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WO2024091453A1 - Dispositif de positionnement de pulvérisation nasale - Google Patents

Dispositif de positionnement de pulvérisation nasale Download PDF

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Publication number
WO2024091453A1
WO2024091453A1 PCT/US2023/035712 US2023035712W WO2024091453A1 WO 2024091453 A1 WO2024091453 A1 WO 2024091453A1 US 2023035712 W US2023035712 W US 2023035712W WO 2024091453 A1 WO2024091453 A1 WO 2024091453A1
Authority
WO
WIPO (PCT)
Prior art keywords
nasal spray
nasal
user
nozzle
guide
Prior art date
Application number
PCT/US2023/035712
Other languages
English (en)
Inventor
Adam Charles Gold
Shira Leah KOSS
Original Assignee
Gold Product Development, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gold Product Development, Inc. filed Critical Gold Product Development, Inc.
Publication of WO2024091453A1 publication Critical patent/WO2024091453A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the present disclosure relates to nasal spray devices having a positioning device incorporated therewith to provide more accurate spraying into a user’s nasal passage.
  • Nasal spray devices are often used to distribute saline or medication into the nasal passage.
  • fluticasone nasal spray is used to treat allergic rhinitis and sinusitis.
  • Other nasal sprays can address system diseases or central nervous system diseases.
  • the spray should be aimed in specific orientations relative to the nasal passage and intranasal anatomy.
  • Known spray devices do not have any guide for the patient to know how best to position the device during spray. The patient uses the spray without any guide and this can result in the spray not reaching to the target area(s) or depositing excess spray in an anatomic region that could be damaged (i.e., thin nasal septum which can lead to bleeding).
  • the present disclosure provides a nasal spray dispensing device that includes a physical guide that allows the patient to easily align the spray dispensing device around and within the nasal passage at desired angles and depth in order to effectively reach the desired target anatomy while avoiding undesirable spray deposition.
  • the present disclosure provides a nasal spray dispensing device, comprising a nasal spray dispenser having an outlet nozzle through which contents of the spray dispenser are expelled into nasal passageways of a user.
  • the device further includes a nasal spray positioning guide configured to be mated to the nasal spray dispenser so that a distal end of the outlet nozzle extends beyond the nasal spray positioning guide so that a distal end of the outlet nozzle can be inserted into the user’s nasal passageway.
  • the nasal spray positioning guide includes at least one guide member affixed thereto at a preselected angle to abut against a user’s upper lip so that when the distal end of the outlet nozzle is inserted into the user’s nasal passageway said at least one guide member abuts against the user’s upper lip and when activated the nasal spray dispensing bottle directs spray from the nasal spray dispenser at a first preselected angle into the user’s nasal passageway.
  • the nasal spray positioning guide may include a housing adapted to receive therein a nozzle of a nasal spray dispensing dispenser with the at least one guide member being affixed to the housing at the preselected angle.
  • the at least one guide member may be affixed to the housing at said preselected angle to provide a preselected sagittal alignment between the at least one guide member and the nasal passageway of the user.
  • the housing may include inwardly projecting first detents
  • the nasal spray dispenser may include outwardly projecting second detents with the first and second detents positioned relative to each other so that when the housing is pushed down over the nasal spray dispenser the first detents pass over the second detents snapping the housing in place with nozzle of the nasal spray dispensing dispenser extending beyond the housing a preselected distance.
  • the nasal at least one guide member affixed to said nasal spray positioning guide is two guide members with the guide members angled at preselected angles in both the sagittal and coronal planes to provide sagittal and coronal alignment.
  • One of these two guide members may be labelled “left” to abut the user’s upper lip when liquid is being dispensed into the user’s left nostril and the other guide member may be labelled “right” to abut the user’s upper lip when liquid is being dispensed into the user’s right nostril.
