosure is intended to encompass any such further components that are readily apparent to those skilled in the art of tobacco and tobacco -related or tobacco-derived products. See, e.g., Gutcho, Tobacco Flavoring Substances and Methods, Noyes Data Corp. (1972) and Leffingwell et al., Tobacco Flavoring for Smoking Products (1972), the disclosures of which are incorporated herein by reference in their entireties. It should be noted that reference to a flavorant should not be limited to any single flavorant as described above, and may, in fact, represent a combination of one or more flavorants. Additional flavorants, flavoring agents, additives, and other possible enhancing constituents are described in U.S. Pat. App. No. 15/707,461 to Phillips et al., which is incorporated herein by reference in its entirety.
  • the quantity of flavorant present may vary, and when present, is generally less than about 30%, or less than about 20% by weight of the aerosol precursor composition.
  • a flavorant may be present in a quantity of from about 0.1%, about 0.5%, about 1%, or about 5%, to about 10%, about 20%, or about 30% by weight of the aerosol precursor composition.
  • the aerosol precursor composition may also include one or more functional materials.
  • Functional materials may include one or more of binders, fillers, pH regulators, coloring agents, preservatives, stabilizers, and/or antioxidants.
  • Suitable binders include, for example, pectin, guar gum, fruit pectin, citrus pectin, tobacco pectin, hydroxyethyl guar gum, hydroxypropyl guar gum, hydroxy ethyl locust bean gum, hydroxypropyl locust bean gum, alginate, starch, modified starch, derivatized starch, methyl cellulose, ethyl cellulose, ethylhydroxymethyl cellulose, carboxymethyl cellulose, tamarind gum, dextran, pullalon, konjac flour or xanthan gum.
  • the aerosol precursor composition as described herein is capable of generating an aerosol, for example when heated, irradiated, or energized in any other way.
  • the form of the aerosol precursor composition may vary.
  • the aerosol precursor composition may be, for example, in the form of a solid, semi-solid, liquid or gel.
  • the aerosol precursor composition is in the form of a liquid, and may be described as a liquid aerosol precursor composition.
  • the aerosol precursor composition may include an "amorphous solid," which may be alternatively referred to as a "monolithic solid” (i.e., non-fibrous).
  • the amorphous solid may be a dried gel.
  • the amorphous solid is a solid material that may retain some fluid, such as liquid, within it.
  • the aerosol precursor composition may include from about 50wt%, 60wt% or 70wt% of amorphous solid, to about 90wt%, 95wt% or 100wt% of amorphous solid. Aerosol Delivery Devices
  • Example implementations of the present disclosure are further directed to delivery systems designed to deliver at least one substance to a user, such as to satisfy a particular "consumer moment.”
  • Delivery systems for the aerosol precursor composition provided herein may take many forms. Examples of suitable delivery systems include aerosol provision systems such as powered aerosol provision systems designed to release one or more substances or compounds from an aerosol generating material (e.g., an aerosol precursor composition as disclosed herein, such as a liquid aerosol precursor composition) without combusting the aerosol generating material. These aerosol provision systems may at times be referred to as non-combustible aerosol provision systems, aerosol delivery devices or the like.
  • the substance may include constituents that impart a physiological effect on the user, a sensorial effect on the user, or both.
  • suitable aerosol provision systems include vapor products, heat-not-bum products, hybrid products and the like.
  • Vapor products are commonly known as “electronic cigarettes,” “e- cigarettes” or electronic nicotine delivery systems (ENDS), although the aerosol-generating material need not include nicotine.
  • Many vapor products are designed to heat a liquid material to generate an aerosol.
  • Other vapor products are designed to break up an aerosol generating material into an aerosol without heating, or with only secondary heating.
  • Heat-not-bum products include tobacco heating products (THPs) and carbon-tipped tobacco heating products (CTHPs), and many are designed to heat a solid material to generate an aerosol without combusting the material.
  • Hybrid products use a combination of aerosol generating materials, one or a plurality of which may be heated.
