WO2024197798A1 - Composition pour le soin des matières kératiniques - Google Patents
Composition pour le soin des matières kératiniques Download PDFInfo
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- WO2024197798A1 WO2024197798A1 PCT/CN2023/085408 CN2023085408W WO2024197798A1 WO 2024197798 A1 WO2024197798 A1 WO 2024197798A1 CN 2023085408 W CN2023085408 W CN 2023085408W WO 2024197798 A1 WO2024197798 A1 WO 2024197798A1
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- WIPO (PCT)
- Prior art keywords
- composition
- acid
- magnesium
- composition according
- pca
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 133
- 102000011782 Keratins Human genes 0.000 title claims abstract description 21
- 108010076876 Keratins Proteins 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 title claims abstract description 21
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 29
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229910052751 metal Inorganic materials 0.000 claims abstract description 24
- 239000002184 metal Substances 0.000 claims abstract description 24
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 229940075887 saccharomyces cerevisiae extract Drugs 0.000 claims abstract description 16
- 235000019160 vitamin B3 Nutrition 0.000 claims abstract description 16
- 239000011708 vitamin B3 Substances 0.000 claims abstract description 16
- 229930003537 Vitamin B3 Natural products 0.000 claims abstract description 15
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 11
- 239000008103 glucose Substances 0.000 claims abstract description 11
- 150000002772 monosaccharides Chemical class 0.000 claims abstract description 10
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 7
- 229930091371 Fructose Natural products 0.000 claims abstract description 7
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 7
- 239000005715 Fructose Substances 0.000 claims abstract description 7
- 229930182830 galactose Natural products 0.000 claims abstract description 7
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims abstract description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 19
- 239000002537 cosmetic Substances 0.000 claims description 12
- ZBSGKPYXQINNGF-UHFFFAOYSA-N N-nicotinoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CN=C1 ZBSGKPYXQINNGF-UHFFFAOYSA-N 0.000 claims description 10
- 235000010216 calcium carbonate Nutrition 0.000 claims description 10
- 235000005152 nicotinamide Nutrition 0.000 claims description 10
- 239000011570 nicotinamide Substances 0.000 claims description 10
- 229960003966 nicotinamide Drugs 0.000 claims description 10
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 9
- MVQVNTPHUGQQHK-UHFFFAOYSA-N 3-pyridinemethanol Chemical compound OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 claims description 8
- 229960004738 nicotinyl alcohol Drugs 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000011575 calcium Substances 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 239000010949 copper Substances 0.000 claims description 7
- 229910052802 copper Inorganic materials 0.000 claims description 7
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 6
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 6
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 claims description 6
- 235000001968 nicotinic acid Nutrition 0.000 claims description 6
- 239000011664 nicotinic acid Substances 0.000 claims description 6
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims description 6
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 5
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 150000001735 carboxylic acids Chemical class 0.000 claims description 5
- 229940108925 copper gluconate Drugs 0.000 claims description 5
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims description 5
- 239000011654 magnesium acetate Substances 0.000 claims description 5
- 235000011285 magnesium acetate Nutrition 0.000 claims description 5
- 229940069446 magnesium acetate Drugs 0.000 claims description 5