  • the nasal spray positioning guide may have a nozzle shaped structure with and internal diameter size suitable to receive therein the outlet nozzle of the nasal spray device, and has a length selected so that the outlet nozzle protrudes through a distal end of the nozzle shaped structure, and wherein the at least one guide member is integrally formed with the nozzle shaped structure as a single unitary piece.
  • the at least one guide member integrally formed with the nozzle shaped structure is integrally formed with a bracket, and the bracket is integrally formed with an outer surface of the nozzle shaped structure.
  • the nasal spray dispensing device may include two guide members with the guide members angled at preselected angles in both the sagittal and coronal planes to provide both sagittal and coronal alignment.
  • These two guide members may be integrally formed with the bracket and are inclined away from each other and inclined with respect to the nozzle shaped structure by preselected angles selected to provide the sagittal and coronal alignment between each guide member and the nasal passageways of the user.
  • the bracket may be integrally formed with the nozzle shaped structure at a location along a length of the nozzle shaped structure so that the distal end of the outlet nozzle can only be inserted into the user’s nasal passageways a maximum preselected distance.
  • the two guide members may each be integrally formed with a bracket with each bracket being integrally formed with the nozzle shaped structure.
  • the two brackets may be integrally formed with the nozzle shaped structure at a location along a length of the nozzle shaped structure so that the distal end of said outlet nozzle can only be inserted into the user’s nasal passageways a maximum preselected distance.
  • the nozzle shaped structure includes a finger ledge extending peripherally around a distal end of the nozzle shaped structure such that when a user’s compresses together a bottom of the nasal spray dispenser and the finger ledge, the liquid in the nasal spray dispenser is forced out of the distal end of the outlet nozzle into the user’s nasal passageway.
  • the present disclosure provides a nasal spray dispensing device, comprising a nasal spray dispenser having an outlet nozzle through which contents of the spray dispenser are expelled into nasal passageways of a user; and a nasal spray positioning guide configured to be mated to the nasal spray dispenser so that a distal end of the outlet nozzle extends beyond the nasal spray positioning guide so that a distal end of the outlet nozzle can be inserted into a user’s nasal passageway, said nasal spray positioning guide including two guide members angled at preselected angles in both the sagittal and coronal planes to provide sagittal and coronal alignment of the nasal spray dispenser once the outlet nozzle is inserted into a nasal passageway of the user and a guide member is bearing against the user’s upper lip.
  • Figure 1a is a side elevation view of a Prior Art standard nasal spray dispenser bottle.
  • Figure 1b is a sagittal angle view of the standard nasal spray device of Figure 1a inserted into the user's nostril where the angle M between the dashed lines represents the angle between the longitudinal axis of the spray nozzle and the horizontal axis (assuming the patient's head is vertical), when looking from the side. This is the sagittal angle.
  • Figure 1c is a coronal angle view of the standard nasal spray device of Figure 1a inserted into the user's nostril where the angle N between the dashed lines represents the angle between the vertical and the spray axis (assuming the patient's head is vertical) when looking from the front. This is the coronal angle.
  • Figure 2 is perspective view of an embodiment of an assembly view of an assembled nasal spray dispenser with the nasal spray positioning device as disclosed herein.
  • Figure 3 is a perspective view of the assembled nasal spray dispenser bottle with the nasal spray positioning device as disclosed herein.
  • Figure 4a shows a side view of a guide section 300 which attaches to spray bottle 301.
  • Figure 4b is a view taken along the line A-A of Figure 4a.
  • Figure 4c is a view looking along arrow C in Figure 3.
  • Figure 5 shows a cutaway of a user’s head and nostrils using the assembled spray dispensing device of Figure 3.
  • Figure 6a shows a sagittal angle view of a user dispensing the contents of the nasal spry dispenser bottle of Figures 7 to 15.
  • Figure 6b shows a coronal angle view of a user dispensing the contents of the nasal spry dispenser bottle of Figures 7 to 15.
  • Figure 7 shows perspective view of another embodiment of a guide attachable to a dispensing container looking up at it.