  • Each of the aerosol generating materials may be, for example, in the form of a solid, semisolid, liquid, or gel.
  • Some hybrid products are similar to vapor products except that the aerosol generated from a liquid or gel aerosol generating material passes through a second material (such as tobacco) to pick up additional constituents before reaching the user.
  • the hybrid system includes a liquid or gel aerosol generating material, and a solid aerosol generating material.
  • a solid aerosol generating material may include, for example, tobacco or a non-tobacco product.
  • an aerosol delivery device in another aspect is provided an aerosol delivery device.
  • the aerosol delivery device according to the present disclosure may take on a variety of embodiments, as discussed in detail below. However, typically, the use of the aerosol delivery device by a consumer will be similar in scope.
  • the foregoing description of the aerosol precursor composition is applicable to the various embodiments described through minor modifications, which are apparent to the person of skill in the art in light of the further disclosure provided herein. The description of use, however, is not intended to limit the use of the aerosol precursor composition as disclosed herein but is provided to comply with all necessary requirements of disclosure herein.
  • FIG. 1 is a block diagram of an aerosol delivery device 100 according to some example implementations, incorporating an aerosol generating material 124, comprising an aerosol precursor composition as disclosed herein, such as a liquid aerosol precursor composition.
  • the aerosol delivery device 100 may be a vapor product, a heat-not-bum product, or a hybrid product.
  • the aerosol delivery device 100 includes one or more of each of a number of components including, for example, an aerosol provision device 102, and a consumable 104 (sometimes referred to as an article) for use with the aerosol provision device 102.
  • the aerosol generating material 124 can be included within an article of a consumable 104, part or all of which is intended to be consumed during use by a user.
  • the aerosol delivery device 100 may include one or more consumables 104, and each consumable 104 may include one or more aerosol generating material 124 (which can comprise or can be a liquid aerosol precursor composition as described herein, or which can be alternative types of compositions).
  • each consumable 104 may include one or more aerosol generating material 124 (which can comprise or can be a liquid aerosol precursor composition as described herein, or which can be alternative types of compositions).
  • the aerosol generating material 124 may be present on or in a support to form a substrate 134.
  • a liquid aerosol precursor composition as described herein may be adsorbed on, absorbed in, or otherwise associated with a support to form a substrate 134.
  • the support may be or include, for example, paper, card, paperboard, cardboard, reconstituted material (e.g., a material formed from reconstituted plant material, such as reconstituted tobacco, reconstituted hemp, etc.), a plastics material, a ceramic material, a composite material, glass, a metal, or a metal alloy.
  • the support includes a susceptor, which may be embedded within the support, or on one or either side of the support.
  • the consumable 104 may further include receptacle structured to engage and hold the aerosol generating material 124, or substrate 126 comprising the aerosol generating material.
  • the receptacle may be or include a reservoir, tank, container, cavity, receiving chamber or the like that is structured to receive and contain the aerosol generating material 124 or the substrate 126.
  • the aerosol delivery device 100 also includes an aerosol generator 106.
  • the aerosol generator 106 (also referred to as an atomizer, aerosolizer, or aerosol production component) is configured to energize the aerosol generating material 124 to generate an aerosol, or otherwise cause generation of an aerosol from the aerosol generating material 124.
  • the aerosol generator 106 may be part of the aerosol provision device 102 or the consumable 104. In other implementations, the aerosol generator 106 may be separate from the aerosol provision device 102 and the consumable 104, and removably engaged with the aerosol provision device 102 and/or the consumable 104.
  • the aerosol provision system 100 and its components including the aerosol provision device 102 and the consumable 104 may be reusable or single-use.
  • the aerosol delivery device 100 including both the aerosol provision device 102 and the consumable 104 may be single use.
  • the aerosol provision device 102 may be reusable, and the consumable 104 may be reusable (e.g., refillable) or single use (e.g., replaceable).
  • the consumable 104 may be both refillable and also replaceable.