- 229960001983 magnesium aspartate Drugs 0.000 claims description 5
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 5
- 239000001095 magnesium carbonate Substances 0.000 claims description 5
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 5
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 5
- 239000001755 magnesium gluconate Substances 0.000 claims description 5
- 235000015778 magnesium gluconate Nutrition 0.000 claims description 5
- 229960003035 magnesium gluconate Drugs 0.000 claims description 5
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical group O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 claims description 5
- JQAACYUZYRBHGG-QHTZZOMLSA-L magnesium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Mg+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 JQAACYUZYRBHGG-QHTZZOMLSA-L 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000011670 zinc gluconate Substances 0.000 claims description 5
- 235000011478 zinc gluconate Nutrition 0.000 claims description 5
- 229960000306 zinc gluconate Drugs 0.000 claims description 5
- 235000001465 calcium Nutrition 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- ZQZAHPFFZWEUCL-UHFFFAOYSA-N 2-chloropyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1Cl ZQZAHPFFZWEUCL-UHFFFAOYSA-N 0.000 claims description 3
- WYKHFQKONWMWQM-UHFFFAOYSA-N 2-sulfanylidene-1h-pyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1S WYKHFQKONWMWQM-UHFFFAOYSA-N 0.000 claims description 3
- NOIIUHRQUVNIDD-UHFFFAOYSA-N 3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide Chemical compound C=1C=CC=CC=1CNC(=O)CCNNC(=O)C1=CC=NC=C1 NOIIUHRQUVNIDD-UHFFFAOYSA-N 0.000 claims description 3
- OSMAGAVKVRGYGR-UHFFFAOYSA-N 3-methylpyridine-4-carboxylic acid Chemical compound CC1=CN=CC=C1C(O)=O OSMAGAVKVRGYGR-UHFFFAOYSA-N 0.000 claims description 3
- ZLWYEPMDOUQDBW-UHFFFAOYSA-N 6-aminonicotinamide Chemical compound NC(=O)C1=CC=C(N)N=C1 ZLWYEPMDOUQDBW-UHFFFAOYSA-N 0.000 claims description 3
- IJXDURUAYOKSIS-UHFFFAOYSA-N 6-methylpyridine-3-carboxamide Chemical compound CC1=CC=C(C(N)=O)C=N1 IJXDURUAYOKSIS-UHFFFAOYSA-N 0.000 claims description 3
- ZYVXHFWBYUDDBM-UHFFFAOYSA-N N-methylnicotinamide Chemical compound CNC(=O)C1=CC=CN=C1 ZYVXHFWBYUDDBM-UHFFFAOYSA-N 0.000 claims description 3
- VRAHPESAMYMDQI-UHFFFAOYSA-N Nicomol Chemical compound C1CCC(COC(=O)C=2C=NC=CC=2)(COC(=O)C=2C=NC=CC=2)C(O)C1(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 VRAHPESAMYMDQI-UHFFFAOYSA-N 0.000 claims description 3
- BRZANEXCSZCZCI-UHFFFAOYSA-N Nifenazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C)C(C)=C1NC(=O)C1=CC=CN=C1 BRZANEXCSZCZCI-UHFFFAOYSA-N 0.000 claims description 3
- JRFKIOFLCXKVOT-UHFFFAOYSA-N hydroxymethylnicotinamide Chemical compound OCNC(=O)C1=CC=CN=C1 JRFKIOFLCXKVOT-UHFFFAOYSA-N 0.000 claims description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 3
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 3
- 229960001238 methylnicotinate Drugs 0.000 claims description 3
- FJEVKYZLIRAAKE-UHFFFAOYSA-N n,n-dimethylpyridine-3-carboxamide Chemical compound CN(C)C(=O)C1=CC=CN=C1 FJEVKYZLIRAAKE-UHFFFAOYSA-N 0.000 claims description 3
- JIAOUYONZMRJJD-UHFFFAOYSA-N n-benzylpyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NCC1=CC=CC=C1 JIAOUYONZMRJJD-UHFFFAOYSA-N 0.000 claims description 3
- ZXOAHASJYIUCBG-UHFFFAOYSA-N n-ethylpyridine-3-carboxamide Chemical compound CCNC(=O)C1=CC=CN=C1 ZXOAHASJYIUCBG-UHFFFAOYSA-N 0.000 claims description 3
- NYQXIOZBHWFCBU-UHFFFAOYSA-N n-phenylpyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC1=CC=CC=C1 NYQXIOZBHWFCBU-UHFFFAOYSA-N 0.000 claims description 3
- 229960003057 nialamide Drugs 0.000 claims description 3
- RSKQGBFMNPDPLR-UHFFFAOYSA-N niaprazine Chemical compound C=1C=CN=CC=1C(=O)NC(C)CCN(CC1)CCN1C1=CC=C(F)C=C1 RSKQGBFMNPDPLR-UHFFFAOYSA-N 0.000 claims description 3
- 229960002686 niaprazine Drugs 0.000 claims description 3
- 229950001071 nicomol Drugs 0.000 claims description 3
- 229960002187 nifenazone Drugs 0.000 claims description 3
