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WO2023186984A3 - Chip, device and method for analysing suspended particles - Google Patents

Chip, device and method for analysing suspended particles Download PDF

Info

Publication number
WO2023186984A3
WO2023186984A3 PCT/EP2023/058145 EP2023058145W WO2023186984A3 WO 2023186984 A3 WO2023186984 A3 WO 2023186984A3 EP 2023058145 W EP2023058145 W EP 2023058145W WO 2023186984 A3 WO2023186984 A3 WO 2023186984A3
Authority
WO
WIPO (PCT)
Prior art keywords
suspended particles
chip
analysing
base body
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2023/058145
Other languages
German (de)
French (fr)
Other versions
WO2023186984A2 (en
Inventor
Stephan Quint
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cysmic GmbH
Original Assignee
Cysmic GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102022107729.2A external-priority patent/DE102022107729A1/en
Application filed by Cysmic GmbH filed Critical Cysmic GmbH
Publication of WO2023186984A2 publication Critical patent/WO2023186984A2/en
Publication of WO2023186984A3 publication Critical patent/WO2023186984A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to a chip (10) for the analysis of suspended particles, wherein the chip (10) comprises a base body (12), wherein the base body (12) has at least one microchannel (20) for the passage of the suspended particles. The invention also relates to a device (48), a system (78) and a method for analysing suspended particles.
PCT/EP2023/058145 2022-03-30 2023-03-29 Chip, device and method for analysing suspended particles Ceased WO2023186984A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102022107557.5 2022-03-30
DE102022107557 2022-03-30
DE102022107729.2A DE102022107729A1 (en) 2022-03-30 2022-03-31 Chip, device and method for analyzing suspended particles
DE102022107729.2 2022-03-31

Publications (2)

Publication Number Publication Date
WO2023186984A2 WO2023186984A2 (en) 2023-10-05
WO2023186984A3 true WO2023186984A3 (en) 2023-11-23

Family

ID=86006830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2023/058145 Ceased WO2023186984A2 (en) 2022-03-30 2023-03-29 Chip, device and method for analysing suspended particles

Country Status (2)

Country Link
DE (1) DE202023002875U1 (en)
WO (1) WO2023186984A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050000312A (en) * 2003-06-23 2005-01-03 (주) 세원메디텍 Apparatus For Measuring Blood Cell Deformability
US20060119836A1 (en) * 2003-06-23 2006-06-08 Yun-Hee Ku Apparatus for measuring blood cell deformability
US20090269837A1 (en) * 2003-03-01 2009-10-29 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US20170087550A1 (en) * 2015-09-29 2017-03-30 Foxconn Interconnect Technology Limited Microfluidic device for detecting cells of blood
WO2021087301A1 (en) * 2019-10-30 2021-05-06 Case Western Reserve University Biochip having microchannel provided with capturing agent for performing cytological analysis
US20210268498A1 (en) * 2020-02-10 2021-09-02 Anpac Bio-Medical Science Co., Ltd. Apparatus and methods for disease detection and treatment
US20220088583A1 (en) * 2019-02-26 2022-03-24 Truvian Sciences, Inc. Assay device and method of use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090269837A1 (en) * 2003-03-01 2009-10-29 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
KR20050000312A (en) * 2003-06-23 2005-01-03 (주) 세원메디텍 Apparatus For Measuring Blood Cell Deformability
US20060119836A1 (en) * 2003-06-23 2006-06-08 Yun-Hee Ku Apparatus for measuring blood cell deformability
US20170087550A1 (en) * 2015-09-29 2017-03-30 Foxconn Interconnect Technology Limited Microfluidic device for detecting cells of blood
US20220088583A1 (en) * 2019-02-26 2022-03-24 Truvian Sciences, Inc. Assay device and method of use thereof
WO2021087301A1 (en) * 2019-10-30 2021-05-06 Case Western Reserve University Biochip having microchannel provided with capturing agent for performing cytological analysis
US20210268498A1 (en) * 2020-02-10 2021-09-02 Anpac Bio-Medical Science Co., Ltd. Apparatus and methods for disease detection and treatment

Also Published As

Publication number Publication date
DE202023002875U1 (en) 2024-12-07
WO2023186984A2 (en) 2023-10-05

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