  • the aerosol generator 106 is part of the aerosol provision device 102 or the consumable 104, the aerosol generator 106 may be reusable or single use in the same manner as the aerosol provision device 102 or the consumable 104.
  • the consumable may include an aerosol generating material transfer component (also referred to as a liquid transport element) configured to transport aerosol generating material to the aerosol generator 106.
  • the aerosol generating material transfer component may be adapted to wick or otherwise transport aerosol generating material via capillary action.
  • the aerosol generating material transfer component may include a microfluidic chip, a micro pump or other suitable component to transport aerosol generating material (e.g., a liquid aerosol precursor composition as described herein).
  • the aerosol provision device 102 may include a housing 108 with a power source 110 and circuitry 112.
  • the power source is configured to provide a source of power to the aerosol provision device and thereby the aerosol provision system 100.
  • the power source may be or include, for example, an electric power source such as a non-rechargeable battery or a rechargeable battery, solid-state battery (SSB), lithium-ion battery, supercapacitor, or the like.
  • the circuitry 112 may be configured to enable one or more functionalities (at times referred to as services) of the aerosol provision device 102 and thereby the aerosol provision system 100.
  • the circuitry includes electronic components, and in some examples one or more of the electronic components may be formed as a circuit board such as a printed circuit board (PCB).
  • PCB printed circuit board
  • the circuitry 112 includes at least one switch 114 that may be directly or indirectly manipulated by a user to activate the aerosol provision device 102 and thereby the aerosol delivery device 100.
  • the switch may be or include a pushbutton, touch-sensitive surface or the like that may be operated manually by a user. Additionally, or alternatively, the switch may be or include a sensor configured to sense one or more process variables that indicate use of the aerosol provision device or aerosol provision system.
  • One example is a flow sensor, pressure sensor, pressure switch or the like that is configured to detect airflow or a change in pressure caused by airflow when a user draws on the consumable 104.
  • the switch 114 may provide user interface functionality.
  • the circuitry 112 may include a user interface (UI) 116 that is separate from or that is or includes the switch.
  • the UI may include one or more input devices and/or output devices to enable interaction between the user and the aerosol provision device 102.
  • suitable input devices include pushbuttons, touch-sensitive surfaces and the like.
  • the one or more output devices generally include devices configured to provide information in a human-perceptible form that may be visual, audible or tactile / haptic. Examples of suitable output devices include light sources such as lightemitting diodes (LEDs), quantum dot-based LEDs and the like. Other examples of suitable output devices include display devices (e.g., electronic visual displays), touchscreens (integrated touch-sensitive surface and display device), loudspeakers, vibration motors and the like.
  • the circuitry 112 includes processing circuitry 118 configured to perform data processing, application execution, or other processing, control or management services according to one or more example implementations.
  • the processing circuitry may include a processor embodied in a variety of forms such as at least one processor core, microprocessor, coprocessor, controller, microcontroller or various other computing or processing devices including one or more integrated circuits such as, for example, an ASIC (application specific integrated circuit), an FPGA (field programmable gate array), some combination thereof, or the like.
  • the processing circuitry may include memory coupled to or integrated with the processor, and which may store data, computer program instructions executable by the processor, some combination thereof, or the like.
  • the housing 108 and thereby the aerosol provision device 102 may also include a coupler 120 and/or a receptacle 122 structured to engage and hold the consumable 104, and thereby couple the aerosol provision device 102 with the consumable 104.
  • the coupler may be or include a connector, fastener or the like that is configured to connect with a corresponding coupler of the consumable, such as by a press fit (or interference fit) connection, threaded connection, magnetic connection or the like.
  • the receptacle may be or include a reservoir, tank, container, cavity, receiving chamber or the like that is structured to receive and contain the consumable or at least a portion of the consumable.
  • the aerosol generator 106 may be powered by the power source 110 under control of the circuitry 112 to energize the aerosol-generating material to generate an aerosol.
  • the aerosol generator 106 is an electric heater configured to perform electric heating in which electrical energy from the power source 110 is converted to heat energy, which the aerosol generating material 124 is subject to so as to release one or more volatiles from the aerosol generating material 124 to form an aerosol.