- QJZUKDFHGGYHMC-UHFFFAOYSA-N pyridine-3-carbaldehyde Chemical compound O=CC1=CC=CN=C1 QJZUKDFHGGYHMC-UHFFFAOYSA-N 0.000 claims description 3
- XQWBMZWDJAZPPX-UHFFFAOYSA-N pyridine-3-carbothioamide Chemical compound NC(=S)C1=CC=CN=C1 XQWBMZWDJAZPPX-UHFFFAOYSA-N 0.000 claims description 3
- ZRKGTINFVOLLNT-UHFFFAOYSA-N pyrrolo[3,4-b]pyridine-5,7-dione Chemical compound C1=CC=C2C(=O)NC(=O)C2=N1 ZRKGTINFVOLLNT-UHFFFAOYSA-N 0.000 claims description 3
- KFLRWGSAMLBHBV-UHFFFAOYSA-M sodium;pyridine-3-carboxylate Chemical compound [Na+].[O-]C(=O)C1=CC=CN=C1 KFLRWGSAMLBHBV-UHFFFAOYSA-M 0.000 claims description 3
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 210000005253 yeast cell Anatomy 0.000 claims description 2
- CRSJYWPXKKSOCQ-CBAPHJFVSA-L magnesium;(2s)-2-aminobutanedioate;hydron;tetrahydrate Chemical compound O.O.O.O.[Mg+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O CRSJYWPXKKSOCQ-CBAPHJFVSA-L 0.000 claims 2
- 239000001967 plate count agar Substances 0.000 claims 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract description 5
- 230000001953 sensory effect Effects 0.000 description 25
- 210000003491 skin Anatomy 0.000 description 23
- 230000000052 comparative effect Effects 0.000 description 22
- 239000012071 phase Substances 0.000 description 18
- 239000003921 oil Substances 0.000 description 11
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 10
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 7
- 229960003957 dexamethasone Drugs 0.000 description 7
- 239000001963 growth medium Substances 0.000 description 7
- JQAACYUZYRBHGG-UHFFFAOYSA-L magnesium pidolate Chemical compound [Mg+2].[O-]C(=O)C1CCC(=O)N1.[O-]C(=O)C1CCC(=O)N1 JQAACYUZYRBHGG-UHFFFAOYSA-L 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000032683 aging Effects 0.000 description 6
- -1 mandelates Chemical class 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 210000002744 extracellular matrix Anatomy 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 150000007522 mineralic acids Chemical class 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
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- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 3
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
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- 230000007423 decrease Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- 229940050168 zinc lactate Drugs 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- WWRJFSIRMWUMAE-ZZMNMWMASA-L zinc;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate Chemical compound [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] WWRJFSIRMWUMAE-ZZMNMWMASA-L 0.000 description 1
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- Human skin is constituted of three compartments, namely a superficial compartment, which is the epidermis, the dermis and a deep compartment, which is the hypodermis.
- the dermis is mainly constituted of fibroblasts and an extracellular matrix (ECM) .
- ECM extracellular matrix
- This extracellular matrix is constituted of various macromolecules responsible for the mechanical strength of the skin, its suppleness, its tonicity and its elasticity, and also for physiologically important functions (hydration, thermoregulation and regulation of the permeability of the skin) .
- macromolecules include, in particular, collagens, elastin and glycoconjugates (glycoproteins and proteoglycans) .
- Collagens represent 70%of the proteins of the ECM. Naturally, collagens are constantly renewed, but this renewal decreases with age, which leads to thinning of the dermis.
- MMPI matrix metalloproteinase 1 or else interstitial collagenase
- a wide variety of cosmetic products have been used to care for the skin, for example, to resist the ageing of the skin.
- some cosmetic products do not deliver a good skin sensory after application.
- An object of the present invention is thus to develop a composition for caring for the skin, which can effectively resist skin ageing and deliver a good skin sensory after application.