  • Figure 8 shows perspective view of the guide shown in Figure 7 but looking down at it.
  • Figure 9 is a perspective view similar to Figure 8 but rotated.
  • Figure 10 is a side elevational view of the guide of Figures 7 to 9.
  • Figure 11 is a view along the line 11-11 of Figure 10.
  • Figure 12 is a bottom view of the guide of Figures 7 to 9.
  • Figure 13 is a side elevational view of the guide of Figures 7 to 9.
  • Figure 14 is a disassembled perspective of the guide of Figures 7 to 12 and the spray dispensing bottle.
  • Figure 15 is an assembled perspective view of the device of Figure 14.
  • Figure 16 shows a perspective view of an embodiment of a nasal spray dispenser in which the alignment guide can be affixed to a standard nasal spray nozzle.
  • Figure 17 is a perspective view of the alignment guide of Figure 16 but rotated clockwise.
  • Figure 18 is a perspective view of the alignment guide of Figures 16 and 17 taken from below the guide.
  • Figure 19 is a top view of the alignment guide of Figures 16 to 18.
  • Figure 20 is a view along the line H-H of Figure 19.
  • Figure 21 is a perspective view of the alignment guide of Figures 16 to 20 and a standard nasal spray dispenser bottle disassembled.
  • Figure 22 is a perspective view of the alignment guide of Figures 16 to 20 and a standard nasal spray dispenser bottle of Figure 21 assembled together.
  • Figure 23 is a top view of the alignment guide of Figures 16 to 20 assembled as in Figure 22.
  • Figure 24 is a view along line 24-24 of Figure 23.
  • Figure 25 shows an expanded view of encircled detail J of Figure 24.
  • Figure 26 is a perspective view of another embodiment of an alignment guide integrally formed with a nozzle on a standard nasal spray dispenser.
  • Figure 27 is a perspective view of the alignment guide of Figure 26 from a different angle.
  • Figure 28 is a top view looking down of the alignment guide of Figures 26 and 27.
  • Figure 29 is a view along the line 29-29 of Figure 28.
  • Figure 30 is a vertical elevation view of the alignment guide of Figures 26 to 29.
  • the terms “comprises”, “comprising”, “includes” and “including” are to be construed as being inclusive and open ended, and not exclusive. Specifically, when used in this specification including claims, the terms “comprises”, “comprising”, “includes” and “including” and variations thereof mean the specified features, steps or components are included. These terms are not to be interpreted to exclude the presence of other features, steps or components.
  • the sagittal plane is a vertical plane which passes through the body longitudinally. It divides the body into a left section and a right section.
  • a specific sagittal plane is the median sagittal plane, which passes down the midline of the body, separating it into equal halves.
  • the coronal plane is a vertical plane running from side to side and divides the body or any of its parts into anterior and posterior portions.
  • a standard nasal spray dispenser consists of a bottle 101 that contains medication contained therein and a nozzle 102 which terminates at a swirl atomizer 104.
  • the nozzle 102 is removeable and includes a finger ledge 103.
  • the bottle 101 and nozzle 102 are connected via an internally located pump (not shown).
  • the pump forces mediation up the nozzle 102 and out of swirl atomizer 104 at the distal tip of the nozzle.
  • Known spray bottles such as the one shown in Figure 1a do not have any guide for the patient to know how best to position the bottle during spray.
  • the patient typically uses the spray dispenser without any guide.
  • Figures 1 b sagittal angle view
  • Figure 1c coronal angle view
  • IFU instructions are often ignored and clinicians often do not spend the time during office visits to counsel patients on how to most accurately use nasal sprays. This can result in the spray not reaching to the target area(s) or depositing excess spray in an anatomic region that could be damaged, for example the thin center nasal septum which can lead to bleeding and discontinuation of the medication.
  • FIG. 2 an embodiment of the nasal spray positioning device disclosed herein is shown disassembled in which a guide 300 is attached to the nasal spray bottle 308 as shown in Figure 2.