  • suitable forms of electric heating include resistance (Joule) heating, induction heating, dielectric and micro wave heating, radiant heating, arc heating and the like. More particular examples of suitable electric heaters include resistive heating elements such as wire coils, flat plates, prongs, micro heaters or the like.
  • the aerosol generator 106 is configured to cause an aerosol to be generated from the aerosol generating material 124 without heating, or with only secondary heating.
  • the aerosol generator 106 may be configured to subject the aerosol generating material 124 to one or more of increased pressure, vibration, or electrostatic energy. More particular examples of these aerosol generators include jet nebulizers, ultrasonic wave nebulizers, vibrating mesh technology (VMT) nebulizers, surface acoustic wave (SAW) nebulizers, and the like.
  • a jet nebulizer is configured to use compressed gas (e.g., air, oxygen) to break up aerosol generating material into an aerosol
  • an ultrasonic wave nebulizer is configured to use ultrasonic waves to break up aerosol generating material into an aerosol.
  • a VMT nebulizer includes a mesh, and a piezo material (e.g., piezoelectric material, piezomagnetic material) that may be driven to vibrate and cause the mesh to break up aerosol generating material into an aerosol.
  • a SAW nebulizer is configured to use surface acoustic waves or Rayleigh waves to break up aerosol generating material into an aerosol.
  • the aerosol generator 106 may include a susceptor, or the susceptor may be part of the substrate 126.
  • the susceptor is a material that is heatable by penetration with a varying magnetic field generated by a magnetic field generator that may be separate from or part of the aerosol generator.
  • the susceptor may be an electrically conductive material, so that penetration thereof with a varying magnetic field causes induction heating of the heating material.
  • the heating material may be magnetic material, so that penetration thereof with a varying magnetic field causes magnetic hysteresis heating of the heating material.
  • the susceptor in some examples may be both electrically conductive and magnetic, so that the susceptor of these examples is heatable by both heating mechanisms.
  • the aerosol provision device 102 or the consumable 104 may include an aerosol modifying agent.
  • the aerosol modifying agent is a substance configured to modify the aerosol generated from the aerosol generating material 124, such as by changing the taste, flavor, acidity or another characteristic of the aerosol.
  • the aerosol modifying agent may be an additive or a sorbent.
  • the aerosol modifying agent may include, for example, one or more of a flavorant, colorant, water, or carbon adsorbent.
  • the aerosol modifying agent may be a solid, semisolid, liquid or gel.
  • the aerosol modifying agent may be in powder, thread or granule form.
  • the aerosol modifying agent may be free from filtration material.
  • the aerosol modifying agent may be provided in an aerosol modifying agent release component, that is operable to selectively release the aerosol modifying agent.
  • the aerosol delivery device 100 and its components including the aerosol provision device 102, consumable 104, and aerosol generator 106 may be manufactured with any of a number of different form factors, and with additional or alternative components relative to those described above.
  • FIGS. 2 and 3 illustrate an aerosol delivery device 200 in the form of a vapor product, and that in some example implementations may correspond to the aerosol delivery device 100.
  • the aerosol delivery device 200 may include an aerosol provision device 202 (also referred to as a control body or power unit) and a consumable 204 (also referred to as a cartridge or tank), which may correspond to respectively the aerosol provision device 102 and the consumable 104.
  • the aerosol delivery device 200 and in particular the consumable 204 may also include an aerosol generator corresponding to the aerosol generator 106, and in the form of an electric heater 306 such as a heating element like a metal wire coil configured to convert electrical energy to heat energy through resistance (Joule) heating.
  • the aerosol provision device 202 and the consumable 204 can be permanently or detachably aligned in a functioning relationship.
  • FIGS. 2 and 3 illustrate respectively a perspective view and a partially cut-away side view of the aerosol provision system in a coupled configuration.
  • the aerosol provision device 202 and consumable 204 each include a number of respective components.