- Another object of the present invention is to provide a cosmetic process for caring for the skin.
- compositions for caring for the skin which can effectively resist skin ageing and deliver a good skin sensory after application.
- the present invention provides a composition for caring for keratin materials comprising:
- composition of the present invention can inhibit MMP-1 production, and effectively resist skin ageing.
- composition of the present invention also can deliver a good smoothness and softness sensory.
- the present invention provides a non-therapeutic method for caring for keratin materials, comprising applying the composition according to the first aspect of the present invention to the keratin materials.
- Fig. 1 shows MMP-1 levels of different groups of cells in an in-vitro test.
- keratin materials is intended to cover human skin, mucous membranes such as the lips. Facial skin is most particularly considered according to the present invention.
- composition of the present invention comprises:
- composition of the present invention comprises at least one Saccharomyces cerevisiae extract.
- the Saccharomyces cerevisiae extract is an extract of the yeast cells of Saccharomyces cerevisiae.
- the extract may exclude any other part or element of the yeast such as the wall or the membranes of the yeast.
- the extract can be obtained by a process comprising the following steps: a. solubilization of at least 50 g/L of Saccharomyces cerevisiae in water, by mechanical homogenization, b. separation of the soluble and insoluble phases, c. ultrafiltration and filtrate recovery, and d. molecular sorting, in particular by membrane filtration.
- the extract may comprise a protein fraction.
- the distribution and quantity of the protein fraction can be determined by measuring total nitrogen according to the KJELDHAL method (reference: Official method of analysis of the A.O.C., 12th ed. W Horwitz, E.D., New-York, 15-60, 1975) .
- the extract can be in liquid form or dry form.
- the Saccharomyces cerevisiae extract is present in the composition of the present invention in an amount of dry matter ranging from 0.001 wt. %to 0.375 wt. %, preferably from 0.01 wt. %to 0.175 wt. %, more preferably from 0.05 wt. %to 0.1 wt. %, relative to the total weight of the composition.
- Vitamin B3 and derivatives thereof
- the composition of the present invention comprises at least one compound selected from vitamin B3 and derivatives thereof.
- Vitamin B3 also called vitamin PP, is a compound of the following formula (A) :
- R may be -CONH 2 (niacinamide) , -COOH (nicotinic acid or niacin) , or CH 2 OH (nicotinyl alcohol) , -CO-NH-CH 2 -COOH (nicotinuric acid) or -CO-NH-OH (niconityl hydroxamic acid) .
- Vitamin B3 derivatives that may be mentioned include, for example, nicotinic acid esters such as tocopherol nicotinate, amides derived from niacinamide by substitution of the hydrogen groups of-CONH 2 , products from reaction with carboxylic acids and amino acids, esters of nicotinyl alcohol and of carboxylic acids such as acetic acid, salicyclic acid, glycolid acid or palmitic acid.
- nicotinic acid esters such as tocopherol nicotinate
- amides derived from niacinamide by substitution of the hydrogen groups of-CONH 2 products from reaction with carboxylic acids and amino acids
- esters of nicotinyl alcohol and of carboxylic acids such as acetic acid, salicyclic acid, glycolid acid or palmitic acid.
- vitamin B3 derivatives that may also be mentioned include its inorganic salts, such as chlorides, bromides, iodides or carbonates, and its organic salts, such as the salts obtained by reaction with carboxylic acids, such as acetate, salicylate, glycolate, lactate, malate, citrate, mandelate, tartrate, etc.
- carboxylic acids such as acetate, salicylate, glycolate, lactate, malate, citrate, mandelate, tartrate, etc.
- the compound selected from vitamin B3 and derivatives thereof is selected from niacinamide, nicotinic acid, nicotinyl alcohol, nicotinuric acid, niconityl hydroxamic acid, nicotinic acid esters, esters of nicotinyl alcohol and of carboxylic acids, 2-chloronicotinamide, 6- methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N, N-dimethylnicotinamide, N- (hydroxymethyl) nicotinamide, quinolinic acid imide, nicotinanilide, N-benzylnicotinamide, N-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, nialamide, 2-mercaptonicotinic acid, nicomol and
- the compound selected from vitamin B3 and derivatives thereof is selected from niacinamide, nicotinic acid, nicotinyl alcohol, nicotinuric acid, niconityl hydroxamic acid, and combination thereof.