  • the guide 300 includes an outlet channel 306 and guide 300 fits over the nozzle 305 of bottle 301 while allowing the atomizer 304 to protrude out of outlet channel 306.
  • Figure 3 is a perspective view of the assembled nasal spry dispenser device of Figure 2.
  • Figure 4a shows a side view of a guide section 300 which attaches to spray bottle 301 and
  • Figure 4b is a view taken along the line A-A of Figure 4a while Figure 4c is a view looking along arrow C in Figure 3.
  • Bottle 301 may be a standard commercially available bottle produced with the detents 307 as part of the design.
  • the guide 300 is comprised of a body 303 and an aligner 302 member.
  • bottle 308 includes outwardly projecting detents 307 (Figure 2) and guide 300 has internal protrusions 400 (Figure 4b) which when guide 300 is pushed down over the bottle 308 they pass over detents 307 snapping the guide on place on bottle 308 to hold it in place to secure guide 300 in place on bottle 308.
  • An aligner 302 is rigidly connected to the outlet channel 306 and is include at an angle “X” shown at 401 that is formed between a plane of the aligner 302 and the longitudinal axis of the nozzle 305. This angle X can be between about 10 and about 90 degrees, but is preferably between 60 and 80 degrees.
  • the patient attaches the guide 300 to the nasal spray bottle 301 modified to include detents 307.
  • the patient then inserts the nozzle 305 and atomizer 304 into their nostril and presses the aligner 302 against their lip 501 .
  • the placement of the aligner 302 against the lip 501 ensures the proper spray angle.
  • the user then actuates the nozzle 305 to spray the medication into their nose.
  • the guide 300 may be detached and reattached from the modified spray bottle 300 as desired.
  • This embodiment shown in Figures 2 to 5 has only one alignment surface that can be placed on the upper lip which provides for sagittal angle alignment only of the spray dispenser since it controls the angle M shown in Figure 1 b, but does not control for the angle N shown in Figure 1 c.
  • the guide 300 may be made of plastic such as, but not limited to, polypropylene, elastomer such as silicone, or foam such as polyurethane.
  • the aligner 302 has dimensions of 0.5” wide x 1 ” long in one embodiment. However, smaller or larger dimensions may be used.
  • the above embodiment is one example of the invention. Variations on the invention are also considered.
  • the detents and protrusions that secure the guide 300 to the nozzle 305 may be replaced with adhesive tape.
  • the guide 300 may be made of two halves that clamp around the nozzle in a clam-shell configuration.
  • the guide 300 may be designed to fit over various geometries of nozzle 305, such as those that are radially symmetric.
  • the aligner 302 may also be removable.
  • the guide 300 is not a separate part from the nozzle 305, but rather, they are integrated into one component. This can be adapted to any nozzle shape.
  • guide 105 has a nozzle shaped structure 200 and the guide 105 includes two alignment plates: a left plate 106 and a right plate 107 integrally formed with a bracket 110 shown in Figure 7 and bracket 110 is integrally formed with nozzle shaped housing or structure 200 so the entire guide 105 may be molded as a single unitary piece.
  • bracket 110 is integrally formed with nozzle shaped housing or structure 200 so the entire guide 105 may be molded as a single unitary piece.
  • the plates 106 and 107 are oriented such that their flat faces are at an angle “E” to longitudinal axis “F” of nozzle shaped housing 200, as well as angles “C” and “D” to axis B as shown in Figure 11 .
  • a hole 601 in the bottom of the nozzle 200 as seen in Figure 12 allows it to be removeably attached to the pump 710 shown in Figure 14 in the bottle 704.
  • angle “E” is 60 degrees and angles “C” and “D” are each 72 degrees. However, it is noted that angle “E” can vary from about 10 to about 80 degrees, and angles “C” and “D” can range from about 45 to about 110 degrees.
  • the distance Z from the edge of the plates to center axis “F” may be 1 .3”, but can range from about 0.5” to about 3”.