  • the components illustrated in FIG. 3 are representative of the components that may be present in an aerosol provision device and consumable and are not intended to limit the scope of components that are encompassed by the present disclosure.
  • the aerosol provision device 202 may include a housing 208 (sometimes referred to as an aerosol provision device shell) that may include a power source 310.
  • the housing may also include circuitry 312 with a switch in the form of a sensor 314, a user interface including a light source 316 that may be illuminated with use of the aerosol provision system 200, and processing circuitry 318 (also referred to as a control component).
  • the housing may also include a receptacle in the form of a consumable receiving chamber 322 structured to engage and hold the consumable 204.
  • the consumable 204 may include an aerosol generating material 324 that may correspond to aerosol generating material 124 as described herein.
  • the aerosol provision device 202 may also include electrical connectors 336 positioned in the consumable receiving chamber 322 configured to electrically couple the circuitry and thereby the aerosol provision device 202 with the consumable 204, and in particular electrical contacts 338 on the consumable 204.
  • the electrical connectors and electrical contacts may form a connection interface of the aerosol provision device and consumable.
  • the aerosol provision device 202 may include an external electrical connector 340 to connect the aerosol provision device with one or more external devices. Examples of suitable external electrical connectors include USB connectors, proprietary connectors such as Apple’s Lightning connector, and the like.
  • the consumable 204 includes a tank portion and a mouthpiece portion.
  • the tank portion and the mouthpiece portion may be integrated or permanently fixed together, or the tank portion may itself define the mouthpiece portion (or vice versa).
  • the tank portion and the mouthpiece portion may be separate and removably engaged with one another.
  • the tank portion and/or mouthpiece portion of consumable 204 may be separately defined in relation to a longitudinal axis (L), a first transverse axis (Tl) that is perpendicular to the longitudinal axis, and a second transverse axis (T2) that is perpendicular to the longitudinal axis and is perpendicular to the first transverse axis.
  • the consumable 204 can be formed of a housing 342 (sometimes referred to as the consumable shell) enclosing a reservoir 344 (in the tank portion) configured to retain the aerosol generating material 324.
  • the consumable may include an aerosol generator, such as electric heater 306 in the illustrated example.
  • the electrical connectors 336 on the aerosol provision device 202 and electrical contacts 338 on the consumable may electrically connect the electric heater with the power source 310 and/or circuitry 312 of the aerosol provision device.
  • the reservoir 344 may be in fluid communication with an aerosol generating material transfer component 346 adapted to wick or otherwise transport aerosol generating material 324 stored in the reservoir housing to the electric heater 306. At least a portion of the aerosol generating material transfer component may be positioned proximate (e.g., directly adjacent, adjacent, in close proximity to, or in relatively close proximity to) the electric heater. The aerosol generating material transfer component may extend between the electric heater and the aerosol generating material stored in the reservoir, and at least a portion of the electric heater may be located above a proximal end the reservoir.
  • the term "above” in this particular context should be interpreted as meaning toward a proximal end of the reservoir and/or the consumable 204 in direction substantially along the longitudinal axis (L).
  • Other arrangements of the aerosol generating material transfer component are also contemplated within the scope of the disclosure.
  • the aerosol generating material transfer component may be positioned proximate a distal end of the reservoir and/or arranged transverse to the longitudinal axis (L).
  • the electric heater 306 and aerosol generating material transfer component 346 may be configured as separate elements that are fluidly connected, the electric heater and aerosol-generating material transfer component or may be configured as a combined element.
  • an electric heater may be integrated into an aerosol generating material transfer component.
  • the electric heater and the aerosol-generating material transfer component may be formed of any construction as otherwise described herein.
  • a valve may be positioned between the reservoir 344 and electric heater and configured to control an amount of aerosol generating material 324 passed or delivered from the reservoir to the electric heater.
  • An opening 348 may be present in the housing 342 (e.g., at the mouth end of the mouthpiece portion) to allow for egress of formed aerosol from the consumable 204.