- the composition of the present invention comprises niacinamide.
- the compound selected from vitamin B3 and derivatives thereof is present in the composition of the present invention in an amount ranging from 0.01 wt. %to 7 wt. %, preferably from 0.1 wt. %to 5 wt. %, more preferably from 0.5 wt. %to 3 wt. %, relative to the total weight of the composition.
- the composition of the present invention comprises at least one divalent metal salt.
- the divalent metal salt comprises a metal ion M1 2+ .
- M1 2+ is selected from Mg 2+ , Ca 2+ , Zn 2+ , and Cu 2+ .
- the divalent metal salt is selected from metal salts of an organic acid or an inorganic acid.
- organic acid mention can be made of ascorbic acid, formic acid, acetic acid, glycolic acid, gluconic acid, aspartic acid, lactic acid, mandelic acid, oxalic acid, maleic acid, malonic acid, glyoxylic acid, succinic acid, adipic acid, fumaric acid, sebacic acid, citric acid, tartaric acid, malic acid, tricarboxylic acid, glutaric acid, glucaric acid, pyrrolidone carboxylic acid, phenol sulfonic acid, salicylic acid, etc.
- ascorbic acid formic acid, acetic acid, glycolic acid, gluconic acid, aspartic acid, lactic acid, mandelic acid, oxalic acid, maleic acid, malonic acid, glyoxylic acid, succinic acid, adipic acid, fumaric acid, sebacic acid, citric acid, tartaric acid, malic acid, tricarboxylic acid, glutaric acid
- inorganic acid mention can be made of sulfuric acid, carbonic acid, silicic acid, hydrochloric acid, nitric acid, phosphoric acid, etc.
- divalent metal salts of an inorganic acid are selected from metal chlorides, sulfates, nitrates, carbonates and hydrogen carbonates, phosphates, silicates, and mixtures thereof, wherein the metal is selected from Mg, Ca, Zn, and Cu.
- divalent metal salts of an inorganic acid are selected from calcium chloride, calcium sulfate, calcium nitrate, calcium carbonate and hydrogen carbonate, calcium phosphate, zinc chloride, zinc sulfate, zinc nitrate, zinc carbonate and hydrogen carbonate, zinc phosphate, magnesium chloride, magnesium sulfate, magnesium nitrate, magnesium carbonate and hydrogen carbonate, magnesium phosphate, copper chloride, copper sulfate, copper nitrate, copper carbonate and hydrogen carbonate, copper phosphate, and mixtures thereof.
- divalent metal salts of an organic acid are selected from metal ascorbates, formates, acetates, glycolates, aspartates, gluconates, lactates, mandelates, oxalates, maleates, malonates, glyoxylates, succinates, adipates, fumarates, sebacates, citrates, tartarates, malates, tricarboxylates, glutarates, glucarates, pyrrolidone carboxylates, phenolsulfonate, salicylates, and mixtures thereof, wherein the metal is selected from Mg, Ca, Zn, and Cu.
- divalent metal salts of an organic acid are selected from magnesium gluconate, magnesium aspartate, magnesium PCA (Magnesium pyrrolidone carboxylate) , magnesium acetate, calcium PCA (calcium pyrrolidone carboxylate) , zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc PCA (zinc pyrrolidone carboxylate) , zinc citrate, zinc ascorbate, zinc aspartate, copper PCA (copper pyrrolidone carboxylate) , copper gluconate, copper aspartate, and mixtures thereof.
- magnesium PCA Magnnesium pyrrolidone carboxylate
- magnesium acetate calcium PCA (calcium pyrrolidone carboxylate)
- calcium PCA calcium pyrrolidone carboxylate
- zinc lactate zinc lactate
- zinc gluconate zinc phenolsulfonate
- zinc salicylate zinc PCA (zinc pyrrolidone carboxylate
- the divalent metal salt is selected from magnesium gluconate, magnesium aspartate, magnesium PCA, magnesium sulfate, magnesium acetate, magnesium carbonate, calcium carbonate, calcium PCA, calcium chloride, calcium carbonate, zinc PCA, zinc gluconate, copper PCA, copper gluconate, and a mixture thereof.
