WO2023106971A1 - Device for reducing pathogens in blood components - Google Patents

Abstract

An apparatus for reducing pathogens in blood components, consisting of two sources of ultraviolet light and two rigid ultraviolet transparent plates, as well as a peristaltic pump and a film cell with serpentine channels and a system of tubing, wherein the ultraviolet light sources are contained in a single housing that forms an irradiation chamber, said chamber having an opening for the introduction of an irradiation assembly consisting of the two rigid ultraviolet transparent plates, which are arranged horizontally with a gap therebetween for receiving the film cell with the serpentine channels. The device is characterized in that the light source is disposed on one side only. The device is further characterized in that the ultraviolet light source has an element for altering the intensity of the ultraviolet light stream. The device is further characterized in that the apparatus includes an assembly for monitoring the weight of a container holding a non-irradiated cellular mass. The device is further characterized in that the distance of the ultraviolet light source to the cell can be adjusted, thus altering the radiation intensity. The technical result is a simplified structure.

Description

Device for pathogenic reduction of blood components.

The device refers to devices for irradiating donor blood components with ultraviolet light of a certain range.

Known apparatus for photophoresis includes a housing that houses a peristaltic pump, a container for blood cells and two blocks of irradiation with ultraviolet lamps. In each block, ultraviolet lamps are located in the same plane. Between the blocks there is a cuvette, which, together with a container for blood cells and tubes, is included in a disposable system. The planes of the ultraviolet lamps in the irradiation blocks are horizontal and parallel. Irradiation blocks are located one above the other and have rigid plates transparent for ultraviolet radiation in front of ultraviolet lamps. The cuvette, which is a film cuvette, is located between rigid plates. [EN 196 088 U1]

The disadvantage of this apparatus is the presence of covers of each body in which solid plates are installed that transmit ultraviolet light.

In addition, the bodies are connected by a hinge and racks of their fixation for the installation of a serpentine film cuvette.

Between the lids it is difficult to fix the cuvette and provide thickness in the cuvette for the flow of blood components.

Fixation is difficult. A system of pins on which the cuvette is pulled is made. Otherwise, she leaves.

EFFECT: simplification of the design.

The technical result is achieved by using a device for pathogenic reduction of blood components, separated from two sources ultraviolet radiation, two rigid plates that transmit ultraviolet, as well as a peristaltic pump, a film cuvette with serpentine channels and tubes, ultraviolet radiation sources are combined into one housing forming an irradiation chamber, which has an opening for introducing an irradiation unit into it, consisting of two rigid plates that transmit ultraviolet, located horizontally with a gap between the plates, while the gap serves to locate a film cuvette with serpentine channels in it.

Alternatively, the UV source can be located on one side only.

The source of ultraviolet radiation may have an element that provides a change in the intensity of the ultraviolet flux.

A node controlling the weight of the container with non-irradiated cell mass can be introduced into the device. The source of ultraviolet radiation can change the distance to the cuvette by changing the intensity of irradiation.

Fixation of a film cuvette with serpentine channels is not difficult. There is no system of pins on which the cuvette is pulled. It is impossible to change its position. It is placed in a kind of tray.

Figure 1 shows the device from the front. Figure 2 is a side view of the device without a wall. Figure 3 - part of the irradiation node.

The device consists of the following elements.

1- Container with non-irradiated cell mass

2- Container with irradiated cell mass

3- Peristaltic pump

4- Tubes

5- Irradiation chamber

6- UV Sources

7- Irradiation unit 8- The plates are rigid, transmitting ultraviolet

9- Cuvette serpentine film

10- Housing of the irradiation unit

The device works as follows.

The cell mass is placed in a container with non-irradiated cell mass 1 and a disposable system is installed, which includes a container with non-irradiated cell mass 1, a container with irradiated cell mass 2, tubes 4. From the container, the cell mass through tube 4 enters the peristaltic pump and from it through the tube into the inlet fitting of the cuvette and from the outlet fitting of the cuvette into a container with irradiated cell mass 2.

The tube 4 is connected to the container with the irradiated cell mass 2. Position 5 in the device indicates the irradiation chamber.

In the irradiation chamber, ultraviolet sources are located at position 6. Position 7 - the irradiation unit, which includes position 8 - rigid plates that transmit ultraviolet. Position 9 - serpentine film cuvette

Position 10 - housing of the irradiation unit.

The device works as follows. The peristaltic pump 3 is turned on and the cell mass from the container 1 through the tube 4 with the help of the pump 3 enters the cuvette, where it is irradiated using ultraviolet irradiation sources.

The cell mass is drained through tube 4 into the Container with irradiated cell mass 2.

The irradiation process is completed.

The pump and radiation source are turned off.

Tube 4 on the fitting through which the serpentine 9 cell mass flows out of the cuvette is raised above the plane of the cuvette. Or at the outlet of the tube through which the cell mass flows out of the cuvette 9 is installed jet. Each of these options creates an overpressure in the cuvette channels, which presses the film cuvette against both UV-transmitting plates.

It is possible to place an element that provides a change in the intensity of radiation. From time to time, the brightness of the LEDs decreases, and if the measurement with a luxmeter shows this, it can be increased with a regulator or by changing the height.

It is possible to place a display and a weighing device on the device, and when the weight becomes zero (minus the weight of the container), the device will turn off.

By changing the height between the rigid plates, which transmit ultraviolet, it is possible to change the thickness of the cell mass flowing through the channels of the cuvette.

Claims

Claim A device for pathogenic reduction of blood components, consisting of two ultraviolet radiation sources, two rigid plates capable of transmitting ultraviolet radiation, a container with non-irradiated cell mass, a container with irradiated cell mass, inlet and outlet fittings of the cuvette, as well as a peristaltic pump, a film cuvette with serpentine channels and tubes, in which ultraviolet radiation sources are combined into one housing forming an irradiation chamber, which has an opening for introducing an irradiation unit into it, consisting of two rigid plates, made with the possibility of transmitting ultraviolet radiation, located horizontally with a gap between the plates, while the gap is made with the possibility of placing a film cuvette with serpentine channels in it, while the ultraviolet radiation source has an element configured to provide a change in the intensity of the ultraviolet flux, in addition, the device is configured to create excess pressure in the channels of the cuvette, which presses the film cuvette against both plates that pass ultraviolet. 2. The device according to paragraph 1, characterized in that the radiation source is located only on one side. 3. The device according to claim 1, characterized in that the ultraviolet radiation source is configured to change the distance to the cuvette and thus change the irradiation intensity. 5