  • the circuitry 312 of the aerosol provision device 202 may include a number of electronic components, and in some examples may be formed of a circuit board such as a PCB that supports and electrically connects the electronic components.
  • the sensor 314 (switch) may be one of these electronic components positioned on the circuit board.
  • the sensor may comprise its own circuit board or other base element to which it can be attached.
  • a flexible circuit board may be utilized.
  • a flexible circuit board may be configured into a variety of shapes.
  • a flexible circuit board may be combined with, layered onto, or form part or all of a heater substrate.
  • the reservoir 344 may be a container for storing the aerosol generating material 324.
  • the reservoir may be or include a fibrous reservoir with a substrate with the aerosol-generating material present on or in a support.
  • the reservoir can comprise one or more layers of nonwoven fibers substantially formed into the shape of a tube encircling the interior of the housing 342, in this example.
  • the aerosol generating material 324 may be retained in the reservoir. Liquid components, for example, may be sorptively retained by the reservoir.
  • the reservoir may be in fluid connection with the aerosol-generating material transfer component 346.
  • the aerosol generating material transfer component may transport the aerosol generating material 324 stored in the reservoir via capillary action - or via a micro pump - to the electric heater 306. As such, the electric heater is in a heating arrangement with the aerosol-generating material transfer component.
  • the aerosol generator of the aerosol provision system 200 is an electric heater 306 designed to heat the aerosol generating material 324 to generate an aerosol.
  • the aerosol generator is designed to break up the aerosol generating material without heating, or with only secondary heating.
  • FIG. 4 illustrates a nebulizer 400 that may be used to implement the aerosol generator of an aerosol provision system, according to some these other example implementations.
  • the nebulizer 400 includes a mesh plate 402 and a piezo material 404 that may be affixed to one another. The piezo material may be driven to vibrate and cause the mesh plate to break up aerosol-generating material into an aerosol.
  • the nebulizer may also include a supporting component located on a side of the mesh plate opposite the piezo material to increase the longevity of the mesh plate, and/or an auxiliary component between the mesh plate and the piezo material to facilitate interfacial contact between the mesh plate and the piezo material.
  • the mesh plate 402 may have a variety of different configurations.
  • the mesh plate may have a flat profile, a domed shape (concave or convex with respect to the aerosol-generating material), or a flat portion and a domed portion.
  • the mesh plate defines a plurality of perforations 406 that may be substantially uniform or vary in size across a perforated portion of the mesh plate.
  • the perforations may be circular openings or non-circular openings (e.g., oval, rectangular, triangular, regular polygon, irregular polygon).
  • the perforations may have a fixed cross section such as in the case of cylindrical perforations with a fixed circular cross section, or a variable cross section such as in the case of truncated cone perforations with a variable circular cross section.
  • the perforations may be tetragonal or pyramidal.
  • the piezo material 404 may be or include a piezoelectric material or a piezomagnetic material.
  • a piezoelectric material may be coupled to circuitry configured to produce an oscillating electric signal to drive the piezoelectric material to vibrate.
  • the circuitry may produce a pair of antiphase, oscillating electric signals to drive a pair of magnets to produce antiphase, oscillating magnetic fields that drives the piezomagnetic material to vibrate.
  • the piezo material 404 may be affixed to the mesh plate 402, and vibration of the piezo material may in turn cause the mesh plate to vibrate.
  • the mesh plate may be in contact with or immersed in aerosolgenerating material, in sufficient proximity of aerosol-generating material, or may otherwise receive aerosol-generating material via an aerosol-generating material transfer component.
  • the vibration of the mesh plate then, may cause the aerosol-generating material to pass through the perforations 406 that break up the aerosol-generating material into an aerosol. More particularly, in some examples, aerosol-generating material may be driven through the perforations 406 in the vibrating mesh plate 402 resulting in aerosol particles.
  • the vibrating mesh plate may create ultrasonic waves within aerosol-generating material that cause formation of an aerosol at the surface of the aerosol-generating material.