- the divalent metal salt is present in the composition of the present invention in an amount ranging from 0.00001 wt. %to 1 wt. %, preferably from 0.00005 wt. %to 0.5 wt. %, more preferably from 0.0001 wt. %to 0.1 wt. %, relative to the total weight of the composition.
- composition of the present invention comprises at least one at least one monosaccharide selected from mannose, glucose, galactose, fructose, and combinations thereof.
- composition according to the present invention comprises mannose, i.e., the compound of the following formula:
- composition according to the present invention comprises glucose, i.e., the compound of the following formula:
- composition according to the present invention comprises galactose, i.e., the compound of the following formula:
- composition according to the present invention comprises fructose, i.e., the compound of the following formula:
- the composition comprises glucose.
- the monosaccharide is present in the composition of the present invention in an amount ranging from 0.01 wt. %to 2 wt. %, preferably from 0.05 wt. %to 1.5 wt. %, more preferably from 0.1 wt. %to 1 wt. %, relative to the total weight of the composition.
- composition of the present invention may comprise an aqueous phase.
- Said aqueous phase comprises water.
- water is present in the composition of the present invention in an amount ranging from 50 wt. %to 98 wt. %, preferably from 60 wt. %to 95 wt. %, more preferably from 70 wt. %to 93 wt. %, relative to the total weight of the composition.
- the aqueous phase comprises an organic solvent miscible with water (at room temperature 25°C) selected from monoalcohols, glycols and polyols having from 2 to 20 carbon atoms, such as octyldodecanol, glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol, diethylene glycol; and mixtures thereof, so as to provide a hydration effect.
- an organic solvent miscible with water selected from monoalcohols, glycols and polyols having from 2 to 20 carbon atoms, such as octyldodecanol, glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol, diethylene glycol; and mixtures thereof, so as to provide a hydration effect.
- the organic solvent miscible with water selected from monoalcohols, glycols and polyols is present in the composition in an amount ranging from 0.5 wt. %to 20 wt. %, preferably from 1 wt. %to 10 wt. %, relative to the total weight of the composition.
- the continuous aqueous phase of the composition of the present invention comprises water and glycerin.
- composition of the present invention may comprise an oily phase.
- the oily phase contains at least one oil, notably a cosmetic oil. It may also contain other fatty substances.
- oil means a water-immiscible non-aqueous compound that is liquid at room temperature (20°C) and at atmospheric pressure (760 mmHg) .
- the oils may be volatile or non-volatile.
- non-volatile refers to an oil whose vapour pressure at room temperature and atmospheric pressure is non-zero and is less than 10-3 mmHg (0.13 Pa) .
- volatile oil means any oil that is capable of evaporating on contact with the skin in less than one hour, at room temperature and atmospheric pressure.
- the oily phase may comprise hydrocarbon-based oils, silicone oils, or mixtures thereof.
- They may be of animal, plant, mineral or synthetic origin.
- hydrocarbon-based oil means an oil mainly containing hydrogen and carbon atoms.
- the oils may optionally comprise oxygen, nitrogen, sulfur and/or phosphorus atoms, for example in the form of hydroxyl or acid radicals.
- composition of the present invention may comprise an additional cosmetic active ingredient in addition to the cosmetic active compound of formula (I) as defined previously.
- moisturizing agents examples include moisturizing agents; vitamins such as vitamin A (retinol) , vitamin E (tocopherol) , vitamin C (ascorbic acid) , vitamin B5 (panthenol) , and derivatives of said vitamins (in particular esters) and mixtures thereof; brightening agents; tightening agents; peeling agents; moisturizing and hydration agents (HA) , repairing and soothing agents; other anti-aging agents; agents acting on the microcirculation, and mixtu res thereof.