  • the distance “Y” may be 0.2”, but can range from about 0” to about 0.1 ”.
  • the distance “X” may be about 0.5”, but can range from about 0” to about 2.0”.
  • the user is placing it in their left nostril where they place the alignment plate 106 labeled “Left” flat against their upper lip.
  • This sets the sagittal angle as shown in Figure 1a, as well as the coronal angle as shown in Figure 1b. It also sets the distance that the nozzle 200 is inserted into the nostril.
  • the user then actuates the device to spray into the left nostril.
  • the device can then be switched to the other nostril and the procedure repeated using the other labelled “Right” alignment plate 107.
  • Each guide plate 106 and 107 sets both the coronal and sagittal angles due to the fact that they are each angled in both the sagittal and coronal planes which is the reason for having two plates that are mirror images for left and right nostrils. It is noted that they are not used at the same time. One guide plate is used for the left nostril, then the other is used for the right nostril.
  • Figures 16 to 25 show an embodiment of a nasal spray dispenser in which the alignment guide can be removeably affixed to a standard nasal spray nozzle with Figure 16 being a perspective view of the alignment guide, Figure 17 is a perspective view but rotated clockwise and Figure 18 is a perspective view of the alignment guide taken from below the guide, Figure 19 shows a top view of the alignment guide of and Figure 20 is a view along the line H-H of Figure 19.
  • Figure 21 is a perspective view of the alignment guide and a standard nasal spray dispenser bottle disassembled.
  • the positioning guide can be removably attached to a standard nasal spray nozzle 1402 (Figure 21).
  • the housing 91 is comprised of two alignment plates 92 and 93 integrated into the housing 91 , a hole 94 sized to receive the distal end of nozzle 200 of the dispenser bottle ( Figures 21 and 22), two tabs 95 and 96, and two finger ledges 97 and 98.
  • the tabs 95 and 96 are flexible and have locking wedges 1302 and 1303 on their internal surfaces respectively projecting into the interior of housing 91 .
  • a bottom 1301 surface is defined on the housing 91 to which the positioning guide is mated to.
  • the housing 91 is slid on top of a standard nasal spray nozzle.
  • the tip of the nozzle 200 protrudes through the hole 94 in the housing 91 and the finger grip 1401 (Figure 21) of the nozzle 200 is locked between the bottom surface 1301 of the housing 91 and the locking wedges 1302 and 1303 of housing 91 as seen in Figures 24 and 25.
  • the user can then use the device in a similar manner to that described in the previous embodiment.
  • the two tabs 95 and 96 can be pulled away from the center so that the ramp clears the nozzle finger ledges 97 and 98 and the housing 91 is slid off.
  • the plates may have pin and/or ball and socket connections to allow for adjustable angles. These connections may be held in place by friction or locking screws.
  • the housing 91 shown in Figures 16 to 25 may be attached to the nozzle finger grip 1401 with adhesive tape. In another embodiment, the housing shown in Figures 16 to 25 may be of a clam-shell design to secure onto the nozzle 1402.
  • the medication is not delivered from a multi-dose bottle with metered delivery pump, but rather from a syringe. In another embodiment, the medication is not delivered from a multi-dose bottle with metered delivery pump, but rather from a single or bi-dose delivery mechanism.
  • FIG. 26 to 30 Another embodiment of the invention is illustrated in Figures 26 to 30.
  • This embodiment also is comprised of two alignment plates 1901 and 1902.
  • each alignment plate has an angle to set the sagittal angle, as illustrated by angle “W” in Figure 29, as well as an angle to set the coronal angle, as illustrated by angle “M” in Figure 29.
  • these plates are offset to each other about center axis “N” by angle “L” as shown in Figure 28.
  • alignment plate 1901 is placed against the upper lip with edge 1903 oriented vertically (parallel to the centerline of the face) to spray in the patient’s right nostril.