  • hybrid products use a combination of aerosol generating materials, and some hybrid products are similar to vapor products except that the aerosol generated from one aerosol generating material may pass through a second aerosol generating material to pick up additional constituents.
  • Another similar aerosol provision system in the form of a hybrid product may therefore be constructed similar to the vapor product in FIGS. 2 and 3 (with an electric heater 306 or a nebulizer 400).
  • the hybrid product may include a second aerosol generating material through which aerosol from the aerosol generating material 324 is passed to pick up additional constituents before passing through the opening 348 in the mouth end of the aerosol provision system.
  • FIGS. 5, 6 and 7 illustrate an aerosol provision system 500 in the form of a heat-not-bum product, and that in some example implementations may correspond to the aerosol provision system 100.
  • the aerosol provision system may include an aerosol provision device 502 (also referred to as a control body or power unit) and a consumable 504 (also referred to as an aerosol source member), which may correspond to respectively the aerosol provision device 102 and the consumable 104.
  • the aerosol provision system and in particular the aerosol provision device may also include an aerosol generator corresponding to the aerosol generator 106, and in the form of an electric heater 706.
  • the aerosol provision device and the consumable can be permanently or detachably aligned in a functioning relationship.
  • FIG. 5 illustrates the aerosol provision system in a coupled configuration
  • FIG. 6 illustrates the aerosol provision system in a decoupled configuration.
  • FIG. 7 illustrates a partially cut-away side view of the aerosol provision system in the coupled configuration.
  • the aerosol provision device 502 and consumable 504 each include a number of respective components.
  • the components illustrated in the figures are representative of the components that may be present in an aerosol provision device and consumable and are not intended to limit the scope of components that are encompassed by the present disclosure.
  • the aerosol provision device 502 may include a housing 708 (sometimes referred to as an aerosol provision device shell) that may include a power source 710.
  • the housing may also include circuitry 712 with a switch in the form of a sensor 714, a user interface including a light source 716 that may be illuminated with use of the aerosol provision system 500, and processing circuitry 718 (also referred to as a control component).
  • processing circuitry 718 also referred to as a control component.
  • at least some of the electronic components of the circuitry may be formed of a circuit board or a flexible circuit board that supports and electrically connects the electronic components.
  • the housing 708 may also include a receptacle in the form of a consumable receiving chamber 722 structured to engage and hold the consumable 504.
  • the consumable may include an aerosol generating material 624 that may correspond to aerosol generating material 124, and that may include one or more of each of a number of constituents in addition to the aerosol former, nicotine, and organic acid component described above, such as an active substance, flavorant, or functional material.
  • the aerosol generating material 624 may be present on or in a support to form a substrate 634.
  • the consumable 504 may be held in the receiving chamber 722 in varying degrees. In some examples, less than half or approximately half of the consumable may be held in the receiving chamber. In other examples, more than half of the consumable may be held in the receiving chamber. In yet other examples, substantially the entire consumable may be held in the receiving chamber.
  • the consumable 504 may include a heated end 636 sized and shaped for insertion into the aerosol provision device 502, and a mouth end 638 upon which a user draws to create the aerosol.
  • the heated end may include the aerosol-generating material 624.
  • the mouth end 608 of the consumable 504 may include a filter 640 made of a material such as cellulose acetate or polypropylene.
  • the filter may additionally or alternatively contain strands of tobacco containing material.
  • at least a portion of the consumable may be wrapped in an exterior overwrap material, which may be formed of any material useful to provide additional structure, support and/or thermal resistance.
  • an excess length of the overwrap at the mouth end of the consumable may function to simply separate the aerosol-generating material 624 from the mouth of a user or to provide space for positioning of a filter material, or to affect draw on the consumable or to affect flow characteristics of the aerosol leaving the consumable during draw.
  • the electric heater 706 may perform electric heating of the aerosol generating material 624 by resistance (Joule) heating, induction heating, dielectric and microwave heating, radiant heating, arc heating and the like.
  • the electric heater may have a variety of different configurations.
  • at least a portion of the electric heater may surround or at least partially surround at least a portion of the consumable 504 including the aerosol-generating material when inserted in the aerosol provision device 502.