- vitamins such as vitamin A (retinol) , vitamin E (tocopherol) , vitamin C (ascorbic acid) , vitamin B5 (panthenol) , and derivatives of said vitamins (in particular esters) and mixtures thereof
- brightening agents tightening agents
- peeling agents moisturizing and hydration agents (HA) , repairing and soothing agents
- other anti-aging agents agents acting on the microcirculation, and mixtu res thereof.
- composition of the present invention may comprise may also contain conventional cosmetic adjuvants or additives, for instance fragrances, chelating agents, preserving agents and bactericides, surfactants, thickeners, pH regulators, and mixtures thereof.
- conventional cosmetic adjuvants or additives for instance fragrances, chelating agents, preserving agents and bactericides, surfactants, thickeners, pH regulators, and mixtures thereof.
- the present invention provides a composition for caring for keratin materials comprising, relative to the total weight of the composition:
- At least one divalent metal salt is selected from magnesium gluconate, magnesium aspartate, magnesium PCA, magnesium acetate, magnesium carbonate, calcium carbonate, calcium PCA, calcium chloride, calcium carbonate, zinc PCA, zinc gluconate, copper PCA, copper gluconate, and a mixture thereof; and
- composition of the present invention is in the form of emulsion, cream, lotion, or hydrogel.
- composition of the present invention can be used for caring for keratin materials.
- the present invention provides a non-therapeutic method for caring for keratin materials, comprising applying the composition according to the first aspect of the present invention to the keratin materials.
- the present invention provides a non-therapeutic method for antiaging of keratin materials, comprising applying the composition according to the first aspect of the present invention to the keratin materials.
- the keratin material is the skin.
- compositions of invention example (IE) 1 and comparative examples (CE) 1-4 were prepared based on the amounts given in Table 2. The amounts are given in%by weight of active ingredient relative to the total weight of the composition.
- Composition of invention example 1 represents composition according to the present invention.
- Composition of comparative example 1 does not comprise a divalent metal salt.
- Composition of comparative example 2 does not comprise Saccharomyces cerevisiae extract.
- Composition of comparative example 3 does not comprise a compound selected from vitamin B3 and derivatives thereof.
- Composition of comparative example 4 does not comprise a monosaccharide selected from mannose, glucose, galactose, fructose, and combination.
- compositions listed above were prepared as follows:
- phase A1 1) . introducing the components of phase A1 into a main container with mixing and heating to 80°C for 6 minutes;
- phase A2 1) introducing the components of phase A2, the components of Phase A3 with mixing, phase by phase to obtain an uniform mixture;
- phase B water
- HDFs Human primary dermal fibroblasts
- the first group was treated with 0.3 wt. % (based on the total weight of the culture medium) of composition of comparative example 1 for another 24 hours, then subjected to 10J UVA light, and lastly treated with 0.3 wt. %of composition of comparative example 1 for 48 hours.
- the second group was treated with 0.3 wt. %of composition of invention example 1 for another 24 hours, then subjected to 10J UVA light, and lastly treated with 0.3 wt. %of composition of invention example 1 for 48 hours.
- the third group (as positive control) was treated with 0.1uM dexamethasone (DT, as positive control) for another 24 hours, then the human primary dermal fibroblasts were subjected to 10J UVA light, and lastly treated with 0.1uM dexamethasone for 48 hours.
- the fourth group (as blank control A) was cultured with normal culture medium (i.e., not treated with any composition or dexamethasone) for another 24 hours, not subjected to UVA light, and lastly cultured with normal culture medium for 48hours.
- normal culture medium i.e., not treated with any composition or dexamethasone
- the fifth group (as blank control B) was cultured with normal culture medium (i.e., not treated with any composition or dexamethasone) for another 24 hours, then subjected to UVA light, and lastly cultured with normal culture medium for 48hours.
- normal culture medium i.e., not treated with any composition or dexamethasone
- Table 3 shows grouping with different treatment conditions.
- Fig. 1 shows MMP-1 levels of different groups of cells in an in-vitro test.
- composition of inventive example 1 can reverse the MMP-1 release induced by UVA more significantly than composition of comparative example 1.