  • alignment plate 1902 is placed against the upper lip with edge 1904 oriented vertically (parallel to the centerline of the face) to spray in the patient’s left nostril.
  • This embodiment can have similar dimensions to the previous embodiment. Additionally, angle “L” can range from 15 to 180 degrees.
  • Figure 30 shows vertical elevation view of the alignment guide of Figures 26 to 29.
  • FIG. 7 to 30 provides for control of both angles M and N of Figures 1b and 1c thereby controlling both the sagittal and coronal angle alignment of the spray dispenser in both nostrils.
  • One plate is placed against the upper lip when liquid is being sprayed into the left nostril and the other plate is placed against the upper lip when the liquid is being sprayed into the right nostril.
  • Using these alignment plates properly aims the spray in both the sagittal and coronal planes for each nostril.
  • the placement of plates along nozzle 200 controls the depth of insertion of the end section of nozzle 200 into the nostril.
  • the invention can be manufactured from plastic (e.g., polypropylene), elastomer (e.g., silicone), foam (e.g., polyurethane) metal (e.g., stainless steel), or a combination of these materials.
  • plastic e.g., polypropylene
  • elastomer e.g., silicone
  • foam e.g., polyurethane
  • metal e.g., stainless steel
  • part or all of the device may be made from a malleable material (e.g., annealed stainless steel) so that the angle of the plates are adjustable.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

La présente divulgation concerne un dispositif de distribution de pulvérisation nasale ayant une buse de sortie à travers laquelle le contenu du distributeur de pulvérisation est expulsé dans des voies nasales d'un utilisateur et un guide de positionnement de pulvérisation nasale conçu pour être accouplé au distributeur de telle sorte qu'une extrémité distale de la buse de sortie s'étend au-delà du guide de positionnement de façon qu'une extrémité distale de la buse de sortie peut être insérée dans une voie nasale d'un utilisateur. Le guide de positionnement comprend au moins un élément de guidage fixé à celui-ci à un angle présélectionné pour venir en butée contre la lèvre supérieure de l'utilisateur de telle sorte que, lorsque l'extrémité distale de la buse de sortie est insérée dans la voie nasale de l'utilisateur, le ou les éléments de guidage viennent en butée contre la lèvre supérieure de l'utilisateur et lorsqu'ils sont activés, la bouteille de distribution de pulvérisation nasale dirige la pulvérisation depuis le distributeur de pulvérisation nasale à un premier angle présélectionné pour fournir un alignement sagittal optimisé.
PCT/US2023/035712 2022-10-23 2023-10-23 Dispositif de positionnement de pulvérisation nasale WO2024091453A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263418549P 2022-10-23 2022-10-23
US63/418,549 2022-10-23
US202363504513P 2023-05-26 2023-05-26
US63/504,513 2023-05-26

Publications (1)

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WO2024091453A1 true WO2024091453A1 (fr) 2024-05-02

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020174864A1 (en) * 1999-10-14 2002-11-28 Alchas Paul G. Nasal delivery device including spray nozzle
US20130298902A1 (en) * 2010-11-12 2013-11-14 Wolfe Tory Medical, Inc. Atomizer for nasal therapy
US20210220262A1 (en) * 2011-03-15 2021-07-22 Optinose As Nasal delivery
US20220032022A1 (en) * 2019-03-28 2022-02-03 The Board Of Trustees Of The Leland Stanford Junior University Nasal drug delivery system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020174864A1 (en) * 1999-10-14 2002-11-28 Alchas Paul G. Nasal delivery device including spray nozzle
US20130298902A1 (en) * 2010-11-12 2013-11-14 Wolfe Tory Medical, Inc. Atomizer for nasal therapy
US20210220262A1 (en) * 2011-03-15 2021-07-22 Optinose As Nasal delivery
US20220032022A1 (en) * 2019-03-28 2022-02-03 The Board Of Trustees Of The Leland Stanford Junior University Nasal drug delivery system

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