  • at least a portion of the electric heater may penetrate the consumable when the consumable is inserted into the aerosol provision device.
  • the substrate 634 material may include a susceptor, which may be embedded within the aerosol generating material, or on one or either side of the aerosol generating material.
  • the electric heater 706 may instead be a part of the consumable 504.
  • the electric heater or a part of the electric heater may be may be combined, packaged or integral with (e.g., embedded within) the aerosol-generating material 624.
  • the electric heater 706 may extend proximate an engagement end of the housing 708, and may be configured to substantially surround a portion of the heated end 636 of the consumable 504 that includes the aerosol-generating material 624.
  • the electric heater 706 may be or may include an outer cylinder 742, and one or more resistive heating elements 744 such as prongs surrounded by the outer cylinder to create the receiving chamber 722, which may extend from a receiving base 746 of the aerosol provision device to an opening 748 of the housing 708 of the aerosol provision device.
  • the outer cylinder may be a double-walled vacuum tube constructed of stainless steel so as to maintain heat generated by the resistive heating element(s) within the outer cylinder, and more particularly, maintain heat generated by the resistive heating element(s) within the aerosol generating material.
  • the resistive heating element(s) 744 may have a variety of different configurations and vary in number from one resistive heating element to a plurality of resistive heating elements. As shown, the resistive heating element(s) may extend from a receiving base 746 of the aerosol provision device 502. In some examples, the resistive heating element(s) may be located at or around an approximate radial center of the heated end 636 of the consumable 504 when inserted into the aerosol provision device. In some examples, the resistive heating element(s) may penetrate into the heated end of the consumable and in direct contact with the aerosol-generating material. In other examples, the resistive heating element(s) may be located inside (but out of direct contact with) a cavity defined by an inner surface of the heated end of the consumable.
  • the resistive heating element(s) 744 of the electric heater 706 may be connected in an electrical circuit that includes the power source 710 such that electric current produced by the power source may pass through the resistive heating element(s). The passage of the electric current through the resistive heating element(s) may in turn cause the resistive heating element(s) to produce heat through resistance (Joule) heating.
  • the electric heater 706 including the outer cylinder 742 and the resistive heating element(s) 744 may be configured to perform induction heating in which the outer cylinder may be connected in an electrical circuit that includes the power source 710, and the resistive heating element(s) may be connected in another electrical circuit.
  • the outer cylinder and resistive heating element(s) may function as a transformer in which the outer cylinder is an induction transmitter, and the resistive heating element(s) is/are an induction receiver.
  • the outer cylinder and the resistive heating element(s) may parts of the aerosol provision device 502.
  • the outer cylinder may be a part of the aerosol provision device, and the resistive heating element(s) may be a part of the consumable 504.
  • the outer cylinder 730 may be provided an alternating current directly from the power source 710, or indirectly from the power source in which an inverter (as part of the circuitry 712) is configured to convert direct current from the power source to an alternating current.
  • the alternating current drives the outer cylinder to generate an oscillating magnetic field, which induces eddy currents in the resistive heating element(s) 744.
  • the eddy currents in turn cause the resistive heating element(s) to generate heat through resistance (Joule) heating.
  • the resistive heating element(s) may be wirelessly heated to form an aerosol from the aerosol generating material 624 positioned in proximity to the resistive heating element(s).

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions de précurseur d'aérosol conçues pour être utilisées dans un dispositif de distribution d'aérosol. Les compositions de précurseur d'aérosol comprennent un agent de formation d'aérosol, de la nicotine et un composant d'acide organique qui comprend un ester de monomenthyle d'un acide dicarboxylique. L'invention concerne en outre des dispositifs et des kits incorporant de telles compositions de précurseur d'aérosol.
PCT/IB2024/052899 2023-03-30 2024-03-26 Composition de précurseur d'aérosol comprenant un ester de monomenthyle WO2024201300A1 (fr)

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US63/455,872 2023-03-30

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