- composition of invention example 1 delivers better softness sensory
- four experts deem that there is no difference on softness sensory between the two compositions
- one experts deems that composition of comparative example 1 is better than composition of invention example 1 in terms of softness sensory
- six experts deem that composition of invention example 1 delivers better smoothness sensory
- four experts deem that there is no difference on smoothness sensory between the two composition.
- composition of invention example 1 delivers better softness sensory, and three experts deem that there is no difference on softness sensory between the two compositions, while all of 10 experts deem that composition of invention example 1 delivers better smoothness sensory.
- composition of comparative example 3 As compared with composition of comparative example 3, seven experts deem that composition of invention example 1 delivers better softness sensory, and three experts deems that composition of comparative example 3 is better than composition of invention example 1 in terms of softness sensory, while five experts deem that composition of invention example 1 delivers better smoothness sensory, and five experts deem that composition of comparative example 3 is better than composition of invention example 1 in terms of smoothness sensory.
- composition of comparative example 4 delivers better softness sensory and four experts deems that composition of comparative example 4 is better than composition of invention example 1 in terms of softness sensory, while five experts deem that composition of invention example 1 delivers better smoothness sensory and five experts deems that composition of comparative example 4 is better than composition of invention example 1 in terms of smoothness sensory.
- composition of invention example 1 delivers significantly better softness and smoothness sensory than compositions of comparative examples 1 and 2, and significantly better softness sensory than composition of comparative example 3, sightly better softness sensory than compositions of comparative example 4.
- composition according to the present invention can inhibit MMP-1 production, therefore can effectively resist skin ageing, meanwhile, it can deliver a deliver a good smoothness and softness sensory.
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- Microbiology (AREA)
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Abstract
L'invention concerne une composition pour le soin des matières kératiniques comprenant : (i) au moins un extrait de Saccharomyces cerevisiae ; (ii) au moins un composé choisi parmi la vitamine B3 et ses dérivés ; (iii) au moins un sel métallique divalent ; et (iv) au moins un monosaccharide choisi parmi le mannose, le glucose, le galactose, le fructose, et des associations de ceux-ci. L'invention concerne également un procédé non thérapeutique pour le soin des matières kératiniques, comprenant l'application de ladite composition sur les matières kératiniques.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2023/085408 WO2024197798A1 (fr) | 2023-03-31 | 2023-03-31 | Composition pour le soin des matières kératiniques |
FR2304785A FR3147107A1 (fr) | 2023-03-31 | 2023-05-15 | Composition de soin de matières kératineuses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2023/085408 WO2024197798A1 (fr) | 2023-03-31 | 2023-03-31 | Composition pour le soin des matières kératiniques |
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WO2024197798A1 true WO2024197798A1 (fr) | 2024-10-03 |
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PCT/CN2023/085408 WO2024197798A1 (fr) | 2023-03-31 | 2023-03-31 | Composition pour le soin des matières kératiniques |
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FR (1) | FR3147107A1 (fr) |
WO (1) | WO2024197798A1 (fr) |
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CN103153321A (zh) * | 2010-09-30 | 2013-06-12 | Elc管理公司 | 含有吡咯烷酮羧酸锌(zinc pca)和榆绿木(anogeissus)提取物的组合物 |
WO2012072951A1 (fr) * | 2010-12-02 | 2012-06-07 | L'oreal | Utilisation d'extrait de levure du genre saccharomycespour améliorer l'éclat du teint et composition comprenant au moins cet extrait et un agent dépigmentant |
CN108882951A (zh) * | 2016-02-12 | 2018-11-23 | 罗丹菲尔茨有限责任公司 | 保湿组合物及其用途 |
CN105640870A (zh) * | 2016-03-02 | 2016-06-08 | 名臣健康用品股份有限公司 | 一种含酵母提取物的皮肤护理组合物及皮肤护理产品 |
CN110917054A (zh) * | 2019-12-11 | 2020-03-27 | 广州皇伽生物科技有限公司 | 一种护肤品用美白祛斑组合物 |
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